BR0010984A - Matrizes porosas de medicamento e processos para fabricação das mesmas - Google Patents

Matrizes porosas de medicamento e processos para fabricação das mesmas

Info

Publication number
BR0010984A
BR0010984A BR0010984-3A BR0010984A BR0010984A BR 0010984 A BR0010984 A BR 0010984A BR 0010984 A BR0010984 A BR 0010984A BR 0010984 A BR0010984 A BR 0010984A
Authority
BR
Brazil
Prior art keywords
drug
porous matrix
forming agent
pore forming
volatile
Prior art date
Application number
BR0010984-3A
Other languages
English (en)
Inventor
Julie Straub
Howard Bernstein
Donald E Chickering Iii
Sarwat Khatak
Greg Randall
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27495210&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0010984(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/433,486 external-priority patent/US6395300B1/en
Application filed by Acusphere Inc filed Critical Acusphere Inc
Publication of BR0010984A publication Critical patent/BR0010984A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Epoxy Compounds (AREA)

Abstract

"MATRIZES POROSAS DE MEDICAMENTO E PROCESSOS PARA FABRICAçãO DAS MESMAS". Medicamentos, especialmente medicamentos de solubilidade aquosa baixa são providos em uma forma de matriz porosa, preferivelmente micropartículas, o que melhora a dissolução do medicamento em um meio aquoso. As matrizes de medicamento preferivelmente são feitas usando um processo que inclui (i) dissolução de um medicamento, preferivelmente um medicamento possuindo uma solubilidade aquosa baixa, em um solvente volátil, para formar uma solução de medicamento, (ii) combinação de pelo menos um agente de formação de poro com a solução de medicamento para formar uma emulsão, suspensão ou segunda solução e (iii) remoção do solvente volátil e agente de formação de poro da emulsão, suspensão ou segunda solução para render a matriz porosa do medicamento. O agente de formação de poro pode ser tanto um líquido volátil que é imiscível com o solvente de medicamento ou um composto sólido volátil, preferivelmente um sal volátil. Em uma concretização preferida, a secagem por aspersão é usada para remover os solventes e o agente de formação de poro. A matriz porosa resultante possui uma razão mais rápida de dissolução, seguindo administração a um paciente, conforme comparado às formas de matriz não porosa do medicamento. Em uma concretização preferida, as micropartículas da matriz de medicamento porosa são reconstituídas com um meio aquoso e administradas parenteralmente ou processadas usando técnica padrão em comprimidos ou cápsulas para administração oral. Paclitaxel ou docetaxel podem ser providos em forma de matriz porosa, o que permite que o medicamento seja formulado sem agentes de solubilização e administrado como um bolo.
BR0010984-3A 1999-05-27 2000-05-25 Matrizes porosas de medicamento e processos para fabricação das mesmas BR0010984A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13632399P 1999-05-27 1999-05-27
US15865999P 1999-10-08 1999-10-08
US09/433,486 US6395300B1 (en) 1999-05-27 1999-11-04 Porous drug matrices and methods of manufacture thereof
US18631000P 2000-03-02 2000-03-02
PCT/US2000/014578 WO2000072827A2 (en) 1999-05-27 2000-05-25 Porous drug matrices and methods of manufacture thereof

Publications (1)

Publication Number Publication Date
BR0010984A true BR0010984A (pt) 2002-04-30

Family

ID=27495210

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0010984-3A BR0010984A (pt) 1999-05-27 2000-05-25 Matrizes porosas de medicamento e processos para fabricação das mesmas

Country Status (18)

Country Link
EP (1) EP1180020B2 (pt)
JP (1) JP4722295B2 (pt)
KR (2) KR100752000B1 (pt)
CN (1) CN1240373C (pt)
AT (1) ATE312601T1 (pt)
AU (1) AU768022B2 (pt)
BR (1) BR0010984A (pt)
CA (1) CA2371836C (pt)
DE (1) DE60024811T3 (pt)
DK (1) DK1180020T4 (pt)
ES (1) ES2250141T5 (pt)
HK (2) HK1048956B (pt)
IL (2) IL146659A0 (pt)
MX (1) MXPA01012106A (pt)
NO (1) NO323761B1 (pt)
NZ (1) NZ516083A (pt)
TW (1) TWI274589B (pt)
WO (1) WO2000072827A2 (pt)

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Also Published As

Publication number Publication date
WO2000072827A2 (en) 2000-12-07
AU768022B2 (en) 2003-11-27
CN1240373C (zh) 2006-02-08
WO2000072827A9 (en) 2002-01-31
KR100752000B1 (ko) 2007-08-28
KR100883477B1 (ko) 2009-02-16
KR20070069219A (ko) 2007-07-02
HK1048956B (zh) 2006-07-28
NO20015753L (no) 2002-01-28
IL146659A (en) 2010-05-31
EP1180020B1 (en) 2005-12-14
ATE312601T1 (de) 2005-12-15
HK1048956A1 (en) 2003-04-25
CA2371836A1 (en) 2000-12-07
CA2371836C (en) 2006-01-31
IL146659A0 (en) 2002-07-25
CN1365274A (zh) 2002-08-21
HK1094775A1 (en) 2007-04-13
TWI274589B (en) 2007-03-01
DE60024811D1 (de) 2006-01-19
JP2003500438A (ja) 2003-01-07
DK1180020T3 (da) 2006-03-27
ES2250141T5 (es) 2009-11-05
DE60024811T2 (de) 2006-09-14
DE60024811T3 (de) 2010-01-07
KR20020011992A (ko) 2002-02-09
NO20015753D0 (no) 2001-11-26
JP4722295B2 (ja) 2011-07-13
EP1180020B2 (en) 2009-06-24
AU5445900A (en) 2000-12-18
DK1180020T4 (da) 2009-10-05
EP1180020A2 (en) 2002-02-20
NO323761B1 (no) 2007-07-02
ES2250141T3 (es) 2006-04-16
MXPA01012106A (es) 2003-06-30
WO2000072827A3 (en) 2001-01-25
NZ516083A (en) 2003-08-29

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