BR0008847A - Composições analgésicas que compreendemcompostos antiepilépticos, e métodos de uso dasmesmas - Google Patents

Composições analgésicas que compreendemcompostos antiepilépticos, e métodos de uso dasmesmas

Info

Publication number
BR0008847A
BR0008847A BR0008847-1A BR0008847A BR0008847A BR 0008847 A BR0008847 A BR 0008847A BR 0008847 A BR0008847 A BR 0008847A BR 0008847 A BR0008847 A BR 0008847A
Authority
BR
Brazil
Prior art keywords
compounds
methods
pain
antiepileptic
antiepileptic compounds
Prior art date
Application number
BR0008847-1A
Other languages
English (en)
Inventor
Mark Richard Hurtt
Trevor Mundell
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0008847A publication Critical patent/BR0008847A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: "COMPOSIçõES ANALGéSICAS QUECOMPREENDEM COMPOSTOS ANTIEPILéPTICOS, EMéTODOS DE USO DAS MESMAS". A presente invençãorefere-se a novas combinações de um ou mais compostosantiepilépticos que demonstram propriedades de alívio de dor, comum ou mais compostos selecionados do grupo que consiste emanalgésicos, antagonistas de receptor de NMDA, NSAIDs ecombinações dos mesmos, e a composições farmacêuticas quecompreendem esses compostos. Verificou-se que a administraçãode compostos antiepilépticos que demonstram propriedades dealívio de dor nessas novas combinações resulta em uma reduçãoaperfeiçoada na freq³ência e gravidade da dor. Acredita-setambém que a incidência de efeitos colaterais indesejáveis podeser reduzida através dessas novas combinações em comparaçãocom o uso de doses mais altas de um tratamento com agente únicopara obter um efeito terapêutico similar. A presente invençãotambém refere-se a métodos de uso de quantidades eficazes dasnovas composições farmacêuticas para tratar dor em mamíferos.
BR0008847-1A 1999-03-10 2000-01-27 Composições analgésicas que compreendemcompostos antiepilépticos, e métodos de uso dasmesmas BR0008847A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12373999P 1999-03-10 1999-03-10
PCT/US2000/002080 WO2000053225A1 (en) 1999-03-10 2000-01-27 Analgesic compositions comprising anti-epileptic compounds and methods of using same

Publications (1)

Publication Number Publication Date
BR0008847A true BR0008847A (pt) 2001-12-26

Family

ID=22410582

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008847-1A BR0008847A (pt) 1999-03-10 2000-01-27 Composições analgésicas que compreendemcompostos antiepilépticos, e métodos de uso dasmesmas

Country Status (11)

Country Link
US (1) US6451857B1 (pt)
EP (1) EP1161263A1 (pt)
JP (1) JP2002538221A (pt)
AR (1) AR022723A1 (pt)
AU (1) AU3216600A (pt)
BR (1) BR0008847A (pt)
CA (1) CA2359485A1 (pt)
CO (1) CO5150189A1 (pt)
PE (1) PE20001558A1 (pt)
UY (1) UY26052A1 (pt)
WO (1) WO2000053225A1 (pt)

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PL189872B1 (pl) 1996-07-24 2005-10-31 Warner Lambert Co Zastosowanie izobutylogaby i jej pochodnych do wytwarzania leku do leczenia bólu
US6593368B2 (en) 1997-09-08 2003-07-15 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same
MXPA02000170A (es) * 1999-07-02 2002-07-02 Warner Lambert Co Una combinacion sinergica: gabapentin y pregablin.
ZA200108038B (en) * 2000-10-02 2003-04-01 Pfizer Prod Inc Prophylactic use of n-methyl-d-asparrate (NMDA) antagonists.
CA2449987C (en) 2001-06-07 2015-11-03 Christine N. Sang Treatment of central neuropathic pain
AU2002333374B2 (en) 2001-09-03 2007-03-22 Newron Pharmaceuticals S.P.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an (alpha)- aminoamide and its analgesic use
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
US7612112B2 (en) 2001-10-25 2009-11-03 Depomed, Inc. Methods of treatment using a gastric retained gabapentin dosage
US6730667B2 (en) * 2001-11-26 2004-05-04 William R. Deagle Iontophoresis disc pain blocker
CN1642547A (zh) * 2002-01-16 2005-07-20 恩多制药公司 治疗中枢神经系统障碍的药物组合物和方法
JP4428053B2 (ja) * 2002-02-05 2010-03-10 味の素株式会社 ガバペンチン若しくはプレガバリンおよびｎ型カルシウムチャンネル拮抗剤を含有する医薬組成物
AU2003246864A1 (en) * 2002-02-22 2003-09-09 Warner-Lambert Company Llc Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
FR2862875B1 (fr) * 2003-12-02 2006-04-07 Mathey Acoustique Service Preparation pharmaceutique pour le traitement des acouphenes
WO2005102390A2 (en) * 2004-04-22 2005-11-03 Pfizer Japan, Inc. Combinations comprising alpha-2-delta ligands and nmda receptor antagonists
DK1963280T3 (en) 2005-12-22 2015-12-14 Newron Pharm Spa 2-phenylethylamine derivatives by calcium and / or sodium channel
US20090176882A1 (en) 2008-12-09 2009-07-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
KR20090079191A (ko) * 2006-08-23 2009-07-21 밸리언트 파마슈티컬즈 인터내셔널 칼륨 채널 조절제로서 ４-(ｎ-아자사이클로알킬) 아닐리드의 유도체
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
CN101578259A (zh) * 2006-11-28 2009-11-11 威朗国际制药公司 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物
MX2009006575A (es) * 2006-12-22 2009-07-02 Recordati Ireland Ltd Terapia de combinacion de trastornos del tracto urinario inferior con ligandos a2d y farmacos anti-inflamatorios no esteroidales (nsaids).
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
EP2116539A1 (en) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof
EP2116618A1 (en) 2008-05-09 2009-11-11 Agency for Science, Technology And Research Diagnosis and treatment of Kawasaki disease
US20100190752A1 (en) 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
CN102223791A (zh) 2008-09-27 2011-10-19 塔阿克斯有限公司 用于神经病变治疗的局部用制剂
AU2009302241B2 (en) 2008-10-08 2015-10-29 Xgene Pharmaceutical Inc. GABA conjugates and methods of use thereof
MA39147B1 (fr) 2013-12-17 2019-12-31 Esteve Labor Dr Combinaisons d'inhibiteurs de la recapture de sérotonine-norépinéphrine (snri) et de ligands des récepteurs sigma
TN2016000229A1 (en) * 2013-12-17 2017-10-06 Esteve Labor Dr Gabapentinoids and sigma receptor ligands combinations.
CR20160573A (es) 2014-06-16 2017-03-14 Farmacéuticos Rayere S A Composición farmaceutica que combina un anticonvulsivante y un derivado del ácido nicotínico
MX2015016589A (es) 2015-12-02 2017-06-01 Samuel CHAIT AUERBACH Jaime Composicion oral veterinaria con gabapentina.
US10052296B2 (en) * 2016-04-07 2018-08-21 Nevakar Inc. Formulations for treating pain
WO2017200700A1 (en) * 2016-05-16 2017-11-23 PixarBio Corporation Methods for treating incisional pain
EP3687520A4 (en) * 2017-09-28 2021-06-23 Nevakar, Inc FIXED-DOSE COMBINATION FORMULATIONS FOR THE TREATMENT OF PAIN
US11547686B2 (en) 2017-10-03 2023-01-10 Nevakar Injectables Inc. Acetaminophen pregabalin combinations and methods of treating pain

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WO1998007447A1 (en) 1996-08-23 1998-02-26 Algos Pharmaceutical Corporation Anticonvulsant containing composition for treating neuropathic pain
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US6593368B2 (en) * 1997-09-08 2003-07-15 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same

Also Published As

Publication number Publication date
AU3216600A (en) 2000-09-28
JP2002538221A (ja) 2002-11-12
WO2000053225A1 (en) 2000-09-14
CO5150189A1 (es) 2002-04-29
EP1161263A1 (en) 2001-12-12
US6451857B1 (en) 2002-09-17
AR022723A1 (es) 2002-09-04
CA2359485A1 (en) 2000-09-14
PE20001558A1 (es) 2001-01-28
UY26052A1 (es) 2000-08-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A,11A E 12A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2138 DE 27/12/2011.