ATE460498T1 - Verfahren zur herstellung eines kapselpolysaccharids zur verwendung in konjugat- impfstoffen - Google Patents
Verfahren zur herstellung eines kapselpolysaccharids zur verwendung in konjugat- impfstoffenInfo
- Publication number
- ATE460498T1 ATE460498T1 AT04774932T AT04774932T ATE460498T1 AT E460498 T1 ATE460498 T1 AT E460498T1 AT 04774932 T AT04774932 T AT 04774932T AT 04774932 T AT04774932 T AT 04774932T AT E460498 T1 ATE460498 T1 AT E460498T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- polysaccharide
- conjugate vaccines
- capsule polysaccharide
- base
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03077881 | 2003-09-11 | ||
| PCT/NL2004/000627 WO2005024038A2 (en) | 2003-09-11 | 2004-09-10 | Process for producing a capsular polysaccharide for use in conjugate vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE460498T1 true ATE460498T1 (de) | 2010-03-15 |
Family
ID=34259185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04774932T ATE460498T1 (de) | 2003-09-11 | 2004-09-10 | Verfahren zur herstellung eines kapselpolysaccharids zur verwendung in konjugat- impfstoffen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7582459B2 (de) |
| EP (1) | EP1664319B1 (de) |
| KR (1) | KR101161033B1 (de) |
| AT (1) | ATE460498T1 (de) |
| CA (1) | CA2538691C (de) |
| DE (1) | DE602004025951D1 (de) |
| DK (1) | DK1664319T3 (de) |
| ES (1) | ES2341863T3 (de) |
| PL (1) | PL1664319T3 (de) |
| PT (1) | PT1664319E (de) |
| SI (1) | SI1664319T1 (de) |
| WO (1) | WO2005024038A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0502096D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
| EP2425855A1 (de) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalente Pneumokokken-Polysaccharidproteinkonjugatzusammensetzung |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| GB0605757D0 (en) * | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| KR101045881B1 (ko) * | 2008-09-11 | 2011-07-01 | 전남대학교산학협력단 | 연쇄상구균으로부터의 협막다당 생산 배지, 생산 방법 및 정제 방법 |
| WO2010080486A2 (en) * | 2008-12-18 | 2010-07-15 | Wyeth Llc | Method for controlling streptococcus pneumoniae serotype 19a polysaccharide molecular weight |
| HUE046859T2 (hu) * | 2008-12-18 | 2020-03-30 | Wyeth Llc | Eljárás Streptococcus pneumoniae poliszacharid molekulatömegének szabályozására szén alkalmazásával |
| DE102009022251A1 (de) * | 2009-05-20 | 2010-11-25 | Technische Universität Bergakademie Freiberg | Verfahren und Mittel zur extraktiven Gewinnung organischer Substanzen |
| PT2493498T (pt) * | 2009-10-30 | 2017-05-24 | Glaxosmithkline Biologicals Sa | Purificação de sacáridos capsulares de staphylococcus aureus tipo 5 e tipo 8 |
| WO2011148382A1 (en) * | 2010-05-28 | 2011-12-01 | Biological E Limited | An improved process for the purification of capsular polysaccharides of haemophilus influenza - b, neisseria meningitis such as serotypes a, c, y and w-135, and other similar related capsular polysaccharides produced from both gram negative and gram positive microorganisms using aluminium phosphate with alcohol. |
| CN102175841A (zh) * | 2010-12-30 | 2011-09-07 | 北京民海生物科技有限公司 | 一种脑膜炎球菌多糖结合物中游离多糖含量的测定方法 |
| MX348547B (es) * | 2011-12-15 | 2017-06-19 | Serum Inst India Ltd | Nuevo proceso para cultivar bacterias para el mejoramiento del rendimiento de las poliosas capsulares. |
| CN102628068B (zh) * | 2012-04-23 | 2013-09-04 | 成都欧林生物科技股份有限公司 | b型流感嗜血杆菌高密度培养生产细菌荚膜多糖的方法 |
| WO2014009971A2 (en) | 2012-07-07 | 2014-01-16 | Bharat Biotech International Limited | Non-alcoholic vaccine compositions free from animal- origin and process for preparation thereof |
| EP4169929A1 (de) * | 2012-12-20 | 2023-04-26 | Pfizer Inc. | Immunogene zusammensetzungen mit pn-serotype 12f |
| MY186874A (en) * | 2014-02-25 | 2021-08-26 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | A novel downstream process for purifying polysaccharides |
| EP3530285B1 (de) * | 2016-10-20 | 2023-08-09 | KM Biologics Co., Ltd. | VERFAHREN ZUR HERSTELLUNG EINES HIB-KONJUGATIMPFSTOFFS UNTER
VERWENDUNG VON PRP MIT VERRINGERTEM MOLEKULARGEWICHT |
| KR102028693B1 (ko) * | 2017-04-27 | 2019-10-04 | 주식회사 유바이오로직스 | 스트렙토코커스 뉴모니아 협막 다당체의 생산방법 |
| RU2704452C1 (ru) * | 2019-04-22 | 2019-10-28 | Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства | Способ получения вакцины гемофильной тип b конъюгированной |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4220717A (en) * | 1977-12-22 | 1980-09-02 | American Cyanamid Company | Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b. |
| US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| US4644059A (en) | 1982-07-06 | 1987-02-17 | Connaught Laboratories, Inc. | Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine |
| US5316926A (en) * | 1983-11-25 | 1994-05-31 | Miles Inc. | Method for the microbiological production of non-antigenic hyaluronic acid |
| US5192540A (en) | 1988-04-19 | 1993-03-09 | American Cyanamid Company | Haemophilus influenzae type b oxidized polysaccharide-outer membrane protein conjugate vaccine |
| GB9024223D0 (en) * | 1990-11-07 | 1990-12-19 | Fermentech Ltd | Production of hyaluronic acid |
| US6410025B1 (en) * | 1996-02-14 | 2002-06-25 | Merck & Co., Inc. | Polysaccharide precipitation process |
| US6891037B1 (en) * | 1997-01-24 | 2005-05-10 | Schweiz. Serum- & Impfinstitut Bern | Method for the isolation of polysaccharides |
-
2004
- 2004-09-10 AT AT04774932T patent/ATE460498T1/de active
- 2004-09-10 PL PL04774932T patent/PL1664319T3/pl unknown
- 2004-09-10 SI SI200431412T patent/SI1664319T1/sl unknown
- 2004-09-10 DE DE602004025951T patent/DE602004025951D1/de not_active Expired - Lifetime
- 2004-09-10 ES ES04774932T patent/ES2341863T3/es not_active Expired - Lifetime
- 2004-09-10 KR KR1020067006249A patent/KR101161033B1/ko active IP Right Grant
- 2004-09-10 DK DK04774932.0T patent/DK1664319T3/da active
- 2004-09-10 EP EP04774932A patent/EP1664319B1/de not_active Expired - Lifetime
- 2004-09-10 PT PT04774932T patent/PT1664319E/pt unknown
- 2004-09-10 WO PCT/NL2004/000627 patent/WO2005024038A2/en active Application Filing
- 2004-09-10 CA CA2538691A patent/CA2538691C/en not_active Expired - Fee Related
- 2004-09-10 US US10/571,600 patent/US7582459B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2538691A1 (en) | 2005-03-17 |
| US7582459B2 (en) | 2009-09-01 |
| ES2341863T3 (es) | 2010-06-29 |
| PL1664319T3 (pl) | 2010-07-30 |
| DK1664319T3 (da) | 2010-05-10 |
| KR101161033B1 (ko) | 2012-06-28 |
| EP1664319B1 (de) | 2010-03-10 |
| KR20060092234A (ko) | 2006-08-22 |
| SI1664319T1 (sl) | 2010-06-30 |
| EP1664319A2 (de) | 2006-06-07 |
| WO2005024038A2 (en) | 2005-03-17 |
| CA2538691C (en) | 2014-01-14 |
| WO2005024038A3 (en) | 2005-12-29 |
| DE602004025951D1 (de) | 2010-04-22 |
| PT1664319E (pt) | 2010-06-17 |
| US20070065460A1 (en) | 2007-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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