IL146659A0 - Porous drug matrices and method of manufacture thereof - Google Patents
Porous drug matrices and method of manufacture thereofInfo
- Publication number
- IL146659A0 IL146659A0 IL14665900A IL14665900A IL146659A0 IL 146659 A0 IL146659 A0 IL 146659A0 IL 14665900 A IL14665900 A IL 14665900A IL 14665900 A IL14665900 A IL 14665900A IL 146659 A0 IL146659 A0 IL 146659A0
- Authority
- IL
- Israel
- Prior art keywords
- drug
- porous matrix
- forming agent
- pore forming
- volatile
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13632399P | 1999-05-27 | 1999-05-27 | |
US15865999P | 1999-10-08 | 1999-10-08 | |
US09/433,486 US6395300B1 (en) | 1999-05-27 | 1999-11-04 | Porous drug matrices and methods of manufacture thereof |
US18631000P | 2000-03-02 | 2000-03-02 | |
PCT/US2000/014578 WO2000072827A2 (en) | 1999-05-27 | 2000-05-25 | Porous drug matrices and methods of manufacture thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IL146659A0 true IL146659A0 (en) | 2002-07-25 |
Family
ID=27495210
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14665900A IL146659A0 (en) | 1999-05-27 | 2000-05-25 | Porous drug matrices and method of manufacture thereof |
IL146659A IL146659A (en) | 1999-05-27 | 2001-11-21 | Methods for preparing a porous matrix of drug |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL146659A IL146659A (en) | 1999-05-27 | 2001-11-21 | Methods for preparing a porous matrix of drug |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1180020B2 (da) |
JP (1) | JP4722295B2 (da) |
KR (2) | KR100752000B1 (da) |
CN (1) | CN1240373C (da) |
AT (1) | ATE312601T1 (da) |
AU (1) | AU768022B2 (da) |
BR (1) | BR0010984A (da) |
CA (1) | CA2371836C (da) |
DE (1) | DE60024811T3 (da) |
DK (1) | DK1180020T4 (da) |
ES (1) | ES2250141T5 (da) |
HK (2) | HK1048956B (da) |
IL (2) | IL146659A0 (da) |
MX (1) | MXPA01012106A (da) |
NO (1) | NO323761B1 (da) |
NZ (1) | NZ516083A (da) |
TW (1) | TWI274589B (da) |
WO (1) | WO2000072827A2 (da) |
Families Citing this family (79)
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US6342533B1 (en) | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
DE60039132D1 (de) | 1999-04-06 | 2008-07-17 | Sepracor Inc | O-Desmethylvenlafaxin-Succinat |
US8771740B2 (en) * | 1999-12-20 | 2014-07-08 | Nicholas J. Kerkhof | Process for producing nanoparticles by spray drying |
MY120279A (en) | 2000-05-26 | 2005-09-30 | Pharmacia Corp | Use of a celecoxib composition for fast pain relief |
US6589557B2 (en) * | 2000-06-15 | 2003-07-08 | Acusphere, Inc. | Porous celecoxib matrices and methods of manufacture thereof |
US6514482B1 (en) | 2000-09-19 | 2003-02-04 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
US6613308B2 (en) * | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
DE10059020A1 (de) * | 2000-11-28 | 2002-05-29 | Gruenenthal Gmbh | Parenteral applizierbare Darreichungsformen |
KR100743404B1 (ko) | 2000-12-21 | 2007-07-30 | 넥타르 테라퓨틱스 | 폴리엔 항균제의 폐 전달 |
JP2004520398A (ja) * | 2001-01-18 | 2004-07-08 | ファルマシア・アンド・アップジョン・カンパニー | 経口生物学的利用能が改善されたパクリタキセルの化学療法マイクロエマルジョン組成物 |
US7115565B2 (en) | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
PT1360169E (pt) † | 2001-02-12 | 2007-10-29 | Wyeth Corp | Sal succinato de o-desmetil-venlafaxina |
WO2002094231A1 (en) * | 2001-05-24 | 2002-11-28 | Alexza Molecular Delivery Corporation | Delivery of analgesics through an inhalation route |
US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
US6805853B2 (en) | 2001-11-09 | 2004-10-19 | Alexza Molecular Delivery Corporation | Delivery of diazepam through an inhalation route |
JP2005503425A (ja) | 2001-05-24 | 2005-02-03 | アレックザ モレキュラー デリヴァリー コーポレイション | 所定の吸入ルートによる薬剤エステルの送出 |
US20030051728A1 (en) | 2001-06-05 | 2003-03-20 | Lloyd Peter M. | Method and device for delivering a physiologically active compound |
US7105178B2 (en) | 2001-07-17 | 2006-09-12 | Sun Pharmaceutical Industries Limited | Cardiotonic composition |
US7005138B2 (en) * | 2001-12-21 | 2006-02-28 | Duramed Pharmaceuticals, Inc. | Method of systematically delivering SSRIs |
WO2003079992A2 (en) | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery for levodopa |
JP4452970B2 (ja) * | 2002-03-27 | 2010-04-21 | 日本臓器製薬株式会社 | ジクロフェナクナトリウム経口製剤 |
US9060941B2 (en) | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US7959946B2 (en) | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US7785627B2 (en) | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US8084058B2 (en) | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US8980870B2 (en) | 2002-09-24 | 2015-03-17 | Boehringer Ingelheim International Gmbh | Solid telmisartan pharmaceutical formulations |
WO2004030659A1 (en) * | 2002-09-30 | 2004-04-15 | Acusphere, Inc. | Sustained release porous microparticles for inhalation |
NZ542548A (en) | 2003-03-31 | 2009-04-30 | Titan Pharmaceuticals Inc | Implantable polymeric device for sustained release of dopamine agonist |
WO2004104490A1 (en) | 2003-05-21 | 2004-12-02 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
GB0401947D0 (en) | 2004-01-28 | 2004-03-03 | Unilever Plc | Porous bodies and method of production thereof |
KR100681660B1 (ko) * | 2004-03-17 | 2007-02-09 | 주식회사종근당 | 방출제어 펠릿의 약제학적 조성물 |
GB0425758D0 (en) | 2004-11-23 | 2004-12-22 | Vectura Ltd | Preparation of pharmaceutical compositions |
EP1681056A1 (en) * | 2005-01-14 | 2006-07-19 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for preparing lansoprazole |
WO2007004236A2 (en) * | 2005-07-04 | 2007-01-11 | Ramu Krishnan | Improved drug or pharmaceutical compounds and a preparation thereof |
GB0517688D0 (en) * | 2005-08-31 | 2005-10-05 | Cambridge Biostability Ltd | Improvements in the stabilisation of biological materials |
GB0523638D0 (en) | 2005-11-21 | 2005-12-28 | Cambridge Biostability Ltd | Pharmaceutical device for the administration of substances to patients |
AR054215A1 (es) * | 2006-01-20 | 2007-06-13 | Eriochem Sa | Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit |
US20100226990A1 (en) * | 2006-01-27 | 2010-09-09 | The Provost, Fellows And Scholars Of The College O | Method of Producing Porous Microparticles |
KR100917809B1 (ko) | 2006-05-22 | 2009-09-18 | 에스케이케미칼주식회사 | 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물 |
GB0613925D0 (en) * | 2006-07-13 | 2006-08-23 | Unilever Plc | Improvements relating to nanodispersions |
EP2121088B1 (en) | 2007-03-09 | 2016-07-13 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
RU2463079C2 (ru) | 2007-04-27 | 2012-10-10 | Эндо Фармасьютикалз Солюшнз Инк. | Разделительные агенты для имплантируемого устройства и способы их применения |
PT103743B (pt) * | 2007-05-16 | 2013-01-15 | Hovione Farmaciencia S A | Processo para preparar derivados de 21-disódio fosfato de pregnanos. |
WO2009027644A2 (en) | 2007-08-24 | 2009-03-05 | Stichting Het Nederlands Kanker Instituut | Composition |
GB0716591D0 (en) * | 2007-08-24 | 2007-10-03 | Vereniging Het Nl Kanker I | Composition |
AU2008311053B2 (en) * | 2007-10-09 | 2012-08-30 | Novartis Ag | Pharmaceutical formulation of valsartan |
KR101024742B1 (ko) * | 2007-12-31 | 2011-03-24 | 주식회사 삼양사 | 탁산 함유 양친성 블록 공중합체 미셀 조성물 및 그 제조방법 |
US9801818B2 (en) | 2007-12-31 | 2017-10-31 | Samyang Biopharmaceuticals Corporation | Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug |
CA2767560A1 (en) * | 2008-07-25 | 2010-01-28 | Alphapharm Pty Ltd | Atovaquone with a particle size diameter range (d90) of greater than 3um to about 10um |
EP2328555A2 (en) * | 2008-08-22 | 2011-06-08 | Slotervaart Participaties BV | Compositions for the treatment of neoplastic diseases |
WO2010102065A1 (en) | 2009-03-05 | 2010-09-10 | Bend Research, Inc. | Pharmaceutical compositions of dextran polymer derivatives |
WO2010111132A2 (en) | 2009-03-27 | 2010-09-30 | Bend Research, Inc. | Spray-drying process |
PT2611529T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Método de secagem por pulverização |
US9084944B2 (en) | 2010-09-03 | 2015-07-21 | Bend Research, Inc. | Spray-drying apparatus and methods of using the same |
WO2012040502A1 (en) | 2010-09-24 | 2012-03-29 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
WO2012114342A1 (en) | 2011-02-23 | 2012-08-30 | Coeruleus Ltd. | Flumazenil complexes, compositions comprising same and uses thereof |
US9084727B2 (en) | 2011-05-10 | 2015-07-21 | Bend Research, Inc. | Methods and compositions for maintaining active agents in intra-articular spaces |
CN103301095B (zh) * | 2012-03-13 | 2016-04-13 | 中国科学院上海药物研究所 | 一种用于提高普罗布考口服吸收的多孔复合载药组合物及其制备方法 |
US20150150788A1 (en) * | 2012-06-22 | 2015-06-04 | The University Of Queensland | Method and composition for delivering a compound through a biological barrier |
US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
PL3154528T3 (pl) * | 2014-06-11 | 2023-07-10 | SpecGx LLC | Suszone rozpyłowo kompozycje o różnych profilach rozpuszczania i sposoby ich wytwarzania |
CA2962719A1 (en) | 2014-10-31 | 2016-05-06 | Bend Research Inc. | Process for forming active domains dispersed in a matrix |
AU2015364280A1 (en) * | 2014-12-18 | 2017-07-06 | Windgap Medical, Inc. | Method and compositions for dissolving or solubilizing therapeutic agents |
RU2750163C2 (ru) * | 2015-06-04 | 2021-06-22 | Крититек, Инк. | Таксановые частицы и их применение |
BR112018005200A2 (pt) | 2015-09-16 | 2018-10-09 | Dfb Soria Llc | liberação de nanopartículas de fármaco e métodos de uso dos mesmos |
RU2737934C2 (ru) | 2016-04-04 | 2020-12-07 | Крититек, Инк. | Способы лечения солидных опухолей |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
KR101965708B1 (ko) * | 2016-08-30 | 2019-04-04 | 이화여자대학교 산학협력단 | 스폰지 유사 구조를 갖는 고분자 미립자 및 이의 제조방법 |
CN110636833A (zh) | 2017-03-15 | 2019-12-31 | Dfb索里亚有限责任公司 | 使用紫杉烷纳米颗粒治疗皮肤恶性肿瘤的局部疗法 |
SG10201913649TA (en) | 2017-06-09 | 2020-03-30 | Crititech Inc | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
CA3063436A1 (en) | 2017-06-14 | 2018-12-20 | Crititech, Inc. | Methods for treating lung disorders |
CN111278436A (zh) | 2017-10-03 | 2020-06-12 | 克里蒂泰克公司 | 局部递送抗肿瘤颗粒与全身递送免疫治疗剂相结合用于治疗癌症 |
CN111836615A (zh) | 2018-01-05 | 2020-10-27 | 英倍尔药业股份有限公司 | 通过精密鼻装置的奥氮平的鼻内递送 |
WO2019178024A1 (en) | 2018-03-16 | 2019-09-19 | Dfb Soria, Llc | Topical therapy for the treatment of cervical intraepithelial neoplasia (cin) and cervical cancer using nanoparticles of taxanes |
AU2020216278A1 (en) * | 2019-01-29 | 2021-07-15 | Bayer Healthcare Llc | Topical gel compositions of naproxen |
CN114269816B (zh) * | 2019-05-10 | 2023-09-19 | 阿诺米拉公司 | 多孔纤维素微粒及其制备方法 |
EP4037666B1 (en) | 2020-12-08 | 2024-05-01 | Ruminant Biotech Corp Limited | Improvements to devices and methods for delivery of substances to animals |
CN113081971A (zh) * | 2021-05-14 | 2021-07-09 | 江西中医药大学 | 一种中药多孔核壳型复合粒子粉体及其制备方法和应用 |
CN117538462B (zh) * | 2024-01-10 | 2024-03-26 | 地奥集团成都药业股份有限公司 | 一种氨氯地平贝那普利胶囊有关物质的检测方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1265615A (da) * | 1970-09-10 | 1972-03-01 | ||
NL7313626A (nl) † | 1973-10-04 | 1975-04-08 | Philips Nv | Gecombineerde inrichting voor het produceren en sselen van warmte met een warmte ver- ende inrichting. |
GB8322007D0 (en) † | 1983-08-16 | 1983-09-21 | Wellcome Found | Pharmaceutical delivery system |
IL82245A (en) * | 1986-04-25 | 1990-07-26 | Basf Ag | Preparation of spray-dried granules of active ingredients |
EP0655237A1 (de) * | 1993-11-27 | 1995-05-31 | Hoechst Aktiengesellschaft | Medizinische Aerosolformulierung |
US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
PT954282E (pt) † | 1997-01-16 | 2005-06-30 | Massachusetts Inst Technology | Preparacao de particulas para inalacao |
JP2001517692A (ja) * | 1997-09-29 | 2001-10-09 | インヘール セラピューティック システムズ, インコーポレイテッド | ネブライザにおける使用のための安定化調製物 |
JP4758525B2 (ja) * | 1998-03-20 | 2011-08-31 | 武田薬品工業株式会社 | 生理活性ポリペプチドの徐放性製剤およびその製造法 |
US6423345B2 (en) * | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
-
2000
- 2000-05-25 AT AT00939365T patent/ATE312601T1/de active
- 2000-05-25 NZ NZ516083A patent/NZ516083A/en not_active IP Right Cessation
- 2000-05-25 EP EP00939365A patent/EP1180020B2/en not_active Expired - Lifetime
- 2000-05-25 MX MXPA01012106A patent/MXPA01012106A/es active IP Right Grant
- 2000-05-25 DE DE60024811T patent/DE60024811T3/de not_active Expired - Lifetime
- 2000-05-25 ES ES00939365T patent/ES2250141T5/es not_active Expired - Lifetime
- 2000-05-25 BR BR0010984-3A patent/BR0010984A/pt not_active IP Right Cessation
- 2000-05-25 DK DK00939365T patent/DK1180020T4/da active
- 2000-05-25 KR KR1020017015052A patent/KR100752000B1/ko not_active IP Right Cessation
- 2000-05-25 WO PCT/US2000/014578 patent/WO2000072827A2/en not_active Application Discontinuation
- 2000-05-25 CN CNB008081611A patent/CN1240373C/zh not_active Expired - Fee Related
- 2000-05-25 IL IL14665900A patent/IL146659A0/xx unknown
- 2000-05-25 AU AU54459/00A patent/AU768022B2/en not_active Ceased
- 2000-05-25 JP JP2000620939A patent/JP4722295B2/ja not_active Expired - Fee Related
- 2000-05-25 CA CA002371836A patent/CA2371836C/en not_active Expired - Fee Related
- 2000-05-25 KR KR1020077012286A patent/KR100883477B1/ko not_active IP Right Cessation
- 2000-05-29 TW TW089110363A patent/TWI274589B/zh not_active IP Right Cessation
-
2001
- 2001-11-21 IL IL146659A patent/IL146659A/en not_active IP Right Cessation
- 2001-11-26 NO NO20015753A patent/NO323761B1/no not_active IP Right Cessation
-
2003
- 2003-02-20 HK HK03101310.8A patent/HK1048956B/zh not_active IP Right Cessation
-
2007
- 2007-02-27 HK HK07102209A patent/HK1094775A1/xx not_active IP Right Cessation
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