YU48105B - Derivati triazola i postupak za njihovo dobijanje - Google Patents

Derivati triazola i postupak za njihovo dobijanje

Info

Publication number
YU48105B
YU48105B YU17591A YU17591A YU48105B YU 48105 B YU48105 B YU 48105B YU 17591 A YU17591 A YU 17591A YU 17591 A YU17591 A YU 17591A YU 48105 B YU48105 B YU 48105B
Authority
YU
Yugoslavia
Prior art keywords
triazole
derivatives
procedure
obtaining
alkyl
Prior art date
Application number
YU17591A
Other languages
English (en)
Serbo-Croatian (sh)
Other versions
YU17591A (sh
Inventor
S.J. Ray
K. Richardson
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10670334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU48105(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU17591A publication Critical patent/YU17591A/sh
Publication of YU48105B publication Critical patent/YU48105B/sh
Priority to BA970298A priority Critical patent/BA97298A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
YU17591A 1990-02-02 1991-02-01 Derivati triazola i postupak za njihovo dobijanje YU48105B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BA970298A BA97298A (bs) 1990-02-02 1998-03-30 Triazolni fungicidni agensi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909002375A GB9002375D0 (en) 1990-02-02 1990-02-02 Triazole antifungal agents

Publications (2)

Publication Number Publication Date
YU17591A YU17591A (sh) 1994-01-20
YU48105B true YU48105B (sh) 1997-03-07

Family

ID=10670334

Family Applications (1)

Application Number Title Priority Date Filing Date
YU17591A YU48105B (sh) 1990-02-02 1991-02-01 Derivati triazola i postupak za njihovo dobijanje

Country Status (42)

Country Link
US (2) US5567817A (OSRAM)
EP (1) EP0440372B1 (OSRAM)
JP (2) JP2625584B2 (OSRAM)
KR (1) KR930011039B1 (OSRAM)
CN (2) CN1026788C (OSRAM)
AP (2) AP223A (OSRAM)
AT (1) ATE90090T1 (OSRAM)
AU (1) AU625188B2 (OSRAM)
BA (1) BA97298A (OSRAM)
BG (1) BG60032B2 (OSRAM)
BR (1) BR9100435A (OSRAM)
CA (2) CA2285891C (OSRAM)
CZ (1) CZ279339B6 (OSRAM)
DE (2) DE69100095T2 (OSRAM)
DK (1) DK0440372T3 (OSRAM)
EG (1) EG19750A (OSRAM)
ES (1) ES2055523T4 (OSRAM)
FI (3) FI971238A0 (OSRAM)
GB (1) GB9002375D0 (OSRAM)
HK (1) HK219396A (OSRAM)
HU (2) HU205351B (OSRAM)
IE (1) IE64774B1 (OSRAM)
IL (2) IL97045A (OSRAM)
IN (1) IN176148B (OSRAM)
IS (1) IS1629B (OSRAM)
LU (1) LU90960I2 (OSRAM)
LV (1) LV10615B (OSRAM)
MA (1) MA22054A1 (OSRAM)
MX (1) MX24363A (OSRAM)
MY (1) MY105494A (OSRAM)
NL (1) NL300100I2 (OSRAM)
NO (2) NO176796C (OSRAM)
NZ (1) NZ247205A (OSRAM)
OA (1) OA09480A (OSRAM)
PE (1) PE31691A1 (OSRAM)
PL (3) PL169307B1 (OSRAM)
PT (1) PT96617B (OSRAM)
RO (1) RO109648B1 (OSRAM)
RU (2) RU2114838C1 (OSRAM)
SK (1) SK278215B6 (OSRAM)
YU (1) YU48105B (OSRAM)
ZA (1) ZA91761B (OSRAM)

Families Citing this family (70)

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NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
DE19500379A1 (de) * 1995-01-09 1996-07-11 Basf Ag Fluorierte Pyrimidine als Herbizide
GB9516121D0 (en) * 1995-08-05 1995-10-04 Pfizer Ltd Organometallic addition to ketones
GB9602080D0 (en) 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
GB9605705D0 (en) * 1996-03-19 1996-05-22 Pfizer Ltd Therapeutic agents
RU2207119C2 (ru) * 1996-05-24 2003-06-27 Шеринг Корпорейшн Противогрибковый состав с повышенной биодоступностью
US7193083B2 (en) * 1996-07-26 2007-03-20 Pfizer, Inc. Preparation of triazoles by organometallic addition to ketones and intermediates therefor
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GB9818258D0 (en) * 1998-08-21 1998-10-14 Pfizer Ltd Antifungal compositions
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US6319933B1 (en) 2000-04-17 2001-11-20 Basilea Pharmaceutica Ag Azole derivatives
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EP2316469A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
CN100379733C (zh) * 2002-10-08 2008-04-09 南京康泽医药科技有限公司 三唑类抗真菌药物及其制备方法
US20040098839A1 (en) * 2002-11-27 2004-05-27 Pfizer Inc. Crystallization method and apparatus using an impinging plate assembly
US20080194820A1 (en) * 2004-12-14 2008-08-14 Venkataraman Sundaram Process For Preparing Voriconazole
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AR061889A1 (es) 2006-07-13 2008-10-01 Medichem Sa Proceso mejorado para la preparacion de voriconazol
CN1919846B (zh) * 2006-09-14 2013-01-02 大道隆达（北京）医药科技发展有限公司 伏立康唑及其药用盐、中间体的一种新定向合成制备方法
JP2010510248A (ja) * 2006-11-21 2010-04-02 ビアメト ファーマシューティカルズ，インク． 金属結合部分をターゲティング部分と組み合わせて使用する金属酸化還元酵素阻害剤
KR100889937B1 (ko) * 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
GB2452049A (en) * 2007-08-21 2009-02-25 Alpharma Aps Process for the preparation of voriconazole
CN101575330B (zh) * 2008-05-05 2012-10-31 丽珠医药集团股份有限公司 伏立康唑广谱抗真菌药物化合物、其组合物及用途
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WO2010095145A1 (en) * 2009-02-17 2010-08-26 Glenmark Generics Limited Process for the preparation of voriconazole
KR101109215B1 (ko) 2009-06-17 2012-01-30 보령제약 주식회사 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법
EA201270283A1 (ru) 2009-08-19 2012-12-28 Рациофарм Гмбх Способ получения соэвапоратов и комплексы, содержащие вориконазол и циклодекстрин
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CN102753543A (zh) 2009-12-30 2012-10-24 麦迪凯姆股份公司 药用用途的1-(1h-1,2,4-三唑-1-基)-2-丁醇衍生物，以及使用具有基本上未定义晶形的1-(1h-1,2,4-三唑-1-基)-2-丁醇衍生物制备所述1-(1h-1,2,4-三唑-1-基) -2-丁醇衍生物
KR100971371B1 (ko) * 2010-02-04 2010-07-20 동국제약 주식회사 신규한 중간체를 이용한 보리코나졸의 제조방법
WO2011110198A1 (en) 2010-03-10 2011-09-15 Synthron B.V. A process for making voriconazole
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CN101914091B (zh) * 2010-07-25 2015-05-27 浙江华海药业股份有限公司 一种制备伏立康唑中间体的方法
US20140350252A1 (en) 2011-02-21 2014-11-27 Nitin Maheshwari Process for the preparation of voriconazole and intermediates thereof
RU2566262C2 (ru) 2011-06-15 2015-10-20 Синтон Бв Стабилизированная композиция вориконазола
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JP6262972B2 (ja) * 2013-09-17 2018-01-17 公益財団法人微生物化学研究会 化合物、及びその製造方法、並びにボリコナゾールの製造方法
JP2018511608A (ja) * 2015-04-02 2018-04-26 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 殺真菌剤としてのトリアゾール誘導体
CN104987325B (zh) * 2015-06-30 2017-03-29 扬子江药业集团南京海陵药业有限公司 一种伏立康唑的制备方法
CN106117186B (zh) * 2016-06-12 2018-08-24 重庆莱美隆宇药业有限公司 一种伏立康唑及其中间体的制备方法
CN107556294A (zh) * 2016-06-30 2018-01-09 陕西合成药业股份有限公司 一种新型抗真菌感染药物及其制备方法和用途
TWI777515B (zh) 2016-08-18 2022-09-11 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
RU2019119089A (ru) * 2016-11-28 2020-12-21 Целликс Био Прайвет Лимитед Композиции и способы лечения грибковых инфекций
WO2018115319A2 (en) 2016-12-23 2018-06-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases
CN108456194B (zh) * 2017-02-17 2021-06-22 武汉朗来科技发展有限公司 三氮唑抗菌衍生物、其药物组合物和用途
CN109705102A (zh) 2019-02-19 2019-05-03 浙江华海立诚药业有限公司 伏立康唑及其中间体的制备方法
CN111440152B (zh) * 2020-05-18 2022-09-27 浙江诚意药业股份有限公司 一种伏立康唑的制备方法
CN112079819B (zh) * 2020-09-24 2022-06-17 南京易亨制药有限公司 一种改进的伏立康唑消旋体制备方法
CN114907319B (zh) * 2021-02-06 2024-06-14 华创合成制药股份有限公司 一种氘代三唑类化合物及其制备方法和用途
CN117069693A (zh) * 2022-05-16 2023-11-17 上海济煜医药科技有限公司 一类含胺基结构化合物的制备方法及作为抗菌剂的应用
CN115724829A (zh) * 2022-12-23 2023-03-03 天津力生制药股份有限公司 一种分离真菌药物中间体杂质的液相色谱制备方法
CN116730985A (zh) * 2023-06-20 2023-09-12 天津力生制药股份有限公司 一锅法制备伏立康唑的合成方法
CN118307408B (zh) * 2024-04-10 2025-03-21 上海恩氟佳科技有限公司 2-氟丙酰乙酸乙酯的制备方法

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CA2035314A1 (en) 1991-08-03
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AU625188B2 (en) 1992-07-02
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FI971238A7 (fi) 1997-03-25
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IL97045A0 (en) 1992-03-29
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EP0440372A1 (en) 1991-08-07
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