ZA200709483B - Multivalent pneumococcal polysaccharide-protein conjugate composition - Google Patents

Multivalent pneumococcal polysaccharide-protein conjugate composition

Info

Publication number
ZA200709483B
ZA200709483B ZA200709483A ZA200709483A ZA200709483B ZA 200709483 B ZA200709483 B ZA 200709483B ZA 200709483 A ZA200709483 A ZA 200709483A ZA 200709483 A ZA200709483 A ZA 200709483A ZA 200709483 B ZA200709483 B ZA 200709483B
Authority
ZA
South Africa
Prior art keywords
protein conjugate
conjugate composition
pneumococcal polysaccharide
multivalent pneumococcal
multivalent
Prior art date
Application number
ZA200709483A
Other languages
English (en)
Inventor
William P Hausdorff
Siber George Rainer
Peter R Paradiso
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36709976&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200709483(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ZA200709483B publication Critical patent/ZA200709483B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
ZA200709483A 2005-04-08 2007-11-02 Multivalent pneumococcal polysaccharide-protein conjugate composition ZA200709483B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66960505P 2005-04-08 2005-04-08

Publications (1)

Publication Number Publication Date
ZA200709483B true ZA200709483B (en) 2009-03-25

Family

ID=36709976

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200709483A ZA200709483B (en) 2005-04-08 2007-11-02 Multivalent pneumococcal polysaccharide-protein conjugate composition

Country Status (29)

Country Link
US (9) US20060228380A1 (fr)
EP (9) EP2425851A1 (fr)
JP (3) JP4472770B2 (fr)
KR (11) KR101730749B1 (fr)
CN (6) CN104815327A (fr)
AR (2) AR053354A1 (fr)
AT (1) ATE548051T1 (fr)
AU (1) AU2006235013B2 (fr)
BR (1) BRPI0607025B8 (fr)
CA (4) CA3165042A1 (fr)
CL (2) CL2016000566A1 (fr)
CY (1) CY1112777T1 (fr)
DK (1) DK1868645T3 (fr)
ES (1) ES2382048T3 (fr)
HK (3) HK1120416A1 (fr)
HR (1) HRP20120278T1 (fr)
IL (5) IL308456A (fr)
ME (1) ME01334B (fr)
MX (3) MX358148B (fr)
MY (1) MY145150A (fr)
NZ (1) NZ562406A (fr)
PL (1) PL1868645T3 (fr)
PT (1) PT1868645E (fr)
RS (1) RS52249B (fr)
SA (1) SA06270323B1 (fr)
SI (1) SI1868645T1 (fr)
TW (3) TWI386222B (fr)
WO (1) WO2006110381A1 (fr)
ZA (1) ZA200709483B (fr)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7709001B2 (en) * 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
CN104815327A (zh) 2005-04-08 2015-08-05 惠氏有限责任公司 多价肺炎球菌多糖-蛋白质缀合物组合物
US7955605B2 (en) 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US20070184072A1 (en) 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
HUE031380T2 (en) * 2005-06-27 2017-07-28 Glaxosmithkline Biologicals Sa A method for producing vaccines
GB0607088D0 (en) * 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
CA2808919C (fr) * 2005-12-22 2016-04-19 Glaxosmithkline Biologicals S.A. Vaccin comportant des conjugues polysaccharides capsulaires streptococcus pneumoniae
AU2013200552B9 (en) * 2006-04-07 2014-07-03 Glaxosmithkline Biologicals S.A. Conjugate vaccines
AU2016204760A1 (en) * 2006-04-26 2016-07-28 Wyeth Llc Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
AU2012216628B9 (en) * 2006-04-26 2021-10-21 Wyeth Llc Novel Formulations which Stabilize and Inhibit Precipitation of Immunogenic Compositions
TW200806315A (en) * 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
SI2436700T1 (sl) 2007-03-23 2018-09-28 Wyeth Llc Skrajšan postopek čiščenja za proizvodnjo kapsularnih polisaharidov streptococcusa pneumoniae
EP2155244B1 (fr) * 2007-04-23 2017-03-22 Serum Institute of India Private Limited Polysaccharides antigéniques et procédé pour leur préparation
UY31064A1 (es) * 2007-05-02 2009-01-05 Glaxosmithkline Biolog Sa Vacuna
DK2167121T3 (en) 2007-06-26 2015-11-23 Glaxosmithkline Biolog Sa A vaccine comprising Streptococcus pneumoniae kapselpolysaccharidkonjugater
GB0713880D0 (en) * 2007-07-17 2007-08-29 Novartis Ag Conjugate purification
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
WO2009106085A1 (fr) * 2008-02-28 2009-09-03 Nordic Vaccine A/S Compositions vaccinales comprenant des antigènes saccharidiques
EP2293815A4 (fr) * 2008-05-22 2013-04-03 Childrens Medical Center Conjugué immunogène synergique protéine de fusion-polysaccharide
GB0822634D0 (en) 2008-12-11 2009-01-21 Novartis Ag Meningitis vaccines
RU2524436C2 (ru) * 2008-12-18 2014-07-27 УАЙТ ЭлЭлСи Способ получения жидкой фракции, содержащей изолированные высокомолекулярные капсульные полисахариды streptococcus pneumoniae, и жидкая фракция, полученная таким способом
RU2511404C2 (ru) 2008-12-18 2014-04-10 УАЙТ ЭлЭлСи Способ получения раствора, содержащего высокомолекулярные изолированные капсульные полисахариды streptococcus pneumoniae серотипа 19а (варианты)
EP2411048B1 (fr) 2009-03-24 2020-05-06 GlaxoSmithKline Biologicals SA Protéine de liaison du facteur h méningococcique utilisée comme adjuvant
RU2555757C2 (ru) 2009-03-24 2015-07-10 Новартис Аг Комбинации менингококкового фактор н-связывающего белка и пневмококковых сахаридных конъюгатов
KR101450958B1 (ko) * 2009-04-30 2014-10-15 콜레이 파마시티컬 그룹, 인코포레이티드 폐렴구균 백신 및 그의 용도
TW201136603A (en) * 2010-02-09 2011-11-01 Merck Sharp & Amp Dohme Corp 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
CN101785857B (zh) * 2010-03-05 2012-09-26 成都安特金生物技术有限公司 一种新的肺炎球菌结合疫苗及其制备方法
GB201003924D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Immunogenic composition
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
WO2011148382A1 (fr) 2010-05-28 2011-12-01 Biological E Limited Procédé amélioré de purification de polysaccharides capsulaires de haemophilus influenza - b, neisseria meningitides tels que les sérotypes a, c, y et w-135, et d'autres polysaccharides capsulaires apparentés produits à partir de microorganismes à la fois à gram négatif et à gram positif en utilisant un phosphate d'aluminium avec un alcool.
HUE048398T2 (hu) 2010-06-04 2020-07-28 Wyeth Llc Vakcinakészítmények
WO2011161653A1 (fr) 2010-06-25 2011-12-29 Novartis Ag Associations de protéines de liaison du facteur h méningococcique
CA2828844C (fr) 2011-03-02 2020-07-14 Novartis Ag Vaccins combines comprenant des doses inferieures d'antigene et/ou d'adjuvant
KR101315599B1 (ko) * 2011-10-25 2013-10-10 건국대학교 산학협력단 폐렴균점막다당질 유형14 (cps14)와 호스래디시 퍼옥시다제의 당단백중합체
BR112014016223A8 (pt) 2011-12-29 2017-07-04 Novartis Ag combinações adjuvantes de proteínas de ligação de fator h meningocócico
US20150132339A1 (en) 2012-03-07 2015-05-14 Novartis Ag Adjuvanted formulations of streptococcus pneumoniae antigens
JP2015509963A (ja) 2012-03-08 2015-04-02 ノバルティス アーゲー Tlr4アゴニストを含む混合ワクチン
KR102057217B1 (ko) 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
WO2014009971A2 (fr) * 2012-07-07 2014-01-16 Bharat Biotech International Limited Compositions vaccinales sans alcool excluant toute origine animale et leur procédé de préparation
US9517274B2 (en) 2012-08-16 2016-12-13 Pfizer Inc. Glycoconjugation processes and compositions
AU2013311702A1 (en) 2012-09-06 2015-02-19 Novartis Ag Combination vaccines with serogroup B meningococcus and D/T/P
BR112015005081B1 (pt) 2012-09-07 2021-10-26 Sk Bioscience Co., Ltd. Método para produzir um polissacarídeo capsular tendo um sorotipo de pneumococo
KR20140075196A (ko) * 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
KR20140075201A (ko) * 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
JP2016502994A (ja) 2012-12-18 2016-02-01 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム ジフテリア及び/又は破傷風から防御するためのコンジュゲート
ITMI20130142A1 (it) 2013-01-31 2014-08-01 Biosynth Srl Vaccini glicoconiugati comprendenti unita' di base di un costrutto molecolare esprimente epitopi multipli incorporati
CN104151426A (zh) * 2013-05-14 2014-11-19 北京天成新脉生物技术有限公司 肺炎链球菌十三种荚膜多糖单克隆抗体及其应用
CN103495161B (zh) * 2013-10-08 2019-06-18 江苏康泰生物医学技术有限公司 一种多元肺炎球菌荚膜多糖-蛋白质结合物的混合物及其制备方法
CN105934251A (zh) 2014-01-21 2016-09-07 辉瑞大药厂 肺炎链球菌荚膜多糖及其缀合物
MX371453B (es) 2014-01-21 2020-01-29 Pfizer Polisacaridos capsulares de streptococcus pneumoniae y conjugados de los mismos.
US11160855B2 (en) 2014-01-21 2021-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
AU2015208821B2 (en) * 2014-01-21 2017-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
ES2930318T3 (es) 2014-02-14 2022-12-09 Pfizer Conjugados glucoproteicos inmunogénicos
US9815886B2 (en) 2014-10-28 2017-11-14 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
FI3244917T3 (fi) 2015-01-15 2023-05-25 Pfizer Immunogeenisiä koostumuksia pneumokokkirokotteissa käytettäväksi
IL297740A (en) * 2015-05-04 2022-12-01 Pfizer Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses
LT3313436T (lt) 2015-06-23 2021-06-10 Biological E Limited Daugiavalentė pneumokokinė konjuguota vakcina
TWI756893B (zh) 2015-07-21 2022-03-01 美商輝瑞股份有限公司 包含經共軛之莢膜糖抗原的致免疫性組成物、包含該致免疫性組成物之套組及彼等之用途
KR20200038339A (ko) * 2015-09-10 2020-04-10 인벤트프라이즈 엘엘씨 다가 vlp 접합체
CA3005524C (fr) 2015-11-20 2023-10-10 Pfizer Inc. Compositions immunogenes destinees a etre utilisees dans des vaccins pneumococciques
EP3493840B1 (fr) 2016-08-05 2022-08-24 Sanofi Pasteur Inc. Composition d'un conjugué polysaccharide-protéine pneumococcique multivalent
MX2019001342A (es) * 2016-08-05 2019-07-04 Sanofi Pasteur Inc Composicion de conjugado de proteina-polisacarido de neumococo multivalente.
MX2019002552A (es) * 2016-09-06 2019-07-01 Lg Chemical Ltd Composicion que comprende polisacarido capsular neumococico multivalente-proteina transportadora y uso de la misma.
EP3518965A1 (fr) * 2016-09-30 2019-08-07 Biological E Limited Compositions de vaccin antipneumococcique multivalent comprenant des conjugués polysaccharide-protéine
US10751402B2 (en) 2016-11-09 2020-08-25 Pfizer Inc. Immunogenic compositions and uses thereof
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
KR20190103256A (ko) 2016-12-30 2019-09-04 수트로박스, 인코포레이티드 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체
DK3570879T3 (da) 2017-01-20 2022-04-11 Pfizer Immunogene sammensætninger til anvendelse i pneumokokvacciner
EP3576759A4 (fr) * 2017-01-31 2020-11-11 Merck Sharp & Dohme Corp. Procédés de production de conjugués protéine-polysaccharide capsulaire à partir du sérotype 19f de streptococcus pneumoniae
EP3576784A4 (fr) 2017-01-31 2020-11-11 Merck Sharp & Dohme Corp. Procédés de fabrication de conjugués polysaccharides-protéine
CA3052621A1 (fr) 2017-02-03 2018-08-09 Schadeck, Eva Barbara Compositions de conjugue saccharide d'haemophilus influenzae-excipient et leurs utilisations
JP2020514326A (ja) 2017-02-24 2020-05-21 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 肺炎連鎖球菌多糖−タンパク質コンジュゲートの免疫原性の増強
BR112019017390A2 (pt) * 2017-02-24 2020-03-31 Merck Sharp & Dohme Corp. Formulações de vacina pneumocócica conjugada e uso das mesmas
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
KR102028693B1 (ko) * 2017-04-27 2019-10-04 주식회사 유바이오로직스 스트렙토코커스 뉴모니아 협막 다당체의 생산방법
KR20240018697A (ko) 2017-06-10 2024-02-13 인벤트프라이즈 인크. 면역원성과 항원항체 결합성이 개선된 2가 또는 다가 접합체 다당류를 가진 다가 접합체 백신
US10729763B2 (en) 2017-06-10 2020-08-04 Inventprise, Llc Mixtures of polysaccharide-protein pegylated compounds
SG11201912601RA (en) 2017-06-23 2020-01-30 Nosocomial Vaccine Corp Immunogenic compositions
EP3431168A1 (fr) * 2017-07-19 2019-01-23 Bayer Aktiengesellschaft Élimination de médicament non lié après accouplement conjugué anticorps-médicament
KR20200051003A (ko) * 2017-09-07 2020-05-12 머크 샤프 앤드 돔 코포레이션 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도
KR20200051005A (ko) 2017-09-07 2020-05-12 머크 샤프 앤드 돔 코포레이션 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도
CA3074708A1 (fr) 2017-09-07 2019-03-14 Merck Sharp & Dohme Corp. Polysaccharides antipneumococciques et leur utilisation dans des conjugues immunogenes polysaccharide-proteine porteuse
AU2018328035B2 (en) 2017-09-07 2024-03-07 Chitrananda Abeygunawardana Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates
EP3720483A2 (fr) 2017-12-06 2020-10-14 Merck Sharp&Dohme Corp. Compositions comprenant des conjugués polysaccharide-protéine de streptococcus pneumoniae et leurs méthodes d'utilisation
EP3749358A4 (fr) * 2018-02-05 2022-04-20 Sanofi Pasteur, Inc. Composition de conjugué polysaccharide-protéine pneumococcique multivalent
IL304977A (en) 2018-02-05 2023-10-01 Sanofi Pasteur Inc A multivalent pneumococcal protein-polysaccharide conjugate preparation
BR112020021296A2 (pt) 2018-04-18 2021-01-26 Sk Bioscience Co., Ltd. polissacarídeo capsular de streptococcus pneumoniae e conjugado imunogênico do mesmo
WO2019212846A1 (fr) 2018-04-30 2019-11-07 Merck Sharp & Dohme Corp. Procédés de production de conjugués protéine porteuse-polysaccharide capsulaire de streptococcus pneumoniae
KR20210002641A (ko) 2018-04-30 2021-01-08 머크 샤프 앤드 돔 코포레이션 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법
JP7489324B2 (ja) * 2018-04-30 2024-05-23 メルク・シャープ・アンド・ドーム・エルエルシー リオスフィアから肺炎連鎖球菌莢膜多糖類キャリアタンパク質コンジュゲートを生産する方法
WO2019220304A1 (fr) * 2018-05-14 2019-11-21 Tergene Biotech Pvt. Ltd. Vaccin conjugué de polysaccharide pneumococcique 15-valent
WO2020010000A1 (fr) 2018-07-04 2020-01-09 Sutrovax, Inc. Procédés améliorés pour la préparation de conjugués immunogènes
AU2019299836A1 (en) 2018-07-04 2021-02-25 Vaxcyte, Inc. Improvements in immunogenic conjugates
WO2020010016A1 (fr) 2018-07-04 2020-01-09 Sutrovax, Inc. Conjugués immunogènes auto-adjuvés
US11260119B2 (en) 2018-08-24 2022-03-01 Pfizer Inc. Escherichia coli compositions and methods thereof
SG11202102007UA (en) * 2018-09-12 2021-03-30 Affinivax Inc Multivalent pneumococcal vaccines
WO2020075201A1 (fr) * 2018-10-12 2020-04-16 Biological E Limited Vaccin conjugué polysaccharide pneumococcique-protéine multivalent
JP2022512345A (ja) 2018-12-12 2022-02-03 ファイザー・インク 免疫原性多重ヘテロ抗原多糖-タンパク質コンジュゲートおよびその使用
CR20210333A (es) 2018-12-19 2021-08-18 Merck Sharp & Dohme Composiciones que comprenden conjugados de polisacárido de streptococcus pneumoniae con proteína y sus métodos de uso
JP7239509B6 (ja) 2019-02-22 2023-03-28 ファイザー・インク 細菌多糖類を精製するための方法
JP2022528158A (ja) 2019-04-10 2022-06-08 ファイザー・インク コンジュゲート化莢膜糖抗原を含む免疫原性組成物、それを含むキットおよびその使用
CN110302375A (zh) * 2019-06-27 2019-10-08 康希诺生物股份公司 一种糖缀合物及其用途
EP4003410A1 (fr) 2019-07-31 2022-06-01 Sanofi Pasteur, Inc. Compositions de conjugués de polysaccharide-protéine pneumococcique multivalents leurs méthodes d'utilisation
CN112741901B (zh) * 2019-10-31 2024-05-10 北京科兴中维生物技术有限公司 一种含有5型肺炎链球菌荚膜多糖的疫苗及其制备方法
IL292494A (en) 2019-11-01 2022-06-01 Pfizer Preparations of Escherichia coli and their methods
AU2021207701A1 (en) * 2020-01-17 2022-09-15 Bill & Melinda Gates Foundation Multivalent Streptococcus vaccines
AU2021224078B2 (en) * 2020-02-21 2024-01-18 Pfizer Inc. Purification of saccharides
EP4107170A2 (fr) 2020-02-23 2022-12-28 Pfizer Inc. Escherichia coli compositions d'et méthodes associées
CA3192786A1 (fr) 2020-08-26 2022-03-03 Pfizer Inc. Conjugues polysaccharide-proteine de streptococcus du groupe b, procedes de production de conjugues, compositions immunogenes comprenant les conjugues et leurs utilisations
GB202016165D0 (en) 2020-10-12 2020-11-25 Optivalent Ltd Vaccine
EP4232593A1 (fr) 2020-10-22 2023-08-30 Pfizer Inc. Procédés de purification de polysaccharides bactériens
TW202227467A (zh) 2020-10-27 2022-07-16 美商輝瑞大藥廠 大腸桿菌組合物及其方法
KR20230097160A (ko) 2020-11-04 2023-06-30 화이자 인코포레이티드 폐렴구균 백신에 사용하기 위한 면역원성 조성물
JP2023549736A (ja) 2020-11-10 2023-11-29 ファイザー・インク コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用
US20220202923A1 (en) 2020-12-23 2022-06-30 Pfizer Inc. E. coli fimh mutants and uses thereof
KR102610292B1 (ko) * 2021-02-10 2023-12-04 에스케이바이오사이언스(주) 스트랩토코커스 뉴모니애 다당류와 운반체 단백질의 접합체 제조 방법
WO2022234416A1 (fr) 2021-05-03 2022-11-10 Pfizer Inc. Vaccination contre des infections à pneumocoque et à covid-19
JP2024517780A (ja) 2021-05-03 2024-04-23 ファイザー・インク 細菌およびベータコロナウイルス感染症に対するワクチン接種
TW202306969A (zh) 2021-05-28 2023-02-16 美商輝瑞大藥廠 包含結合之莢膜醣抗原的免疫原組合物及其用途
PE20240090A1 (es) 2021-05-28 2024-01-16 Pfizer Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados y sus usos
CN114106210A (zh) * 2021-11-09 2022-03-01 北京智飞绿竹生物制药有限公司 一种23价肺炎球菌多糖疫苗的生产工艺
WO2023135515A1 (fr) 2022-01-13 2023-07-20 Pfizer Inc. Compositions immunogènes à base d'antigènes saccharidiques capsulaires conjugués et leurs utilisations
GB2614916A (en) 2022-01-25 2023-07-26 Optivalent Ltd Intradermal vaccine complement
WO2023161817A1 (fr) 2022-02-25 2023-08-31 Pfizer Inc. Procédés d'incorporation de groupes azido dans des polysaccharides capsulaires bactériens
WO2023218322A1 (fr) 2022-05-11 2023-11-16 Pfizer Inc. Procédé de production de formulations de vaccin avec des conservateurs
WO2024062494A1 (fr) 2022-09-19 2024-03-28 Biological E Limited Procédé de purification de polysaccharides capsulaires
WO2024084397A1 (fr) 2022-10-19 2024-04-25 Pfizer Inc. Vaccination contre infections à pneumocoques et à covid-19

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37741A (en) 1863-02-24 Improvement in bee-hives
US4097666A (en) 1976-04-29 1978-06-27 The Institute Of Paper Chemistry Solvent system for polysaccharides
CA1115210A (fr) 1977-11-28 1981-12-29 Dennis J. Carlo Vaccin contre les pneumocoques
US4372945A (en) 1979-11-13 1983-02-08 Likhite Vilas V Antigen compounds
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
BE889979A (fr) 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4902506A (en) * 1983-07-05 1990-02-20 The University Of Rochester Immunogenic conjugates
US5360897A (en) * 1981-08-31 1994-11-01 The University Of Rochester Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad
US5097020A (en) 1983-07-05 1992-03-17 The University Of Rochester Immunogenic conjugates
US4619828A (en) 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
CH660375A5 (it) 1983-02-08 1987-04-15 Sclavo Spa Procedimento per la produzione di proteine correlate alla tossina difterica.
US4762713A (en) * 1983-07-05 1988-08-09 The University Of Rochester Boosting of immunogenic conjugate vaccinations by unconjugated bacterial capsular polymers
US4761283A (en) * 1983-07-05 1988-08-02 The University Of Rochester Immunogenic conjugates
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
IT1187753B (it) 1985-07-05 1987-12-23 Sclavo Spa Coniugati glicoproteici ad attivita' immunogenica trivalente
US5110908A (en) 1986-12-31 1992-05-05 Praxis Biologics, Inc. Haemophilus influenzae peptides and proteins
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
DE69012318T2 (de) 1989-03-09 1995-03-09 Praxis Biolog Inc Impfstoffe gegen hämophilus influenzae.
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
SE466259B (sv) 1990-05-31 1992-01-20 Arne Forsgren Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
US5153312A (en) * 1990-09-28 1992-10-06 American Cyanamid Company Oligosaccharide conjugate vaccines
CA2059693C (fr) 1991-01-28 2003-08-19 Peter J. Kniskern Antigenes polysaccharides de streptococcus pneumoniae
CA2059692C (fr) * 1991-01-28 2004-11-16 Peter J. Kniskern Vaccin conjugue de polysaccharide contre les pneumocoques
IL101715A (en) 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs
US5552146A (en) 1991-08-15 1996-09-03 Board Of Regents, The University Of Texas System Methods and compositions relating to useful antigens of Moraxella catarrhalis
WO1993013302A1 (fr) 1991-12-23 1993-07-08 Michael Zoche Moteur avec deshuileur
IT1253009B (it) 1991-12-31 1995-07-10 Sclavo Ricerca S R L Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini
DE69434079T2 (de) 1993-03-05 2005-02-24 Wyeth Holdings Corp. Plasmid zur Herstellung von CRM-Protein und Diphtherie-Toxin
JP3828145B2 (ja) 1993-09-22 2006-10-04 ヘンリー エム.ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン 免疫原性構成物の製造のための新規シアン化試薬を使った可溶性炭水化物の活性化方法
US5712118A (en) 1993-09-29 1998-01-27 Research Foundation Of State University Of New York Vaccine for branhamella catarrhalis
US5770213A (en) 1994-05-05 1998-06-23 American Cyanamid Company Purified nontypable haemophilus influenzae P5 protein as a vaccine for nontypable haemophilus influenzae infection
US5607846A (en) 1994-05-17 1997-03-04 Research Foundation Of State University Of New York Vaccine for moraxella catarrhalis
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US5643725A (en) 1994-07-19 1997-07-01 American Cyanamid Company Sequence and analysis of LKP pilin structural genes and the LKP pili operon of nontypable haemophilus influenzae
US5565204A (en) 1994-08-24 1996-10-15 American Cyanamid Company Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
US6676948B2 (en) 1994-08-25 2004-01-13 Washington University Haemophilus adherence and penetration proteins
US6245337B1 (en) 1994-08-25 2001-06-12 Washington University Haemophilus adherence and penetration proteins
US5714354A (en) 1995-06-06 1998-02-03 American Home Products Corporation Alcohol-free pneumococcal polysaccharide purification process
US5695768A (en) * 1995-06-07 1997-12-09 Alberta Research Council Immunostimulating activity of Streptococcus pneumoniae serotype 8 oligosaccharides
US7341727B1 (en) 1996-05-03 2008-03-11 Emergent Product Development Gaithersburg Inc. M. catarrhalis outer membrane protein-106 polypeptide, methods of eliciting an immune response comprising same
PT854925E (pt) 1996-07-26 2004-12-31 Wyeth Corp Proteina nuca de haemophilus influenzae e gene codificador da mesma
BR9714160A (pt) 1996-12-20 2000-05-02 Univ Texas Antìgenos uspa1 e uspa2 de moraxella catarrhalis
EP1005487B1 (fr) 1997-01-31 2006-08-09 Wyeth Holdings Corporation Proteine 74 kilodalton de membrane externe provenant de moraxella catarrhalis
US6113918A (en) 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
FR2763244B1 (fr) 1997-05-14 2003-08-01 Pasteur Merieux Serums Vacc Composition vaccinale multivalente a porteur mixte
EP1051506B2 (fr) * 1997-12-23 2019-08-21 Pfizer Ireland Pharmaceuticals Procedures permettant d'extraire et d'isoler des polysaccharides capsulaires bacteriens destines a etre utilises seuls, en tant que vaccins ou, lies a des proteines, en tant que vaccins conjugues
EP1053015A2 (fr) * 1998-02-12 2000-11-22 American Cyanamid Company Vaccins pneumococciques ou meningococciques formules avec l'interleukine-12
US7018637B2 (en) * 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
CA2233725A1 (fr) * 1998-03-31 1999-09-30 Hemosol Inc. Complexes d'amidon hydroxyethyles d'hemoglobine
US7227011B2 (en) 1998-06-04 2007-06-05 United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Nucleic acid vaccines for prevention of flavivirus infection
IL142017A0 (en) * 1998-09-24 2002-03-10 Univ Minnesota Human complement c3-degrading polypeptide from streptococcus pneumoniae
JP4673974B2 (ja) 1998-09-30 2011-04-20 ワイス・ホールディングズ・コーポレイション アジュバントとしての変異コレラホロトキシン
EP1034792A1 (fr) 1999-03-11 2000-09-13 Pasteur Merieux Serums Et Vaccins Administration par voie intranasale de vaccins à base de polyosides de Pneumococcus
EP1035137A1 (fr) 1999-03-12 2000-09-13 Pasteur Merieux Serums Et Vaccins Procédé d'amination réductrice des polysaccharides
GB9909077D0 (en) 1999-04-20 1999-06-16 Smithkline Beecham Biolog Novel compositions
CA2365296A1 (fr) * 1999-03-19 2000-09-28 Pierre Michel Desmons Vaccin
US7452715B1 (en) 1999-06-25 2008-11-18 Wyeth Holdings Corporation Production of the lipidated form of the peptidoglycan associated lipoproteins of gram-negative bacteria
GB0011108D0 (en) 2000-05-08 2000-06-28 Microscience Ltd Virulence gene and protein and their use
GB0012079D0 (en) 2000-05-18 2000-07-12 Microscience Ltd Virulence gene and protein, and their use
GB0108364D0 (en) 2001-04-03 2001-05-23 Glaxosmithkline Biolog Sa Vaccine composition
MXPA03000198A (es) 2000-06-29 2004-09-13 Glaxosmithkline Biolog Sa Composicion de vacuna multivalente.
GB0020952D0 (en) 2000-08-24 2000-10-11 Microscience Ltd Genes and proteins and their uses
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
ATE267767T1 (de) 2000-12-13 2004-06-15 Sca Hygiene Prod Zeist Bv Rückgewinnungsprozess für gebrauchtes periodat
IL155726A0 (en) 2000-12-28 2003-11-23 Wyeth Corp Recombinant protective protein from streptococcus pneumoniae
MXPA03009415A (es) 2001-04-16 2004-01-29 Wyeth Corp ESTRUCTURAS NOVEDOSAS DE LECTURA ABIERTA DE STREPTOCOCCUS PNEUMONIAE QUE CODIFICAN ANTIGENOS DE POLIPePTIDOS Y USOS DE LAS MISMAS.
KR100898648B1 (ko) 2001-06-07 2009-05-22 와이어쓰 홀딩스 코포레이션 보조제로서 콜레라 홀로톡신의 돌연변이체 형태
CA2449670A1 (fr) 2001-06-07 2002-12-12 Wyeth Holdings Corporation Formes mutantes de l'holotoxine du cholera utilisees comme adjuvant
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
EP1409013B1 (fr) 2001-07-26 2009-11-18 Novartis Vaccines and Diagnostics S.r.l. Vaccins comprenant des adjuvants aluminium et histidine
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
WO2003048304A2 (fr) 2001-11-29 2003-06-12 Wyeth Holdings Corporation Cadres de lecture ouverts (orf) de la bacterie alloiococcus otitidis codant des polypeptides antigeniques, compositions imunogenes, et leurs utilisations
GB0130215D0 (en) * 2001-12-18 2002-02-06 Glaxosmithkline Biolog Sa Vaccine
WO2003078453A1 (fr) 2002-03-15 2003-09-25 Wyeth Holdings Corporation Mutants de la proteine p4 de haemophilus influenzae non typable a activite enzymatique reduite
WO2003094961A1 (fr) 2002-05-09 2003-11-20 Massimo Porro Vaccins de polysaccharides et de glycoconjugues ameliores
AU2003257003A1 (en) 2002-07-30 2004-02-16 Baxter Healthcare S.A. Chimeric multivalent polysaccharide conjugate vaccines
EP1549135A4 (fr) 2002-09-20 2006-01-11 Us Agriculture Compositions vaccinales et adjuvant
FR2850106B1 (fr) * 2003-01-17 2005-02-25 Aventis Pasteur Conjugues obtenus par amination reductrice du polysaccharide capsulaire du pneumocoque de serotype 5
CA2519511A1 (fr) 2003-03-17 2004-09-30 Wyeth Holdings Corporation Holotoxine du cholera mutante en tant qu'adjuvant et proteine de support d'antigene
WO2004094596A2 (fr) 2003-04-16 2004-11-04 Wyeth Holdings Corporation Nouvelles compositions immunogenes de prevention de traitement de meningococcie
CN1241937C (zh) * 2003-07-04 2006-02-15 上海健益科技发展有限公司 多价肺炎球菌多糖结合疫苗
EP1651262A2 (fr) 2003-08-06 2006-05-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Procede de preparation de vaccins conjugues polyssacharide-proteine
EP1664319B1 (fr) 2003-09-11 2010-03-10 De Staat der Nederlanden, vert. door de minister van VWS Procede de preparation de la polysaccharide capsulaire utilisant en vaccins conjugues
FR2857364B1 (fr) 2003-12-08 2005-09-23 Aventis Pasteur Dosage des acides techoiques des bacteries gram+
WO2005058940A2 (fr) 2003-12-17 2005-06-30 Wyeth Conjugues porteurs de peptides immunogenes et procedes de production associes
US20060022838A1 (en) 2004-07-27 2006-02-02 Fisher Richard A Speed limit indicia for traffic signals
US7709001B2 (en) 2005-04-08 2010-05-04 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
CN104815327A (zh) * 2005-04-08 2015-08-05 惠氏有限责任公司 多价肺炎球菌多糖-蛋白质缀合物组合物
US7955605B2 (en) 2005-04-08 2011-06-07 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
US20070184072A1 (en) 2005-04-08 2007-08-09 Wyeth Multivalent pneumococcal polysaccharide-protein conjugate composition
CA2808919C (fr) 2005-12-22 2016-04-19 Glaxosmithkline Biologicals S.A. Vaccin comportant des conjugues polysaccharides capsulaires streptococcus pneumoniae
ZA200902155B (en) 2006-09-29 2010-06-30 Japan Poliomyelitis Res Inst IPV-DPT vaccine
DK2167121T3 (en) 2007-06-26 2015-11-23 Glaxosmithkline Biolog Sa A vaccine comprising Streptococcus pneumoniae kapselpolysaccharidkonjugater
EA021393B1 (ru) 2007-12-24 2015-06-30 Глаксосмитклайн Байолоджикалс С.А. Рекомбинантные антигены rsv
TW201136603A (en) 2010-02-09 2011-11-01 Merck Sharp & Amp Dohme Corp 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition
KR102057217B1 (ko) 2012-06-20 2020-01-22 에스케이바이오사이언스 주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
KR20140075201A (ko) 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
KR20140075196A (ko) 2012-12-11 2014-06-19 에스케이케미칼주식회사 다가 폐렴구균 다당류-단백질 접합체 조성물
AU2015208821B2 (en) 2014-01-21 2017-11-02 Pfizer Inc. Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof
JP2020514326A (ja) * 2017-02-24 2020-05-21 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 肺炎連鎖球菌多糖−タンパク質コンジュゲートの免疫原性の増強

Also Published As

Publication number Publication date
US20200179508A1 (en) 2020-06-11
CN108404126B (zh) 2022-10-18
JP2013006881A (ja) 2013-01-10
HK1120416A1 (en) 2009-04-03
IL308456A (en) 2024-01-01
KR102017842B1 (ko) 2019-09-03
ATE548051T1 (de) 2012-03-15
CN101180079B (zh) 2012-07-18
EP2425854A1 (fr) 2012-03-07
EP2425855A1 (fr) 2012-03-07
PL1868645T3 (pl) 2012-07-31
SI1868645T1 (sl) 2012-04-30
KR20150061021A (ko) 2015-06-03
JP2008535838A (ja) 2008-09-04
AU2006235013B2 (en) 2011-11-03
EP1868645A1 (fr) 2007-12-26
US8808708B2 (en) 2014-08-19
AU2006235013A1 (en) 2006-10-19
DK1868645T3 (da) 2012-04-10
US11191830B2 (en) 2021-12-07
CN113198013A (zh) 2021-08-03
JP5173920B2 (ja) 2013-04-03
IL282638A (en) 2021-06-30
MY145150A (en) 2011-12-30
MX2019008863A (es) 2019-09-13
US8895024B2 (en) 2014-11-25
US10780160B2 (en) 2020-09-22
EP4005595A1 (fr) 2022-06-01
US20120237542A1 (en) 2012-09-20
TWI445545B (zh) 2014-07-21
CY1112777T1 (el) 2016-02-10
CN102716480A (zh) 2012-10-10
SA06270323B1 (ar) 2010-10-05
KR102611449B1 (ko) 2023-12-06
KR20230118200A (ko) 2023-08-10
KR101730749B1 (ko) 2017-04-26
KR102220506B1 (ko) 2021-03-02
TW201438734A (zh) 2014-10-16
MX2007012336A (es) 2007-11-21
KR101298053B1 (ko) 2013-08-20
CN113198012A (zh) 2021-08-03
KR20210022768A (ko) 2021-03-03
CN104815327A (zh) 2015-08-05
KR101730748B1 (ko) 2017-04-26
US10716848B2 (en) 2020-07-21
KR20130048262A (ko) 2013-05-09
KR20150061019A (ko) 2015-06-03
US20210283247A1 (en) 2021-09-16
CN102716480B (zh) 2023-03-21
AR107018A2 (es) 2018-03-14
CN113198013B (zh) 2024-02-20
EP2425853A1 (fr) 2012-03-07
JP5730261B2 (ja) 2015-06-03
ES2382048T3 (es) 2012-06-04
TW200719911A (en) 2007-06-01
US20180250390A1 (en) 2018-09-06
US20060228380A1 (en) 2006-10-12
US20160158345A1 (en) 2016-06-09
KR20150061020A (ko) 2015-06-03
HK1213184A1 (zh) 2016-06-30
IL186367A0 (en) 2008-01-20
WO2006110381A1 (fr) 2006-10-19
MX358148B (es) 2018-08-07
PT1868645E (pt) 2012-05-17
CL2017002206A1 (es) 2018-03-23
EP2425851A1 (fr) 2012-03-07
KR102378962B1 (ko) 2022-03-28
KR20070118700A (ko) 2007-12-17
CA2878579A1 (fr) 2006-10-19
KR20190104241A (ko) 2019-09-06
ME01334B (me) 2013-12-20
US20190388537A1 (en) 2019-12-26
IL186367A (en) 2013-09-30
HRP20120278T1 (hr) 2012-04-30
CA2986862A1 (fr) 2006-10-19
HK1257962A1 (zh) 2019-11-01
CN108404126A (zh) 2018-08-17
KR20150061018A (ko) 2015-06-03
RS52249B (en) 2012-10-31
EP2425856A1 (fr) 2012-03-07
EP1868645B1 (fr) 2012-03-07
JP4472770B2 (ja) 2010-06-02
AR053354A1 (es) 2007-05-02
JP2009161567A (ja) 2009-07-23
BRPI0607025B8 (pt) 2021-05-25
KR20220042483A (ko) 2022-04-05
US9981035B2 (en) 2018-05-29
US20140314805A1 (en) 2014-10-23
BRPI0607025A2 (pt) 2009-07-28
BRPI0607025B1 (pt) 2019-11-12
TWI386222B (zh) 2013-02-21
US20090130137A1 (en) 2009-05-21
EP2425852A1 (fr) 2012-03-07
US9399060B2 (en) 2016-07-26
IL228035A0 (en) 2013-09-30
TWI511739B (zh) 2015-12-11
CA2878579C (fr) 2018-01-23
TW201212937A (en) 2012-04-01
KR101730750B1 (ko) 2017-04-26
CN101180079A (zh) 2008-05-14
EP3311836A1 (fr) 2018-04-25
CA3165042A1 (fr) 2006-10-19
NZ562406A (en) 2009-09-25
IL267125B (en) 2021-05-31
CA2604363C (fr) 2015-06-16
CA2604363A1 (fr) 2006-10-19
CA2986862C (fr) 2022-09-27
CL2016000566A1 (es) 2016-10-28
KR20170086139A (ko) 2017-07-25
IL267125A (en) 2019-08-29
KR102564388B1 (ko) 2023-08-08
KR101588939B1 (ko) 2016-01-26

Similar Documents

Publication Publication Date Title
HK1257962A1 (zh) 多價肺炎球菌多糖-蛋白質綴合物組合物
ZA200904331B (en) Multivalent pneumococcal polysaccharide-protein conjugate composition
ZA200904619B (en) Multivalent pneumococcal polysaccharide-protein conjugate composition
HRP20190037T1 (hr) Cjepivo na bazi konjugata pneumokoknih polisaharida
PL1968630T3 (pl) Multiwalentne immunogenne kompozycje PCV2
AP2436A (en) Immunogenic composition
IL198466A0 (en) Immunization protocol against the 4 dengue serotypes
GB0526038D0 (en) Immunogenic composition
EP1976974A4 (fr) Serotypes pneumococciques
GB0513069D0 (en) Immunogenic composition
EP1963522A4 (fr) Conjugues de polysaccharides-proteines derivatises meningococciques multivalents et vaccin
ZA200805347B (en) Pneumococcal polysaccharide conjugate vaccine
GB0526040D0 (en) Immunogenic composition
GB0526041D0 (en) Immunogenic composition
GB0515556D0 (en) Immunogenic composition
GB0503143D0 (en) Immunogenic composition
GB0524204D0 (en) Immunogenic composition