DE69812690D1 - Arzneistoffverabreichungssystem auf basis von flüssigkristall-strukturen - Google Patents

Arzneistoffverabreichungssystem auf basis von flüssigkristall-strukturen

Info

Publication number
DE69812690D1
DE69812690D1 DE69812690T DE69812690T DE69812690D1 DE 69812690 D1 DE69812690 D1 DE 69812690D1 DE 69812690 T DE69812690 T DE 69812690T DE 69812690 T DE69812690 T DE 69812690T DE 69812690 D1 DE69812690 D1 DE 69812690D1
Authority
DE
Germany
Prior art keywords
drug
tpgs
liquid crystal
vitamin
dissolution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69812690T
Other languages
English (en)
Other versions
DE69812690T2 (de
Inventor
L Myers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant International Bermuda
Original Assignee
Biovail Technologies Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovail Technologies Ltd filed Critical Biovail Technologies Ltd
Publication of DE69812690D1 publication Critical patent/DE69812690D1/de
Application granted granted Critical
Publication of DE69812690T2 publication Critical patent/DE69812690T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Liquid Crystal Substances (AREA)
  • Liquid Crystal (AREA)
DE69812690T 1997-11-21 1998-11-03 Arzneistoffverabreichungssystem auf basis von flüssigkristall-strukturen Expired - Lifetime DE69812690T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/975,827 US5891845A (en) 1997-11-21 1997-11-21 Drug delivery systems utilizing liquid crystal structures
US975827 1997-11-21
PCT/US1998/023359 WO1999026607A1 (en) 1997-11-21 1998-11-03 Drug delivery systems utilizing crystal structures

Publications (2)

Publication Number Publication Date
DE69812690D1 true DE69812690D1 (de) 2003-04-30
DE69812690T2 DE69812690T2 (de) 2004-01-22

Family

ID=25523448

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69812690T Expired - Lifetime DE69812690T2 (de) 1997-11-21 1998-11-03 Arzneistoffverabreichungssystem auf basis von flüssigkristall-strukturen

Country Status (9)

Country Link
US (1) US5891845A (de)
EP (1) EP1032373B1 (de)
JP (1) JP2001523705A (de)
AT (1) ATE235235T1 (de)
AU (1) AU1301199A (de)
CA (1) CA2309836C (de)
DE (1) DE69812690T2 (de)
ES (1) ES2196621T3 (de)
WO (1) WO1999026607A1 (de)

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Also Published As

Publication number Publication date
CA2309836C (en) 2006-06-13
WO1999026607A1 (en) 1999-06-03
EP1032373B1 (de) 2003-03-26
AU1301199A (en) 1999-06-15
EP1032373A1 (de) 2000-09-06
ATE235235T1 (de) 2003-04-15
JP2001523705A (ja) 2001-11-27
DE69812690T2 (de) 2004-01-22
CA2309836A1 (en) 1999-06-03
ES2196621T3 (es) 2003-12-16
US5891845A (en) 1999-04-06

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Owner name: BIOVAIL LABORATORIES INTERNATIONAL SRL, ST. MI, BB