WO2004081002A1 - Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia - Google Patents
Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia Download PDFInfo
- Publication number
- WO2004081002A1 WO2004081002A1 PCT/US2004/006546 US2004006546W WO2004081002A1 WO 2004081002 A1 WO2004081002 A1 WO 2004081002A1 US 2004006546 W US2004006546 W US 2004006546W WO 2004081002 A1 WO2004081002 A1 WO 2004081002A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkylene
- group
- alkyl
- residue
- independently selected
- Prior art date
Links
- 0 CC(C)C(*1CCC(CC(CC(NCCC(Oc2ccc(C(C(CCC(c(cc3)ccc3F)O)C3=O)N3c(cc3)ccc3F)cc2)=O)=O)O)O)=C(*(c2ccccc2)=O)C(c2ccccc2)=C1c(cc1)ccc1F Chemical compound CC(C)C(*1CCC(CC(CC(NCCC(Oc2ccc(C(C(CCC(c(cc3)ccc3F)O)C3=O)N3c(cc3)ccc3F)cc2)=O)=O)O)O)=C(*(c2ccccc2)=O)C(c2ccccc2)=C1c(cc1)ccc1F 0.000 description 1
- KHLVIMQXFBBFRW-MVWRIWLRSA-N CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c(cc2)ccc2F)c1/C=C/[C@H](C[C@H](CC(NCCC(Oc1ccc([C@H]([C@@H](CC[C@@H](c(cc2)ccc2F)O)C2=O)N2c(cc2)ccc2F)cc1)=O)=O)O)O Chemical compound CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c(cc2)ccc2F)c1/C=C/[C@H](C[C@H](CC(NCCC(Oc1ccc([C@H]([C@@H](CC[C@@H](c(cc2)ccc2F)O)C2=O)N2c(cc2)ccc2F)cc1)=O)=O)O)O KHLVIMQXFBBFRW-MVWRIWLRSA-N 0.000 description 1
- CXEKTOVWWOIHNR-IDQYINAESA-N CC/C(/CCC[C@H]([C@@H](c(cc1)ccc1OCCCN)N1c2ccccc2)C1=O)=C\C=C/C Chemical compound CC/C(/CCC[C@H]([C@@H](c(cc1)ccc1OCCCN)N1c2ccccc2)C1=O)=C\C=C/C CXEKTOVWWOIHNR-IDQYINAESA-N 0.000 description 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N CC[C@H](C)C(O[C@@H]1[C@H]([C@@H](CC[C@H](C[C@H](C2)O)OC2=O)[C@@H](C)C=C2)C2=C[C@H](C)C1)=O Chemical compound CC[C@H](C)C(O[C@@H]1[C@H]([C@@H](CC[C@H](C[C@H](C2)O)OC2=O)[C@@H](C)C=C2)C2=C[C@H](C)C1)=O PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 description 1
- BADJQEOAARZRBP-XAHBOUPSSA-N CC[C@H](C)C(O[C@@H]1[C@H]([C@@H](CC[C@H](C[C@H](CC(NCCCOc2ccc([C@H]([C@@H](CCCc3ccccc3)C3=O)N3c3ccccc3)cc2)=O)O)O)[C@@H](C)C=C2)C2=C[C@H](C)C1)=O Chemical compound CC[C@H](C)C(O[C@@H]1[C@H]([C@@H](CC[C@H](C[C@H](CC(NCCCOc2ccc([C@H]([C@@H](CCCc3ccccc3)C3=O)N3c3ccccc3)cc2)=O)O)O)[C@@H](C)C=C2)C2=C[C@H](C)C1)=O BADJQEOAARZRBP-XAHBOUPSSA-N 0.000 description 1
- PBOONDLROHJMJA-RMTZWNOUSA-N NCCC(Oc1ccc([C@H]([C@@H](CC[C@@H](c(cc2)ccc2F)O)C2=O)N2c(cc2)ccc2F)cc1)=O Chemical compound NCCC(Oc1ccc([C@H]([C@@H](CC[C@@H](c(cc2)ccc2F)O)C2=O)N2c(cc2)ccc2F)cc1)=O PBOONDLROHJMJA-RMTZWNOUSA-N 0.000 description 1
- OQJBFFCUFALWQL-BUHFOSPRSA-N O=C(N1CCCCC1)/N=N/C(N1CCCCC1)=O Chemical compound O=C(N1CCCCC1)/N=N/C(N1CCCCC1)=O OQJBFFCUFALWQL-BUHFOSPRSA-N 0.000 description 1
- BNZKOZMKEFEXEK-CZNDPXEESA-N O=C([C@H](CCCc1ccccc1)[C@H]1c(cc2)ccc2OCCCOCc2ccccc2)N1c1ccccc1 Chemical compound O=C([C@H](CCCc1ccccc1)[C@H]1c(cc2)ccc2OCCCOCc2ccccc2)N1c1ccccc1 BNZKOZMKEFEXEK-CZNDPXEESA-N 0.000 description 1
- FUCYABRIJPUVAT-UHFFFAOYSA-N OCCCOCc1ccccc1 Chemical compound OCCCOCc1ccccc1 FUCYABRIJPUVAT-UHFFFAOYSA-N 0.000 description 1
- JGYJSYKKOCYFDN-DHIUTWEWSA-N Oc1ccc([C@H]([C@@H](CCCc2ccccc2)C2=O)N2c2ccccc2)cc1 Chemical compound Oc1ccc([C@H]([C@@H](CCCc2ccccc2)C2=O)N2c2ccccc2)cc1 JGYJSYKKOCYFDN-DHIUTWEWSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006509068A JP5137228B2 (ja) | 2003-03-07 | 2004-03-03 | 高コレステロール血症の処置のための置換アゼチジノン化合物、置換アゼチジノン処方物およびそれらの使用 |
CA2517571A CA2517571C (en) | 2003-03-07 | 2004-03-03 | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
EP04716953A EP1601668B1 (en) | 2003-03-07 | 2004-03-03 | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
MXPA05009503A MXPA05009503A (es) | 2003-03-07 | 2004-03-03 | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
DE602004016123T DE602004016123D1 (de) | 2003-03-07 | 2004-03-03 | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
HK06105697A HK1085727A1 (en) | 2003-03-07 | 2006-05-16 | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45280903P | 2003-03-07 | 2003-03-07 | |
US60/452,809 | 2003-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004081002A1 true WO2004081002A1 (en) | 2004-09-23 |
Family
ID=32990687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/006546 WO2004081002A1 (en) | 2003-03-07 | 2004-03-03 | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
Country Status (11)
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005061451A1 (en) * | 2003-12-23 | 2005-07-07 | Astrazeneca Ab | Diphenylazetidinone derivates processing cholesterol absorption inhibitory activity |
WO2006107936A1 (en) * | 2005-04-04 | 2006-10-12 | Pontificia Universidad Catolica De Chile | The use of ezetimibe in the prevention and treatment of cholesterol gallstones |
WO2006137782A1 (en) * | 2005-06-20 | 2006-12-28 | Astrazeneca Ab | Novel 2-azetidinone derivatives and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia |
US7470678B2 (en) | 2002-07-05 | 2008-12-30 | Astrazeneca Ab | Diphenylazetidinone derivatives for treating disorders of the lipid metabolism |
EP2124549A1 (en) * | 2006-12-20 | 2009-12-02 | Merck & Co., Inc. | Anti-hypercholesterolemic compounds |
WO2010100255A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
US7842684B2 (en) | 2006-04-27 | 2010-11-30 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitor activity |
US7871998B2 (en) | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
US7893048B2 (en) | 2005-06-22 | 2011-02-22 | Astrazeneca Ab | 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7176194B2 (en) * | 2002-06-19 | 2007-02-13 | Sanofi-Aventis Deutschland Gmbh | Ring-substituted diphenylazetidinones, process for their preparation, medicaments comprising these compounds, and their use |
JP2006519869A (ja) * | 2003-03-07 | 2006-08-31 | シェーリング コーポレイション | 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用 |
EP1601669B1 (en) * | 2003-03-07 | 2008-12-24 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US7410483B2 (en) * | 2003-05-23 | 2008-08-12 | Novare Surgical Systems, Inc. | Hand-actuated device for remote manipulation of a grasping tool |
US7803838B2 (en) * | 2004-06-04 | 2010-09-28 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
US7838552B2 (en) | 2004-06-04 | 2010-11-23 | Forest Laboratories Holdings Limited | Compositions comprising nebivolol |
AU2006259646A1 (en) * | 2005-06-15 | 2006-12-28 | Merck Sharp & Dohme Corp. | Anti-hypercholesterolemic compounds |
US7635705B2 (en) * | 2005-06-20 | 2009-12-22 | Schering Corporation | Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists |
AR057383A1 (es) * | 2005-06-22 | 2007-12-05 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
AR054482A1 (es) * | 2005-06-22 | 2007-06-27 | Astrazeneca Ab | Derivados de azetidinona para el tratamiento de hiperlipidemias |
AR057380A1 (es) * | 2005-06-22 | 2007-11-28 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona y uso terapeutico de los mismos |
AR057072A1 (es) | 2005-06-22 | 2007-11-14 | Astrazeneca Ab | Compuestos quimicos derivados de 2-azetidinona, formulacion farmaceutica y un proceso de preparacion del compuesto |
TW200806623A (en) * | 2005-10-05 | 2008-02-01 | Merck & Co Inc | Anti-hypercholesterolemic compounds |
WO2008030382A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5661145A (en) * | 1992-12-23 | 1997-08-26 | Schering Corporation | Combination of a cholesterol biosynthesis inhibitor and a β-lactam cholesterol absorption inhibitor |
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US7470678B2 (en) | 2002-07-05 | 2008-12-30 | Astrazeneca Ab | Diphenylazetidinone derivatives for treating disorders of the lipid metabolism |
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US8361999B2 (en) | 2005-04-04 | 2013-01-29 | Pontificia Universidad Catolica De Chile | Methods of treating cholesterol gallstone disease with ezetimibe |
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US7863265B2 (en) | 2005-06-20 | 2011-01-04 | Astrazeneca Ab | 2-azetidinone derivatives and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia |
US7893048B2 (en) | 2005-06-22 | 2011-02-22 | Astrazeneca Ab | 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
US7842684B2 (en) | 2006-04-27 | 2010-11-30 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitor activity |
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WO2010100255A1 (en) | 2009-03-06 | 2010-09-10 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
US9212175B2 (en) | 2009-03-06 | 2015-12-15 | Lipideon Biotechnology Ag | Pharmaceutical hypocholesterolemic compositions |
Also Published As
Publication number | Publication date |
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CN1756752A (zh) | 2006-04-05 |
JP2006520822A (ja) | 2006-09-14 |
US20070155674A1 (en) | 2007-07-05 |
US20040198700A1 (en) | 2004-10-07 |
ES2311806T3 (es) | 2009-02-16 |
CN100439361C (zh) | 2008-12-03 |
DE602004016123D1 (de) | 2008-10-09 |
US7368563B2 (en) | 2008-05-06 |
CA2517571C (en) | 2011-07-05 |
US7235543B2 (en) | 2007-06-26 |
JP5137228B2 (ja) | 2013-02-06 |
MXPA05009503A (es) | 2005-10-18 |
ATE406364T1 (de) | 2008-09-15 |
CA2517571A1 (en) | 2004-09-23 |
US7741289B2 (en) | 2010-06-22 |
HK1085727A1 (en) | 2006-09-01 |
US20080207585A1 (en) | 2008-08-28 |
EP1601668B1 (en) | 2008-08-27 |
US7368562B2 (en) | 2008-05-06 |
EP1601668A1 (en) | 2005-12-07 |
US20070155675A1 (en) | 2007-07-05 |
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