PL2436700T3 - Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae - Google Patents
Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniaeInfo
- Publication number
- PL2436700T3 PL2436700T3 PL11194173T PL11194173T PL2436700T3 PL 2436700 T3 PL2436700 T3 PL 2436700T3 PL 11194173 T PL11194173 T PL 11194173T PL 11194173 T PL11194173 T PL 11194173T PL 2436700 T3 PL2436700 T3 PL 2436700T3
- Authority
- PL
- Poland
- Prior art keywords
- production
- purification process
- streptococcus pneumoniae
- pneumoniae polysaccharides
- shortened purification
- Prior art date
Links
- 241000193998 Streptococcus pneumoniae Species 0.000 title 1
- 150000004676 glycans Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920001282 polysaccharide Polymers 0.000 title 1
- 239000005017 polysaccharide Substances 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Mycology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89661607P | 2007-03-23 | 2007-03-23 | |
| EP11194173.8A EP2436700B8 (en) | 2007-03-23 | 2008-03-20 | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides |
| PCT/US2008/057688 WO2008118752A2 (en) | 2007-03-23 | 2008-03-20 | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides |
| EP08732592.4A EP2129693B1 (en) | 2007-03-23 | 2008-03-20 | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2436700T3 true PL2436700T3 (pl) | 2018-12-31 |
Family
ID=39712482
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08732592T PL2129693T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
| PL11194173T PL2436700T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
| PL18177128.8T PL3406635T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08732592T PL2129693T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18177128.8T PL3406635T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8652480B2 (pl) |
| EP (3) | EP2129693B1 (pl) |
| JP (5) | JP5688902B2 (pl) |
| KR (2) | KR20150021127A (pl) |
| CN (1) | CN101663327B (pl) |
| AU (1) | AU2008231041B2 (pl) |
| BR (1) | BRPI0809212B8 (pl) |
| CA (1) | CA2681570C (pl) |
| CL (2) | CL2008000831A1 (pl) |
| CO (1) | CO6251324A2 (pl) |
| CR (1) | CR11041A (pl) |
| DK (3) | DK2129693T3 (pl) |
| EC (1) | ECSP099652A (pl) |
| ES (3) | ES2922132T3 (pl) |
| GT (1) | GT200900249A (pl) |
| HN (1) | HN2009001965A (pl) |
| HU (3) | HUE039169T2 (pl) |
| IL (1) | IL201106A (pl) |
| MX (1) | MX2009010221A (pl) |
| MY (1) | MY150927A (pl) |
| NI (1) | NI200900172A (pl) |
| NZ (1) | NZ580134A (pl) |
| PL (3) | PL2129693T3 (pl) |
| PT (3) | PT2129693T (pl) |
| RU (1) | RU2516340C2 (pl) |
| SI (3) | SI3406635T1 (pl) |
| UA (1) | UA99278C2 (pl) |
| WO (1) | WO2008118752A2 (pl) |
| ZA (1) | ZA200906625B (pl) |
Families Citing this family (101)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3406635T1 (sl) * | 2007-03-23 | 2022-08-31 | Wyeth Llc | Skrajšani postopek purifikacije za proizvajanje kapsularnih polisaharidov Streptococcus pneumoniae |
| GB0818453D0 (en) * | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| US11065323B2 (en) * | 2008-10-27 | 2021-07-20 | Glaxosmithkline Biologicals Sa | Purification method |
| PL2385981T3 (pl) * | 2008-12-18 | 2020-01-31 | Wyeth Llc | Sposób kontroli masy cząsteczkowej polisacharydów streptococcus pneumoniae z zastosowaniem węgla |
| PL2379734T3 (pl) * | 2008-12-18 | 2018-08-31 | Wyeth Llc | Sposób kontrolowania masy cząsteczkowej polisacharydu serotypu 19A Streptococcus pneumoniae |
| CN102413838A (zh) | 2009-04-30 | 2012-04-11 | 科勒制药集团有限公司 | 肺炎球菌疫苗及其用途 |
| NZ597154A (en) | 2009-06-22 | 2013-10-25 | Wyeth Llc | Immunogenic compositions of staphylococcus aureus antigens |
| ES2959890T3 (es) | 2009-06-22 | 2024-02-28 | Wyeth Llc | Composiciones y procedimientos para preparar composiciones inmunogénicas de conjugado de polisacárido capsular de serotipo 8 de Staphylococcus aureus |
| TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| US20110262989A1 (en) | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
| US9476812B2 (en) | 2010-04-21 | 2016-10-25 | Dna Electronics, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
| US8841104B2 (en) | 2010-04-21 | 2014-09-23 | Nanomr, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
| WO2011145108A2 (en) * | 2010-05-15 | 2011-11-24 | Serum Institute Of India Ltd. | Purification of capsular polysaccharides |
| BR112013024322B1 (pt) * | 2011-03-22 | 2020-04-22 | Serum Inst India Ltd | processo para preparação de polissacarídeos |
| CN102660603B (zh) * | 2012-04-17 | 2015-03-25 | 江苏康泰生物医学技术有限公司 | 一种快速纯化细菌荚膜多糖的方法 |
| CN102660602B (zh) * | 2012-04-17 | 2015-03-25 | 江苏康泰生物医学技术有限公司 | 快速纯化细菌荚膜多糖的方法 |
| CN102660601B (zh) * | 2012-04-17 | 2015-10-28 | 江苏康泰生物医学技术有限公司 | 快速纯化细菌荚膜多糖的方法 |
| US9650411B2 (en) * | 2012-08-07 | 2017-05-16 | Kyowa Hakko Kirin Co., Ltd. | Method of purifying protein |
| BR112015005081B1 (pt) * | 2012-09-07 | 2021-10-26 | Sk Bioscience Co., Ltd. | Método para produzir um polissacarídeo capsular tendo um sorotipo de pneumococo |
| ES2773954T3 (es) | 2012-10-03 | 2020-07-15 | Glaxosmithkline Biologicals Sa | Composición inmunogénica |
| US9434940B2 (en) | 2012-12-19 | 2016-09-06 | Dna Electronics, Inc. | Methods for universal target capture |
| US9599610B2 (en) | 2012-12-19 | 2017-03-21 | Dnae Group Holdings Limited | Target capture system |
| US9551704B2 (en) | 2012-12-19 | 2017-01-24 | Dna Electronics, Inc. | Target detection |
| US9995742B2 (en) | 2012-12-19 | 2018-06-12 | Dnae Group Holdings Limited | Sample entry |
| US10000557B2 (en) | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
| US9804069B2 (en) | 2012-12-19 | 2017-10-31 | Dnae Group Holdings Limited | Methods for degrading nucleic acid |
| WO2015005961A1 (en) | 2013-07-12 | 2015-01-15 | Emd Millipore Corporation | A method of determining virus removal from a sample containing a target protein using activated carbon |
| US11708411B2 (en) | 2013-12-20 | 2023-07-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| EP3616716A3 (en) | 2014-01-21 | 2020-05-06 | Pfizer Inc | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| EP3957321A3 (en) | 2014-01-21 | 2022-07-13 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
| KR20210032013A (ko) | 2014-01-21 | 2021-03-23 | 화이자 인코포레이티드 | 스트렙토코쿠스 뉴모니아에 피막 폴리사카라이드 및 그의 접합체 |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| IL252915B2 (en) | 2015-01-15 | 2024-04-01 | Pfizer | Immunogenic compositions for use in pneumococcal vaccines |
| NZ736238A (en) * | 2015-05-04 | 2022-07-01 | Pfizer | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| JPWO2016204265A1 (ja) * | 2015-06-18 | 2018-06-14 | 一般財団法人阪大微生物病研究会 | 肺炎球菌補体依存性殺菌能測定方法 |
| CN108367063A (zh) | 2015-07-21 | 2018-08-03 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途 |
| CN105131139B (zh) * | 2015-07-31 | 2018-02-13 | 兰州生物制品研究所有限责任公司 | 一种肺炎链球菌荚膜多糖的纯化方法 |
| WO2017085586A1 (en) | 2015-11-20 | 2017-05-26 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| US11224652B2 (en) | 2016-08-05 | 2022-01-18 | Sanofi Pasteur Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| CN109862908B (zh) | 2016-08-05 | 2023-05-02 | 圣诺菲·帕斯图尔公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
| US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| KR20240110660A (ko) | 2016-12-30 | 2024-07-15 | 박사이트, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
| CN110198735A (zh) | 2017-01-20 | 2019-09-03 | 辉瑞公司 | 用于肺炎球菌疫苗中的免疫原性组合物 |
| CN110225757A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 由肺炎链球菌血清型19f生产荚膜多糖蛋白缀合物的方法 |
| CN116870144A (zh) | 2017-01-31 | 2023-10-13 | 默沙东有限责任公司 | 制备多糖-蛋白缀合物的方法 |
| US20200054740A1 (en) | 2017-02-24 | 2020-02-20 | Merck Sharp & Dohme Corp. | Pneumococcal conjugate vaccine formulations |
| JP7680185B2 (ja) | 2017-02-24 | 2025-05-20 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎連鎖球菌多糖－タンパク質コンジュゲートの免疫原性の増強 |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| MX2019014829A (es) | 2017-06-10 | 2020-08-17 | Inventprise Llc | Vacunas de conjugado multivalente con polisacáridos de conjugado bivalente o multivalente que proporcionan inmunogenicidad y avidez mejoradas. |
| US10435433B2 (en) | 2017-07-05 | 2019-10-08 | Inventprise, Llc | Polysaccharide purification for vaccine production using lytic enzymes, tangential flow filtration, and multimode chromatography |
| US10702596B2 (en) | 2017-07-05 | 2020-07-07 | Inventprise, Llc | Polysaccharide purification for vaccine production using lytic enzymes, tangential flow filtration, and multimode chromatography |
| PT3678654T (pt) | 2017-09-07 | 2024-08-05 | Merck Sharp & Dohme Llc | Polissacáridos pneumocócicos e sua utilização em conjugados imunogénicos de polissacárido-proteína transportadora |
| AU2018328038B2 (en) | 2017-09-07 | 2024-03-07 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| EP3678653A4 (en) | 2017-09-07 | 2021-05-26 | Merck Sharp & Dohme Corp. | PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC POLYSACCHARIDE CARRIER PROTEIN CONJUGATES |
| CN107936128B (zh) * | 2017-11-22 | 2020-07-03 | 成都欧林生物科技股份有限公司 | 一种简便有效的细菌疫苗纯化方法 |
| BR112020011414B8 (pt) | 2017-12-06 | 2023-01-31 | Merck Sharp & Dohme | Composições imunogênicas multivalentes compreendendo conjugados de proteína carreadora e polissacarídeo de s. pneumoniae |
| KR102827174B1 (ko) | 2018-04-30 | 2025-06-27 | 머크 샤프 앤드 돔 엘엘씨 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
| EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | METHODS FOR PRODUCING CAPSULAR CARRIER PROTEIN-POLYSACCHARIDE CONJUGATES OF STREPTOCOCCUS PNEUMONIAE |
| WO2019212842A1 (en) | 2018-04-30 | 2019-11-07 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| JP7399934B2 (ja) | 2018-07-04 | 2023-12-18 | バックスサイト・インコーポレイテッド | 免疫原性複合体の改良 |
| WO2020010000A1 (en) | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Improved methods for the preparation of immunogenic conjugates |
| WO2020010016A1 (en) | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Self-adjuvanted immunogenic conjugates |
| JP7446279B2 (ja) * | 2018-07-19 | 2024-03-08 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乾燥多糖を調製するための方法 |
| CA3120922A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| US11642406B2 (en) | 2018-12-19 | 2023-05-09 | Merck Sharp & Dohme Llc | Compositions comprising Streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
| JP7239509B6 (ja) | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| CA3136278A1 (en) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| MX2022001241A (es) | 2019-07-31 | 2022-04-20 | Sanofi Pasteur Inc | Composiciones de conjugados neumococicos multivalentes polisacarido - proteina y metodos para usar los mismos. |
| US20210070890A1 (en) * | 2019-09-06 | 2021-03-11 | Serum Institute Of India Private Limited | Method for obtaining purified bacterial polysaccharides |
| CA3171864A1 (en) | 2020-02-21 | 2021-08-26 | Pfizer Inc. | Purification of saccharides |
| CN116075517A (zh) * | 2020-06-12 | 2023-05-05 | 巴斯夫欧洲公司 | 改进的发酵液的脱矿化与诸如寡糖的精细化学品的纯化 |
| JP7630603B2 (ja) | 2020-08-10 | 2025-02-17 | インベントプライズ・インコーポレイテッド | 出現血清型２４ｆを含む多価肺炎球菌複合糖質ワクチン |
| AU2021332183A1 (en) | 2020-08-26 | 2023-03-02 | Pfizer Inc. | Group B streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| GB202016165D0 (en) | 2020-10-12 | 2020-11-25 | Optivalent Ltd | Vaccine |
| WO2022084852A1 (en) | 2020-10-22 | 2022-04-28 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
| EP4240410A1 (en) | 2020-11-04 | 2023-09-13 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| JP2023549736A (ja) | 2020-11-10 | 2023-11-29 | ファイザー・インク | コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用 |
| TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
| WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| CA3218544A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
| JP7714690B2 (ja) | 2021-05-28 | 2025-07-29 | ファイザー・インク | コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用 |
| TW202306969A (zh) | 2021-05-28 | 2023-02-16 | 美商輝瑞大藥廠 | 包含結合之莢膜醣抗原的免疫原組合物及其用途 |
| EP4463186A1 (en) | 2022-01-13 | 2024-11-20 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| GB2614916A (en) | 2022-01-25 | 2023-07-26 | Optivalent Ltd | Intradermal vaccine complement |
| US20250163484A1 (en) | 2022-02-25 | 2025-05-22 | Pfizer Inc. | Methods for Incorporating Azido Groups in Bacterial Capsular Polysaccharides |
| WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| WO2024110827A1 (en) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Methods for preparing conjugated capsular saccharide antigens and uses thereof |
| EP4622665A2 (en) | 2022-11-22 | 2025-10-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| KR20250113501A (ko) | 2022-12-01 | 2025-07-25 | 화이자 인코포레이티드 | 폐렴구균 접합체 백신 제형 |
| WO2024166008A1 (en) | 2023-02-10 | 2024-08-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2024246082A1 (en) | 2023-03-30 | 2025-10-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024214016A1 (en) | 2023-04-14 | 2024-10-17 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| TW202500153A (zh) | 2023-05-18 | 2025-01-01 | 美商默沙東有限責任公司 | 用於肺炎鏈球菌疫苗之化合物及佐劑調配物 |
| WO2024241172A2 (en) | 2023-05-19 | 2024-11-28 | Glaxosmithkline Biologicals Sa | Methods for eliciting an immune response to respiratory syncycial virus and streptococcus pneumoniae infection |
| WO2025057078A1 (en) | 2023-09-14 | 2025-03-20 | Pfizer Inc. | Adjuvanted immunogenic compositions comprising conjugated pneumococcal capsular saccharide antigens and uses thereof |
| WO2025133971A1 (en) | 2023-12-23 | 2025-06-26 | Pfizer Inc. | Improved methods for producing bacterial capsular saccharide glycoconjugates |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002004B1 (en) | 1977-11-07 | 1982-03-24 | Ciba-Geigy Ag | Process for the manufacture of fluorinated cationic compounds and their use as surfactants |
| CA1115210A (en) * | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
| US4221906A (en) * | 1979-03-19 | 1980-09-09 | American Cyanamid Company | Stabilization of pneumococcal polysaccharides |
| US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| FR2495939B1 (fr) * | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| JPS6170994A (ja) * | 1984-09-14 | 1986-04-11 | Daikin Ind Ltd | 環状（１→２）−β−Ｄ−グルカンの製法 |
| IT1187753B (it) * | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| US5714354A (en) * | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
| RU2087156C1 (ru) * | 1995-06-22 | 1997-08-20 | Леонид Николаевич Падюков | Вакцина против пневмококковой инфекции |
| DK1051506T4 (da) * | 1997-12-23 | 2019-10-21 | Pfizer Ireland Pharmaceuticals | Fremgangsmåder til ekstraktion og isolering af bakterielle kapselpolysaccharider til anvendelse som vacciner eller bundet til proteiner som konjugatvacciner |
| US6146902A (en) * | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| GB0108079D0 (en) * | 2001-03-30 | 2001-05-23 | Microbial Technics Ltd | Protein |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| CN102716480B (zh) | 2005-04-08 | 2023-03-21 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| DK1866342T3 (en) * | 2005-04-08 | 2019-01-28 | Wyeth Llc | SEPARATION OF POLLUTANTS CONTAMINATING FROM STREPTOCOCCUS PNEUMONIAE POLYSACCHARID BY PH-MANIPULATION |
| SI3406635T1 (sl) * | 2007-03-23 | 2022-08-31 | Wyeth Llc | Skrajšani postopek purifikacije za proizvajanje kapsularnih polisaharidov Streptococcus pneumoniae |
-
2008
- 2008-03-20 SI SI200832196T patent/SI3406635T1/sl unknown
- 2008-03-20 DK DK08732592.4T patent/DK2129693T3/en active
- 2008-03-20 SI SI200831984T patent/SI2436700T1/sl unknown
- 2008-03-20 CA CA2681570A patent/CA2681570C/en active Active
- 2008-03-20 NZ NZ580134A patent/NZ580134A/en unknown
- 2008-03-20 MY MYPI20093908 patent/MY150927A/en unknown
- 2008-03-20 PT PT87325924T patent/PT2129693T/pt unknown
- 2008-03-20 CN CN200880012946.2A patent/CN101663327B/zh active Active
- 2008-03-20 RU RU2009135485/10A patent/RU2516340C2/ru active
- 2008-03-20 ES ES18177128T patent/ES2922132T3/es active Active
- 2008-03-20 MX MX2009010221A patent/MX2009010221A/es active IP Right Grant
- 2008-03-20 PL PL08732592T patent/PL2129693T3/pl unknown
- 2008-03-20 HU HUE11194173A patent/HUE039169T2/hu unknown
- 2008-03-20 BR BRPI0809212A patent/BRPI0809212B8/pt active IP Right Grant
- 2008-03-20 AU AU2008231041A patent/AU2008231041B2/en active Active
- 2008-03-20 US US12/052,525 patent/US8652480B2/en active Active
- 2008-03-20 HU HUE08732592A patent/HUE031567T2/hu unknown
- 2008-03-20 PT PT181771288T patent/PT3406635T/pt unknown
- 2008-03-20 EP EP08732592.4A patent/EP2129693B1/en active Active
- 2008-03-20 EP EP18177128.8A patent/EP3406635B1/en active Active
- 2008-03-20 EP EP11194173.8A patent/EP2436700B8/en active Active
- 2008-03-20 SI SI200831741A patent/SI2129693T1/sl unknown
- 2008-03-20 HU HUE18177128A patent/HUE059085T2/hu unknown
- 2008-03-20 JP JP2009554744A patent/JP5688902B2/ja active Active
- 2008-03-20 DK DK18177128.8T patent/DK3406635T3/da active
- 2008-03-20 ES ES11194173.8T patent/ES2677353T3/es active Active
- 2008-03-20 PL PL11194173T patent/PL2436700T3/pl unknown
- 2008-03-20 KR KR1020157002150A patent/KR20150021127A/ko not_active Ceased
- 2008-03-20 WO PCT/US2008/057688 patent/WO2008118752A2/en active Application Filing
- 2008-03-20 UA UAA200909741A patent/UA99278C2/ru unknown
- 2008-03-20 DK DK11194173.8T patent/DK2436700T5/en active
- 2008-03-20 CL CL200800831A patent/CL2008000831A1/es unknown
- 2008-03-20 PT PT111941738T patent/PT2436700T/pt unknown
- 2008-03-20 KR KR1020097021976A patent/KR101500771B1/ko active Active
- 2008-03-20 ES ES08732592.4T patent/ES2614249T3/es active Active
- 2008-03-20 PL PL18177128.8T patent/PL3406635T3/pl unknown
-
2009
- 2009-09-17 HN HN2009001965A patent/HN2009001965A/es unknown
- 2009-09-21 GT GT200900249A patent/GT200900249A/es unknown
- 2009-09-21 NI NI200900172A patent/NI200900172A/es unknown
- 2009-09-22 ZA ZA200906625A patent/ZA200906625B/xx unknown
- 2009-09-22 IL IL201106A patent/IL201106A/en active IP Right Grant
- 2009-09-23 CR CR11041A patent/CR11041A/es unknown
- 2009-09-23 EC EC2009009652A patent/ECSP099652A/es unknown
- 2009-10-20 CO CO09117278A patent/CO6251324A2/es active IP Right Grant
-
2014
- 2014-01-24 US US14/163,863 patent/US8999697B2/en active Active
-
2015
- 2015-01-27 JP JP2015013167A patent/JP2015143225A/ja not_active Withdrawn
- 2015-02-27 US US14/633,141 patent/US9675681B2/en active Active
-
2017
- 2017-03-23 JP JP2017056848A patent/JP6825950B2/ja active Active
- 2017-08-08 CL CL2017002029A patent/CL2017002029A1/es unknown
-
2018
- 2018-11-06 JP JP2018208647A patent/JP2019048844A/ja not_active Withdrawn
-
2020
- 2020-01-31 JP JP2020014532A patent/JP6872649B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL201106A0 (en) | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides | |
| EG25753A (en) | Process for the production of alcohols | |
| PL1999134T3 (pl) | Sposób wytwarzania alkoholi anhydrocukrowych | |
| GB2474310B (en) | Process for the production of sucrose-6-ester | |
| IL220430A0 (en) | Process for the production of benzopyran-2-ol derivatives | |
| ZA200907811B (en) | Process for the manufacture of p4o6 | |
| ZA200803921B (en) | Process for the production of oligosaccharides | |
| IL202153A0 (en) | Process for the production of pyrazoles | |
| IL227837A0 (en) | A process for purifying theobromine | |
| SI2089468T1 (sl) | Postopek za pripravo funkcionalnih celuloznih oblikovancev | |
| EP1861408A4 (en) | PROCESS FOR PRODUCING HYDROCHLOROSILANES | |
| EP1874948A4 (en) | PROCESS FOR THE PREPARATION OF Y-GLUTAMYLCYSTEIN | |
| IL185722A0 (en) | Process for the production of methylcobalamin | |
| ZA201000237B (en) | Process for the production of tertiary alcohols | |
| PL2194796T3 (pl) | Sposób wytwarzania czekolady | |
| EP2221294A4 (en) | PROCESS FOR PREPARING N-CARBAMOYL-TERT.-LEUCIN | |
| EP2108036A4 (en) | PROCESS FOR PRODUCING ALCANOLAMINE | |
| EP2221290A4 (en) | PROCESS FOR THE PREPARATION OF ALKOXYINDANONE DERIVATIVES | |
| HK1138861A (en) | Shortened purification process for the production of capsularstreptococcus pneumoniae polysaccharides | |
| GB0718398D0 (en) | Process for the production of alcohols | |
| HU0700244D0 (en) | Process for the production of alcohol | |
| SI2029567T1 (sl) | Postopek za proizvodnjo derivator benzopiran-2-ola | |
| PL381675A1 (pl) | Sposób wytwarzania wyrobów porcelanowych | |
| ZA201002012B (en) | Catalyst production process |