YU48150B - Postupak za dobivanje derivata taksana i dobiveni novi derivati - Google Patents

Postupak za dobivanje derivata taksana i dobiveni novi derivati

Info

Publication number
YU48150B
YU48150B YU182691A YU182691A YU48150B YU 48150 B YU48150 B YU 48150B YU 182691 A YU182691 A YU 182691A YU 182691 A YU182691 A YU 182691A YU 48150 B YU48150 B YU 48150B
Authority
YU
Yugoslavia
Prior art keywords
derivatives
aryl
procedure
obtaining
protecting
Prior art date
Application number
YU182691A
Other languages
English (en)
Other versions
YU182691A (sh
Inventor
J.-D. Bourzat
A. Commercon
J.-M. Paris
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR909014635A external-priority patent/FR2669631B1/fr
Priority claimed from FR9109423A external-priority patent/FR2679557B1/fr
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of YU182691A publication Critical patent/YU182691A/sh
Publication of YU48150B publication Critical patent/YU48150B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

POSTUPAK ZA DOBIVANJE DERIVATA TAKSANA I DOBIVENI NOVI DERIVATI - R1 označava atom vodonika ili radikal acetil i Ar označava radikal aril, na značen time, što se: a) kondenzuje derivat oksazolidina formule u kojoj je Ar definisan kao što je gore dato, Boc označava radikal terc-butoksikarbonil i R6 i R7, identični, ili različiti, označavaju svaki posebno radikal alkil koji sadrži 1 do 4 atoma ugljenika koji je u datom slučaju supstituisan sa jednim ili više radikala aril (fenil), ili aril (fenil), ili R6 i R7 zajedno sa atomom ugljenika za koji su vezani formiraju prsten koji ima 4 do 7 članova, sa derivatom taksana opšte formule: u kojoj R'1 označava radikal acetil ili zaštitnu grupu hidroksi-funkcije i R2 označava zaštitnu grupu hidroksi-funkcije, radi dobivanja produkta opšte formule: u kojoj su Ar, R'1, R2, R6 i R7 definisani kao što je gore dato, b) što se ovaj tretira u kiseloj sredini, pod uslovima koji su bez efekta na grupe R'1 i R2, radi dobivanja produkta opšte for-mule: u kojoj su R'1 i R2 definisani kao što je gore dato, c) što se ovaj tretira sa pogodnim reagensom koji omogućava uvodjenje radikala terc-butoksikarbonil ili benzoil u amino funkciju, radi dobivanja produkta opšte formule: d) što se zamenjuju zaštitne grupe R'1 i R2 atomima vodonika pod odgovarajućim reakcionim uslovima, e) što se dobiveni produkt izoluje i u datom slučaju prečisti. -Prijava sadrži još 9 zavisnih zahteva.
YU182691A 1990-11-23 1991-11-21 Postupak za dobivanje derivata taksana i dobiveni novi derivati YU48150B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR909014635A FR2669631B1 (fr) 1990-11-23 1990-11-23 Nouveaux derives de l'oxazolidine, leur preparation et leur emploi.
FR9109423A FR2679557B1 (fr) 1991-07-25 1991-07-25 Procede de preparation de derives du taxane, nouveaux derives obtenus et compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
YU182691A YU182691A (sh) 1994-01-20
YU48150B true YU48150B (sh) 1997-05-28

Family

ID=26228347

Family Applications (1)

Application Number Title Priority Date Filing Date
YU182691A YU48150B (sh) 1990-11-23 1991-11-21 Postupak za dobivanje derivata taksana i dobiveni novi derivati

Country Status (24)

Country Link
US (1) US5476954A (sh)
EP (2) EP0595370B1 (sh)
JP (1) JP3043411B2 (sh)
KR (1) KR100206457B1 (sh)
AT (2) ATE111905T1 (sh)
AU (1) AU655618B2 (sh)
CA (1) CA2096833C (sh)
CZ (1) CZ286749B6 (sh)
DE (2) DE69128971T2 (sh)
DK (2) DK0595370T3 (sh)
ES (2) ES2112377T3 (sh)
FI (2) FI105184B (sh)
GR (1) GR3026238T3 (sh)
HU (1) HU214332B (sh)
IE (2) IE80681B1 (sh)
MX (1) MX9102128A (sh)
NO (1) NO302699B1 (sh)
NZ (2) NZ247867A (sh)
PL (1) PL166893B1 (sh)
PT (2) PT99580B (sh)
RU (1) RU2095356C1 (sh)
SK (1) SK282162B6 (sh)
WO (1) WO1992009589A1 (sh)
YU (1) YU48150B (sh)

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FI106261B (fi) 2000-12-29
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