NO166321C - Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridinforbindelser. - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridinforbindelser.Info
- Publication number
- NO166321C NO166321C NO864665A NO864665A NO166321C NO 166321 C NO166321 C NO 166321C NO 864665 A NO864665 A NO 864665A NO 864665 A NO864665 A NO 864665A NO 166321 C NO166321 C NO 166321C
- Authority
- NO
- Norway
- Prior art keywords
- carbon atoms
- hydrogen
- preparation
- group
- phenyl
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical class C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 pyridine compound Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Inorganic Insulating Materials (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853541428 DE3541428A1 (de) | 1985-11-23 | 1985-11-23 | Neue basisch substituierte pyridinverbindungen, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO864665D0 NO864665D0 (no) | 1986-11-21 |
| NO864665L NO864665L (no) | 1987-05-25 |
| NO166321B NO166321B (no) | 1991-03-25 |
| NO166321C true NO166321C (no) | 1991-07-03 |
Family
ID=6286631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO864665A NO166321C (no) | 1985-11-23 | 1986-11-21 | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridinforbindelser. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4792554A (no) |
| EP (1) | EP0224159B1 (no) |
| JP (1) | JPS62129271A (no) |
| CN (1) | CN86107899A (no) |
| AT (1) | ATE59637T1 (no) |
| AU (1) | AU587086B2 (no) |
| CA (1) | CA1256873A (no) |
| DE (2) | DE3541428A1 (no) |
| DK (1) | DK558786A (no) |
| ES (1) | ES2032377T3 (no) |
| FI (1) | FI864737A7 (no) |
| GR (1) | GR3001470T3 (no) |
| HU (1) | HU196998B (no) |
| IL (1) | IL80715A (no) |
| NO (1) | NO166321C (no) |
| NZ (1) | NZ218359A (no) |
| PH (1) | PH24129A (no) |
| PT (1) | PT83786B (no) |
| ZA (1) | ZA868834B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
| US4916142A (en) * | 1987-02-02 | 1990-04-10 | Boc, Inc. | N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and their use as analgesics |
| US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US6080428A (en) | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
| US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE786565A (fr) * | 1971-07-23 | 1973-01-22 | Upjohn Co | Nouveaux oxydes de pyridine substitues et leur preparation |
| DE2334401A1 (de) * | 1973-07-06 | 1975-01-23 | Hoechst Ag | 2-nitro-3-aminoalkylamino-pyridine und verfahren zu ihrer herstellung |
| DE2900504A1 (de) * | 1979-01-08 | 1980-07-24 | Hoechst Ag | Neue substituierte 4-aminopyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| GB8320699D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Ethylenediamines |
-
1985
- 1985-11-23 DE DE19853541428 patent/DE3541428A1/de not_active Withdrawn
-
1986
- 1986-11-15 AT AT86115896T patent/ATE59637T1/de not_active IP Right Cessation
- 1986-11-15 ES ES198686115896T patent/ES2032377T3/es not_active Expired - Lifetime
- 1986-11-15 DE DE8686115896T patent/DE3676459D1/de not_active Expired - Fee Related
- 1986-11-15 EP EP86115896A patent/EP0224159B1/de not_active Expired - Lifetime
- 1986-11-20 FI FI864737A patent/FI864737A7/fi not_active Application Discontinuation
- 1986-11-21 DK DK558786A patent/DK558786A/da not_active Application Discontinuation
- 1986-11-21 NZ NZ218359A patent/NZ218359A/xx unknown
- 1986-11-21 PT PT83786A patent/PT83786B/pt not_active IP Right Cessation
- 1986-11-21 JP JP61276897A patent/JPS62129271A/ja active Pending
- 1986-11-21 NO NO864665A patent/NO166321C/no unknown
- 1986-11-21 US US06/933,532 patent/US4792554A/en not_active Expired - Fee Related
- 1986-11-21 HU HU864831A patent/HU196998B/hu not_active IP Right Cessation
- 1986-11-21 PH PH34509A patent/PH24129A/en unknown
- 1986-11-21 ZA ZA868834A patent/ZA868834B/xx unknown
- 1986-11-21 IL IL80715A patent/IL80715A/xx unknown
- 1986-11-21 AU AU65570/86A patent/AU587086B2/en not_active Ceased
- 1986-11-22 CN CN198686107899A patent/CN86107899A/zh active Pending
- 1986-11-24 CA CA000523703A patent/CA1256873A/en not_active Expired
-
1991
- 1991-02-12 GR GR91400031T patent/GR3001470T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62129271A (ja) | 1987-06-11 |
| HUT42473A (en) | 1987-07-28 |
| AU6557086A (en) | 1987-05-28 |
| CA1256873A (en) | 1989-07-04 |
| EP0224159A1 (de) | 1987-06-03 |
| ATE59637T1 (de) | 1991-01-15 |
| IL80715A (en) | 1990-08-31 |
| FI864737A7 (fi) | 1987-05-24 |
| AU587086B2 (en) | 1989-08-03 |
| US4792554A (en) | 1988-12-20 |
| HU196998B (en) | 1989-02-28 |
| GR3001470T3 (en) | 1992-10-08 |
| DK558786D0 (da) | 1986-11-21 |
| ZA868834B (en) | 1987-07-29 |
| NO864665L (no) | 1987-05-25 |
| CN86107899A (zh) | 1987-07-29 |
| PT83786B (pt) | 1989-06-30 |
| NZ218359A (en) | 1989-05-29 |
| DE3541428A1 (de) | 1987-05-27 |
| NO864665D0 (no) | 1986-11-21 |
| EP0224159B1 (de) | 1991-01-02 |
| FI864737A0 (fi) | 1986-11-20 |
| ES2032377T3 (es) | 1993-02-16 |
| PT83786A (de) | 1986-12-01 |
| DE3676459D1 (de) | 1991-02-07 |
| DK558786A (da) | 1987-05-24 |
| NO166321B (no) | 1991-03-25 |
| PH24129A (en) | 1990-03-05 |
| IL80715A0 (en) | 1987-02-27 |
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