WO2015010135A2 - Compositions for modulating tau expression - Google Patents

Compositions for modulating tau expression Download PDF

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Publication number
WO2015010135A2
WO2015010135A2 PCT/US2014/047486 US2014047486W WO2015010135A2 WO 2015010135 A2 WO2015010135 A2 WO 2015010135A2 US 2014047486 W US2014047486 W US 2014047486W WO 2015010135 A2 WO2015010135 A2 WO 2015010135A2
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WO
WIPO (PCT)
Prior art keywords
compound
soooossssssssssooss
modified
seq
tau
Prior art date
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Ceased
Application number
PCT/US2014/047486
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English (en)
French (fr)
Other versions
WO2015010135A3 (en
Inventor
Holly Kordasiewicz
Eric E. Swayze
Susan M. Freier
Huynh-Hoa Bui
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Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
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Filing date
Publication date
Priority to NZ715828A priority Critical patent/NZ715828A/en
Priority to RS20210805A priority patent/RS62054B1/sr
Priority to KR1020247016358A priority patent/KR20240093742A/ko
Priority to CA2918600A priority patent/CA2918600C/en
Priority to HK16111947.3A priority patent/HK1223626B/en
Priority to US14/906,047 priority patent/US9683235B2/en
Priority to SI201431848T priority patent/SI3022217T1/sl
Priority to IL279572A priority patent/IL279572B2/en
Priority to DK14826839.4T priority patent/DK3022217T3/da
Priority to RU2016104824A priority patent/RU2735551C2/ru
Priority to JP2016527154A priority patent/JP6684707B2/ja
Priority to EP14826839.4A priority patent/EP3022217B1/en
Priority to CN202110665888.0A priority patent/CN113667667B/zh
Priority to MX2016000782A priority patent/MX379535B/es
Priority to KR1020217020564A priority patent/KR102424991B1/ko
Priority to KR1020167003896A priority patent/KR102273926B1/ko
Priority to CN201480040726.6A priority patent/CN108064227B/zh
Priority to BR112016000654-2A priority patent/BR112016000654B1/pt
Priority to EP21166766.2A priority patent/EP3910060A1/en
Priority to HRP20211051TT priority patent/HRP20211051T1/hr
Priority to AU2014290395A priority patent/AU2014290395B2/en
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Priority to KR1020257018963A priority patent/KR20250091306A/ko
Priority to PL14826839T priority patent/PL3022217T3/pl
Priority to IL302146A priority patent/IL302146A/en
Priority to CN202510791742.9A priority patent/CN120796262A/zh
Priority to LTEP14826839.4T priority patent/LT3022217T/lt
Priority to ES14826839T priority patent/ES2871533T3/es
Priority to SM20210371T priority patent/SMT202100371T1/it
Priority to KR1020227025324A priority patent/KR102526525B1/ko
Priority to KR1020237013823A priority patent/KR20230062658A/ko
Publication of WO2015010135A2 publication Critical patent/WO2015010135A2/en
Publication of WO2015010135A3 publication Critical patent/WO2015010135A3/en
Priority to IL243609A priority patent/IL243609B/en
Anticipated expiration legal-status Critical
Priority to US15/593,173 priority patent/US10793856B2/en
Priority to IL260378A priority patent/IL260378B/en
Priority to US16/986,770 priority patent/US11591595B2/en
Priority to AU2020250262A priority patent/AU2020250262B2/en
Priority to CY20211100565T priority patent/CY1124292T1/el
Priority to US18/155,945 priority patent/US12091662B2/en
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy

Definitions

  • Alzheimer's disease One of the early indicators that Tau may be important in neurodegenerative syndromes was the recognition that Tau is a key component of neurofibrillary inclusions in Alzheimer's disease.
  • neurofibrillary inclusions are aggregates of hyperphosphorylated Tau protein.
  • amyloid beta containing plaques neurofibrillary inclusions are a hallmark of Alzheimer's disease and correlate
  • Antisense oligonucleotide means a single-stranded oligonucleotide having a nucleobase sequence that permits hybridization to a corresponding segment of a target nucleic acid.
  • Certain embodiments provide methods for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with Tau in an individual in need thereof. Also contemplated are methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with Tau.
  • Tau associated diseases, disorders, and conditions include neurodegenerative diseases.
  • tau associated diseases include Tauopathies,
  • Certain embodiments provide compounds, comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides and comprising a nucleobase sequence comprising at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15, at least 16, at least 17, at least 18, at least 19, or at least 20 consecutive nucleobases complementary to an equal length portion of nucleobases 135783-135929 of SEQ ID NO: 1.
  • an antisense compound targeted to a Tau nucleic acid is 12 to 30 subunits in length. In certain embodiments, an antisense compound targeted to Tau nucleic acid is 12 to 25 subunits in length. In certain embodiments, an antisense compound targeted to Tau nucleic acid is 12 to 22 subunits in length. In certain embodiments, an antisense compound targeted to Tau nucleic acid is 14 to 20 subunits in length. In certain embodiments, an antisense compound targeted to Tau nucleic acid is 15 to 25 subunits in length. In certain embodiments, an antisense compound targeted to Tau nucleic acid is 18 to 22 subunits in length. In certain embodiments, an antisense compound targeted to Tau nucleic acid is 19 to 21 subunits in length.
  • gapmers provided herein include, for example 20-mers having a motif of 5-
  • hybridization occurs between an antisense compound disclosed herein and a Tau nucleic acid.
  • the most common mechanism of hybridization involves hydrogen bonding (e.g., Watson- Crick, Hoogsteen or reversed Hoogsteen hydrogen bonding) between complementary nucleobases of the nucleic acid molecules.
  • an antisense compound in which 18 of 20 nucleobases of the antisense compound are complementary to a target region, and would therefore specifically hybridize, would represent 90 percent complementarity.
  • the remaining noncomplementary nucleobases may be clustered or interspersed with complementary nucleobases and need not be contiguous to each other or to complementary nucleobases.
  • the antisense compounds are complementary to at least an 11 nucleobase portion of a target segment. In certain embodiments, the antisense compounds, are complementary to at least a 12 nucleobase portion of a target segment. In certain embodiments, the antisense compounds, are complementary to at least a 13 nucleobase portion of a target segment. In certain embodiments, the antisense compounds, are complementary to at least a 14 nucleobase portion of a target segment. In certain embodiments, the antisense compounds, are complementary to at least a 15 nucleobase portion of a target segment. Also contemplated are antisense compounds that are complementary to at least a 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or more nucleobase portion of a target segment, or a range defined by any two of these values.
  • Modifications to antisense compounds encompass substitutions or changes to internucleoside linkages, sugar moieties, or nucleobases. Modified antisense compounds are often preferred over native forms because of desirable properties such as, for example, enhanced cellular uptake, enhanced affinity for nucleic acid target, increased stability in the presence of nucleases, or increased inhibitory activity. Chemically modified nucleosides may also be employed to increase the binding affinity of a shortened or truncated antisense oligonucleotide for its target nucleic acid. Consequently, comparable results can often be obtained with shorter antisense compounds that have such chemically modified nucleosides. Modified Internucleoside Linkages
  • Examples of chemically modified sugars include 2'-F-5 '-methyl substituted nucleoside (see PCT International Application WO 2008/101157 Published on 8/21/08 for other disclosed 5',2'-bis substituted nucleosides) or replacement of the ribosyl ring oxygen atom with S with further substitution at the 2'-position (see published U.S. Patent Application US2005-0130923, published on June 16, 2005) or alternatively 5'-substitution of a BNA (see PCT International Application WO 2007/134181 Published on 11/22/07 wherein LNA is substituted with for example a 5'-methyl or a 5'-vinyl group).
  • the modified THP nucleosides of Formula VII are provided wherein q b q 2 , q3, q4, q 5 , q6 and q 7 are each H. In certain embodiments, at least one of qi, q 2 , q 3 , q 4 , q 5 , q 6 and q 7 is other than H. In certain embodiments, at least one of qi, q 2 , q 3 , q 4 , q 5 , q 6 and q 7 is methyl. In certain embodiments, THP nucleosides of Formula VII are provided wherein one of Ri and R 2 is fluoro. In certain embodiments, Ri is fluoro and R 2 is H; R t is methoxy and R 2 is H, and Ri is H and R 2 is methoxyethoxy.
  • 2'-modified or “2 '-substituted” refers to a nucleoside comprising a sugar comprising a substituent at the 2' position other than H or OH.
  • 2'-F refers to a nucleoside comprising a sugar comprising a fluoro group at the 2' position.
  • compositions comprising antisense compounds encompass any pharmaceutically acceptable salts, esters, or salts of such esters, or any other oligonucleotide which, upon administration to an animal, including a human, is capable of providing (directly or indirectly) the biologically active metabolite or residue thereof. Accordingly, for example, the disclosure is also drawn to pharmaceutically acceptable salts of antisense compounds, prodrugs, pharmaceutically acceptable salts of such prodrugs, and other bioequivalents. Suitable pharmaceutically acceptable salts include, but are not limited to, sodium and potassium salts.
  • the effects of antisense compounds on the level, activity or expression of Tau nucleic acids can be tested in vitro in a variety of cell types.
  • Cell types used for such analyses are available from commerical vendors (e.g. American Type Culture Collection, Manassus, VA; Zen-Bio, Inc., Research Triangle Park, NC; Clonetics Corporation, Walkersville, MD) and are cultured according to the vendor's instructions using commercially available reagents (e.g. Invitrogen Life Technologies, Carlsbad, CA).
  • Illustrative cell types include, but are not limited to, HepG2 cells, Hep3B cells, and primary hepatocytes.
  • Cells may be treated with antisense oligonucleotides when the cells reach approximately 60-80% confluency in culture.
  • Example 1 Antisense inhibition of human Tau in HepG2 cells by MOE gapmers
  • Example 2 Dose-dependent antisense inhibition of human tau in HepG2 cells by 5-10-5 MOE gapmers
  • Start site indicates the 5 '-most nucleoside to which the gapmer is targeted in the human gene sequence.
  • “Stop site” indicates the 3 '-most nucleoside to which the gapmer is targeted human gene sequence.
  • Each gapmer listed in the Tables below is targeted to either the human Tau genomic sequence, designated herein as SEQ ID NO: 1 (GENBANK
  • Additional antisense oligonucleotides were designed targeting a Tau nucleic acid and were tested for their effects on Tau mRNA in vitro.
  • Cultured SH-SY5Y cells were plated at a density of 20,000 cells per well and were transfected using electroporation with 6,000 nM antisense oligonucleotide. After a treatment period of approximately 24 hours, RNA was isolated from the cells and Tau mRNA levels were measured by quantitative real-time PCR. Human primer probe set RTS3104 was used to measure mRNA levels. Tau mRNA levels were adjusted according to total RNA content, as measured by RIBOGREEN®. Results are presented as percent inhibition of tau, relative to untreated control cells.

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PCT/US2014/047486 2013-07-19 2014-07-21 Compositions for modulating tau expression Ceased WO2015010135A2 (en)

Priority Applications (37)

Application Number Priority Date Filing Date Title
AU2014290395A AU2014290395B2 (en) 2013-07-19 2014-07-21 Compositions for modulating Tau expression
KR1020257018963A KR20250091306A (ko) 2013-07-19 2014-07-21 타우 발현 조절 조성물
CA2918600A CA2918600C (en) 2013-07-19 2014-07-21 Compositions for modulating tau expression
HK16111947.3A HK1223626B (en) 2013-07-19 2014-07-21 Compositions for modulating tau expression
US14/906,047 US9683235B2 (en) 2013-07-19 2014-07-21 Compositions for modulating Tau expression
SI201431848T SI3022217T1 (sl) 2013-07-19 2014-07-21 Sestave za moduliranje izražanja TAU
IL279572A IL279572B2 (en) 2013-07-19 2014-07-21 Preparations for the modulation of tau expression
DK14826839.4T DK3022217T3 (da) 2013-07-19 2014-07-21 Sammensætninger til modulering af tau-ekspression
RU2016104824A RU2735551C2 (ru) 2013-07-19 2014-07-21 Композиции для модулирования экспрессии тау-белка
JP2016527154A JP6684707B2 (ja) 2013-07-19 2014-07-21 タウ発現を調節するための組成物
EP14826839.4A EP3022217B1 (en) 2013-07-19 2014-07-21 Compositions for modulating tau expression
CN202110665888.0A CN113667667B (zh) 2013-07-19 2014-07-21 用于调节τ蛋白表达的组合物
MX2016000782A MX379535B (es) 2013-07-19 2014-07-21 Composiciones para modular la expresión de tau.
KR1020217020564A KR102424991B1 (ko) 2013-07-19 2014-07-21 타우 발현 조절 조성물
KR1020167003896A KR102273926B1 (ko) 2013-07-19 2014-07-21 타우 발현 조절 조성물
CN201480040726.6A CN108064227B (zh) 2013-07-19 2014-07-21 用于调节τ蛋白表达的组合物
BR112016000654-2A BR112016000654B1 (pt) 2013-07-19 2014-07-21 Oligonucleotídeo modificado, oligonucleotídeo modificado de fita única, seus usos e composição que os compreende e compostos antissenso conjugados
EP21166766.2A EP3910060A1 (en) 2013-07-19 2014-07-21 Compositions for modulating tau expression
HRP20211051TT HRP20211051T1 (hr) 2013-07-19 2014-07-21 Pripravci namijenjeni moduliranju eksprimiranja tau
NZ715828A NZ715828A (en) 2013-07-19 2014-07-21 Compositions for modulating tau expression
RS20210805A RS62054B1 (sr) 2013-07-19 2014-07-21 Kompozicije za modulaciju ekspresije tau
KR1020247016358A KR20240093742A (ko) 2013-07-19 2014-07-21 타우 발현 조절 조성물
PL14826839T PL3022217T3 (pl) 2013-07-19 2014-07-21 Kompozycje do modulowania ekspresji tau
IL302146A IL302146A (en) 2013-07-19 2014-07-21 Preparations for the modulation of tau expression
CN202510791742.9A CN120796262A (zh) 2013-07-19 2014-07-21 用于调节τ蛋白表达的组合物
LTEP14826839.4T LT3022217T (lt) 2013-07-19 2014-07-21 Kompozicijos, skirtos tau ekspresijos moduliavimui
ES14826839T ES2871533T3 (es) 2013-07-19 2014-07-21 Composiciones para modular la expresión de Tau
SM20210371T SMT202100371T1 (it) 2013-07-19 2014-07-21 Composizioni per modulare l'espressione di tau
KR1020227025324A KR102526525B1 (ko) 2013-07-19 2014-07-21 타우 발현 조절 조성물
KR1020237013823A KR20230062658A (ko) 2013-07-19 2014-07-21 타우 발현 조절 조성물
IL243609A IL243609B (en) 2013-07-19 2016-01-14 Compounds and preparations for modulating tau expression
US15/593,173 US10793856B2 (en) 2013-07-19 2017-05-11 Compositions for modulating Tau expression
IL260378A IL260378B (en) 2013-07-19 2018-07-02 Preparations for the modulation of tau expression
US16/986,770 US11591595B2 (en) 2013-07-19 2020-08-06 Compositions for modulating Tau expression
AU2020250262A AU2020250262B2 (en) 2013-07-19 2020-10-08 Compositions for modulating tau expression
CY20211100565T CY1124292T1 (el) 2013-07-19 2021-06-24 Συνθεσεις για τροποποιηση της εκφρασης tau
US18/155,945 US12091662B2 (en) 2013-07-19 2023-01-18 Compositions for modulating tau expression

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361856551P 2013-07-19 2013-07-19
US61/856,551 2013-07-19
US201361879621P 2013-09-18 2013-09-18
US61/879,621 2013-09-18
US201361885371P 2013-10-01 2013-10-01
US61/885,371 2013-10-01
US201462014486P 2014-06-19 2014-06-19
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Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9394333B2 (en) 2008-12-02 2016-07-19 Wave Life Sciences Japan Method for the synthesis of phosphorus atom modified nucleic acids
WO2016126995A1 (en) * 2015-02-04 2016-08-11 Bristol-Myers Squibb Company Tau antisense oligomers and uses thereof
WO2016151523A1 (en) * 2015-03-25 2016-09-29 Università Degli Studi Di Trento Rna interference mediated therapy for neurodegenerative diseases
US9598458B2 (en) 2012-07-13 2017-03-21 Wave Life Sciences Japan, Inc. Asymmetric auxiliary group
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
US9617547B2 (en) 2012-07-13 2017-04-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
US9644207B2 (en) 2013-03-14 2017-05-09 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating Tau expression
US9683235B2 (en) 2013-07-19 2017-06-20 Ionis Pharmaceuticals, Inc. Compositions for modulating Tau expression
WO2017109679A1 (en) * 2015-12-21 2017-06-29 Novartis Ag Compositions and methods for decreasing tau expression
US9744183B2 (en) 2009-07-06 2017-08-29 Wave Life Sciences Ltd. Nucleic acid prodrugs and methods of use thereof
US9840710B2 (en) 2015-11-18 2017-12-12 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
WO2018064593A1 (en) 2016-09-29 2018-04-05 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing tau expression
US9982257B2 (en) 2012-07-13 2018-05-29 Wave Life Sciences Ltd. Chiral control
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
US10149905B2 (en) 2014-01-15 2018-12-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
US10160969B2 (en) 2014-01-16 2018-12-25 Wave Life Sciences Ltd. Chiral design
US10273474B2 (en) 2012-03-30 2019-04-30 Washington University Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10370667B2 (en) 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
US10450568B2 (en) 2015-10-09 2019-10-22 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
WO2019175260A3 (en) * 2018-03-13 2019-11-14 Janssen Pharmaceutica Nv Modified oligonucleotides for use in treatment of tauopathies
WO2019226611A1 (en) * 2018-05-22 2019-11-28 Ionis Pharmaceuticals, Inc. Modulators of apol1 expression
WO2020007892A1 (en) 2018-07-03 2020-01-09 F. Hoffmann-La Roche Ag Oligonucleotides for modulating tau expression
WO2021178237A3 (en) * 2020-03-01 2021-10-21 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
US20210363523A1 (en) * 2020-03-18 2021-11-25 University Of Massachusetts Oligonucleotides for mapt modulation
WO2022125984A1 (en) * 2020-12-11 2022-06-16 Eisai R&D Management Co., Ltd. Tau-targeting oligonucleotide gapmers
JP2022106727A (ja) * 2015-07-10 2022-07-20 アイオーニス ファーマシューティカルズ， インコーポレーテッド ジアシルグリセロールアシルトランスフェラーゼ２（ｄｇａｔ２）の調節剤
RU2777570C2 (ru) * 2015-12-21 2022-08-08 Новартис Аг Композиции и способы для снижения экспрессии tau
US11761951B2 (en) 2015-02-04 2023-09-19 Bristol-Myers Squibb Company Methods of selecting therapeutic molecules
US11781143B2 (en) 2018-09-19 2023-10-10 Ionis Pharmaceuticals, Inc. Modulators of PNPLA3 expression
WO2023217437A1 (en) * 2022-05-13 2023-11-16 Julius-Maximilians-Universität Würzburg Method and molecules for reducing axonal tau protein accumulation through blocking of hnrnp r-mediated mapt mrna transport for treatment of alzheimer's disease
WO2023175091A3 (en) * 2022-03-16 2023-11-23 Janssen Pharmaceutica Nv MAPT siRNA AND USES THEREOF
WO2024145474A3 (en) * 2022-12-29 2024-08-22 Voyager Therapeutics, Inc. Compositions and methods for regulating mapt
US12115225B2 (en) 2016-05-06 2024-10-15 Astrazeneca Ab GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof
WO2024220930A3 (en) * 2023-04-20 2024-12-26 Adarx Pharmaceuticals, Inc. Mapt-modulating compositions and methods of use thereof
EP4143321A4 (en) * 2020-05-01 2025-02-19 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating atxn1
EP4126230A4 (en) * 2020-03-30 2025-07-30 Alnylam Pharmaceuticals Inc MICROTUBULE-ASSOCIATED PROTEIN TAU (MAPT) RNAI AGENT COMPOSITIONS AND METHODS OF USE THEREOF
US12421208B2 (en) 2020-06-25 2025-09-23 Astrazeneca Ab Chemical compounds
US12551569B2 (en) 2024-03-31 2026-02-17 Arrowhead Pharmaceuticals, Inc. RNAi agents for inhibiting expression of microtubule associated protein tau (MAPT), compositions thereof, and methods of use
EP4405484A4 (en) * 2021-09-24 2026-03-04 Alnylam Pharmaceuticals Inc ARNI AGENT COMPOSITIONS TARGETING MICROTUBULE-ASSOCIATED TAU PROTEIN (MAPT) AND THEIR METHODS OF USE
EP4413138A4 (en) * 2021-10-07 2026-04-01 Ionis Pharmaceuticals Inc COMPOUNDS AND METHODS FOR REDUCING TAU PROTEIN EXPRESSION
US12606555B2 (en) 2019-07-19 2026-04-21 Astrazeneca Ab Chemical compounds

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013159108A2 (en) * 2012-04-20 2013-10-24 Isis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleotides and uses thereof
EP4035659A1 (en) 2016-11-29 2022-08-03 PureTech LYT, Inc. Exosomes for delivery of therapeutic agents
CN110214184B (zh) * 2016-12-01 2024-07-02 桑格摩生物治疗股份有限公司 τ蛋白调节剂以及用于其递送的方法和组合物
CA3103429A1 (en) * 2018-06-14 2019-12-19 Don W. Cleveland Compounds and methods for increasing stmn2 expression
TWI833770B (zh) * 2018-06-27 2024-03-01 美商Ionis製藥公司 用於減少 lrrk2 表現之化合物及方法
EP3819378A4 (en) * 2018-07-04 2022-09-14 Aichi Medical University OLIGONUCLEOTIDES FOR CONTROL OF TAU SPLICING AND THEIR USES
KR20210070344A (ko) 2018-10-02 2021-06-14 상가모 테라퓨틱스, 인코포레이티드 타우 단백질의 조정을 위한 방법 및 조성물
PE20220168A1 (es) * 2019-03-15 2022-01-28 Ionis Pharmaceuticals Inc Compuestos y metodos para reducir la expresion de kcnt1
CN117120456A (zh) * 2020-12-11 2023-11-24 卫材R&D管理有限公司 聚-吗啉代寡核苷酸缺口体
CN117337168A (zh) 2021-04-01 2024-01-02 渤健马萨诸塞州股份有限公司 向中枢神经系统的核酸递送
TW202434730A (zh) * 2023-02-10 2024-09-01 日商大塚製藥股份有限公司 Tau剪接轉換寡核苷酸及用於治療或預防tau相關疾病之醫藥組合物
AU2024315297A1 (en) * 2023-08-01 2026-02-12 Tuojie Biotech (Shanghai) Co., Ltd. Dsrna targeting mapt and pharmaceutical use thereof
TW202515584A (zh) * 2023-10-11 2025-04-16 大陸商上海舶望製藥有限公司 用於抑制微管相關蛋白ｔａｕ（ｍａｐｔ）表達的組合物和方法
WO2025188990A1 (en) 2024-03-08 2025-09-12 Eli Lilly And Company Mapt antisense oligonucleotide
WO2026002277A1 (zh) * 2024-06-28 2026-01-02 艾码生物科技(南京)有限公司 靶向Tau的RNA干扰方法、核酸及其应用

Citations (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014226A1 (en) 1992-12-14 1994-06-23 Honeywell Inc. Motor system with individually controlled redundant windings
WO1998039352A1 (en) 1997-03-07 1998-09-11 Takeshi Imanishi Novel bicyclonucleoside and oligonucleotide analogues
WO1999014226A2 (en) 1997-09-12 1999-03-25 Exiqon A/S Bi- and tri-cyclic nucleoside, nucleotide and oligonucleotide analogues
WO2003004602A2 (en) 2001-07-03 2003-01-16 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
US6525191B1 (en) 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
US6670461B1 (en) 1997-09-12 2003-12-30 Exiqon A/S Oligonucleotide analogues
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
US20040171570A1 (en) 2002-11-05 2004-09-02 Charles Allerson Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
WO2004106356A1 (en) 2003-05-27 2004-12-09 Syddansk Universitet Functionalized nucleotide derivatives
WO2005021570A1 (ja) 2003-08-28 2005-03-10 Gene Design, Inc. Ｎ−０結合性架橋構造型新規人工核酸
US20050130923A1 (en) 2003-09-18 2005-06-16 Balkrishen Bhat 4'-thionucleosides and oligomeric compounds
WO2006047673A2 (en) 2004-10-27 2006-05-04 Vanderbilt University Mammalian genes involved in infection
US7053207B2 (en) 1999-05-04 2006-05-30 Exiqon A/S L-ribo-LNA analogues
WO2007134181A2 (en) 2006-05-11 2007-11-22 Isis Pharmaceuticals, Inc. 5'-modified bicyclic nucleic acid analogs
US20080039618A1 (en) 2002-11-05 2008-02-14 Charles Allerson Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US7399845B2 (en) 2006-01-27 2008-07-15 Isis Pharmaceuticals, Inc. 6-modified bicyclic nucleic acid analogs
WO2008101157A1 (en) 2007-02-15 2008-08-21 Isis Pharmaceuticals, Inc. 5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
US20080249058A1 (en) 2007-04-05 2008-10-09 Erik Roberson Agents that reduce neuronal overexcitation
WO2008150729A2 (en) 2007-05-30 2008-12-11 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
WO2008154401A2 (en) 2007-06-08 2008-12-18 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
WO2009006478A2 (en) 2007-07-05 2009-01-08 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1027347A (en) 1910-11-23 1912-05-21 Columbus K Lassiter Multiple-spindle drill.
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US4880635B1 (en) 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5367066A (en) 1984-10-16 1994-11-22 Chiron Corporation Oligonucleotides with selectably cleavable and/or abasic sites
FR2575751B1 (fr) 1985-01-08 1987-04-03 Pasteur Institut Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
US5166315A (en) 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4921757A (en) 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
JPH0825869B2 (ja) 1987-02-09 1996-03-13 株式会社ビタミン研究所 抗腫瘍剤包埋リポソ−ム製剤
US4917951A (en) 1987-07-28 1990-04-17 Micro-Pak, Inc. Lipid vesicles formed of surfactants and steroids
US4911928A (en) 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles
AU598946B2 (en) 1987-06-24 1990-07-05 Howard Florey Institute Of Experimental Physiology And Medicine Nucleoside derivatives
US5175273A (en) 1988-07-01 1992-12-29 Genentech, Inc. Nucleic acid intercalating agents
US5134066A (en) 1989-08-29 1992-07-28 Monsanto Company Improved probes using nucleosides containing 3-dezauracil analogs
US5130302A (en) 1989-12-20 1992-07-14 Boron Bilogicals, Inc. Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
US5457191A (en) 1990-01-11 1995-10-10 Isis Pharmaceuticals, Inc. 3-deazapurines
US5459255A (en) 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5859221A (en) 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5681941A (en) 1990-01-11 1997-10-28 Isis Pharmaceuticals, Inc. Substituted purines and oligonucleotide cross-linking
US5587470A (en) 1990-01-11 1996-12-24 Isis Pharmaceuticals, Inc. 3-deazapurines
US5149797A (en) 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
BR9106702A (pt) 1990-07-27 1993-06-08 Isis Pharmaceuticals Inc Analogo de oligonucleotideos e processos para modular a producao de uma proteina por um organismo e para tratar um organismo
US5432272A (en) 1990-10-09 1995-07-11 Benner; Steven A. Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5948903A (en) 1991-01-11 1999-09-07 Isis Pharmaceuticals, Inc. Synthesis of 3-deazapurines
US5594121A (en) 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
US5484908A (en) 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
TW393513B (en) 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
AU3222793A (en) 1991-11-26 1993-06-28 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
WO2002081494A1 (en) 2001-03-26 2002-10-17 Sirna Therapeutics, Inc. Oligonucleotide mediated inhibition of hepatitis b virus and hepatitis c virus replication
US20040054156A1 (en) 1992-05-14 2004-03-18 Kenneth Draper Method and reagent for inhibiting hepatitis B viral replication
US5434257A (en) 1992-06-01 1995-07-18 Gilead Sciences, Inc. Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
JPH06329551A (ja) * 1993-03-22 1994-11-29 Mitsubishi Kasei Corp アルツハイマー病の予防または治療薬およびそのスクリーニング方法
CA2116460A1 (en) 1993-03-02 1994-09-03 Mitsubishi Chemical Corporation Preventive or therapeutic agents for alzheimer's disease, a screening method of alzheimer's disease and tau-protein kinase i originated from human being
KR940021073A (ko) 1993-03-02 1994-10-17 미야베 요시가즈 알쯔하이머병의 예방 또는 치료제, 그 스크리닝 방법 및 인간 유래의 타우 단백질 키나아제 i
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5801154A (en) 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
GB9323483D0 (en) 1993-11-13 1994-01-05 Cerestar Holding Bv Edible composition and a process for its preparation
US5457187A (en) 1993-12-08 1995-10-10 Board Of Regents University Of Nebraska Oligonucleotides containing 5-fluorouracil
US5596091A (en) 1994-03-18 1997-01-21 The Regents Of The University Of California Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
USRE44779E1 (en) 1997-03-07 2014-02-25 Santaris Pharma A/S Bicyclonucleoside and oligonucleotide analogues
US6617162B2 (en) * 2001-12-18 2003-09-09 Isis Pharmaceuticals, Inc. Antisense modulation of estrogen receptor alpha expression
US7572582B2 (en) 1997-09-12 2009-08-11 Exiqon A/S Oligonucleotide analogues
US5942275A (en) 1997-10-27 1999-08-24 The Procter & Gamble Company Flavored nut spreads having milk chocolate flavor and creamy soft texture
US20030228597A1 (en) 1998-04-13 2003-12-11 Cowsert Lex M. Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation
WO1999062548A1 (en) 1998-06-01 1999-12-09 Advanced Research And Technology Institute Methods and compositions for diagnosing tauopathies
CZ296576B6 (cs) 1999-02-12 2006-04-12 Sankyo Company Limited Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
US7084125B2 (en) 1999-03-18 2006-08-01 Exiqon A/S Xylo-LNA analogues
WO2000063364A2 (en) 1999-04-21 2000-10-26 American Home Products Corporation Methods and compositions for inhibiting the function of polynucleotide sequences
JP4151751B2 (ja) 1999-07-22 2008-09-17 第一三共株式会社 新規ビシクロヌクレオシド類縁体
EP1097941A1 (en) 1999-11-05 2001-05-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Substance capable of controlling the inclusion of exon 10 of the tau gene, and its therapeutic use against tauopathies
EP1779859B1 (en) 1999-12-08 2010-06-09 Cyclacel Pharmaceuticals, Inc. Use of depsipeptide and congeners thereof as immunosuppressants in preventing or treating rejection following transplantation and for induction of apoptosis of activated CD4 or CD8 T-cells
JP2004509604A (ja) 2000-03-28 2004-04-02 アイシス・ファーマシューティカルス・インコーポレーテッド ｍＲＮＡプロセッシングのアンチセンスモジュレーションによる、細胞行動の改変
AU2001250572A1 (en) 2000-04-07 2001-10-23 Epigenomics Ag Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
EP1412515A2 (en) 2001-01-16 2004-04-28 Genset Treatment of cns disorders using d-amino acid oxidase and d-aspartate oxidase antagonists
US20050019915A1 (en) 2001-06-21 2005-01-27 Bennett C. Frank Antisense modulation of superoxide dismutase 1, soluble expression
CA2790034A1 (en) 2001-06-21 2003-01-03 Isis Pharmaceuticals, Inc. Antisense modulation of superoxide dismutase 1, soluble expression
US20030158403A1 (en) 2001-07-03 2003-08-21 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
US20030175906A1 (en) 2001-07-03 2003-09-18 Muthiah Manoharan Nuclease resistant chimeric oligonucleotides
US20040142325A1 (en) 2001-09-14 2004-07-22 Liat Mintz Methods and systems for annotating biomolecular sequences
AU2002364945A1 (en) 2001-10-25 2003-07-09 Neurogenetics, Inc. Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
EP1472335A4 (en) 2001-11-08 2005-12-28 Univ Johns Hopkins METHODS AND SYSTEMS FOR SEQUENCING NUCLEIC ACIDS
US20070203333A1 (en) 2001-11-30 2007-08-30 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20050153336A1 (en) * 2002-03-29 2005-07-14 Bennett C. F. Compositions and their uses directed to nucleic acid binding proteins
US7569575B2 (en) 2002-05-08 2009-08-04 Santaris Pharma A/S Synthesis of locked nucleic acid derivatives
US20040110149A1 (en) * 2002-12-10 2004-06-10 Isis Pharmaceuticals Inc. Modulation of BUB1-beta expression
AU2003268032A1 (en) 2002-07-29 2004-02-16 Epigenesis Pharmaceuticals, Inc. Composition and methods for treatment and screening
US20040241854A1 (en) 2002-08-05 2004-12-02 Davidson Beverly L. siRNA-mediated gene silencing
US20050106731A1 (en) 2002-08-05 2005-05-19 Davidson Beverly L. siRNA-mediated gene silencing with viral vectors
AU2003255435A1 (en) * 2002-08-14 2004-03-03 Universitat Zurich A cellular assay system for neurofibrillary tangle formation
AU2003284323A1 (en) 2002-10-18 2004-05-04 Alnylam Pharmaceuticals Inc Double-stranded rna structures and constructs, and methods for generating and using the same
EP2305812A3 (en) 2002-11-14 2012-06-06 Dharmacon, Inc. Fuctional and hyperfunctional sirna
US20080318210A1 (en) 2003-08-27 2008-12-25 Rosetta Genomics Bioinformatically detectable group of novel regulatory viral and viral associated oligonucleotides and uses thereof
JP2004187609A (ja) * 2002-12-12 2004-07-08 Sankyo Co Ltd 最適アンチセンス配列の決定法
US6673661B1 (en) 2002-12-20 2004-01-06 Taiwan Semiconductor Manufacturing Co., Ltd. Self-aligned method for forming dual gate thin film transistor (TFT) device
AU2003299430B2 (en) 2002-12-31 2009-01-08 Neurovision-Pharma Gmbh Methods of treating neurological conditions with hematopoeitic growth factors
AU2003904328A0 (en) 2003-08-13 2003-08-28 Garvan Institute Of Medical Research Diagnosis and treatment of neurodegenerative disorders
WO2005030928A2 (en) 2003-09-23 2005-04-07 Chihiro Koike PORCINE INVARIANT CHAIN PROTEIN, FULL LENGTH cDNA, GENOMIC ORGANIZATION, AND REGULATORY REGION
US8012944B2 (en) 2003-10-30 2011-09-06 Pharmascience Inc. Method for treating cancer using IAP antisense oligomer and chemotherapeutic agent
US20050244851A1 (en) 2004-01-13 2005-11-03 Affymetrix, Inc. Methods of analysis of alternative splicing in human
CN100410383C (zh) 2004-05-11 2008-08-13 中国农业科学院生物技术研究所 一种昆虫杆状病毒生物反应器的制备方法
EP1752536A4 (en) 2004-05-11 2008-04-16 Alphagen Co Ltd POLYNUCLEOTIDE CAUSING RNA INTERFERENCE AND METHOD OF REGULATING GENE EXPRESSION WITH THE USE OF THE SAME
DK1794313T3 (da) 2004-06-21 2013-07-22 Proteome Sciences Plc Fremgangsmåde til screeninger der anvender C-ABL, FYN og SYK i kombination med tau-protein
US20080003570A1 (en) 2004-12-22 2008-01-03 The General Hospital Corporation Translation enhancer elements of genes encoding human Tau protein and human alpha-synuclein protein
WO2006100627A1 (en) 2005-03-21 2006-09-28 Koninklijke Philips Electronics N.V. Appliance for personal care with automatic fluid dispenser
US20060216722A1 (en) 2005-03-25 2006-09-28 Christer Betsholtz Glomerular expression profiling
US20090176725A1 (en) 2005-08-17 2009-07-09 Sirna Therapeutics Inc. Chemically modified short interfering nucleic acid molecules that mediate rna interference
CA2620856C (en) 2005-08-29 2017-11-28 Isis Pharmaceuticals, Inc. Methods for use in modulating mir-122a
WO2007025987A1 (en) 2005-08-30 2007-03-08 Novo Nordisk A/S Expression of proteins in e.coli
RU2448974C2 (ru) * 2005-11-01 2012-04-27 Элнилэм Фармасьютикалз, Инк. РНКи-ИНГИБИРОВАНИЕ РЕПЛИКАЦИИ ВИРУСА ГРИППА
WO2007089607A2 (en) 2006-01-26 2007-08-09 University Of Massachusetts Rna silencing agents for use in therapy and nanotransporters for efficient delivery of same
US7569686B1 (en) 2006-01-27 2009-08-04 Isis Pharmaceuticals, Inc. Compounds and methods for synthesis of bicyclic nucleic acid analogs
US8178503B2 (en) 2006-03-03 2012-05-15 International Business Machines Corporation Ribonucleic acid interference molecules and binding sites derived by analyzing intergenic and intronic regions of genomes
GB0605337D0 (en) 2006-03-17 2006-04-26 Genomica Sau Treatment of CNS conditions
EP2023940B1 (en) 2006-05-05 2011-06-22 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression of sglt2
US7666854B2 (en) 2006-05-11 2010-02-23 Isis Pharmaceuticals, Inc. Bis-modified bicyclic nucleic acid analogs
JP2010505897A (ja) 2006-10-11 2010-02-25 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ インフルエンザターゲット
JP2010507387A (ja) * 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド 新規のｓｉＲＮＡおよびその使用方法
CN101889086B (zh) 2007-05-01 2014-07-02 桑塔里斯制药公司 Tnf超家族受体的剪接转换寡聚物，以及它们治疗疾病的用途
WO2008151631A2 (en) 2007-06-15 2008-12-18 Exiqon A/S Use of short oligonucleotides for reagent redundancy experiments in rna functional analysis
WO2009023855A2 (en) 2007-08-15 2009-02-19 Isis Pharmaceuticals, Inc. Tetrahydropyran nucleic acid analogs
US20090076725A1 (en) 2007-09-14 2009-03-19 Kulvir Singh Bhogal Conveyance mode aware navigation device
CN102076852A (zh) * 2007-11-09 2011-05-25 Isis药物公司 因子7表达的调节
US8546556B2 (en) 2007-11-21 2013-10-01 Isis Pharmaceuticals, Inc Carbocyclic alpha-L-bicyclic nucleic acid analogs
WO2009100320A2 (en) 2008-02-07 2009-08-13 Isis Pharmaceuticals, Inc. Bicyclic cyclohexitol nucleic acid analogs
WO2009124341A1 (en) 2008-04-07 2009-10-15 The University Of Queensland Rna molecules and uses thereof
BRPI0801674B1 (pt) 2008-06-04 2015-08-18 Carmine Giunti De Oliveira Luiz Formulação de creme de alfarroba com avelã sem adição de açúcar, sem lactose e sem glúten
WO2010036698A1 (en) 2008-09-24 2010-04-01 Isis Pharmaceuticals, Inc. Substituted alpha-l-bicyclic nucleosides
WO2010048497A1 (en) 2008-10-24 2010-04-29 Genizon Biosciences Inc. Genetic profile of the markers associated with alzheimer's disease
BRPI0901526A2 (pt) 2009-05-19 2011-01-18 Laerte Casoni José formulação de pasta de avelã sem adição de sacarose, enriquecida com fibras
PT3305302T (pt) 2009-06-17 2018-12-14 Biogen Ma Inc Composições e métodos de modulação de excisões de smn2 em um sujeito
JP2014501097A (ja) 2009-07-06 2014-01-20 アルナイラム ファーマシューティカルズ， インコーポレイテッド 生物由来物質の産生を高めるための組成物及び方法
EP2451476A4 (en) 2009-07-06 2013-07-03 Alnylam Pharmaceuticals Inc BIOTRAITEMENT BASED ON CELLS
US20110041191A1 (en) 2009-07-09 2011-02-17 Bettina Platt Animal model, and products and methods useful for the production thereof
EP2462153B1 (en) 2009-08-06 2015-07-29 Isis Pharmaceuticals, Inc. Bicyclic cyclohexose nucleic acid analogs
CN102482670B (zh) 2009-08-21 2018-06-15 库尔纳公司 通过抑制‘hsp70-相互作用蛋白的c末端’(chip)的天然反义转录物而治疗chip相关疾病
EP3626823A1 (en) * 2009-09-11 2020-03-25 Ionis Pharmaceuticals, Inc. Modulation of huntingtin expression
RU2619185C2 (ru) 2009-12-23 2017-05-12 Курна, Инк. Лечение заболеваний, связанных с разобщающим белком 2 (ucp2), путем ингибирования природного антисмыслового транскрипта к ucp2
US8653047B2 (en) * 2010-01-08 2014-02-18 Isis Pharmaceuticals, Inc. Modulation of angiopoietin-like 3 expression
WO2011097643A1 (en) 2010-02-08 2011-08-11 Isis Pharmaceuticals, Inc. Selective reduction of allelic variants
GB2471149B (en) 2010-03-04 2011-06-08 Eger Olive Oil Products Industry Ltd Dr Olive oil based flavoured spreads
WO2011123621A2 (en) 2010-04-01 2011-10-06 Alnylam Pharmaceuticals Inc. 2' and 5' modified monomers and oligonucleotides
RU2664452C2 (ru) 2010-04-19 2018-08-17 Нлифе Терапеутикс, С.Л. Конъюгат, медицинское средство и способы лечения и/или профилактики депрессии и болезни, связанной с отложением телец Леви
US10913767B2 (en) 2010-04-22 2021-02-09 Alnylam Pharmaceuticals, Inc. Oligonucleotides comprising acyclic and abasic nucleosides and analogs
KR101869570B1 (ko) 2010-04-28 2018-06-20 아이오니스 파마수티컬즈, 인코포레이티드 변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물
WO2012005898A2 (en) 2010-06-15 2012-01-12 Alnylam Pharmaceuticals, Inc. Chinese hamster ovary (cho) cell transcriptome, corresponding sirnas and uses thereof
WO2012018881A2 (en) 2010-08-03 2012-02-09 Alnylam Pharmaceuticals, Inc. Methods and compositions for the regulation of rna
US20140155462A1 (en) 2011-04-22 2014-06-05 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibitions of egfr by double-stranded rna
EP2709728B1 (en) 2011-05-20 2019-01-23 Oligomerix, Inc. Tau protease methods of use
WO2012177639A2 (en) 2011-06-22 2012-12-27 Alnylam Pharmaceuticals, Inc. Bioprocessing and bioproduction using avian cell lines
US8906441B2 (en) 2011-09-22 2014-12-09 Hormel Foods Corporation Peanut spread
US9670488B2 (en) 2011-11-04 2017-06-06 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of met by double stranded RNA
EP2782571A4 (en) * 2011-11-23 2015-04-01 Intellikine Llc HETEROCYCLIC COMPOUNDS AND USES THEREOF
BE1020640A3 (nl) 2011-12-03 2014-02-04 Cavalier Nv Een met vezels verrijkte vulsamenstelling voor een chocoladeproduct.
AU2013203395A1 (en) 2012-03-30 2013-10-17 Isis Pharmaceuticals, Inc. Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome
EA201492119A1 (ru) 2012-05-16 2015-05-29 Рана Терапьютикс, Инк. Композиции и способы для модулирования экспрессии apoa1 и abca1
JP6453212B2 (ja) 2012-07-13 2019-01-16 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． キラル制御
EP3693460A1 (en) 2012-07-27 2020-08-12 Ionis Pharmaceuticals, Inc. Modulation of renin-angiotensin system (ras) related diseases by angiotensinogen
GB201301233D0 (en) 2013-01-24 2013-03-06 Queen Mary & Westfield College Method
ITGE20130015A1 (it) 2013-02-01 2014-08-02 Microtem Di Mattia Chiodetti E Savi No Larocca Snc Dispositivo di tenuta meccanica, in particolare per alberi di trasmissione in navi, natanti o simili
ES2807379T3 (es) 2013-03-14 2021-02-22 Ionis Pharmaceuticals Inc Composiciones y métodos para regular la expresión de Tau
DK2991656T3 (da) 2013-05-01 2020-03-23 Ionis Pharmaceuticals Inc Sammensætninger og fremgangsmåder til modulering af apolipoprotein c-iii-ekspression
DK3007564T3 (da) 2013-06-10 2020-03-09 Cargill Inc Struktureret fedtsystem
TWI772856B (zh) 2013-07-19 2022-08-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
DE102013108693B3 (de) 2013-08-12 2014-12-24 Mars Inc. Schale
AU2014337506B2 (en) 2013-10-14 2020-10-15 Ionis Pharmaceuticals, Inc. Methods for modulating expression of C9ORF72 antisense transcript
DK3068233T3 (en) 2013-11-15 2019-04-08 Aak Ab Publ COCOA BREAST STABILIZING VEGETABLE FAT COMPOSITION
WO2015106128A2 (en) 2014-01-09 2015-07-16 Alnylam Pharmaceuticals, Inc. MODIFIED RNAi AGENTS
WO2016019063A1 (en) 2014-07-29 2016-02-04 Isis Pharmaceuticals, Inc. Compositions and methods for modulating tau expression
WO2016127002A1 (en) 2015-02-04 2016-08-11 Bristol-Myers Squibb Company Lna oligonucleotides with alternating flanks
AU2016215155A1 (en) 2015-02-04 2017-08-17 F. Hoffmann-La Roche Ag Tau antisense oligomers and uses thereof
EP3274456B1 (en) 2015-03-25 2020-06-24 Università Degli Studi Di Trento Rna interference mediated therapy for neurodegenerative diseases
CN108135921B (zh) 2015-07-22 2023-10-17 波涛生命科学有限公司 寡核苷酸组合物及其方法
BR112018006147B1 (pt) 2015-09-29 2022-06-07 Bunge Loders Croklaan B.V. Composição de creme de chocolate e/ou de recheio, e, método para preparação de uma composição de creme de chocolate e/ou recheio de confeitaria
PH12018501207B1 (en) 2015-12-21 2024-02-23 Novartis Ag Compositions and methods for decreasing tau expression
ES2963428T3 (es) 2016-09-29 2024-03-27 Biogen Ma Inc Compuestos y métodos para reducir la expresión de Tau
AR109750A1 (es) 2016-09-29 2019-01-23 Ionis Pharmaceuticals Inc Compuestos y métodos para reducir la expresión de tau
KR20200131263A (ko) 2018-03-13 2020-11-23 얀센 파마슈티카 엔.브이. 변형 올리고뉴클레오티드 및 타우병증에서의 사용 방법
SG11202012759XA (en) 2018-07-03 2021-01-28 Hoffmann La Roche Oligonucleotides for modulating tau expression
IL287798B2 (en) 2019-05-08 2025-09-01 Biogen Ma Inc Convergent Syntheses of Oligonucleotides in Liquid Phase
CN118872090A (zh) 2022-03-18 2024-10-29 松下新能源株式会社 非水电解质二次电池

Patent Citations (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014226A1 (en) 1992-12-14 1994-06-23 Honeywell Inc. Motor system with individually controlled redundant windings
WO1998039352A1 (en) 1997-03-07 1998-09-11 Takeshi Imanishi Novel bicyclonucleoside and oligonucleotide analogues
US6268490B1 (en) 1997-03-07 2001-07-31 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogues
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
US7034133B2 (en) 1997-09-12 2006-04-25 Exiqon A/S Oligonucleotide analogues
WO1999014226A2 (en) 1997-09-12 1999-03-25 Exiqon A/S Bi- and tri-cyclic nucleoside, nucleotide and oligonucleotide analogues
US6670461B1 (en) 1997-09-12 2003-12-30 Exiqon A/S Oligonucleotide analogues
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US7053207B2 (en) 1999-05-04 2006-05-30 Exiqon A/S L-ribo-LNA analogues
US6525191B1 (en) 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
WO2003004602A2 (en) 2001-07-03 2003-01-16 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
US20040171570A1 (en) 2002-11-05 2004-09-02 Charles Allerson Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US7696345B2 (en) 2002-11-05 2010-04-13 Isis Pharmaceuticals, Inc. Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US20080039618A1 (en) 2002-11-05 2008-02-14 Charles Allerson Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
WO2004106356A1 (en) 2003-05-27 2004-12-09 Syddansk Universitet Functionalized nucleotide derivatives
WO2005021570A1 (ja) 2003-08-28 2005-03-10 Gene Design, Inc. Ｎ−０結合性架橋構造型新規人工核酸
US7427672B2 (en) 2003-08-28 2008-09-23 Takeshi Imanishi Artificial nucleic acids of n-o bond crosslinkage type
US20050130923A1 (en) 2003-09-18 2005-06-16 Balkrishen Bhat 4'-thionucleosides and oligomeric compounds
WO2006047673A2 (en) 2004-10-27 2006-05-04 Vanderbilt University Mammalian genes involved in infection
US7399845B2 (en) 2006-01-27 2008-07-15 Isis Pharmaceuticals, Inc. 6-modified bicyclic nucleic acid analogs
US20090012281A1 (en) 2006-01-27 2009-01-08 Isis Pharmaceuticals, Inc. 6-modified bicyclic nucleic acid analogs
US7547684B2 (en) 2006-05-11 2009-06-16 Isis Pharmaceuticals, Inc. 5′-modified bicyclic nucleic acid analogs
WO2007134181A2 (en) 2006-05-11 2007-11-22 Isis Pharmaceuticals, Inc. 5'-modified bicyclic nucleic acid analogs
WO2008101157A1 (en) 2007-02-15 2008-08-21 Isis Pharmaceuticals, Inc. 5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
US20080249058A1 (en) 2007-04-05 2008-10-09 Erik Roberson Agents that reduce neuronal overexcitation
WO2008150729A2 (en) 2007-05-30 2008-12-11 Isis Pharmaceuticals, Inc. N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
WO2008154401A2 (en) 2007-06-08 2008-12-18 Isis Pharmaceuticals, Inc. Carbocyclic bicyclic nucleic acid analogs
WO2009006478A2 (en) 2007-07-05 2009-01-08 Isis Pharmaceuticals, Inc. 6-disubstituted bicyclic nucleic acid analogs

Non-Patent Citations (42)

* Cited by examiner, † Cited by third party
Title
"GENBANK", Database accession no. DR002467.1
"GENBANK", Database accession no. NM 001123066.3
"GENBANK", Database accession no. NM 001203251.1
"GENBANK", Database accession no. NM 016835.4
"GENBANK", Database accession no. NM 016841.4
"GENBANK", Database accession no. NM_001123066.3
"GENBANK", Database accession no. NM_001203251.1
"GENBANK", Database accession no. NM_016835.4
"GENBANK", Database accession no. NM_016841.4
"GENBANK", Database accession no. NT 010783.14
"GENBANK", Database accession no. NT 010783.15
"GENBANK", Database accession no. NT -010783.15
"GENBANK", Database accession no. NT_010783.15
ADV. APPL. MATH., vol. 2, no. 482, 1981, pages 489
ALBAEK ET AL., J. ORG. CHEM., vol. 71, 2006, pages 7731 - 7740
ALTMANN ET AL., BIOCHEM. SOC. TRANS., vol. 24, 1996, pages 630 - 637
ALTMANN ET AL., CHIMIA, vol. 50, 1996, pages 168 - 176
ALTMANN ET AL., NUCLEOSIDES NUCLEOTIDES, vol. 16, 1997, pages 917 - 926
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, no. 403, 1990, pages 410
BAKER ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 11944 - 12000
BRAASCH ET AL., CHEM. BIOL., vol. 8, 2001, pages 1 - 7
CHATTOPADHYAYA ET AL., J. ORG. CHEM., vol. 74, 2009, pages 118 - 134
DAVIES ET AL., J. NEUROCHEM., vol. 86, 2003, pages 582 - 590
DUFF ET AL., NEUROBIOLOGY OF DISEASE, vol. 7, 2000, pages 87 - 98
ELAYADI ET AL., CURR. OPINION INVEST. DRUGS, vol. 2, 2001, pages 558 - 561
FREIER ET AL., NUCLEIC ACIDS RESEARCH, vol. 25, no. 22, 1997, pages 4429 - 4443
FRIEDEN ET AL., NUCLEIC ACIDS RESEARCH, vol. 21, 2003, pages 6365 - 6372
GAUTSCHI ET AL., J. NATL. CANCER INST., vol. 93, March 2001 (2001-03-01), pages 463 - 471
JONES, L.J. ET AL., ANALYTICAL BIOCHEMISTRY, vol. 265, 1998, pages 368 - 374
KOSHKIN ET AL., TETRAHEDRON, vol. 54, 1998, pages 3607 - 3630
KUMAR ET AL., BIOORG. MED. CHEM. LETT., vol. 8, 1998, pages 2219 - 2222
LEUMANN, BIOORG. MED. CHEM., vol. 10, 2002, pages 841 - 854
MADISON WIS: "Genetics Computer Group", vol. 8, UNIVERSITY RESEARCH PARK, article "Wisconsin Sequence Analysis Package, Version 8 for Unix"
MAHER; DOLNICK, NUC. ACID. RES., vol. 16, 1988, pages 3341 - 3358
MARTIN, HELV. CHIM. ACTA, vol. 78, 1995, pages 486 - 504
ORUM ET AL., CURR. OPINION MOL. THER., vol. 3, 2001, pages 239 - 243
SINGH ET AL., CHEM. COMMUN., vol. 4, 1998, pages 455 - 456
SINGH ET AL., J. ORG. CHEM., vol. 63, 1998, pages 10035 - 10039
SRIVASTAVA ET AL., J. AM. CHEM. SOC., vol. 129, no. 26, 2007, pages 8362 - 8379
WAHLESTEDT ET AL., PROC. NATL. ACAD. SCI. U. S. A., vol. 97, 2000, pages 5633 - 5638
WOOLF ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 7305 - 7309
ZHANG; MADDEN, GENOME RES., vol. 7, no. 649, 1997, pages 656

Cited By (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9695211B2 (en) 2008-12-02 2017-07-04 Wave Life Sciences Japan, Inc. Method for the synthesis of phosphorus atom modified nucleic acids
US9394333B2 (en) 2008-12-02 2016-07-19 Wave Life Sciences Japan Method for the synthesis of phosphorus atom modified nucleic acids
US10329318B2 (en) 2008-12-02 2019-06-25 Wave Life Sciences Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
US10307434B2 (en) 2009-07-06 2019-06-04 Wave Life Sciences Ltd. Nucleic acid prodrugs and methods of use thereof
US9744183B2 (en) 2009-07-06 2017-08-29 Wave Life Sciences Ltd. Nucleic acid prodrugs and methods of use thereof
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
US10280192B2 (en) 2011-07-19 2019-05-07 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
US11781135B2 (en) 2012-03-30 2023-10-10 Washington University Methods for treating Alzheimer's disease
US10273474B2 (en) 2012-03-30 2019-04-30 Washington University Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
US9617547B2 (en) 2012-07-13 2017-04-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
US10167309B2 (en) 2012-07-13 2019-01-01 Wave Life Sciences Ltd. Asymmetric auxiliary group
US9598458B2 (en) 2012-07-13 2017-03-21 Wave Life Sciences Japan, Inc. Asymmetric auxiliary group
US9982257B2 (en) 2012-07-13 2018-05-29 Wave Life Sciences Ltd. Chiral control
US10590413B2 (en) 2012-07-13 2020-03-17 Wave Life Sciences Ltd. Chiral control
US11155815B2 (en) 2013-03-14 2021-10-26 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating Tau expression
US9644207B2 (en) 2013-03-14 2017-05-09 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating Tau expression
US11591595B2 (en) 2013-07-19 2023-02-28 Biogen Ma Inc. Compositions for modulating Tau expression
US9683235B2 (en) 2013-07-19 2017-06-20 Ionis Pharmaceuticals, Inc. Compositions for modulating Tau expression
US10793856B2 (en) 2013-07-19 2020-10-06 Biogen Ma Inc. Compositions for modulating Tau expression
US12091662B2 (en) 2013-07-19 2024-09-17 Biogen Ma Inc. Compositions for modulating tau expression
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10149905B2 (en) 2014-01-15 2018-12-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
US10160969B2 (en) 2014-01-16 2018-12-25 Wave Life Sciences Ltd. Chiral design
US11761951B2 (en) 2015-02-04 2023-09-19 Bristol-Myers Squibb Company Methods of selecting therapeutic molecules
EP3253875B1 (en) * 2015-02-04 2020-01-08 H. Hoffnabb-La Roche Ag Tau antisense oligomers and uses thereof
EP3653712A1 (en) * 2015-02-04 2020-05-20 H. Hoffnabb-La Roche Ag Tau antisense oligomers and uses thereof
CN107922946A (zh) * 2015-02-04 2018-04-17 霍夫曼-拉罗奇有限公司 Tau反义低聚物及其用途
WO2016126995A1 (en) * 2015-02-04 2016-08-11 Bristol-Myers Squibb Company Tau antisense oligomers and uses thereof
US10799523B2 (en) 2015-02-04 2020-10-13 F. Hoffmann-La Roche Ag Tau antisense oligomers and uses thereof
US11077132B2 (en) 2015-02-04 2021-08-03 F. Hoffmann-La Roche Ag Tau antisense oligomers and uses thereof
WO2016151523A1 (en) * 2015-03-25 2016-09-29 Università Degli Studi Di Trento Rna interference mediated therapy for neurodegenerative diseases
US10513701B2 (en) 2015-03-25 2019-12-24 Università Degli Studi Di Trento RNA interference mediated therapy for neurodegenerative diseases
JP2022106727A (ja) * 2015-07-10 2022-07-20 アイオーニス ファーマシューティカルズ， インコーポレーテッド ジアシルグリセロールアシルトランスフェラーゼ２（ｄｇａｔ２）の調節剤
US10450568B2 (en) 2015-10-09 2019-10-22 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
US9840710B2 (en) 2015-11-18 2017-12-12 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
US10370667B2 (en) 2015-11-18 2019-08-06 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of parkinsons disease
US10787669B2 (en) 2015-11-18 2020-09-29 Rosalind Franklin University Of Medicine And Science Antisense compounds targeting Leucine-Rich repeat kinase 2(LRRK2) for the treatment of Parkinsons disease
RU2747734C2 (ru) * 2015-12-21 2021-05-13 Новартис Аг Композиции и способы для снижения экспрессии tau
JP2021118732A (ja) * 2015-12-21 2021-08-12 ノバルティス アーゲー タウ発現を減少させるための組成物および方法
EA036417B1 (ru) * 2015-12-21 2020-11-09 Новартис Аг Композиции и способы для снижения экспрессии tau
AU2016376034B2 (en) * 2015-12-21 2020-12-03 Novartis Ag Compositions and methods for decreasing tau expression
JP7594557B2 (ja) 2015-12-21 2024-12-04 ノバルティス アーゲー タウ発現を減少させるための組成物および方法
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IL296844B1 (en) * 2015-12-21 2023-12-01 Novartis Ag Compositions and methods for decreasing tau expression
KR20180089517A (ko) * 2015-12-21 2018-08-08 노파르티스 아게 타우 발현을 감소시키기 위한 조성물 및 방법
AU2020267282B2 (en) * 2015-12-21 2023-05-18 Novartis Ag Compositions and methods for decreasing tau expression
JP7027328B2 (ja) 2015-12-21 2022-03-01 ノバルティス アーゲー タウ発現を減少させるための組成物および方法
CN109072237A (zh) * 2015-12-21 2018-12-21 诺华股份有限公司 降低tau表达的组合物和方法
JP2022065096A (ja) * 2015-12-21 2022-04-26 ノバルティス アーゲー タウ発現を減少させるための組成物および方法
CN109072237B (zh) * 2015-12-21 2022-12-16 诺华股份有限公司 降低tau表达的组合物和方法
JP2019500428A (ja) * 2015-12-21 2019-01-10 ノバルティス アーゲー タウ発現を減少させるための組成物および方法
US12115225B2 (en) 2016-05-06 2024-10-15 Astrazeneca Ab GLP-1 receptor ligand moiety conjugated oligonucleotides and uses thereof
WO2018064593A1 (en) 2016-09-29 2018-04-05 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing tau expression
EP4335923A2 (en) 2016-09-29 2024-03-13 Biogen MA Inc. Compounds and methods for reducing tau expression
US11053498B2 (en) 2016-09-29 2021-07-06 Biogen Ma Inc. Compounds and methods for reducing Tau expression
US10407680B2 (en) 2016-09-29 2019-09-10 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing Tau expression
EP3922637A1 (en) * 2018-03-13 2021-12-15 Janssen Pharmaceutica NV Modified oligonucleotides for use in treatment of tauopathies
US11453881B2 (en) 2018-03-13 2022-09-27 Janssen Pharmaceutica Nv Modified oligonucleotides for use in treatment of tauopathies
WO2019175260A3 (en) * 2018-03-13 2019-11-14 Janssen Pharmaceutica Nv Modified oligonucleotides for use in treatment of tauopathies
US11525136B2 (en) 2018-05-22 2022-12-13 Ionis Pharmaceuticals, Inc. Modulators of APOL1 expression
KR20210011981A (ko) * 2018-05-22 2021-02-02 아이오니스 파마수티컬즈, 인코포레이티드 Apol1 발현의 조절인자
US10927377B2 (en) 2018-05-22 2021-02-23 Ionis Pharmaceuticals, Inc. Modulators of APOL1 expression
US12168766B2 (en) 2018-05-22 2024-12-17 Astrazeneca Ab Modulators of APOL1 expression
WO2019226611A1 (en) * 2018-05-22 2019-11-28 Ionis Pharmaceuticals, Inc. Modulators of apol1 expression
AU2019274461B2 (en) * 2018-05-22 2025-07-31 Ionis Pharmaceuticals, Inc. Modulators of APOL1 expression
US11753640B2 (en) 2018-07-03 2023-09-12 Hoffmann-La Roche Inc. Oligonucleotides for modulating Tau expression
WO2020007892A1 (en) 2018-07-03 2020-01-09 F. Hoffmann-La Roche Ag Oligonucleotides for modulating tau expression
US11279929B2 (en) 2018-07-03 2022-03-22 Hoffmann-La Roche, Inc. Oligonucleotides for modulating Tau expression
US12163131B2 (en) 2018-07-03 2024-12-10 Hoffmann-La Roche Inc. Oligonucleotides for modulating Tau expression
US11781143B2 (en) 2018-09-19 2023-10-10 Ionis Pharmaceuticals, Inc. Modulators of PNPLA3 expression
US12606555B2 (en) 2019-07-19 2026-04-21 Astrazeneca Ab Chemical compounds
WO2021178237A3 (en) * 2020-03-01 2021-10-21 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
EP4114939A4 (en) * 2020-03-01 2024-03-20 Wave Life Sciences Ltd. OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
US20210363523A1 (en) * 2020-03-18 2021-11-25 University Of Massachusetts Oligonucleotides for mapt modulation
EP4126230A4 (en) * 2020-03-30 2025-07-30 Alnylam Pharmaceuticals Inc MICROTUBULE-ASSOCIATED PROTEIN TAU (MAPT) RNAI AGENT COMPOSITIONS AND METHODS OF USE THEREOF
EP4143321A4 (en) * 2020-05-01 2025-02-19 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating atxn1
US12421208B2 (en) 2020-06-25 2025-09-23 Astrazeneca Ab Chemical compounds
WO2022125984A1 (en) * 2020-12-11 2022-06-16 Eisai R&D Management Co., Ltd. Tau-targeting oligonucleotide gapmers
EP4405484A4 (en) * 2021-09-24 2026-03-04 Alnylam Pharmaceuticals Inc ARNI AGENT COMPOSITIONS TARGETING MICROTUBULE-ASSOCIATED TAU PROTEIN (MAPT) AND THEIR METHODS OF USE
EP4413138A4 (en) * 2021-10-07 2026-04-01 Ionis Pharmaceuticals Inc COMPOUNDS AND METHODS FOR REDUCING TAU PROTEIN EXPRESSION
WO2023175091A3 (en) * 2022-03-16 2023-11-23 Janssen Pharmaceutica Nv MAPT siRNA AND USES THEREOF
WO2023217437A1 (en) * 2022-05-13 2023-11-16 Julius-Maximilians-Universität Würzburg Method and molecules for reducing axonal tau protein accumulation through blocking of hnrnp r-mediated mapt mrna transport for treatment of alzheimer's disease
WO2024145474A3 (en) * 2022-12-29 2024-08-22 Voyager Therapeutics, Inc. Compositions and methods for regulating mapt
WO2024220930A3 (en) * 2023-04-20 2024-12-26 Adarx Pharmaceuticals, Inc. Mapt-modulating compositions and methods of use thereof
US12551569B2 (en) 2024-03-31 2026-02-17 Arrowhead Pharmaceuticals, Inc. RNAi agents for inhibiting expression of microtubule associated protein tau (MAPT), compositions thereof, and methods of use

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