WO2019234167A1 - Bestimmvorrichtung und verfahren zum bestimmen einer viskosität eines fluids - Google Patents

Bestimmvorrichtung und verfahren zum bestimmen einer viskosität eines fluids Download PDF

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Publication number
WO2019234167A1
WO2019234167A1 PCT/EP2019/064808 EP2019064808W WO2019234167A1 WO 2019234167 A1 WO2019234167 A1 WO 2019234167A1 EP 2019064808 W EP2019064808 W EP 2019064808W WO 2019234167 A1 WO2019234167 A1 WO 2019234167A1
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WIPO (PCT)
Prior art keywords
fluid
viscosity
determining
determining device
impeller
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2019/064808
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German (de)
English (en)
French (fr)
Inventor
Ingo STOTZ
Thomas Alexander SCHLEBUSCH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kardion GmbH
Original Assignee
Kardion GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kardion GmbH filed Critical Kardion GmbH
Priority to EP19729730.2A priority Critical patent/EP3801223B1/de
Priority to CN201980048764.9A priority patent/CN112584759B/zh
Priority to US15/734,519 priority patent/US12178554B2/en
Priority to JP2020567751A priority patent/JP7313068B2/ja
Priority to ES19729730T priority patent/ES2923294T3/es
Publication of WO2019234167A1 publication Critical patent/WO2019234167A1/de
Anticipated expiration legal-status Critical
Priority to US18/942,153 priority patent/US20250143587A1/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
    • A61B5/02035—Determining blood viscosity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7246—Details of waveform analysis using correlation, e.g. template matching or determination of similarity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/488—Diagnostic techniques involving Doppler signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
    • A61M60/178—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/403—Details relating to driving for non-positive displacement blood pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/515—Regulation using real-time patient data
    • A61M60/523—Regulation using real-time patient data using blood flow data, e.g. from blood flow transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/515—Regulation using real-time patient data
    • A61M60/531—Regulation using real-time patient data using blood pressure data, e.g. from blood pressure sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3344—Measuring or controlling pressure at the body treatment site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3365—Rotational speed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices

Definitions

  • the invention relates to a determining device and method for determining a viscosity of a fluid.
  • the invention also relates to a computer program and a machine-readable storage medium on which the computer program is stored.
  • PT prothrombin time
  • INR International Normalized Ratio
  • PT prothrombin time
  • INR International Normalized Ratio
  • the INR is determined in blood samples by adding thromboplastin and then measuring the time to coagulation. The determination can be carried out in the laboratory, there are now also test strip devices for self-measurement by the patient available, comparable to the course of a blood glucose measurement.
  • coagulation management is essential for minimizing pump thrombosis. Monitoring the blood viscosity as an INR replacement parameter may be sufficient for coagulation management.
  • EP 2 175 770 B1 describes an explicit blood viscosity sensor based on surface waves, in short SAW, for determining the viscosity.
  • US Pat. No. 7,591,777 B2 describes a viscosity determination in cardiac support systems by the mechanical reaction of the blood viscosity on the drive of the cardiac support system.
  • the object of the invention is to specify an improved method for determining a viscosity of a fluid and an improved determining device for this purpose.
  • a determining device presented here is designed to determine and provide or to transmit the viscosity of a fluid quickly and easily using current flow parameters of the fluid.
  • a device for determining a viscosity of a fluid has at least one determining device and one providing device.
  • the determining device is designed to determine the viscosity of the fluid using at least one sensed volume flow of the fluid and a sensed pressure difference of the fluid and / or a rotational speed of an impeller for conveying the fluid.
  • the providing device is designed to provide or transmit a viscosity signal which represents the viscosity determined by the determining device.
  • the determining means may be adapted to adjust the viscosity using a functional relationship between the volume flow and to determine the pressure difference to the viscosity and / or using a look-up table, in particular wherein in the look-up table a relationship between the volume flow and the pressure difference can be stored to the viscosity.
  • a viscosity associated with these values can be read out quickly and simply from the look-up table.
  • the viscosity can be determined quickly and simply by solving the functional relationship.
  • a calibration of a measurement of the type can be carried out beforehand or be such that both the viscosity in the relevant range and a rotational speed of, for example, a pump device for conveying the fluid vary within the relevant range and the resulting pump flows are measured or were.
  • an example empirical function can be determined or used, with the aid of which the viscosity can subsequently be calculated.
  • the lookup table and / or the functional context may be stored in the determiner or read by the determiner for use.
  • the determining device may, for example, also be arranged outside a body of a patient and data such as the aforementioned sensed volume flow of the fluid and a sensed pressure difference of the fluid and / or a rotational speed of a pump determine the viscosity of the fluid.
  • the determining device can receive the values or parameters required for determining the viscosity wirelessly or via a signal line so that it can also determine the viscosity of the fluid outside the patient's body.
  • the determining device may include a cannula having a receiving interface for receiving the fluid and one of the receiving interface in particular wherein the pressure difference represents a difference between a pressure of the fluid in the region of the receiving interface and a further pressure of the fluid in the region of the outlet interface and / or the volume flow a volume flow of the fluid through the cannula can.
  • a cannula may be designed for use on or in a cardiac assist system.
  • the cannula may be formed or configured to receive blood as the fluid.
  • the current viscosity of the blood in the cannula can be determined using the determining device.
  • the determining device has an impeller for conveying the fluid from the receiving section to the outlet interface of the cannula, in particular wherein the impeller is arranged or can be arranged on or in the region of the outlet interface.
  • the impeller can be arranged, for example, in an outlet section adjacent to the outlet interface. During operation of the impeller, the volume flow of the fluid and the pressure difference can thus be effected.
  • the determining device has a volumetric flow sensor which is designed to sense a volume flow of the fluid through the cannula and to make it available or to send it to the determining device, in particular wherein the volumetric flow sensor is in the region of Recording interface is arranged.
  • a current volume flow can be taken into account for determining the viscosity.
  • This volume flow sensor can have at least one Doppler sensor for the purpose of measuring Doppler ultrasound and / or a thermofilament anemometer sensor and / or an optical sensor.
  • the thermofilament anemometer sensor can have a sensor element, for example a wire, wherein the sensor element can be electrically heated and its electrical resistance depends on the temperature. By the Flow around a heat transfer can take place in the fluid, which varies with the flow rate. By measuring the electrical variables can be concluded that the flow rate.
  • the determining device can also have a pressure sensor device with at least one differential pressure sensor and / or two barometric pressure sensors, in particular wherein the pressure sensor device can be designed to sense a pressure difference between two sensor points on two opposite sides of the impeller and to provide them to the determining device or to send.
  • a current pressure difference can be taken into account.
  • the determining device has a drive device for driving the impeller coupled or coupleable to the impeller, in particular wherein the determining device can be designed to increase the viscosity using a drive parameter of the drive device and / or the impeller to determine.
  • the determining device can be designed to determine the viscosity using a drive parameter of the drive device and / or of the running wheel during operation of the drive device and / or the impeller.
  • the drive parameter can be understood an electrical power consumption of the drive device and / or a rotational speed and / or an angular velocity of the impeller.
  • Such a device may be designed or usable as a cardiac assist system. This cardiac assist system may advantageously determine a current blood viscosity and may, for example, provide or send for a diagnostic procedure.
  • a method for determining a viscosity of a fluid comprises a step of determining and a step of providing.
  • the viscosity of the fluid is determined using at least one sensed volumetric flow of the fluid and a sensed pressure difference of the fluid determined.
  • a viscosity signal is provided or transmitted that represents the viscosity determined in the step of determining.
  • This method may be practicable using the above-mentioned determining device.
  • the method can be implemented, for example, in software or hardware or in a mixed form of software and hardware, for example in a control unit.
  • Also of advantage is a computer program product or computer program with program code which can be stored on a machine-readable medium or storage medium such as a semiconductor memory, a hard disk memory or an optical memory and used for carrying out, implementing and / or controlling the steps of the method, in particular - When the program product or program is running on a computer or a device.
  • a machine-readable medium or storage medium such as a semiconductor memory, a hard disk memory or an optical memory
  • FIG. 1 is a schematic representation of a determining device for determining a viscosity of a fluid according to an embodiment
  • FIG. 2 shows a schematic side view of a determining device according to an embodiment
  • FIG. 3 shows a characteristic diagram of pressure difference over volume flow for different viscosities for use with a determining device according to an embodiment
  • 4 shows an exemplary embodiment of a method for determining a viscosity of a fluid according to one exemplary embodiment.
  • an exemplary embodiment comprises a "and / or" link between a first feature and a second feature
  • this is to be read such that the exemplary embodiment according to one embodiment includes both the first feature and the second feature and according to another embodiment. either only the first feature or only the second feature.
  • FIG. 1 shows a schematic illustration of a determination device 100 for determining a viscosity h of a fluid according to one exemplary embodiment.
  • the determining device 100 has a determining device 110 and a supply device 15.
  • the determining device 110 is designed to determine the viscosity h of the fluid using at least one sensed volume flow Q of the fluid and a sensed pressure difference Dr of the fluid.
  • the provision device 1 15 is designed to provide or transmit a viscosity signal 130, which represents the viscosity h determined by the determining device 1 10.
  • the determining device 1 10 is designed to read in the sensed volume flow Q and the sensed pressure difference Dr in the form of sensor signals.
  • FIG. 2 shows a schematic side view of a determining device 100 according to an exemplary embodiment. These may be the ones based on 1, with the difference that the determining device 100 according to this exemplary embodiment additionally has a cannula 200, an impeller 205, a drive device 210, a volumetric flow sensor 215 and a pressure sensor device 220.
  • the determining device or a determining device 110 can be integrated in the pump or arranged outside a patient's body if no or only too little installation space is available for microelectronic elements for measuring parameters which are required for determining the viscosity.
  • the electronics or corresponding components of the determining device 110 can be accommodated in a remote (implanted) control unit, so that then above all a pressure sensor and / or a transducer element of the volume flow sensor can be accommodated in the pump itself or in the patient can be implanted.
  • the sensor values of the corresponding sensor (s) implanted in the patient can then be led out of the patient, for example wirelessly or by means of a signal line, and processed in the determining device 110, for example in a pocket or on a belt of the patient to determine the viscosity of the fluid (here the blood).
  • a signal line for example a signal line
  • the determining device 110 for example in a pocket or on a belt of the patient to determine the viscosity of the fluid (here the blood).
  • a determining device 110 in the form of a cloud server, so that in this case a transmission of the sensor values required for the determination via the Internet or a corresponding signal line is to perform.
  • a corresponding safeguard or encryption of this data against unauthorized tapping or read-out of this data by unauthorized persons should hereby advantageously be ensured. It is thus conceivable to arrange the determining device 10 in three options:
  • the cannula 200 has a receiving interface 225, which is formed to receive the fluid, and an outlet interface 230, which is opposite to the receiving interface 225, and which is designed to discharge the fluid.
  • the impeller 205 is configured to convey the fluid from the receiving interface 225 to the outlet interface 230 of the cannula 200. According to this exemplary embodiment, the impeller 205 is arranged in the region of the outlet interface 230 and / or in the cannula 200.
  • the volumetric flow sensor 215 is designed to sense and send a volumetric flow of the fluid through the cannula 200 to the determining device 110. Accordingly, the volume flow represents a volume flow of the fluid through the cannula 200. According to this exemplary embodiment, the volume flow sensor 215 is arranged in the region of the receiving interface 225 for this purpose.
  • the volume flow sensor 215 according to this embodiment has a Doppler sensor. According to an alternative embodiment, the volumetric flow sensor 215 Additionally or alternatively, a themofilament anemometer sensor and / or an optical sensor.
  • the pressure sensor device 220 has two barometric pressure sensors 235, which are designed to sense a pressure difference between two sensor points on two opposite sides of the impeller 205 and to provide or send them to the determining device 110.
  • the pressure sensor device 220 additionally or alternatively has at least one differential pressure sensor.
  • the pressure sensors 235 are arranged in the region of the receiving interface 225 and in the region of the outlet interface 230. Accordingly, the pressure difference according to this exemplary embodiment represents a difference between a pressure of the fluid in the region of the receiving interface 225 and a further pressure of the fluid in the region of the outlet interface 230.
  • the drive device 210 is coupled to the impeller 205 and configured to drive the impeller 205.
  • the determining device 110 is configured to determine the viscosity using a drive parameter of the drive device 210 and / or the impeller 205 during an operation of the drive device 210 and / or of the impeller 205.
  • the determining device 1 10 outside of Pati ducks or a pump z. B. be arranged in a portable Steuergelitis. Sensor values of sensors implanted in the patient can then, for example, wirelessly or by means of a signal line of the determining device 1 10 are supplied.
  • the determining device 100 presented here can be used as a cardiac assistance system according to this exemplary embodiment.
  • a cardiac assist system also known as VAD patients
  • VAD stands for "Ventricular Assist Device”
  • coagulation management is essential to minimize pump thrombosis.
  • the patients are treated with drugs to inhibit plasma clotting and, for example, the INR is adjusted in the range from 2 to 2.5.
  • a mechanical load on the drive device 210 of a VAD system depends on the volume flow, the pressure difference and the viscosity.
  • the electrical power consumption of the drive device 210 can be used to deduce the viscosity of the fluid, in this case blood.
  • the determining device 110 is designed to read in as the drive parameter a parameter which represents or makes determinable the mechanical load on the drive device 210 and / or the impeller 205.
  • the determining device 110 is advantageously designed to divide the power consumption of the pump, comprising the drive device 210 and impeller 205, into a volumetric flow contribution and a viscosity contribution.
  • the flow measurement is ultrasound-based according to this,sbeii- game or realized anemometrically according to an alternative embodiment.
  • a direct determination of the viscosity during operation of the determining device 100 is possible by means of an explicit Doppler ultrasonic volume flow measurement.
  • a pumping power of the pump must advantageously not be interrupted.
  • the blood viscosity is ascertained continuously by the determining device 110 in accordance with this exemplary embodiment during operation of the determining device 100 or at fixed time intervals according to an alternative embodiment.
  • the provision device 1 15 is designed to provide the determined viscosity to a doctor and / or patient as a parameter for therapy guidance.
  • the viscosity signal is designed to display the viscosity on a display and / or to transmit it by radio transmission to a web service.
  • the determining device 110 can also be arranged outside the patient, for example in a bag which the patient carries with him. Signal values of sensors implanted in the patient can then be transmitted, for example, wirelessly and / or by means of a signal line to the determining device.
  • a determination device 100 presented here includes a system consisting of a pump drive in the form of the drive device 210, the impeller 205 and the cannula 200, also called inlet cannula, the volumetric flow sensor 215 for measuring the actual pump volumetric flow conveyed by the drive and impeller 205, here via Doppler ultrasound, optionally additionally by means of thermofilament anemometry and / or optical processes.
  • the determining device 100 comprises two barometric pressure sensors 235 for forming the pressure difference in the determining device 110, which according to this exemplary embodiment has a data processing device in the form of a microcontroller. According to an alternative embodiment, the determining device 100 has at least one differential pressure sensor for determining a pressure gradient over the impeller 205 in the form of an impeller.
  • the hydraulic power of the pump P hydraulic is of an angular velocity w, a hydraulic efficiency rj hyraulische and a Load torque M dependent, the load torque M is dependent on the viscosity.
  • This ratio can be represented in the following equation:
  • the hydraulic power P hydrauiisch is also dependent on the pressure difference Dr and the flow rate Q or volume flow. This ratio can be represented in the following equation:
  • the viscosity h can be determined from this measured volume flow Q wi , according to this exemplary embodiment by means of Doppler ultrasound sensors, as illustrated in FIG. 3.
  • a calibration of the type of measurement has been carried out in advance so that both the viscosity in the relevant range and the rotational speed in the relevant range have varied and the resulting pump flows have been measured.
  • look-up tables so-called “look-up tables”, LUT for short, were created, with the aid of which a viscosity can then be assigned by the determining device 110 of a measured pressure difference and a measured volume flow at a given speed / angular velocity. This measurement and calibration was performed in accordance with this embodiment using the determiner 100.
  • the electrical power consumption is used by the determining device 110 according to an alternative embodiment for the calculation, since:
  • the volume flow sensor 215 can be detected optically or by fluoroscopy. The calculation of the viscosity from pressure difference, volumetric flow and / or angular velocity can be demonstrated in the targeted experiment by manipulating the volumetric flow or the pressure difference.
  • FIG. 3 shows a characteristic diagram 300 of pressure difference Dr over volume flow Q for different viscosities h for use with a determining device according to an exemplary embodiment. This may be one of the determining devices 100 described with reference to FIGS. 1 or 2.
  • the map 300 is stored according to this embodiment in the form of the look-up table described in Figure 2 or thejanszusammen- hang in the determining device of the determining device or read by the determining device.
  • FIG. 4 shows a flowchart of a method 400 for determining a viscosity of a fluid according to an exemplary embodiment. This can be a method 400 which can be executed or actuated by one of the determining devices described with reference to FIG. 1 or 2.
  • the method 400 includes a step 405 of determining and a step 410 of providing.
  • step 405 of determining the viscosity of the fluid is determined using at least one sensed volumetric flow of the fluid and a sensed pressure differential of the fluid and / or a rotational speed of an impeller for delivering the fluid.
  • step 410 of providing a viscosity signal is provided or transmitted representing the viscosity determined in step 405 of the determination.
  • the method steps presented here can be repeated and executed in a sequence other than that described.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Computer Vision & Pattern Recognition (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Vascular Medicine (AREA)
  • External Artificial Organs (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PCT/EP2019/064808 2018-06-06 2019-06-06 Bestimmvorrichtung und verfahren zum bestimmen einer viskosität eines fluids Ceased WO2019234167A1 (de)

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EP19729730.2A EP3801223B1 (de) 2018-06-06 2019-06-06 Bestimmvorrichtung und verfahren zum bestimmen einer viskosität eines fluids
CN201980048764.9A CN112584759B (zh) 2018-06-06 2019-06-06 用于确定流体的粘度的确定器具及方法
US15/734,519 US12178554B2 (en) 2018-06-06 2019-06-06 Systems and methods for determining a viscosity of a fluid
JP2020567751A JP7313068B2 (ja) 2018-06-06 2019-06-06 流体の粘度を判定するための判定機器および方法
ES19729730T ES2923294T3 (es) 2018-06-06 2019-06-06 Dispositivo y método para determinar la viscosidad de un fluido
US18/942,153 US20250143587A1 (en) 2018-06-06 2024-11-08 Systems and methods for determining a viscosity of a fluid

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US20250143587A1 (en) 2025-05-08
US20220047173A1 (en) 2022-02-17
DE102018208936A1 (de) 2019-12-12
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