PL2436700T3 - Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae - Google Patents
Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniaeInfo
- Publication number
- PL2436700T3 PL2436700T3 PL11194173T PL11194173T PL2436700T3 PL 2436700 T3 PL2436700 T3 PL 2436700T3 PL 11194173 T PL11194173 T PL 11194173T PL 11194173 T PL11194173 T PL 11194173T PL 2436700 T3 PL2436700 T3 PL 2436700T3
- Authority
- PL
- Poland
- Prior art keywords
- production
- purification process
- streptococcus pneumoniae
- pneumoniae polysaccharides
- shortened purification
- Prior art date
Links
- 241000193998 Streptococcus pneumoniae Species 0.000 title 1
- 150000004676 glycans Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229920001282 polysaccharide Polymers 0.000 title 1
- 239000005017 polysaccharide Substances 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89661607P | 2007-03-23 | 2007-03-23 | |
| PCT/US2008/057688 WO2008118752A2 (en) | 2007-03-23 | 2008-03-20 | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides |
| EP11194173.8A EP2436700B8 (en) | 2007-03-23 | 2008-03-20 | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides |
| EP08732592.4A EP2129693B1 (en) | 2007-03-23 | 2008-03-20 | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2436700T3 true PL2436700T3 (pl) | 2018-12-31 |
Family
ID=39712482
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11194173T PL2436700T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
| PL08732592T PL2129693T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
| PL18177128.8T PL3406635T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08732592T PL2129693T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
| PL18177128.8T PL3406635T3 (pl) | 2007-03-23 | 2008-03-20 | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8652480B2 (pl) |
| EP (3) | EP2436700B8 (pl) |
| JP (5) | JP5688902B2 (pl) |
| KR (2) | KR20150021127A (pl) |
| CN (1) | CN101663327B (pl) |
| AU (1) | AU2008231041B2 (pl) |
| BR (1) | BRPI0809212B8 (pl) |
| CA (1) | CA2681570C (pl) |
| CL (2) | CL2008000831A1 (pl) |
| CO (1) | CO6251324A2 (pl) |
| CR (1) | CR11041A (pl) |
| DK (3) | DK2436700T5 (pl) |
| EC (1) | ECSP099652A (pl) |
| ES (3) | ES2922132T3 (pl) |
| GT (1) | GT200900249A (pl) |
| HN (1) | HN2009001965A (pl) |
| HU (3) | HUE039169T2 (pl) |
| IL (1) | IL201106A (pl) |
| MX (1) | MX2009010221A (pl) |
| MY (1) | MY150927A (pl) |
| NI (1) | NI200900172A (pl) |
| NZ (1) | NZ580134A (pl) |
| PL (3) | PL2436700T3 (pl) |
| PT (3) | PT2129693T (pl) |
| RU (1) | RU2516340C2 (pl) |
| SI (3) | SI2436700T1 (pl) |
| UA (1) | UA99278C2 (pl) |
| WO (1) | WO2008118752A2 (pl) |
| ZA (1) | ZA200906625B (pl) |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE039169T2 (hu) * | 2007-03-23 | 2018-12-28 | Wyeth Llc | Rövidített tisztítási eljárás Streptococcus pneumoniae tok-poliszacharidok elõállítására |
| GB0818453D0 (en) * | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| PL2349520T3 (pl) | 2008-10-27 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Sposób oczyszczania węglowodanów z paciorkowców grupy a |
| ES2749952T3 (es) * | 2008-12-18 | 2020-03-24 | Wyeth Llc | Procedimiento de control del peso molecular de polisacáridos de Streptococcus pneumoniae usando carbono |
| SI2379734T1 (en) * | 2008-12-18 | 2018-05-31 | Wyeth Llc | PROCEDURE FOR THE CONTROL OF THE SEROTYPE 19A STREPTOCOCCUS PNEUMONIAE POLYESAHARIDE MOLECULAR MASS |
| RU2536248C2 (ru) | 2009-04-30 | 2014-12-20 | Коули Фармасьютикал Груп, Инк. | Пневмококковая вакцина и ее применения |
| SG10201406432RA (en) | 2009-06-22 | 2014-11-27 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
| TWI469789B (zh) | 2009-06-22 | 2015-01-21 | Wyeth Llc | 金黃色葡萄球菌抗原之免疫原性組合物 |
| TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| US8841104B2 (en) | 2010-04-21 | 2014-09-23 | Nanomr, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
| US9476812B2 (en) | 2010-04-21 | 2016-10-25 | Dna Electronics, Inc. | Methods for isolating a target analyte from a heterogeneous sample |
| US20110262989A1 (en) | 2010-04-21 | 2011-10-27 | Nanomr, Inc. | Isolating a target analyte from a body fluid |
| WO2011145108A2 (en) * | 2010-05-15 | 2011-11-24 | Serum Institute Of India Ltd. | Purification of capsular polysaccharides |
| JP5944480B2 (ja) * | 2011-03-22 | 2016-07-05 | セルム・インスティテュート・オブ・インディア・ピーブイティー．・リミテッド | 多糖を調製するための新規な方法 |
| CN102660603B (zh) * | 2012-04-17 | 2015-03-25 | 江苏康泰生物医学技术有限公司 | 一种快速纯化细菌荚膜多糖的方法 |
| CN102660602B (zh) * | 2012-04-17 | 2015-03-25 | 江苏康泰生物医学技术有限公司 | 快速纯化细菌荚膜多糖的方法 |
| CN102660601B (zh) * | 2012-04-17 | 2015-10-28 | 江苏康泰生物医学技术有限公司 | 快速纯化细菌荚膜多糖的方法 |
| US9650411B2 (en) * | 2012-08-07 | 2017-05-16 | Kyowa Hakko Kirin Co., Ltd. | Method of purifying protein |
| AU2013313794B2 (en) * | 2012-09-07 | 2016-10-20 | Sk Bioscience Co., Ltd. | Production method for capsular polysaccharide having pneumococcal serotype |
| KR20150073943A (ko) | 2012-10-03 | 2015-07-01 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 조성물 |
| US9551704B2 (en) | 2012-12-19 | 2017-01-24 | Dna Electronics, Inc. | Target detection |
| US9804069B2 (en) | 2012-12-19 | 2017-10-31 | Dnae Group Holdings Limited | Methods for degrading nucleic acid |
| US9995742B2 (en) | 2012-12-19 | 2018-06-12 | Dnae Group Holdings Limited | Sample entry |
| US9434940B2 (en) | 2012-12-19 | 2016-09-06 | Dna Electronics, Inc. | Methods for universal target capture |
| US10000557B2 (en) | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
| US9599610B2 (en) | 2012-12-19 | 2017-03-21 | Dnae Group Holdings Limited | Target capture system |
| CA2912765C (en) | 2013-07-12 | 2018-05-01 | Emd Millipore Corporation | A method of determining virus removal from a sample containing a target protein using activated carbon |
| US11708411B2 (en) | 2013-12-20 | 2023-07-25 | Wake Forest University Health Sciences | Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines |
| CN106102770B (zh) | 2014-01-21 | 2022-03-22 | 辉瑞公司 | 包含缀合荚膜糖抗原的免疫原性组合物及其用途 |
| US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| PT3096783T (pt) | 2014-01-21 | 2021-08-16 | Pfizer | Polissacáridos capsulares de streptococcus pneumoniae e conjugados dos mesmos |
| HUE055553T2 (hu) | 2014-01-21 | 2021-12-28 | Pfizer | Streptococcus pneumoniae kapszulás poliszacharidok és azok konjugátumai |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| IL252915B2 (en) | 2015-01-15 | 2024-04-01 | Pfizer | Immunogenic compositions for use in pneumococcal vaccines |
| IL255106B2 (en) * | 2015-05-04 | 2023-04-01 | Pfizer | Protein-polysaccharide conjugates of group b streptococcus, methods for preparing conjugates, immunogenic preparations containing conjugates and their uses |
| EP3312287A4 (en) * | 2015-06-18 | 2018-12-19 | The Research Foundation for Microbial Diseases of Osaka University | Method for measuring complement-dependent bactericidal function with respect to pneumococci |
| IL303998A (en) | 2015-07-21 | 2023-08-01 | Pfizer | Immunogenic preparations containing conjugated capsular sugar antigens, kits containing them and their uses |
| CN105131139B (zh) * | 2015-07-31 | 2018-02-13 | 兰州生物制品研究所有限责任公司 | 一种肺炎链球菌荚膜多糖的纯化方法 |
| CA3005524C (en) | 2015-11-20 | 2023-10-10 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| BR112019001995A2 (pt) | 2016-08-05 | 2019-05-07 | Sanofi Pasteur, Inc. | composição de conjugado de polissacarídeo pneumocócico multivalente ? proteína |
| US11241489B2 (en) | 2016-08-05 | 2022-02-08 | Sanofi Pasteur Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| MA47223A (fr) | 2016-12-30 | 2019-11-06 | Sutrovax Inc | Conjugués polypeptide-antigène avec des acides aminés non naturels |
| BR112019014833A2 (pt) | 2017-01-20 | 2020-04-14 | Pfizer | composições imunogênicas para uso em vacinas pneumococais |
| KR20190108583A (ko) | 2017-01-31 | 2019-09-24 | 머크 샤프 앤드 돔 코포레이션 | 다당류-단백질 접합체 제조 방법 |
| US20200222550A1 (en) | 2017-01-31 | 2020-07-16 | Merck Sharp & Dohme Corp. | Methods for production of capsular polysaccharide protein conjugates from streptococcus pneumoniae serotype 19f |
| US11090374B2 (en) | 2017-02-24 | 2021-08-17 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of Streptococcus pneumoniae polysaccharide-protein conjugates |
| EP3585803B1 (en) | 2017-02-24 | 2025-09-24 | Merck Sharp & Dohme LLC | Pneumococcal conjugate vaccine formulations |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| CN118356485A (zh) | 2017-06-10 | 2024-07-19 | 创赏公司 | 提供改善的免疫原性和亲合力的具有二价或多价缀合物多糖的多价缀合物疫苗 |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| US10702596B2 (en) | 2017-07-05 | 2020-07-07 | Inventprise, Llc | Polysaccharide purification for vaccine production using lytic enzymes, tangential flow filtration, and multimode chromatography |
| JP7111799B2 (ja) | 2017-07-05 | 2022-08-02 | インベントプライズ リミテッド ライアビリティ カンパニー | 溶菌酵素、接線流濾過、及びマルチモードクロマトグラフィを用いたワクチン生産のための多糖精製 |
| KR102734995B1 (ko) | 2017-09-07 | 2024-11-26 | 머크 샤프 앤드 돔 엘엘씨 | 폐렴구균 폴리사카라이드 및 면역원성 폴리사카라이드-담체 단백질 접합체에서의 그의 용도 |
| WO2019050816A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| WO2019050815A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
| CN107936128B (zh) * | 2017-11-22 | 2020-07-03 | 成都欧林生物科技股份有限公司 | 一种简便有效的细菌疫苗纯化方法 |
| BR112020011414B8 (pt) | 2017-12-06 | 2023-01-31 | Merck Sharp & Dohme | Composições imunogênicas multivalentes compreendendo conjugados de proteína carreadora e polissacarídeo de s. pneumoniae |
| EP3788143B1 (en) | 2018-04-30 | 2023-06-28 | Merck Sharp & Dohme LLC | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| US12144855B2 (en) | 2018-04-30 | 2024-11-19 | Merck Sharp & Dohme Llc | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates from lyospheres |
| CN112074293B (zh) | 2018-04-30 | 2025-07-11 | 默沙东有限责任公司 | 生产肺炎链球菌荚膜多糖载体蛋白缀合物的方法 |
| EP4483896A3 (en) | 2018-07-04 | 2025-04-02 | Vaxcyte, Inc. | Improvements in immunogenic conjugates |
| WO2020010016A1 (en) | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Self-adjuvanted immunogenic conjugates |
| WO2020010000A1 (en) | 2018-07-04 | 2020-01-09 | Sutrovax, Inc. | Improved methods for the preparation of immunogenic conjugates |
| EP3824019A1 (en) * | 2018-07-19 | 2021-05-26 | GlaxoSmithKline Biologicals SA | Processes for preparing dried polysaccharides |
| WO2020121159A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
| KR20240169145A (ko) | 2018-12-19 | 2024-12-02 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
| JP7239509B6 (ja) * | 2019-02-22 | 2023-03-28 | ファイザー・インク | 細菌多糖類を精製するための方法 |
| US20220184199A1 (en) | 2019-04-10 | 2022-06-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
| JP2022542316A (ja) | 2019-07-31 | 2022-09-30 | サノフィ パスツール インコーポレイテッド | 多価肺炎球菌多糖体－タンパク質コンジュゲート組成物およびその使用方法 |
| US12473379B2 (en) * | 2019-09-06 | 2025-11-18 | Serum Institute Of India Private Limited | Method for obtaining purified bacterial polysaccharides |
| US20230085173A1 (en) * | 2020-02-21 | 2023-03-16 | Pfizer Inc. | Purification of saccharides |
| CA3181721A1 (en) * | 2020-06-12 | 2021-12-16 | Johan Fredrik Billing | Improved demineralization of fermentation broths and purification of fine chemicals such as oligosaccharides |
| US12053515B2 (en) | 2020-08-10 | 2024-08-06 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24F |
| US20230321212A1 (en) | 2020-08-26 | 2023-10-12 | Pfizer Inc. | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
| GB202016165D0 (en) | 2020-10-12 | 2020-11-25 | Optivalent Ltd | Vaccine |
| EP4232593A1 (en) | 2020-10-22 | 2023-08-30 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
| IL302413A (en) | 2020-11-04 | 2023-06-01 | Pfizer | Immunogenic preparations for use in pneumococcal vaccines |
| JP2023549736A (ja) | 2020-11-10 | 2023-11-29 | ファイザー・インク | コンジュゲートさせた莢膜糖抗原を含む免疫原性組成物およびその使用 |
| TW202245835A (zh) | 2021-02-04 | 2022-12-01 | 美商默沙東有限責任公司 | 用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物 |
| WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| US20250281601A1 (en) | 2021-05-03 | 2025-09-11 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
| AU2022281543A1 (en) | 2021-05-28 | 2023-11-23 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| TW202306969A (zh) | 2021-05-28 | 2023-02-16 | 美商輝瑞大藥廠 | 包含結合之莢膜醣抗原的免疫原組合物及其用途 |
| AU2023207315A1 (en) | 2022-01-13 | 2024-06-27 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| GB2614916A (en) | 2022-01-25 | 2023-07-26 | Optivalent Ltd | Intradermal vaccine complement |
| US20250163484A1 (en) | 2022-02-25 | 2025-05-22 | Pfizer Inc. | Methods for Incorporating Azido Groups in Bacterial Capsular Polysaccharides |
| WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
| WO2024110827A1 (en) | 2022-11-21 | 2024-05-30 | Pfizer Inc. | Methods for preparing conjugated capsular saccharide antigens and uses thereof |
| EP4622665A2 (en) | 2022-11-22 | 2025-10-01 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024116096A1 (en) | 2022-12-01 | 2024-06-06 | Pfizer Inc. | Pneumococcal conjugate vaccine formulations |
| WO2024166008A1 (en) | 2023-02-10 | 2024-08-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AU2024246082A1 (en) | 2023-03-30 | 2025-10-16 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024214016A1 (en) | 2023-04-14 | 2024-10-17 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2024224266A1 (en) | 2023-04-24 | 2024-10-31 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| AR132702A1 (es) | 2023-05-18 | 2025-07-23 | Merck Sharp & Dohme Llc | Compuestos y formulaciones adyuvantes útiles en vacunas neumocócicas |
| WO2024241172A2 (en) | 2023-05-19 | 2024-11-28 | Glaxosmithkline Biologicals Sa | Methods for eliciting an immune response to respiratory syncycial virus and streptococcus pneumoniae infection |
| TW202527906A (zh) | 2023-09-14 | 2025-07-16 | 美商輝瑞股份有限公司 | 包含經結合之肺炎鏈球菌莢膜醣抗原之佐劑化致免疫性組成物及其用途 |
| WO2025133971A1 (en) | 2023-12-23 | 2025-06-26 | Pfizer Inc. | Improved methods for producing bacterial capsular saccharide glycoconjugates |
| WO2025186705A2 (en) | 2024-03-06 | 2025-09-12 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
| WO2025219904A1 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Improved methods for producing glycoconjugates by reductive amination in aprotic solvent |
| WO2025219908A2 (en) | 2024-04-19 | 2025-10-23 | Pfizer Inc. | Media and fermentation methods for polysaccharide production in bacterial cell culture |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0002004B1 (en) | 1977-11-07 | 1982-03-24 | Ciba-Geigy Ag | Process for the manufacture of fluorinated cationic compounds and their use as surfactants |
| CA1115210A (en) * | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
| US4221906A (en) * | 1979-03-19 | 1980-09-09 | American Cyanamid Company | Stabilization of pneumococcal polysaccharides |
| US4242501A (en) * | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| FR2495939B1 (fr) * | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| JPS6170994A (ja) * | 1984-09-14 | 1986-04-11 | Daikin Ind Ltd | 環状（１→２）−β−Ｄ−グルカンの製法 |
| IT1187753B (it) * | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
| CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| US5714354A (en) * | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
| RU2087156C1 (ru) * | 1995-06-22 | 1997-08-20 | Леонид Николаевич Падюков | Вакцина против пневмококковой инфекции |
| JP4435413B2 (ja) * | 1997-12-23 | 2010-03-17 | バクスター・ヘルスケヤー・ソシエテ・アノニム | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
| US6146902A (en) * | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| GB0108079D0 (en) * | 2001-03-30 | 2001-05-23 | Microbial Technics Ltd | Protein |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| CN113198013B (zh) * | 2005-04-08 | 2024-02-20 | 惠氏有限责任公司 | 多价肺炎球菌多糖－蛋白质缀合物组合物 |
| PL1866342T3 (pl) * | 2005-04-08 | 2019-04-30 | Wyeth Llc | Oddzielanie zanieczyszczeń od polisacharydu Streptococcus pneumoniae przez manipulację pH |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| HUE039169T2 (hu) * | 2007-03-23 | 2018-12-28 | Wyeth Llc | Rövidített tisztítási eljárás Streptococcus pneumoniae tok-poliszacharidok elõállítására |
-
2008
- 2008-03-20 HU HUE11194173A patent/HUE039169T2/hu unknown
- 2008-03-20 AU AU2008231041A patent/AU2008231041B2/en active Active
- 2008-03-20 JP JP2009554744A patent/JP5688902B2/ja active Active
- 2008-03-20 DK DK11194173.8T patent/DK2436700T5/en active
- 2008-03-20 US US12/052,525 patent/US8652480B2/en active Active
- 2008-03-20 CL CL200800831A patent/CL2008000831A1/es unknown
- 2008-03-20 PL PL11194173T patent/PL2436700T3/pl unknown
- 2008-03-20 UA UAA200909741A patent/UA99278C2/ru unknown
- 2008-03-20 PL PL08732592T patent/PL2129693T3/pl unknown
- 2008-03-20 HU HUE08732592A patent/HUE031567T2/hu unknown
- 2008-03-20 ES ES18177128T patent/ES2922132T3/es active Active
- 2008-03-20 BR BRPI0809212A patent/BRPI0809212B8/pt active IP Right Grant
- 2008-03-20 SI SI200831984T patent/SI2436700T1/sl unknown
- 2008-03-20 NZ NZ580134A patent/NZ580134A/en unknown
- 2008-03-20 EP EP11194173.8A patent/EP2436700B8/en active Active
- 2008-03-20 DK DK18177128.8T patent/DK3406635T3/da active
- 2008-03-20 PL PL18177128.8T patent/PL3406635T3/pl unknown
- 2008-03-20 PT PT87325924T patent/PT2129693T/pt unknown
- 2008-03-20 EP EP18177128.8A patent/EP3406635B1/en active Active
- 2008-03-20 KR KR1020157002150A patent/KR20150021127A/ko not_active Ceased
- 2008-03-20 MX MX2009010221A patent/MX2009010221A/es active IP Right Grant
- 2008-03-20 SI SI200832196T patent/SI3406635T1/sl unknown
- 2008-03-20 CN CN200880012946.2A patent/CN101663327B/zh active Active
- 2008-03-20 DK DK08732592.4T patent/DK2129693T3/en active
- 2008-03-20 EP EP08732592.4A patent/EP2129693B1/en active Active
- 2008-03-20 KR KR1020097021976A patent/KR101500771B1/ko active Active
- 2008-03-20 PT PT181771288T patent/PT3406635T/pt unknown
- 2008-03-20 ES ES08732592.4T patent/ES2614249T3/es active Active
- 2008-03-20 PT PT111941738T patent/PT2436700T/pt unknown
- 2008-03-20 CA CA2681570A patent/CA2681570C/en active Active
- 2008-03-20 WO PCT/US2008/057688 patent/WO2008118752A2/en not_active Ceased
- 2008-03-20 MY MYPI20093908 patent/MY150927A/en unknown
- 2008-03-20 ES ES11194173.8T patent/ES2677353T3/es active Active
- 2008-03-20 SI SI200831741A patent/SI2129693T1/sl unknown
- 2008-03-20 HU HUE18177128A patent/HUE059085T2/hu unknown
- 2008-03-20 RU RU2009135485/10A patent/RU2516340C2/ru active
-
2009
- 2009-09-17 HN HN2009001965A patent/HN2009001965A/es unknown
- 2009-09-21 NI NI200900172A patent/NI200900172A/es unknown
- 2009-09-21 GT GT200900249A patent/GT200900249A/es unknown
- 2009-09-22 IL IL201106A patent/IL201106A/en active IP Right Grant
- 2009-09-22 ZA ZA200906625A patent/ZA200906625B/xx unknown
- 2009-09-23 CR CR11041A patent/CR11041A/es unknown
- 2009-09-23 EC EC2009009652A patent/ECSP099652A/es unknown
- 2009-10-20 CO CO09117278A patent/CO6251324A2/es active IP Right Grant
-
2014
- 2014-01-24 US US14/163,863 patent/US8999697B2/en active Active
-
2015
- 2015-01-27 JP JP2015013167A patent/JP2015143225A/ja not_active Withdrawn
- 2015-02-27 US US14/633,141 patent/US9675681B2/en active Active
-
2017
- 2017-03-23 JP JP2017056848A patent/JP6825950B2/ja active Active
- 2017-08-08 CL CL2017002029A patent/CL2017002029A1/es unknown
-
2018
- 2018-11-06 JP JP2018208647A patent/JP2019048844A/ja not_active Withdrawn
-
2020
- 2020-01-31 JP JP2020014532A patent/JP6872649B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL201106A0 (en) | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides | |
| EG25753A (en) | Process for the production of alcohols | |
| PL1999134T3 (pl) | Sposób wytwarzania alkoholi anhydrocukrowych | |
| GB2474310B (en) | Process for the production of sucrose-6-ester | |
| IL220430A0 (en) | Process for the production of benzopyran-2-ol derivatives | |
| IL202046A0 (en) | Process for the manufacture of p4o6 | |
| ZA200803921B (en) | Process for the production of oligosaccharides | |
| IL202153A0 (en) | Process for the production of pyrazoles | |
| IL227837A0 (en) | A process for purifying theobromine | |
| EP2206429A4 (en) | ANTIBIOTIC COMPOSITION AND MANUFACTURING METHOD THEREFOR | |
| SI2089468T1 (sl) | Postopek za pripravo funkcionalnih celuloznih oblikovancev | |
| EP1861408A4 (en) | PROCESS FOR PRODUCING HYDROCHLOROSILANES | |
| IL185722A0 (en) | Process for the production of methylcobalamin | |
| ZA201000237B (en) | Process for the production of tertiary alcohols | |
| PL2194796T3 (pl) | Sposób wytwarzania czekolady | |
| EP2221294A4 (en) | PROCESS FOR PREPARING N-CARBAMOYL-TERT.-LEUCIN | |
| EP2108036A4 (en) | PROCESS FOR PRODUCING ALCANOLAMINE | |
| EP2221290A4 (en) | PROCESS FOR THE PREPARATION OF ALKOXYINDANONE DERIVATIVES | |
| HK1138861A (en) | Shortened purification process for the production of capsularstreptococcus pneumoniae polysaccharides | |
| GB0718398D0 (en) | Process for the production of alcohols | |
| HU0700244D0 (en) | Process for the production of alcohol | |
| SI2029567T1 (sl) | Postopek za proizvodnjo derivator benzopiran-2-ola | |
| PL381675A1 (pl) | Sposób wytwarzania wyrobów porcelanowych | |
| ZA201002012B (en) | Catalyst production process |