ZA200506400B - Expression vectors comprising the MCMV IE2 promoter - Google Patents
Expression vectors comprising the MCMV IE2 promoter Download PDFInfo
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- ZA200506400B ZA200506400B ZA200506400A ZA200506400A ZA200506400B ZA 200506400 B ZA200506400 B ZA 200506400B ZA 200506400 A ZA200506400 A ZA 200506400A ZA 200506400 A ZA200506400 A ZA 200506400A ZA 200506400 B ZA200506400 B ZA 200506400B
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
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- C07K14/04—Varicella-zoster virus
- C07K14/045—Cytomegalovirus
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- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| EP (1) | EP1601776B1 (sl) |
| JP (3) | JP5171033B2 (sl) |
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| CN (1) | CN100429315C (sl) |
| AT (1) | ATE399872T1 (sl) |
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| BR (1) | BRPI0408246A (sl) |
| CA (1) | CA2516157C (sl) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| DK1601776T3 (da) * | 2003-03-11 | 2008-10-13 | Serono Lab | Ekspressionsvektorer omfattende mCmV-IE2-promotoren |
| ATE549353T1 (de) * | 2003-05-13 | 2012-03-15 | Merck Serono Sa | Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen |
| DK1675956T3 (da) * | 2003-10-21 | 2010-11-22 | Merck Serono Sa | Minimal DNA-sekvens, der virksom som chromatinisolator, og dennes anvendelse til proteinekspression |
| AU2004291341B2 (en) * | 2003-11-05 | 2010-08-05 | Ares Trading S.A. | Process for the purification of IL-18 binding protein |
| CA2554238C (en) | 2004-03-01 | 2013-02-12 | Ares Trading S.A. | Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells |
| JP5043654B2 (ja) * | 2004-06-29 | 2012-10-10 | アレス トレーディング ソシエテ アノニム | Ｉｌ−１８結合タンパク質の精製のための方法 |
| CA2593429A1 (en) * | 2004-12-02 | 2006-06-08 | Laboratoires Serono S.A. | The lupac bifunctional marker and its use in protein production |
| KR101302904B1 (ko) | 2005-04-22 | 2013-09-06 | 론자 바이올로직스 피엘씨 | ｈＣＭＶ 주요 즉각 조기 유전자의 제 1 인트론 및ｍＣＭＶ 프로모터를 포함한 포유동물 발현 벡터 |
| CA2608656A1 (en) * | 2005-05-16 | 2006-11-23 | Morphotek, Inc. | Regulated vectors for selection of cells exhibiting desired phenotypes |
| PL2267024T3 (pl) | 2005-06-03 | 2012-10-31 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| JP5091127B2 (ja) * | 2005-06-10 | 2012-12-05 | アレス トレーディング ソシエテ アノニム | Ｉｌ−１８結合タンパク質の精製のための方法 |
| EP1760092A1 (en) * | 2005-08-26 | 2007-03-07 | Applied Research Systems ARS Holding N.V. | System for screening cells for high expression of a protein of interest |
| US20100330572A1 (en) | 2007-12-21 | 2010-12-30 | Assaraf Yehuda G | Organic compounds |
| JP2009276724A (ja) * | 2008-05-19 | 2009-11-26 | Nitto Denko Corp | 光導波路装置の製造方法 |
| KR101707251B1 (ko) | 2009-02-27 | 2017-02-15 | 노파르티스 아게 | 2종의 선택 마커를 포함하는 발현 벡터 시스템 |
| JP5502406B2 (ja) * | 2009-09-14 | 2014-05-28 | ロンザ・バイオロジクス・ピーエルシー | Ｃｈｏ細胞において組換えタンパク質を発現する方法 |
| KR101038126B1 (ko) * | 2010-11-30 | 2011-05-31 | 주식회사 엘지생명과학 | 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터 |
| US9249785B2 (en) * | 2012-01-31 | 2016-02-02 | Brightsource Industries (Isreal) Ltd. | Method and system for operating a solar steam system during reduced-insolation events |
| PL2711426T3 (pl) * | 2012-09-24 | 2015-09-30 | Lonza Biologics Plc | Wektory ekspresyjne zawierające chimeryczne sekwencje promotora i wzmacniacza wirusa cytomegalii |
| ITFI20120221A1 (it) * | 2012-10-22 | 2014-04-23 | Nuovo Pignone Srl | "exhaust gas collector and gas turbine" |
| WO2014133468A1 (en) * | 2013-02-28 | 2014-09-04 | Agency For Science, Technology And Research | Chimeric promoters for high gene expression level and stability in mammalian cells |
| CN103173481A (zh) * | 2013-03-01 | 2013-06-26 | 上海中医药大学附属普陀医院 | 一种含有abcb1基因3′utr序列和报告基因的质粒载体及其构建方法和用途 |
| CN103173480B (zh) * | 2013-03-01 | 2015-06-24 | 上海中医药大学附属曙光医院 | 一种利用双荧光素酶报告基因筛选多药耐药相关microRNA的方法 |
| US20160017319A1 (en) | 2013-03-11 | 2016-01-21 | Audrey Nommay | Method of screening cell clones |
| RU2716977C2 (ru) | 2013-07-31 | 2020-03-17 | Новартис Аг | Новые селективные векторы и способы селекции эукариотических клеток-хозяев |
| CN106029692A (zh) | 2013-12-20 | 2016-10-12 | 诺华股份有限公司 | 用于重组表达感兴趣产物的新型真核细胞和方法 |
| US11242551B2 (en) | 2013-12-20 | 2022-02-08 | Novartis Ag | Eukaryotic cells and methods for recombinantly expressing a product of interest |
| JP6265020B2 (ja) * | 2014-04-16 | 2018-01-24 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| PL3137595T3 (pl) | 2014-04-29 | 2019-09-30 | Novartis Ag | Nowe komórki kręgowców i sposoby ekspresji rekombinowanej polipeptydu będącego przedmiotem zainteresowania |
| WO2015177084A1 (en) * | 2014-05-19 | 2015-11-26 | F. Hoffmann-La Roche Ag | Method for production of polypeptides |
| KR20160068558A (ko) | 2014-12-05 | 2016-06-15 | 삼성바이오에피스 주식회사 | 마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법 |
| BR112017017076A2 (pt) | 2015-03-05 | 2018-04-10 | Ab2 Bio Sa | inibidor de il-18, anticorpo, métodos para o tratamento de uma doença ou um distúrbio associado a il-18 em um indivíduo, para determinar a quantidade de il-18 livre em uma amostra ou in situ, para diagnosticar uma predisposição a uma doença ou um distúrbio associado a il-18, para monitorar doença residual mínima em um paciente que segue o tratamento com o inibidor de il-18 ou a composição e para prever uma resposta de um paciente a um tratamento com o inibidor de il-18 ou composição, e, kit diagnóstico para detectar il-18 livre. |
| CA2981841A1 (en) * | 2015-04-14 | 2016-10-20 | Janssen Vaccines & Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
| US11028410B2 (en) | 2016-01-27 | 2021-06-08 | Just-Evotec Biologics, Inc. | Hybrid promoter and uses thereof |
| JP7046835B2 (ja) * | 2016-05-12 | 2022-04-04 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 強力でバランスのとれた双方向性プロモーター |
| KR102307065B1 (ko) | 2016-06-20 | 2021-09-30 | 얀센 백신스 앤드 프리벤션 비.브이. | 강력하고 균형 잡힌 양방향성 프로모터 |
| KR101864581B1 (ko) * | 2016-11-04 | 2018-07-13 | 국립암센터 | 양방향 프로모터를 포함하는 렌티바이러스 발현 벡터 및 이의 용도 |
| WO2018146205A1 (en) | 2017-02-09 | 2018-08-16 | Janssen Vaccines & Prevention B.V. | Potent and short promoter for expression of heterologous genes |
| WO2019070638A1 (en) | 2017-10-02 | 2019-04-11 | Astrazeneca Ab | CELL LINES AND METHODS FOR INCREASED PROTEIN PRODUCTION |
| MX2021006241A (es) * | 2018-12-04 | 2021-08-11 | Catalent Pharma Solutions Llc | Vectores para la fabricacion de proteinas. |
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| US2007A (en) * | 1841-03-16 | Improvement in the mode of harvesting grain | ||
| JPS63502719A (ja) * | 1985-12-18 | 1988-10-13 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | プロモ−タ−系 |
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| US4963481A (en) * | 1985-12-18 | 1990-10-16 | Genetics Institute Inc | Promoter system |
| JP2002508956A (ja) * | 1998-01-16 | 2002-03-26 | カリフォルニア パシフィック メディカル センター リサーチ インスティテュート | 遺伝子送達のための方法および組成物 |
| CA2401327C (en) * | 2000-03-03 | 2014-05-06 | Valentis, Inc. | Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use |
| JP5122053B2 (ja) * | 2000-05-05 | 2013-01-16 | メルク セロノ ソシエテ アノニム | アテローム性動脈硬化症の治療および／または予防のためのｉｌ−１８阻害剤の用途 |
| US7812148B2 (en) * | 2001-04-05 | 2010-10-12 | Millipore Corporation | Vectors comprising CpG islands without position effect varigation and having increased expression |
| WO2002099089A1 (en) * | 2001-06-04 | 2002-12-12 | Corixa Corporation | Compositions and methods for high-level, large-scale production of recombinant proteins |
| DK1601776T3 (da) * | 2003-03-11 | 2008-10-13 | Serono Lab | Ekspressionsvektorer omfattende mCmV-IE2-promotoren |
| ATE549353T1 (de) | 2003-05-13 | 2012-03-15 | Merck Serono Sa | Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen |
| DK1675956T3 (da) | 2003-10-21 | 2010-11-22 | Merck Serono Sa | Minimal DNA-sekvens, der virksom som chromatinisolator, og dennes anvendelse til proteinekspression |
| AU2004291341B2 (en) | 2003-11-05 | 2010-08-05 | Ares Trading S.A. | Process for the purification of IL-18 binding protein |
| CA2554238C (en) | 2004-03-01 | 2013-02-12 | Ares Trading S.A. | Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells |
| JP5043654B2 (ja) | 2004-06-29 | 2012-10-10 | アレス トレーディング ソシエテ アノニム | Ｉｌ−１８結合タンパク質の精製のための方法 |
| CA2593429A1 (en) * | 2004-12-02 | 2006-06-08 | Laboratoires Serono S.A. | The lupac bifunctional marker and its use in protein production |
| PL2267024T3 (pl) | 2005-06-03 | 2012-10-31 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| JP5091127B2 (ja) | 2005-06-10 | 2012-12-05 | アレス トレーディング ソシエテ アノニム | Ｉｌ−１８結合タンパク質の精製のための方法 |
| AU2012239382B2 (en) * | 2011-04-01 | 2016-04-21 | Chugai Seiyaku Kabushiki Kaisha | Recombinant polypeptide production method |
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