BR9812162A - Composições analgésicas compreendendo compostos antiepiléticos e métodos para o uso das mesmas - Google Patents

Composições analgésicas compreendendo compostos antiepiléticos e métodos para o uso das mesmas

Info

Publication number
BR9812162A
BR9812162A BR9812162-6A BR9812162A BR9812162A BR 9812162 A BR9812162 A BR 9812162A BR 9812162 A BR9812162 A BR 9812162A BR 9812162 A BR9812162 A BR 9812162A
Authority
BR
Brazil
Prior art keywords
pain
compounds
methods
new combinations
antiepileptic
Prior art date
Application number
BR9812162-6A
Other languages
English (en)
Inventor
Leslie Magnus-Miller
Douglas A Saltel
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR9812162A publication Critical patent/BR9812162A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Patente de Invenção:<B>"COMPOSIçõES ANALGéSICAS COMPREENDENDO COMPOSTOS ANTIEPILéTICOS E MéTODOS PARA O USO DAS MESMAS"<D>. A presente invenção é direcionada a novas combinações de compostos antiepiléticos que apresentam propriedades para aliviar a dor, com compostos selecionados do grupo consistindo de analgésicos, antagonistas receptores de NMDA, e NSAIDs e composições farmacêuticas contendo os mesmos. Descobriu-se que a administração de compostos antiepiléticos que apresentam propriedades para aliviar a dor nessas novas combinações resulte em uma maior redução na freq³ência e severidade da dor. Acredita-se também que a incidência de efeitos colaterais indesejáveis possa ser reduzida através dessas novas combinações em comparação com o uso de doses mais altas de um tratamento com agente único para se alcançar um efeito terapêutico similar. A presente invenção é também direcionada a métodos de uso de quantidades efetivas das novas composições farmacêuticas para o tratamento da dor em mamíferos.
BR9812162-6A 1997-09-08 1998-08-18 Composições analgésicas compreendendo compostos antiepiléticos e métodos para o uso das mesmas BR9812162A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5820797P 1997-09-08 1997-09-08
PCT/US1998/017083 WO1999012537A1 (en) 1997-09-08 1998-08-18 Analgesic compositions comprising anti-epileptic compounds and methods of using same

Publications (1)

Publication Number Publication Date
BR9812162A true BR9812162A (pt) 2000-07-18

Family

ID=22015361

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9812162-6A BR9812162A (pt) 1997-09-08 1998-08-18 Composições analgésicas compreendendo compostos antiepiléticos e métodos para o uso das mesmas

Country Status (20)

Country Link
US (3) US6593368B2 (pt)
EP (1) EP1011658B1 (pt)
JP (1) JP3782935B2 (pt)
KR (1) KR100537707B1 (pt)
AT (1) ATE311867T1 (pt)
AU (1) AU750578B2 (pt)
BR (1) BR9812162A (pt)
CA (1) CA2296336C (pt)
CU (1) CU23226B7 (pt)
DE (1) DE69832712T2 (pt)
DK (1) DK1011658T3 (pt)
ES (1) ES2253825T3 (pt)
HU (1) HU226165B1 (pt)
IL (2) IL134165A0 (pt)
IS (1) IS5362A (pt)
NO (1) NO324122B1 (pt)
NZ (1) NZ502671A (pt)
PL (1) PL339142A1 (pt)
WO (1) WO1999012537A1 (pt)
ZA (1) ZA988159B (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9710536A (pt) 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
WO1999012537A1 (en) 1997-09-08 1999-03-18 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same
US6326374B1 (en) * 1998-07-09 2001-12-04 Warner-Lambert Company Compositions comprising GABA analogs and caffeine
AU3216600A (en) * 1999-03-10 2000-09-28 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same
EP1169060B1 (en) * 1999-04-09 2005-08-31 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
AU5824800A (en) * 1999-06-23 2001-01-31 Warner-Lambert Company Use of fosphenytoin for the treatment of acute neuropathic pain
HUP0203198A3 (en) * 1999-08-20 2005-07-28 Ortho Mcneil Pharm Inc Pharmaceutical composition comprising a tramadol material and an anticonvulsant drug, process for its preparation and its use
PT1423168E (pt) * 2001-09-03 2006-05-31 Newron Pharm Spa Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico
US7612112B2 (en) 2001-10-25 2009-11-03 Depomed, Inc. Methods of treatment using a gastric retained gabapentin dosage
US20070184104A1 (en) * 2001-10-25 2007-08-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
US20060159743A1 (en) * 2001-10-25 2006-07-20 Depomed, Inc. Methods of treating non-nociceptive pain states with gastric retentive gabapentin
TWI312285B (en) 2001-10-25 2009-07-21 Depomed Inc Methods of treatment using a gastric retained gabapentin dosage
US6730667B2 (en) * 2001-11-26 2004-05-04 William R. Deagle Iontophoresis disc pain blocker
WO2003066040A1 (fr) 2002-02-05 2003-08-14 Ajinomoto Co.,Inc. Compositions medicinales contenant une gabapentine ou une pregabaline et antagoniste a canal de calcium de type n
WO2003070237A1 (en) * 2002-02-22 2003-08-28 Warner-Lambert Company Llc Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
DK1572173T3 (da) * 2002-12-13 2010-06-14 Warner Lambert Co Alpha-2-delta-ligand til behandling af symptomer i den nedre urinvej
FR2862875B1 (fr) * 2003-12-02 2006-04-07 Mathey Acoustique Service Preparation pharmaceutique pour le traitement des acouphenes
JP2008520584A (ja) * 2004-11-16 2008-06-19 リマリック バイオファーマ，インコーポレイティド 疼痛を治療するための方法と組成物
US20070087977A1 (en) * 2004-11-16 2007-04-19 Wendye Robbins Methods and compositions for treating pain
BRPI0606118A2 (pt) * 2005-09-19 2009-06-02 Teva Pharma uma sìntese assimétrica de (s) - (+) -3- (aminometil) -5- ácido metilhexanóico
MXPA05011735A (es) * 2005-11-01 2007-04-30 Leopoldo Espinosa Abdala Composiciones farmaceuticas que comprenden combinaciones de analgesicos y anticonvulsivantes para el tratamiento del dolor agudo y cronico.
US20090176882A1 (en) * 2008-12-09 2009-07-09 Depomed, Inc. Gastric retentive gabapentin dosage forms and methods for using same
KR20090092307A (ko) * 2006-12-22 2009-08-31 레코르다티 아일랜드 리미티드 하요도 장애에 대한 α2δ 리간드 및 ＮＳＡＩＤｓ의 복합 치료
MX2007006091A (es) * 2007-05-21 2009-02-25 World Trade Imp Export Wtie Ag Composicion farmaceutica que comprende la combinacion de un agente antiinflamatorio no esteroideo y un agente anticonvulsionante.
EP2184986A4 (en) * 2007-08-06 2010-12-15 Trinity Lab Inc PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CHRONIC PAIN AND PAIN RELATING TO NEUROPATHY
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
KR20100107500A (ko) * 2008-06-23 2010-10-05 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ) 또는 (ｒ)-이소-부틸-글루타릭 에스테르의 입체선택적 효소 합성방법
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
US20100190752A1 (en) * 2008-09-05 2010-07-29 Gruenenthal Gmbh Pharmaceutical Combination
US8629184B2 (en) * 2008-09-27 2014-01-14 TARAXOS, Inc. Topical formulations for treatment of neuropathy
AU2009302241B2 (en) 2008-10-08 2015-10-29 Xgene Pharmaceutical Inc. GABA conjugates and methods of use thereof
ES2536534T3 (es) * 2010-07-30 2015-05-26 Toray Industries, Inc. Agente terapéutico o agente profiláctico para el dolor neuropático
WO2013076339A1 (es) * 2011-11-22 2013-05-30 Servicio Andaluz De Salud Composiciones y preparaciones combinadas para el tratamiento de la fibromialgia
WO2013103826A1 (en) * 2012-01-06 2013-07-11 Skyview Enterprise Ltd. Anti-inflammatory compounds in combination with hydrogen for the treatment of inflammation
FR2998892B1 (fr) 2012-12-04 2015-01-02 Pf Medicament Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments
MX2015016589A (es) 2015-12-02 2017-06-01 Samuel CHAIT AUERBACH Jaime Composicion oral veterinaria con gabapentina.
KR102631399B1 (ko) * 2018-03-30 2024-02-01 씨지인바이츠 주식회사 폴마콕시브 및 프레가발린을 포함하는 통증 치료용 약제학적 조성물
CA3079509C (en) * 2018-07-04 2020-11-03 AMEZCUA AMEZCUA, Federico Synergic drug combination of the active enantiomer (s)-ketorolac and gabapentin for the treatment of neuropathic pain
MX2019008467A (es) * 2019-07-16 2019-11-07 Federico Amezcua Amezcua Combinacion sinergica de s-ketorolaco y pregabalina en una composicion farmaceutica para el tratamiento del dolor neuropatico.
US11147780B2 (en) * 2020-02-24 2021-10-19 Algia Pharma, Llc Multidrug pain management package

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE634102A (pt)
DE1966802C3 (de) 1969-12-20 1975-11-06 Desitin-Werk, Carl Klinke Gmbh, 2000 Hamburg 5,5-Diphenylhydantoin-N hoch 3 -carbonsäureester
US4087544A (en) * 1974-12-21 1978-05-02 Warner-Lambert Company Treatment of cranial dysfunctions using novel cyclic amino acids
DE2460891C2 (de) * 1974-12-21 1982-09-23 Gödecke AG, 1000 Berlin 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
JPS54110334A (en) 1978-02-16 1979-08-29 Fuji Chem Ind Co Ltd Novel compounded anodyne and antiiinflammatory agent
JPS61221121A (ja) 1985-03-27 1986-10-01 Nitto Electric Ind Co Ltd テ−プ製剤
US4694010A (en) 1985-08-16 1987-09-15 New York University Anticonvulsant compositions and method
AU2929489A (en) 1987-12-22 1989-07-19 John W. FERKANY Dextrorphan potentiator for anticonvulsant composition and method
US6197819B1 (en) * 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
GB9108362D0 (en) 1991-04-18 1991-06-05 Radoslavov Alexander A pharmaceutical composition suitable for alleviation of headaches,migraine and other painful conditions
WO1993023383A1 (en) 1992-05-20 1993-11-25 Northwestern University Gaba and l-glutamic acid analogs for antiseizure treatment
US5234929A (en) * 1992-07-20 1993-08-10 William Chelen Method of treating motion sickness with anticonvulsants and antitussive agents
JPH06100468A (ja) * 1992-09-25 1994-04-12 Kibun Food Chemifa Co Ltd 徐放性組成物
US5321012A (en) 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
JPH06227969A (ja) 1993-02-02 1994-08-16 Masayasu Sugihara 薬品の腸溶性改善方法およびそれにより得られた薬品組成物
US5420270A (en) * 1993-10-07 1995-05-30 G. D. Searle & Co. Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US5352638A (en) 1994-02-22 1994-10-04 Corning Incorporated Nickel aluminosilicate glass-ceramics
JPH10505087A (ja) 1994-09-02 1998-05-19 バージニア カマンウェルス ユニバーシティ 非麻薬性鎮痛剤および無痛エンハンサーを含有する疼痛緩和組成物
CN1046199C (zh) 1994-12-13 1999-11-10 凌吉安 复方消炎止痛霜剂
BR9710536A (pt) * 1996-07-24 1999-08-17 Warner Lambert Co Isobutilgaba e seus derivados para o tratamento da dor
EP0942752B1 (en) * 1996-08-23 2005-04-20 Algos Pharmaceutical Corporation Anticonvulsant containing composition for treating neuropathic pain
US6057373A (en) 1997-05-22 2000-05-02 Synchroneuron, Llc Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
AU8668598A (en) 1997-08-20 1999-03-08 University Of Oklahoma, The Gaba analogs to prevent and treat gastrointestinal damage
WO1999012537A1 (en) 1997-09-08 1999-03-18 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same
AU3216600A (en) 1999-03-10 2000-09-28 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same

Also Published As

Publication number Publication date
CA2296336A1 (en) 1999-03-18
NO324122B1 (no) 2007-08-27
EP1011658B1 (en) 2005-12-07
EP1011658A1 (en) 2000-06-28
ATE311867T1 (de) 2005-12-15
IL134165A0 (en) 2001-04-30
US6942876B2 (en) 2005-09-13
PL339142A1 (en) 2000-12-04
AU9198798A (en) 1999-03-29
AU750578B2 (en) 2002-07-25
CU23226B7 (es) 2007-09-26
HU226165B1 (en) 2008-05-28
IS5362A (is) 2000-01-25
HUP0003705A2 (hu) 2001-04-28
HUP0003705A3 (en) 2002-01-28
NO20001175L (no) 2000-03-07
DE69832712D1 (de) 2006-01-12
US6593368B2 (en) 2003-07-15
DE69832712T2 (de) 2006-06-22
NO20001175D0 (no) 2000-03-07
WO1999012537A1 (en) 1999-03-18
JP3782935B2 (ja) 2006-06-07
ES2253825T3 (es) 2006-06-01
US20020115705A1 (en) 2002-08-22
DK1011658T3 (da) 2006-04-03
CA2296336C (en) 2004-04-20
JP2001515859A (ja) 2001-09-25
KR100537707B1 (ko) 2005-12-20
NZ502671A (en) 2003-01-31
US20030065028A1 (en) 2003-04-03
US20030176505A1 (en) 2003-09-18
ZA988159B (en) 1999-03-11
IL185345A0 (en) 2008-01-06
KR20010023745A (ko) 2001-03-26

Similar Documents

Publication Publication Date Title
BR9812162A (pt) Composições analgésicas compreendendo compostos antiepiléticos e métodos para o uso das mesmas
BR0008847A (pt) Composições analgésicas que compreendemcompostos antiepilépticos, e métodos de uso dasmesmas
BR0111207A (pt) Combinações de um antagonista receptor de endotelina e um composto antiepiléptico tendo propriedades de alìvio da dor ou analgésicos
Argoff New analgesics for neuropathic pain: the lidocaine patch
BR9908030A (pt) Composição farmacêutica compreendendo uma ou mais unidades de dose oralmente ministráveis, e, processos para prepará-la, para uso da mesma, e para tratar uma condição ou distúrbio médico em um indivìduo em que tratamento com um inibidor da ciclooxigenase-2 é indicado
BR0109150A (pt) Método para administração de um anestésico local a um indivìduo em necessidade de um efeito anestésico local, emplastro, composição, e, recipiente
BR9909903A (pt) Eficácia máxima de substâncias usadas para melhorar a saúde e bem-estar
BR0113447A (pt) Método de tratamento ou prevenção do câncer em um ser humano, e, composição farmacêutica
BR0012136A (pt) Inibidores de reabsorção de norepinefrina altamente seletivos e métodos de uso dos mesmos
AR040603A1 (es) El uso de un anticuerpo anti-tnfalfa neutralizador de alta afinidad en la fabricacion de un medicamento y conjunto de elementos
BR0016275A (pt) Combinações farmacêuticas e seu uso no tratamento de distúrbios gastrointestinais
BR9914901A (pt) Agonistas do receptor 5ht1 e metoclopramida para o tratamento de enxaqueca
US20190374491A1 (en) Topical preparation for pain relief
Brown et al. Utilization and mechanism of action of tricyclic antidepressants in the treatment of chronic facial pain: a review of the literature.
AR015744A1 (es) Uso de dexmedetomidina para sedacion en terapia intensiva
JP7305654B2 (ja) ウォゴニンで疼痛を治療するための組成物および方法
BR0201974A (pt) Composição farmacêutica para tratamento de alterações do sono
US20050256187A1 (en) Method and composition for synergistic topical therapy for neuromuscular pains
BR112023000598A2 (pt) Composições de dose oral unitária composta de ibuprofeno e famotidina para o tratamento da dor aguda e redução da gravidade e/ou risco de azia
Liu et al. Comparative study between three analgesic agents for the pain management during extracorporeal shock wave lithotripsy
KR970705390A (ko) 비마약성 진통제(non-narcotic analgesic) 및 진통효과 향상제(analgesia enhancer)를 포함하는 통증 완화 조성물(COMPOSITION ALLEVIATING PAIN, CONTAINING A NON-NARCOTIC ANALGESIC AND AN ANALGESIA ENHANCER)
Argoff A review of the use of topical analgesics for myofascial pain
KR890007728A (ko) 진통제 제조방법
BR9914981A (pt) Regime analgésico
Liedtke Pharmacological concept for topical synergistic analgesia of peripheral neuromuscular pain

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO COM BASE NO ARTIGOS 10 ( VIII ), 24 E 25 , 8O C/C 15, DA LPI 9.279, DE 14 DE MAIO DE 1996