CL2007002455A1 - Compuestos derivados de 2-fenil-3,4-dihidro-1h-isoquinolina, moduladores de canales de potasio; compuesto intermediario; composicion farmaceutica; y uso para prevenir o tratar un trastorno provocado por hiperexcitabilidad del sistema nervioso, tal co - Google Patents

Compuestos derivados de 2-fenil-3,4-dihidro-1h-isoquinolina, moduladores de canales de potasio; compuesto intermediario; composicion farmaceutica; y uso para prevenir o tratar un trastorno provocado por hiperexcitabilidad del sistema nervioso, tal co

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Publication number
CL2007002455A1
CL2007002455A1 CL200702455A CL2007002455A CL2007002455A1 CL 2007002455 A1 CL2007002455 A1 CL 2007002455A1 CL 200702455 A CL200702455 A CL 200702455A CL 2007002455 A CL2007002455 A CL 2007002455A CL 2007002455 A1 CL2007002455 A1 CL 2007002455A1
Authority
CL
Chile
Prior art keywords
dihidro
hyperexcitability
isoquinoline
treat
phenyl
Prior art date
Application number
CL200702455A
Other languages
English (en)
Inventor
Vernier Jim Zhen W Jean-Michel
Original Assignee
Vernier Jim Zhen W Jean-Michel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernier Jim Zhen W Jean-Michel filed Critical Vernier Jim Zhen W Jean-Michel
Publication of CL2007002455A1 publication Critical patent/CL2007002455A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
CL200702455A 2006-08-23 2007-08-23 Compuestos derivados de 2-fenil-3,4-dihidro-1h-isoquinolina, moduladores de canales de potasio; compuesto intermediario; composicion farmaceutica; y uso para prevenir o tratar un trastorno provocado por hiperexcitabilidad del sistema nervioso, tal co CL2007002455A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83994106P 2006-08-23 2006-08-23

Publications (1)

Publication Number Publication Date
CL2007002455A1 true CL2007002455A1 (es) 2008-04-18

Family

ID=39107384

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200702455A CL2007002455A1 (es) 2006-08-23 2007-08-23 Compuestos derivados de 2-fenil-3,4-dihidro-1h-isoquinolina, moduladores de canales de potasio; compuesto intermediario; composicion farmaceutica; y uso para prevenir o tratar un trastorno provocado por hiperexcitabilidad del sistema nervioso, tal co

Country Status (23)

Country Link
US (1) US8293911B2 (es)
EP (1) EP2061465B1 (es)
JP (1) JP5419691B2 (es)
KR (1) KR20090079191A (es)
CN (1) CN101563085A (es)
AR (1) AR062508A1 (es)
AU (1) AU2007288253B2 (es)
BR (1) BRPI0716715B1 (es)
CA (1) CA2661462C (es)
CL (1) CL2007002455A1 (es)
DK (1) DK2061465T3 (es)
ES (1) ES2420960T3 (es)
IL (1) IL197161A (es)
MX (1) MX2009002002A (es)
NO (1) NO343575B1 (es)
NZ (1) NZ575652A (es)
PL (1) PL2061465T3 (es)
PT (1) PT2061465E (es)
RU (1) RU2009110172A (es)
SG (1) SG174095A1 (es)
TW (1) TW200827339A (es)
WO (1) WO2008024398A2 (es)
ZA (1) ZA200901977B (es)

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TW202128627A (zh) * 2019-10-10 2021-08-01 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
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CN114057641A (zh) * 2020-08-07 2022-02-18 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢异喹啉类化合物及其制备和应用
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