HUP0401750A2 - Cinnamidszármazékok mint KCNQ káliumcsatorna-modulátorok és ezeket tartalmazó gyógyszerkészítmények - Google Patents

Cinnamidszármazékok mint KCNQ káliumcsatorna-modulátorok és ezeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0401750A2
HUP0401750A2 HU0401750A HUP0401750A HUP0401750A2 HU P0401750 A2 HUP0401750 A2 HU P0401750A2 HU 0401750 A HU0401750 A HU 0401750A HU P0401750 A HUP0401750 A HU P0401750A HU P0401750 A2 HUP0401750 A2 HU P0401750A2
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Hungary
Prior art keywords
group
alkyl
potassium channel
kcnq potassium
pharmaceutical compositions
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HU0401750A
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English (en)
Inventor
Yong-Jin Wu
Li-Qiang Sun
Jie Chen
Huan He
Alexandre L'heureux
Pierre Dextraze
Jean-Paul Daris
Gene G. Kinney
Steven I. Dworetzky
Piyasena Hewawasam
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Bristol-Myers Squibb Company
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Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HUP0401750A2 publication Critical patent/HUP0401750A2/hu

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Abstract

A találmány tárgyát általános képletű új cinnamidszármazékok - ahol R1-4 szénatomos alkil- vagy trifluor-metil-csoport; Rl piridil-,kinolinil-, tienil-, furil-, 1,4-benzodioxanil-, 1,3-benzodioxolil-,kromanil-, indanil-, bifenilil-, fenil vagy szubsztituáltfenilcsoport; R2 és R3 egymástól függetlenül hidrogén-, halogénatomvagy alkilcsoport; R4 dialkil-amino-, trifluor-metoxi-, adott esetbenszubsztituált morfolinil-, piridil-, pirimidinil-, piperazinil- vagypirazinil-csoport; R5 hidrogén-, klór-, fluoratom; vagy R4 és R5együtt -CH=CH-CH=CH- csoportot vagy -X-(CH2)mY- általános képletűcsoportot képeznek, amelyben X és Y egymástól függetlenül -CH2-, -O-vagy -(CH2)nN(R9)-, ahol m=1 vagy 2, n=0 vagy l; R6, R7 és R8egymástól függetlenül hidrogén-, klór-, fluoratom; és R9 hidrogénatom,alkil-, hidroxi- vagy alkoxi-etil-csoport, ciklopropil-metil-, alkoxi-karbonil-, adott esetben alkilezett 2-amino-etil-csoport és sóik, valamint ezeket tartalmazó, KCNQ káliumcsatorna-nyitóhatású gyógyyszerkészítmények képezik. Ó
HU0401750A 2001-05-31 2002-05-31 Cinnamidszármazékok mint KCNQ káliumcsatorna-modulátorok és ezeket tartalmazó gyógyszerkészítmények HUP0401750A2 (hu)

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