CL2017002029A1 - Proceso para extraer exceso de proteina soluble e impurezas a partir de lisados celulares de serotipos de streptococcus pneumoniae utilizados en la producción de polisacaridos neumococales (divisional de sol. n°831-08). - Google Patents
Proceso para extraer exceso de proteina soluble e impurezas a partir de lisados celulares de serotipos de streptococcus pneumoniae utilizados en la producción de polisacaridos neumococales (divisional de sol. n°831-08).Info
- Publication number
- CL2017002029A1 CL2017002029A1 CL2017002029A CL2017002029A CL2017002029A1 CL 2017002029 A1 CL2017002029 A1 CL 2017002029A1 CL 2017002029 A CL2017002029 A CL 2017002029A CL 2017002029 A CL2017002029 A CL 2017002029A CL 2017002029 A1 CL2017002029 A1 CL 2017002029A1
- Authority
- CL
- Chile
- Prior art keywords
- streptococcus pneumoniae
- impurities
- production
- cell lysates
- soluble protein
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title abstract 4
- 229920001282 polysaccharide Polymers 0.000 title abstract 4
- 239000005017 polysaccharide Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 241000193998 Streptococcus pneumoniae Species 0.000 title abstract 2
- 239000013592 cell lysate Substances 0.000 title abstract 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 title abstract 2
- 239000012535 impurity Substances 0.000 title 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 1
- 239000006166 lysate Substances 0.000 abstract 1
- 238000010979 pH adjustment Methods 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
- 238000013060 ultrafiltration and diafiltration Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
Abstract
<p>Se describe un proceso abreviado para producir una solución que contiene polisacáridos capsulares esencialmente purificados a partir de un caldo de lisado celular de Streptococcus pneumoniae. La ultrafiltración de un lisado clarificado de S. pneumoniae, seguido por ajuste del pH hasta menos de 4, 5, preferiblemente más o menos 3, 5, precipitó por lo menos 98% de la proteína contenida en la solución sin afectar seriamente al rendimiento de polisacárido. Además, después de la ultrafiltración y diafiltración y acidificación hasta un pH de menos de 4, 5, la filtración utilizando carbono activado precipitó por 10 menos 90% de la proteína restante sin afectar seriamente el rendimiento del polisácarido. Ejemplos de serotipos no limitativos de S. pneumoniae que pueden ser purificados utilizando el proceso abreviado de la invención son 1, 4, 5, 6, 6A, 7F, 9V, 14, 18C, 19A y 23F. </p>
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89661607P | 2007-03-23 | 2007-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2017002029A1 true CL2017002029A1 (es) | 2018-05-18 |
Family
ID=39712482
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200800831A CL2008000831A1 (es) | 2007-03-23 | 2008-03-20 | Procesos para extraer exceso de proteina soluble e impurezas a partir de lisados celulares de serotipos de streptococcus pneumoniae utilizados en la produccion de polisacaridos neumococales. |
CL2017002029A CL2017002029A1 (es) | 2007-03-23 | 2017-08-08 | Proceso para extraer exceso de proteina soluble e impurezas a partir de lisados celulares de serotipos de streptococcus pneumoniae utilizados en la producción de polisacaridos neumococales (divisional de sol. n°831-08). |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200800831A CL2008000831A1 (es) | 2007-03-23 | 2008-03-20 | Procesos para extraer exceso de proteina soluble e impurezas a partir de lisados celulares de serotipos de streptococcus pneumoniae utilizados en la produccion de polisacaridos neumococales. |
Country Status (30)
Country | Link |
---|---|
US (3) | US8652480B2 (es) |
EP (3) | EP2436700B8 (es) |
JP (5) | JP5688902B2 (es) |
KR (2) | KR101500771B1 (es) |
CN (1) | CN101663327B (es) |
AU (1) | AU2008231041B2 (es) |
BR (1) | BRPI0809212B8 (es) |
CA (1) | CA2681570C (es) |
CL (2) | CL2008000831A1 (es) |
CO (1) | CO6251324A2 (es) |
CR (1) | CR11041A (es) |
DK (3) | DK2436700T5 (es) |
EC (1) | ECSP099652A (es) |
ES (3) | ES2677353T3 (es) |
GT (1) | GT200900249A (es) |
HK (1) | HK1141815A1 (es) |
HN (1) | HN2009001965A (es) |
HU (3) | HUE031567T2 (es) |
IL (1) | IL201106A (es) |
MX (1) | MX2009010221A (es) |
MY (1) | MY150927A (es) |
NI (1) | NI200900172A (es) |
NZ (1) | NZ580134A (es) |
PL (3) | PL2129693T3 (es) |
PT (3) | PT2129693T (es) |
RU (1) | RU2516340C2 (es) |
SI (3) | SI2436700T1 (es) |
UA (1) | UA99278C2 (es) |
WO (1) | WO2008118752A2 (es) |
ZA (1) | ZA200906625B (es) |
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