WO2008024398B1 - Dérivés de 4-(n-azacycloalkyl) anilides en tant que modulateurs du canal potassique - Google Patents
Dérivés de 4-(n-azacycloalkyl) anilides en tant que modulateurs du canal potassiqueInfo
- Publication number
- WO2008024398B1 WO2008024398B1 PCT/US2007/018571 US2007018571W WO2008024398B1 WO 2008024398 B1 WO2008024398 B1 WO 2008024398B1 US 2007018571 W US2007018571 W US 2007018571W WO 2008024398 B1 WO2008024398 B1 WO 2008024398B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- chr
- cycloalkyl
- cycloalkenyl
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07837199.4A EP2061465B1 (fr) | 2006-08-23 | 2007-08-22 | Dérivés de 4-(n-azacycloalkyl) anilides en tant que modulateurs du canal potassique |
NZ575652A NZ575652A (en) | 2006-08-23 | 2007-08-22 | Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators |
MX2009002002A MX2009002002A (es) | 2006-08-23 | 2007-08-22 | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potasio. |
CA2661462A CA2661462C (fr) | 2006-08-23 | 2007-08-22 | Derives de 4-(n-azacycloalkyl) anilides en tant que modulateurs du canal potassique |
ES07837199T ES2420960T3 (es) | 2006-08-23 | 2007-08-22 | Derivados de 4-(N-azacicloalquil)anilidas como moduladores de los canales de potasio |
PL07837199T PL2061465T3 (pl) | 2006-08-23 | 2007-08-22 | Pochodne 4-(N-azacykloalkilo) anilidów jako modulatory kanałów potasowych |
DK07837199.4T DK2061465T3 (da) | 2006-08-23 | 2007-08-22 | Derivater af 4-(N-azacycloalkyl)anilider som kaliumkanalmodulatorer |
AU2007288253A AU2007288253B2 (en) | 2006-08-23 | 2007-08-22 | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
BRPI0716715-6A BRPI0716715B1 (pt) | 2006-08-23 | 2007-08-22 | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potássio, seus usos, produto, composição, comprimido e cápsula |
JP2009525618A JP5419691B2 (ja) | 2006-08-23 | 2007-08-22 | カリウムチャネルモジュレーターとしての4−(n−アザシクロアルキル)アニリドの誘導体 |
IL197161A IL197161A (en) | 2006-08-23 | 2009-02-22 | Derivatives 4- (n-azacycloalkyl) anilides Preparations containing and using them |
NO20091183A NO343575B1 (no) | 2006-08-23 | 2009-03-20 | Derivater av 4-(N-azacykloalkyl)-anilider, fremgangsmåte for fremstilling av slike forbindelser, preparater omfattende slike forbindelser samt anvendelse av slike forbindelser for forhindring eller behandling av sykdom |
ZA2009/01977A ZA200901977B (en) | 2006-08-23 | 2009-03-20 | Derivatives of 4-(in-azacycloalkyl) anilides as potassium channel modulators |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83994106P | 2006-08-23 | 2006-08-23 | |
US60/839,941 | 2006-08-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008024398A2 WO2008024398A2 (fr) | 2008-02-28 |
WO2008024398A3 WO2008024398A3 (fr) | 2008-06-26 |
WO2008024398B1 true WO2008024398B1 (fr) | 2008-08-14 |
Family
ID=39107384
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/018571 WO2008024398A2 (fr) | 2006-08-23 | 2007-08-22 | Dérivés de 4-(n-azacycloalkyl) anilides en tant que modulateurs du canal potassique |
Country Status (23)
Country | Link |
---|---|
US (1) | US8293911B2 (fr) |
EP (1) | EP2061465B1 (fr) |
JP (1) | JP5419691B2 (fr) |
KR (1) | KR20090079191A (fr) |
CN (1) | CN101563085A (fr) |
AR (1) | AR062508A1 (fr) |
AU (1) | AU2007288253B2 (fr) |
BR (1) | BRPI0716715B1 (fr) |
CA (1) | CA2661462C (fr) |
CL (1) | CL2007002455A1 (fr) |
DK (1) | DK2061465T3 (fr) |
ES (1) | ES2420960T3 (fr) |
IL (1) | IL197161A (fr) |
MX (1) | MX2009002002A (fr) |
NO (1) | NO343575B1 (fr) |
NZ (1) | NZ575652A (fr) |
PL (1) | PL2061465T3 (fr) |
PT (1) | PT2061465E (fr) |
RU (1) | RU2009110172A (fr) |
SG (1) | SG174095A1 (fr) |
TW (1) | TW200827339A (fr) |
WO (1) | WO2008024398A2 (fr) |
ZA (1) | ZA200901977B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013060097A1 (fr) | 2011-10-25 | 2013-05-02 | 中国科学院上海药物研究所 | Nouveau composé utilisé comme agoniste des canaux potassiques kcnq, son procédé de préparation et son utilisation |
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US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
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US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
US20080045534A1 (en) * | 2006-08-18 | 2008-02-21 | Valeant Pharmaceuticals North America | Derivatives of 1,3-diamino benzene as potassium channel modulators |
US8993593B2 (en) * | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
KR20090079191A (ko) | 2006-08-23 | 2009-07-21 | 밸리언트 파마슈티컬즈 인터내셔널 | 칼륨 채널 조절제로서 4-(n-아자사이클로알킬) 아닐리드의 유도체 |
US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
JP2010511052A (ja) | 2006-11-28 | 2010-04-08 | バレアント ファーマシューティカルズ インターナショナル | カリウムチャネル調節因子としての1,4ジアミノ二環式レチガビンアナログ |
US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
WO2010008894A1 (fr) * | 2008-06-24 | 2010-01-21 | Valeant Pharmaceuticals International | Dérivés de benzyloxy anilide utiles en tant que modulateurs du canal potassique |
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EP3917907A1 (fr) | 2019-01-29 | 2021-12-08 | Universitá Degli Studi Di Salerno | Modulateurs de canaux ioniques potassiques et leurs utilisations |
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CN113698345B (zh) | 2021-10-27 | 2022-02-01 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的化合物及其制备和应用 |
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- 2007-08-22 EP EP07837199.4A patent/EP2061465B1/fr active Active
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013060097A1 (fr) | 2011-10-25 | 2013-05-02 | 中国科学院上海药物研究所 | Nouveau composé utilisé comme agoniste des canaux potassiques kcnq, son procédé de préparation et son utilisation |
Also Published As
Publication number | Publication date |
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CN101563085A (zh) | 2009-10-21 |
PL2061465T3 (pl) | 2014-03-31 |
EP2061465A2 (fr) | 2009-05-27 |
ZA200901977B (en) | 2010-02-24 |
EP2061465B1 (fr) | 2013-04-10 |
NZ575652A (en) | 2011-08-26 |
IL197161A (en) | 2015-07-30 |
CA2661462A1 (fr) | 2008-02-28 |
JP5419691B2 (ja) | 2014-02-19 |
IL197161A0 (en) | 2009-12-24 |
AR062508A1 (es) | 2008-11-12 |
RU2009110172A (ru) | 2010-09-27 |
PT2061465E (pt) | 2013-07-15 |
BRPI0716715A2 (pt) | 2013-09-03 |
DK2061465T3 (da) | 2013-07-08 |
US8293911B2 (en) | 2012-10-23 |
US20080139610A1 (en) | 2008-06-12 |
JP2010501568A (ja) | 2010-01-21 |
WO2008024398A3 (fr) | 2008-06-26 |
SG174095A1 (en) | 2011-09-29 |
MX2009002002A (es) | 2009-07-22 |
WO2008024398A2 (fr) | 2008-02-28 |
NO20091183L (no) | 2009-05-08 |
BRPI0716715B1 (pt) | 2021-07-06 |
CA2661462C (fr) | 2015-09-29 |
ES2420960T3 (es) | 2013-08-28 |
CL2007002455A1 (es) | 2008-04-18 |
NO343575B1 (no) | 2019-04-08 |
AU2007288253A1 (en) | 2008-02-28 |
EP2061465A4 (fr) | 2011-03-16 |
KR20090079191A (ko) | 2009-07-21 |
AU2007288253B2 (en) | 2013-05-02 |
TW200827339A (en) | 2008-07-01 |
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