MX358148B - Composicion de conjugados de proteina-polisacaridos multivalentes para neumococos. - Google Patents
Composicion de conjugados de proteina-polisacaridos multivalentes para neumococos.Info
- Publication number
- MX358148B MX358148B MX2015010176A MX2015010176A MX358148B MX 358148 B MX358148 B MX 358148B MX 2015010176 A MX2015010176 A MX 2015010176A MX 2015010176 A MX2015010176 A MX 2015010176A MX 358148 B MX358148 B MX 358148B
- Authority
- MX
- Mexico
- Prior art keywords
- protein conjugate
- conjugate composition
- pneumococcal polysaccharide
- multivalent pneumococcal
- immunogenic composition
- Prior art date
Links
- 230000002163 immunogen Effects 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 208000035109 Pneumococcal Infections Diseases 0.000 abstract 1
- 241000193998 Streptococcus pneumoniae Species 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Abstract
La presente invención se refiere a un método para preparar una composición inmunogénica multivalente que comprende 13 distintos conjugados de polisacáridos-proteína, junto con un vehículo fisiológicamente aceptable, en donde cada uno de los conjugados comprende un polisacárido capsular de un serotipo diferente de Streptococcus pneumoniae conjugado con una proteína portadora, en donde la proteína portadora es CRM197, serotipos 1, 3, 4, 5 6A, 6B, UF, 9V, 14, 18C, 19A, 19F y 23F, el método caracterizado porque comprende: (a) activar químicamente polisacáridos capsulares individuales purificados; (b) conjugar por separado los polisacáridos capsulares activados individuales a CRM197 para formar un conjugado de polisacárido-proteína; (c) purificar los conjugados individuales de polisacárido-proteína; y (d) mezclar los conjugados de polisacárido-proteína purificados individuales para preparar la composición inmunogénica multivalente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66960505P | 2005-04-08 | 2005-04-08 | |
PCT/US2006/012354 WO2006110381A1 (en) | 2005-04-08 | 2006-03-31 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
Publications (1)
Publication Number | Publication Date |
---|---|
MX358148B true MX358148B (es) | 2018-08-07 |
Family
ID=36709976
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015010176A MX358148B (es) | 2005-04-08 | 2006-03-31 | Composicion de conjugados de proteina-polisacaridos multivalentes para neumococos. |
MX2007012336A MX2007012336A (es) | 2005-04-08 | 2006-03-31 | Composicion de conjugados de proteina-polisacaridos multivalentes par neumococos. |
MX2019008863A MX2019008863A (es) | 2005-04-08 | 2007-10-04 | Composicion de conjugados de proteina-polisacaridos multivalentes para neumococos. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007012336A MX2007012336A (es) | 2005-04-08 | 2006-03-31 | Composicion de conjugados de proteina-polisacaridos multivalentes par neumococos. |
MX2019008863A MX2019008863A (es) | 2005-04-08 | 2007-10-04 | Composicion de conjugados de proteina-polisacaridos multivalentes para neumococos. |
Country Status (29)
Country | Link |
---|---|
US (9) | US20060228380A1 (es) |
EP (9) | EP2425854A1 (es) |
JP (3) | JP4472770B2 (es) |
KR (11) | KR102220506B1 (es) |
CN (6) | CN102716480B (es) |
AR (2) | AR053354A1 (es) |
AT (1) | ATE548051T1 (es) |
AU (1) | AU2006235013B2 (es) |
BR (1) | BRPI0607025B8 (es) |
CA (4) | CA3165042A1 (es) |
CL (2) | CL2016000566A1 (es) |
CY (1) | CY1112777T1 (es) |
DK (1) | DK1868645T3 (es) |
ES (1) | ES2382048T3 (es) |
HK (3) | HK1120416A1 (es) |
HR (1) | HRP20120278T1 (es) |
IL (5) | IL308456A (es) |
ME (1) | ME01334B (es) |
MX (3) | MX358148B (es) |
MY (1) | MY145150A (es) |
NZ (1) | NZ562406A (es) |
PL (1) | PL1868645T3 (es) |
PT (1) | PT1868645E (es) |
RS (1) | RS52249B (es) |
SA (1) | SA06270323B1 (es) |
SI (1) | SI1868645T1 (es) |
TW (3) | TWI511739B (es) |
WO (1) | WO2006110381A1 (es) |
ZA (1) | ZA200709483B (es) |
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US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
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KR20140075201A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
NZ759686A (en) | 2014-01-21 | 2023-07-28 | Pfizer | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
BR112019017560A2 (pt) * | 2017-02-24 | 2020-04-07 | Merck Sharp & Dohme | intensificação da imunogenicidade dos conjugados de polissacarídeo-proteína de streptococcus pneumoniae |
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