WO2011022509A3 - Benzoazépines substituées comme modulateurs des récepteurs de type toll - Google Patents

Benzoazépines substituées comme modulateurs des récepteurs de type toll Download PDF

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Publication number
WO2011022509A3
WO2011022509A3 PCT/US2010/045935 US2010045935W WO2011022509A3 WO 2011022509 A3 WO2011022509 A3 WO 2011022509A3 US 2010045935 W US2010045935 W US 2010045935W WO 2011022509 A3 WO2011022509 A3 WO 2011022509A3
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WO
WIPO (PCT)
Prior art keywords
toll
receptor modulators
disease
compositions
substituted benzoazepines
Prior art date
Application number
PCT/US2010/045935
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English (en)
Other versions
WO2011022509A2 (fr
Inventor
James Jeffry Howbert
Gregory Dietsch
Robert Hershberg
Laurence E. Burgess
George A. Doherty
C. Todd Eary
Robert D. Groneberg
Zachary Jones
Original Assignee
Ventirx Pharmaceuticals, Inc.
Array Biopharma, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to RU2012110246/04A priority Critical patent/RU2580320C2/ru
Priority to BR112012003703-0A priority patent/BR112012003703A2/pt
Priority to EP10810564.4A priority patent/EP2467380B1/fr
Priority to DK10810564.4T priority patent/DK2467380T3/en
Application filed by Ventirx Pharmaceuticals, Inc., Array Biopharma, Inc filed Critical Ventirx Pharmaceuticals, Inc.
Priority to CN201080047962.2A priority patent/CN102781933B/zh
Priority to JP2012525676A priority patent/JP5756805B2/ja
Priority to AU2010284241A priority patent/AU2010284241B2/en
Priority to CA2771484A priority patent/CA2771484C/fr
Priority to ES10810564.4T priority patent/ES2617676T3/es
Publication of WO2011022509A2 publication Critical patent/WO2011022509A2/fr
Publication of WO2011022509A3 publication Critical patent/WO2011022509A3/fr
Priority to IL218155A priority patent/IL218155A/en
Priority to IL243710A priority patent/IL243710A/en
Priority to AU2017200936A priority patent/AU2017200936A1/en
Priority to HRP20170268TT priority patent/HRP20170268T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Luminescent Compositions (AREA)

Abstract

L'invention porte sur des compositions et des procédés utiles pour la modulation de la signalisation par l'intermédiaire des récepteurs de type Toll TLR7 et/ou TLR8. Les compositions et procédés trouvent utilisation dans le traitement ou la prévention de maladies, comprenant le cancer, une maladie auto-immunitaire, une maladie infectieuse, un trouble inflammatoire, un rejet de greffe et une maladie du greffon contre l'hôte.
PCT/US2010/045935 2009-08-18 2010-08-18 Benzoazépines substituées comme modulateurs des récepteurs de type toll WO2011022509A2 (fr)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP2012525676A JP5756805B2 (ja) 2009-08-18 2010-08-18 Ｔｏｌｌ様レセプターモジュレーターとしての置換ベンゾアゼピン
EP10810564.4A EP2467380B1 (fr) 2009-08-18 2010-08-18 Benzoazépines substituées comme modulateurs des récepteurs de type toll
DK10810564.4T DK2467380T3 (en) 2009-08-18 2010-08-18 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS
CA2771484A CA2771484C (fr) 2009-08-18 2010-08-18 Benzoazepines substituees comme modulateurs des recepteurs de type toll
CN201080047962.2A CN102781933B (zh) 2009-08-18 2010-08-18 作为toll样受体调节剂的取代的苯并氮杂*
BR112012003703-0A BR112012003703A2 (pt) 2009-08-18 2010-08-18 Benzoazepinas substituídas como moduladores do receptor tipo toll
AU2010284241A AU2010284241B2 (en) 2009-08-18 2010-08-18 Substituted benzoazepines as Toll-like receptor modulators
RU2012110246/04A RU2580320C2 (ru) 2009-08-18 2010-08-18 Замещенные бензоазепины в качестве модуляторов toll-подобного рецептора
ES10810564.4T ES2617676T3 (es) 2009-08-18 2010-08-18 Benzodiacepinas sustituidas como moduladores de receptores de tipo toll
IL218155A IL218155A (en) 2009-08-18 2012-02-16 Benzoazapines are preserved as toll receptor modulators, preparations containing them and their uses
IL243710A IL243710A (en) 2009-08-18 2016-01-21 Benzoazapines are preserved as toll receptor modulators, preparations containing them and their uses
AU2017200936A AU2017200936A1 (en) 2009-08-18 2017-02-10 Substituted Benzoazepines As Toll-like Receptor Modulators
HRP20170268TT HRP20170268T1 (hr) 2009-08-18 2017-02-20 Supstituirani benzodiazepeni kao modulatori receptora sličnih tollu

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23497109P 2009-08-18 2009-08-18
US61/234,971 2009-08-18

Publications (2)

Publication Number Publication Date
WO2011022509A2 WO2011022509A2 (fr) 2011-02-24
WO2011022509A3 true WO2011022509A3 (fr) 2011-06-16

Family

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Family Applications (1)

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PCT/US2010/045935 WO2011022509A2 (fr) 2009-08-18 2010-08-18 Benzoazépines substituées comme modulateurs des récepteurs de type toll

Country Status (16)

Country Link
US (3) US8524702B2 (fr)
EP (2) EP2467380B1 (fr)
JP (2) JP5756805B2 (fr)
CN (2) CN105669552A (fr)
AU (2) AU2010284241B2 (fr)
BR (1) BR112012003703A2 (fr)
CA (1) CA2771484C (fr)
DK (1) DK2467380T3 (fr)
ES (1) ES2617676T3 (fr)
HR (1) HRP20170268T1 (fr)
HU (1) HUE031797T2 (fr)
IL (2) IL218155A (fr)
PL (1) PL2467380T3 (fr)
PT (1) PT2467380T (fr)
RU (2) RU2016108987A (fr)
WO (1) WO2011022509A2 (fr)

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