HUP0104476A2 - Hidroxi-propil-mutil-cellulóz kapszulákban formázott gyógyszerkészítmények - Google Patents

Hidroxi-propil-mutil-cellulóz kapszulákban formázott gyógyszerkészítmények

Info

Publication number
HUP0104476A2
HUP0104476A2 HU0104476A HUP0104476A HUP0104476A2 HU P0104476 A2 HUP0104476 A2 HU P0104476A2 HU 0104476 A HU0104476 A HU 0104476A HU P0104476 A HUP0104476 A HU P0104476A HU P0104476 A2 HUP0104476 A2 HU P0104476A2
Authority
HU
Hungary
Prior art keywords
capsules
pharmaceutical formulations
active ingredient
hydroxypropylmethylcellulose
hydroxypropylmethylcellulose capsules
Prior art date
Application number
HU0104476A
Other languages
English (en)
Inventor
Paola Civaroli
Alessandro Martini
Lorena Muggetti
Original Assignee
Pharmacia & Upjohn S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn S.P.A. filed Critical Pharmacia & Upjohn S.P.A.
Publication of HUP0104476A2 publication Critical patent/HUP0104476A2/hu
Publication of HUP0104476A3 publication Critical patent/HUP0104476A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány hatóanyagként camptothecin (CPT) analógok félkeménymátrixban diszpergált vagy oldott és hidroxi-propil-metil-cellulózkapszulákba töltött gyógyszerformáira vonatkozik. E kapszulákalkalmazásával kiküszöbölhető a keményzselatin-kapszulák azonhátránya, hogy a tárolás során a kapszulában fellépő térhálósodásifolyamatok eredményeként csökken a hatóanyag oldódásának mértéke. Atalálmány szerinti gyógyszerkészítmények tumorgátló hatásúak. Ó
HU0104476A 1999-08-10 2000-07-11 Pharmaceutical formulations in hydroxypropylmethylcellulose capsules HUP0104476A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9918885.6A GB9918885D0 (en) 1999-08-10 1999-08-10 Pharmaceutical formulations in hydroxypropymethycellulose capsules
PCT/EP2000/006590 WO2001010443A1 (en) 1999-08-10 2000-07-11 Pharmaceutical formulations in hydroxypropylmethylcellulose capsules

Publications (2)

Publication Number Publication Date
HUP0104476A2 true HUP0104476A2 (hu) 2002-03-28
HUP0104476A3 HUP0104476A3 (en) 2004-05-28

Family

ID=10858930

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104476A HUP0104476A3 (en) 1999-08-10 2000-07-11 Pharmaceutical formulations in hydroxypropylmethylcellulose capsules

Country Status (18)

Country Link
US (1) US6569452B1 (hu)
EP (1) EP1126851B1 (hu)
CN (1) CN1245976C (hu)
AR (1) AR025060A1 (hu)
AT (1) ATE262905T1 (hu)
AU (1) AU6158200A (hu)
CA (1) CA2354039C (hu)
CO (1) CO5200854A1 (hu)
CZ (1) CZ293749B6 (hu)
DE (1) DE60009442D1 (hu)
EA (1) EA200100568A1 (hu)
GB (1) GB9918885D0 (hu)
HK (1) HK1040930B (hu)
HU (1) HUP0104476A3 (hu)
IL (2) IL143502A0 (hu)
NO (1) NO319712B1 (hu)
PE (1) PE20010407A1 (hu)
WO (1) WO2001010443A1 (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9925127D0 (en) * 1999-10-22 1999-12-22 Pharmacia & Upjohn Spa Oral formulations for anti-tumor compounds
CN1316970C (zh) * 2002-11-14 2007-05-23 武汉华中科大纳米药业有限公司 一种羟喜树碱固体分散物及其制剂
JP2005183361A (ja) * 2003-10-03 2005-07-07 Ngk Insulators Ltd 電子放出素子、電子放出装置、ディスプレイ及び光源
US20050208146A1 (en) * 2003-10-30 2005-09-22 Pfizer Inc Novel dosage and administration method for oral camptosar
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos
SA06270147B1 (ar) 2005-06-09 2009-12-22 نوفارتيس ايه جي عملية لتخليق 5-(مثيل–1h–إيميدازول–1-يل )–3-(ثلاثي فلـورو مثيل)–بنزامـين
WO2007033522A1 (fr) * 2005-09-21 2007-03-29 Shenzhen Tys R & D Co., Ltd. Formulation de gélule contenant de la moxifloxacine et son procédé de préparation
GB0526419D0 (en) * 2005-12-23 2006-02-08 Cyclacel Ltd Formulation
KR100946275B1 (ko) * 2006-09-26 2010-03-08 주식회사 삼양사 수 난용성 캄토테신 유도체의 미세 나노입자 및 그의제조방법
CA2844367C (en) * 2011-06-24 2016-02-16 Acenda Pharma, Inc. Method and improved pharmaceutical composition for improving the absorption of an ester prodrug
CN103110605A (zh) * 2011-11-17 2013-05-22 天士力制药集团股份有限公司 一种热熔胶囊制剂及其制备方法
EP3094635B1 (en) 2014-01-17 2018-07-04 Oncoral Pharma ApS Solid oral dosage form of irinotecan for the treatment of cancer
CN105287427B (zh) * 2015-10-20 2017-04-19 沈阳红旗制药有限公司 一种利福平半固体胶囊及其制备方法
KR102066402B1 (ko) * 2017-12-22 2020-01-15 대화제약 주식회사 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678516A (en) * 1984-10-09 1987-07-07 The Dow Chemical Company Sustained release dosage form based on highly plasticized cellulose ether gels
EP0758237B1 (en) 1994-04-28 2003-08-27 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin or 7-ethyl camptothecin in dimethylisosorbide or dimethylacetamide
US5597829A (en) 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5756123A (en) * 1994-12-01 1998-05-26 Japan Elanco Co., Ltd. Capsule shell
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
KR20000029784A (ko) 1996-08-02 2000-05-25 나까도미 히로다카 경구제제용캡슐과경구캡슐제제
AR013261A1 (es) * 1997-08-01 2000-12-13 Smithkline Beecham Corp Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina

Also Published As

Publication number Publication date
CZ20012089A3 (cs) 2001-10-17
ATE262905T1 (de) 2004-04-15
WO2001010443A1 (en) 2001-02-15
IL143502A0 (en) 2002-04-21
CZ293749B6 (cs) 2004-07-14
EP1126851B1 (en) 2004-03-31
IL143502A (en) 2006-12-10
CA2354039A1 (en) 2001-02-15
NO319712B1 (no) 2005-09-05
HK1040930A1 (en) 2002-06-28
US6569452B1 (en) 2003-05-27
EA200100568A1 (ru) 2001-10-22
AU6158200A (en) 2001-03-05
NO20013205D0 (no) 2001-06-26
EP1126851A1 (en) 2001-08-29
NO20013205L (no) 2001-06-26
DE60009442D1 (de) 2004-05-06
HK1040930B (zh) 2006-10-27
CN1245976C (zh) 2006-03-22
CN1327387A (zh) 2001-12-19
AR025060A1 (es) 2002-11-06
PE20010407A1 (es) 2001-03-28
HUP0104476A3 (en) 2004-05-28
GB9918885D0 (en) 1999-10-13
CA2354039C (en) 2008-09-23
CO5200854A1 (es) 2002-09-27

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees