WO1998020862A1 - Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation - Google Patents

Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation Download PDF

Info

Publication number
WO1998020862A1
WO1998020862A1 PCT/EP1997/005820 EP9705820W WO9820862A1 WO 1998020862 A1 WO1998020862 A1 WO 1998020862A1 EP 9705820 W EP9705820 W EP 9705820W WO 9820862 A1 WO9820862 A1 WO 9820862A1
Authority
WO
WIPO (PCT)
Prior art keywords
film
preparation according
water
water soluble
cellulose
Prior art date
Application number
PCT/EP1997/005820
Other languages
English (en)
French (fr)
Inventor
Horst Georg Zerbe
Anthony J. Serino
Jian-Hwa Guo
Original Assignee
Lts Lohmann Therapie-Systeme Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU48682/97A priority Critical patent/AU739698B2/en
Priority to CZ0164799A priority patent/CZ297354B6/cs
Application filed by Lts Lohmann Therapie-Systeme Gmbh filed Critical Lts Lohmann Therapie-Systeme Gmbh
Priority to DE59710670T priority patent/DE59710670D1/de
Priority to EP97911237A priority patent/EP0936905B1/de
Priority to DK03014213T priority patent/DK1362584T3/da
Priority to SK622-99A priority patent/SK285100B6/sk
Priority to IL12981997A priority patent/IL129819A0/xx
Priority to SK5041-2005A priority patent/SK285999B6/sk
Priority to HU0500666A priority patent/HU230022B1/hu
Priority to HU9904207A priority patent/HU228464B1/hu
Priority to JP52208898A priority patent/JP4063331B2/ja
Priority to SI9730590T priority patent/SI0936905T1/xx
Priority to CA002265651A priority patent/CA2265651C/en
Priority to PL97333677A priority patent/PL190376B1/pl
Priority to AT97911237T priority patent/ATE247954T1/de
Priority to DK97911237T priority patent/DK0936905T3/da
Publication of WO1998020862A1 publication Critical patent/WO1998020862A1/de
Priority to NO19991921A priority patent/NO325073B1/no
Priority to HK00101167A priority patent/HK1035316A1/xx
Priority to NO20053307A priority patent/NO20053307D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
    • A61K8/8176—Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/90—Block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention discloses a preparation which contains pharmaceutical active substances and / or breath-refreshing active substances for use in the oral cavity.
  • the carrier comprises water-soluble polymers in combination with certain ingredients and has a therapeutic and / or cosmetic effect.
  • the film is spread and dried using existing coating technologies and has immediate wettability, followed by rapid dissolution / decomposition when applied in the oral cavity.
  • a water-insoluble film can be added to make the surface non-adhesive.
  • WO 91/06270 by the same inventor discloses a three-layer film for prolonged release of an active ingredient in the oral cavity.
  • US 4,876,092 discloses a sheet-like, adhesive preparation comprising an adhesive layer which contains certain water-soluble and water-insoluble polymers and a water-insoluble carrier which adheres to the oral mucosa and thereby releases an active ingredient into the oral cavity. All of the aforesaid devices are not completely water-soluble and remain in the oral cavity even after the therapeutic goal has been achieved and cause some discomfort to the patient in the mouth, mainly caused by the backing layer which leaves an insoluble residue in the mouth.
  • CA 1 263 312 discloses the use of polyolefins such as polyethylene, polypropylene, polyester, PVC and nonwovens as soft carrier materials. Nevertheless, these leave a considerable amount of residues of the water-insoluble carrier film in the patient and therefore still cause an uncomfortable feeling.
  • An obvious solution to overcome this problem was to develop films that stick to the mucous membrane and which completely disintegrate or dissolve in the saliva.
  • Fuchs and Hilmann (DE 24 49 865.5) produced homogeneous, water-soluble films for buccal delivery of hormones. They proposed the use of water-soluble cellulose derivatives such as hydroxyethyl cellulose, hydroxypropyl cellulose or methyl hydroxypropyl cellulose as film formers.
  • the two patents DE 36 30 603 and EP 0 219 762 disclose the use of swellable polymers such as gelatin or corn starch as film formers, which according to Ap- slowly dissolve in the oral cavity, releasing an active ingredient that is contained in the film.
  • the same polymers can also be used to make films for dental care, as described in EP 0 452 446. But these preparations also cause an uncomfortable feeling in the mouth, particularly caused by their initial rigidity and delayed softening. This results in a need for a composition for use in the oral cavity that takes into account the need for a feeling of well-being in the mouth.
  • the present invention discloses methods and preparations by which an uncomfortable feeling can be avoided by providing an instantly wettable film / layer for application to the oral mucosa and by which a tear strength in the free film is achieved which is problem-free Coating, processing and packaging of a consumer-friendly product enables.
  • the present invention relates to a film or layer which dissolves in a film and which adheres to the oral cavity and thereby releases a pharmaceutical or cosmetic active substance, the film / layer being water-soluble polymers, one or more polyalcohols and one or more pharmaceutically or contains cosmetic active ingredients.
  • the formulation can optionally contain a combination of certain plasticizers or surface-active substances, colorants, sweeteners, flavoring agents, taste improvers or other corrigents, as are usually used to modify the taste of formulations intended for application in the oral cavity.
  • the resulting film is characterized by immediate wettability, which allows the film to soften immediately after application to the mucosal tissue, which means that the patient has a longer the unpleasant feeling in the mouth is prevented, as well as a tear resistance suitable for normal coating, cutting, slicing and packaging operations.
  • the mucoadhesive film of the present invention contains as essential components a water-soluble polymer or a combination of water-soluble polymers, one or more plasticizers or surface-active substances, one or more polyalcohols and a pharmaceutical or cosmetic active ingredient.
  • the polymers used for the mucoadhesive film include hydrophilic and / or water dispersible polymers.
  • Preferred polymers are water-soluble cellulose derivatives. Hydroxypropylmethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose, alone or mixed, are particularly preferred.
  • polyvinyl pyrrolidone polyvinyl pyrrolidone
  • carboxymethyl cellulose polyvinyl alcohol, sodium alginate
  • polyethylene glycol polyethylene glycol
  • natural gums such as xanthan resin, tragacanth, guar resin, acacia resin, gum arabic
  • water-dispersible polyacrylates such as polyacrylic acid, Methyl methacrylate copolymer, carboxyvinyl copolymers.
  • concentration of the water-soluble polymer in the finished film can be between 20 and 75% by weight. A preferred concentration is between 50 and 75% by weight.
  • the surfactants used for the mucoadhesive film can be one or more nonionic surfactants.
  • the first component can be a polyethoxysorbitan fatty acid ester or an ⁇ -hydro- ⁇ -hydroxypoly (ethoxy) poly (propoxy) poly (ethoxy) block copolymer
  • the second component can be a polye - can be thoxyalkyl ether or a polyethoxy castor oil derivative.
  • the HLB value of the polyethoxysorbitan fatty acid esters should preferably be between 10 and 20, a range between 13 and 17 being particularly preferred.
  • the ⁇ -hydro- ⁇ -hydroxypoly (ethoxy) poly (propoxy) poly (ethoxy) block copolymer should contain at least 35 propoxy units, preferably at least 50 propoxy units.
  • the polyethoxyalkyl ether should have an HLB value between 10 and 20, preferably not less than 15.
  • the polyethoxy castor oil derivative should have an HLB value between 14 and 16.
  • the ratio between the first and the second component of a binary surface-active mixture should be kept between 1:10 and 1: 1, preferably between 1: 5 and 1: 3.
  • the total concentration of surface-active substances in the finished film depends on the properties of the other ingredients, but should normally be between 0.1 and 5% by weight.
  • the polyalcohol is required to achieve the desired level of softness in the film.
  • examples of polyalcohols include glycerin, polyethylene glycol, propylene glycol, glycerol monoesters with fatty acids, or other pharmaceutically used polyalcohols.
  • concentration of polyalcohol in the dry mass of the film is usually 0.1 to 5% by weight.
  • the film is particularly well suited for delivering a wide range of pharmaceutically active ingredients through a patient's mucous membrane, particularly through the buccal mucosa.
  • Therapeutic agents that have absorption problems due to limited solubility, breakdown in the gastrointestinal tract or have extensive metabolism are particularly well suited.
  • the therapeutic agents that can be used include: hypnotics, sedatives, antiepileptics, weckamines, psychoneurotropics, neuromuscle blockers, antispasmodics, antihistamines, antiallergics, cardiotonica, antiarrhythmics, diuretics, hypotensives, vasopressors, antitussives Expectorantia, thyroid hormones, sex hormones, antidiabetics, antitumor agents, antibiotics as well as chemotherapeutics and narcotics.
  • the amount of active ingredient to be stored in the film depends on its type and is usually between 0.01 and 20% by weight, but it can be higher if necessary to achieve the desired effect.
  • Cosmetic active ingredients include breath fresheners such as menthol, other flavors, aromas or fragrances as are usually used for oral hygiene, and / or active ingredients for dental care and / or oral hygiene, for example quaternary ammonium bases.
  • breath fresheners such as menthol
  • other flavors, aromas or fragrances as are usually used for oral hygiene
  • active ingredients for dental care and / or oral hygiene, for example quaternary ammonium bases.
  • flavor enhancers such as tartaric acid, citric acid, vanillin or the like.
  • Dyes that are optionally added to the film must be safe in terms of toxicity and should be approved for use in cosmetics by the responsible authorities.
  • the mucoadhesive film according to the invention can be produced as follows:
  • the polyalcohol, surfactants, plasticizers, and other possible ingredients other than the water-soluble or water-dispersible polymer (s) are dissolved with a sufficient amount of a compatible solvent.
  • a compatible solvent include water, alcohols or mixtures thereof.
  • suitable materials include non-siliconized polyethylene terephthalate films, non-siliconized kraft paper, polyethylene-impregnated kraft paper or non-siliconized polyethylene film.
  • the solution can be applied to the carrier material using any conventional device.
  • a particularly preferred application technique relates to a roller doctor coating machine.
  • the thickness of the resulting film layer depends on the concentration of solids in the coating solution and on the gap width of the coating machine and can vary between 5 and 200 ⁇ m.
  • the film is dried in a hot air bath using a drying oven, drying tunnel, vacuum dryer or other suitable drying devices which do not adversely affect the action of the active ingredient (s) or flavorings. In order to reliably avoid an uncomfortable feeling in the mouth, the film thickness should not exceed 70 ⁇ m. For better ease of use, the film can be cut into pieces of suitable size and shape and packaged.
  • Example 1 The invention is illustrated by the following examples.
  • Example 1 Example 1 :
  • hydroxypropylmethyl cellulose are slowly added to the solution with stirring until a clear and homogeneous solution is formed.
  • the resulting solution is then allowed to cool to room temperature and spread onto a suitable substrate, such as non-siliconized polyethylene coated kraft paper, using a conventional coating / drying device.
  • Coating gap and web speed must be controlled so that a dry film thickness between 20 and 50 ⁇ m is achieved.
  • the drying temperature depends on the length of the drying oven and the material speed and should be set so that the solvents are completely or at least largely completely removed from the film.
  • the resulting film is peeled off the support and cut into pieces of suitable size and shape for use.
  • 165.4 g of Kollidon 30 are at room temperature in a solution of 720 ml of water and 2660 ml of ethanol with stirring solves. Then 220.5 g of hydroxypropylmethyl cellulose are added at 55-60 ° C. and stirred vigorously until the solution is clear and homogeneous. After the mixture has cooled, 78.75 g of flavor, followed by a mixture of 26.88 g of nicotine salicylate and 31.5 g of caramel liquid in 120 ml of water are added with stirring. The clear, yellow-brown liquid is brushed on and dried under the conditions described in Example 1 and the dry film is cut into pieces of a suitable shape and size to give a nicotine dose of 1-2 mg per piece.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Eine Zubereitung zur Anwendung in der Mundhöhle mit einer/einem an der Schleimhaut haftklebenden Schicht oder Film ist dadurch gekennzeichnet, daß die haftklebende Schicht oder der haftklebende Film eine homogene Mischung enthält, bestehend aus einem wasserlöslichen Polymer, einer Mischung nichtionischer oberflächenaktiver Stoffe, einem Polyalkohol, einem kosmetischen oder pharmazeutischen Wirkstoff, und einem Geschmacks- oder Aromastoff.

Description

Sofortige Benetzbarkeit aufweisende (r) wasserlöslicher Film oder wasserlösliche Schicht zur oralen Applikation
Die vorliegende Erfindung offenbart eine Zubereitung, die pharmazeutische Wirkstoffe und/oder die Atmung erfrischende Wirkstoffe enthalten, zur Anwendung in der Mundhöhle. Der Träger umfaßt wasserlösliche Polymere in Kombination mit bestimmten Inhaltsstoffen und hat eine therapeutische und/oder kosmetische Wirkung. Der Film wird unter Verwendung bestehender Beschichtungstechnologien aufgestrichen und getrocknet und weist eine sofortige Benetzbarkeit auf, gefolgt von schneller Auflösung/Zersetzung bei Applikation in der Mundhöhle.
An der Schleimhaut haftende (mukoadhäsive) Dosiersysteme zur Anwendung in der Mundhöhle, mit denen therapeutische und/oder kosmetische Wirkstoffe an die Mundschleimhaut abgegeben werden sollen, sind im Stand der Technik bekannt. Das US-Patent 5,047,244 beschreibt einen an der Mundschleimhaut haftenden Träger zur kontrollierten Abgabe eines therapeutischen Wirkstoffs durch das Schleimhautgewebe, der eine wasserfreie, aber hydratisierbare Polymermatrix und amorphes Siliciumdioxid enthält.
Fakultativ kann ein wasserunlöslicher Film beigefügt werden, um die Oberfläche nichtadhäsiv zu gestalten. Die WO 91/06270 des gleichen Erfinders offenbart einen dreischichtigen Film zur verlängerten Abgabe eines aktiven Wirkstoffs in der Mundhöhle.
In gleicher Weise offenbart US 4,876,092 eine flächenförmi- ge, adhäsive Zubereitung, umfassend eine adhäsive Schicht, welche bestimmte wasserlösliche und wasserunlösliche Polymere und einen wasserunlöslichen Träger enthält, welcher an der Mundschleimhaut haftet und dabei einen aktiven Wirkstoff an die Mundhöhle abgibt. Alle diese vorgenannten Vorrichtungen sind nicht vollständig wasserlöslich und verbleiben in der Mundhöhle, selbst nach Erreichen des therapeutischen Ziels, und bereiten dem Patienten ein gewisses Unbehagen im Mund, das hauptsächlich durch die Trägerschicht verursacht wird, welche einen unlöslichen Rückstand im Mund zurückläßt.
Eine Reihe von Versuchen wurde unternommen, um das ungute Gefühl in der Mundhöhle zu verringern, welches durch die Starrheit und mangelnde Flexibilität der Trägerschicht verursacht wurde, indem man weiche Filmträgβr einführte. Die Dokumente EP 0 200 508 und EP 0 381 194 schlagen die Verwendung von Polyethylenfilmen, Polyvinylacetat, Ethylen- Vinylacetat-Copolymeren, Metallfolien, Laminaten aus Stoff oder Papier und einem Plastikfilm, und ähnlichen Materialien als weiche Träger vor, wobei synthetische Harze wie Po- lyethylen, Vinylacetat-Homopolymere und Ethylen-Vinyl- Acetat bevorzugte Materialien sind.
In gleicher Weise offenbart CA 1 263 312 die Verwendung von Polyolefinen wie Polyethylen, Polypropylen, Polyester, PVC, sowie Vliesstoffen als weiche Trägermaterialien. Dennoch hinterlassen diese beim Patienten eine beträchtliche Menge von Rückständen des wasserunlöslichen Trägerfilms und verursachen daher immer noch ein unbehagliches Gefühl. Eine naheliegende Lösung zur Überwindung dieses Problems war die Entwicklung schleimhauthaftender Filme, welche vollständig zerfallen oder sich im Speichel auflösen. Fuchs und Hilmann (DE 24 49 865.5) stellten homogene, wasserlösliche Filme für buccale Zuführung von Hormonen her. Sie schlugen die Verwendung von wasserlöslichen Cellulose- derivaten wie Hydroxyethylcellulose, Hydroxypropylcellulose oder Methylhydroxypropylcellulose als Filmbildner vor.
Die beiden Patentschriften DE 36 30 603 und EP 0 219 762 offenbaren die Verwendung von quellbaren Polymeren wie Gelatine oder Maisstärke als Filmbildner, welche nach Ap- plikation in der Mundhöhle langsam zerfallen, wobei sie einen aktiven Wirkstoff freisetzen, der im Film enthalten ist. Die gleichen Polymere können ebenfalls verwendet werden, um Filme herzustellen, die zur Zahnpflege dienen sollen, entsprechend der Beschreibung in EP 0 452 446. Aber auch diese Zubereitungen rufen ebenfalls ein ungutes Gefühl im Mund hervor, insbesondere verursacht durch ihre anfängliche Starrheit und verzögerte Erweichung. Hieraus resultiert ein Bedarf für eine Komposition zur Verwendung in der Mundhöhle, die dem Erfordernis eines Wohlgefühls im Mund Rechnung trägt .
Die vorliegende Erfindung offenbart Verfahren und Zubereitungen, durch die ein unangenehmes Gefühl vermieden werden kann, und zwar durch Bereitstellen eines/einer sofortige Benetzbarkeit aufweisenden Films/Schicht zur Applikation an die Mundschleimhaut, und durch die eine Reißfestigkeit im freien Film erzielt wird, welche eine problemlose Beschichtung, Weiterverarbeitung und Verpackung eines verbraucherfreundlichen Produktes ermöglicht.
Die vorliegende Erfindung betrifft einen/eine schneilauflösende (n) Film/Schicht, der/die an der Mundhöhle haftet und dabei einen pharmazeutischen oder kosmetischen Wirkstoff abgibt, wobei der Film/die Schicht wasserlösliche Polymere, einen oder mehrere Polyalkohole und einen oder mehrere pharmazeutisch oder kosmetische wirksame Inhaltsstoffe enthält. Wahlweise kann die Formulierung eine Kombination von bestimmten Weichmachern oder oberflächenaktiven Stoffen, Farbstoffen, Süßmitteln, Geschmacksstoffen, Geschmacksverbesserern oder anderer Corrigenzien enthalten, wie sie üblicherweise zur Modifikation des Geschmacks von für die Applikation in der Mundhöhle bestimmten Formulierungen Verwendung finden. Der resultierende Film ist gekennzeichnet durch eine sofortige Benetzbarkeit, welche den Film unverzüglich nach Applikation an das Schleimhautgewebe erweichen läßt, wodurch beim Patienten ein länger anhalten- des unangenehmes Gefühl im Mund verhindert wird, sowie durch eine für normale Beschichtungs-, Schneid-, Auf- schneid- und Verpackungsoperationen geeignete Reißfestigkeit.
Der mukoadhäsive Film der vorliegenden Erfindung enthält als wesentliche Bestandteile ein wasserlösliches Polymer oder eine Kombination von wasserlöslichen Polymeren, eine oder mehrere Weichmacher oder oberflächenaktive Stoffe, ein oder mehrere Polyalkohole und einen pharmazeutischen oder kosmetischen Wirkstoff.
Die für den mukoadhäsiven Film verwendeten Polymere umfassen hydrophile und/oder wasserdispergierbare Polymere. Bevorzugte Polymere sind wasserlösliche Cellulosederivate. Hydroxypropylmethylcellulose, Hydroxyethylcellulose und Hydroxypropylcellulose sind, allein oder gemischt, besonders bevorzugt. Beispiele für andere, fakultative, Polymere werden nachfolgend genannt, ohne die Erfindung einzuschränken: Polyvinylpyrrolidon, Carboxymethylcellulose, Polyvinylalko- hol, Natriumalginat, Polyethylenglycol, natürliche Gummen wie Xanthanharz, Traganth, Guarharz, Akazienharz, Gummiara- bicum, wasserdispergierbare Polyacrylate wie Polyacryl- säure, Methylmethacrylatcopolymer, Carboxyvinylcopolymere . Die Konzentration des wasserlöslichen Polymers im fertigen Film kann zwischen 20 und 75 Gew.-% betragen. Eine bevorzugte Konzentration beträgt zwischen 50 und 75 Gew.-%.
Die für den mukoadhäsiven Film verwendeten oberflächenaktiven Stoffe können ein oder mehrere nichtionische oberflächenaktive Stoffe sein. Bei Verwendung einer Kombination von oberflächenaktiven Stoffen kann die erste Komponente ein Polyethoxysorbitan-fettsäureester oder ein α-hydro-ω- hydroxypoly(ethoxy) -poly- (propoxy) -poly(ethoxy) -Block- copolymer sein, während die zweite Komponente ein Polye- thoxyalkylether oder ein Polyethoxy-rizinusölderivat sein kann.
Bevorzugt soll der HLB-Wert der Polyethoxysorbitanfett- säurester zwischen 10 und 20 betragen, wobei ein Bereich zwischen 13 und 17 besonders bevorzugt ist. Das α-hydro-ω- hydroxypoly(ethoxy) -poly(propoxy) -poly(ethoxy) -Block- copolymer soll mindestens 35 Propoxy-Einheiten, bevorzugt mindestens 50 Propoxy-Einheiten enthalten.
Der Polyethoxyalkylether sollte einen HLB-Wert zwischen 10 und 20 besitzen, bevorzugt nicht weniger als 15. Das Polyethoxy-rizinusölderivat soll einen HLB-Wert zwischen 14 und 16 besitzen.
Um die erwünschte, sofortige Benetzbarkeit zu erreichen, soll das Verhältnis zwischen der ersten und der zweiten Komponente einer binären oberflächenaktiven Mischung zwischen 1:10 und 1:1 gehalten werden, bevorzugt zwischen 1:5 und 1:3.
Die Gesamtkonzentration der oberflächenaktiven Stoffe im fertigen Film hängt ab von den Eigenschaften der anderen Ingredienzien, soll jedoch üblicherweise zwischen 0.1 und 5 Gew. -% betragen.
Der Polyalkohol wird benötigt, um den erwünschten Weichheitsgrad des Filmes zu erreichen. Beispiele von Polyalko- holen umfassen Glycerin, Polyethylenglycol, Propylenglycol, Glycerinmonoester mit Fettsäuren, oder sonstige pharmazeutisch verwendete Polyalkohole. Die Konzentration von Polyalkohol in der Trockenmasse des Filmes beträgt üblicherweise 0.1 bis 5 Gew.-%.
Der Film ist besonders gut geeignet zur Abgabe eines weiten Bereiches pharmazeutisch aktiver Wirkstoffe durch die Schleimhautmembranen eines Patienten, insbesondere durch die buccalen Schleimhäute.
Therapeutische Wirkstoffe, die Absorptionsprobleme infolge begrenzter Löslichkeit, Abbau im Gastrointestinaltrakt oder extensiven Metabolismus haben, sind besonders gut geeignet. Als Beispiele der einsetzbaren therapeutischen Wirkstoffe sind zu nennen: Hypnotica, Sedativa, Antiepileptica, Weck- amine, Psychoneurotropica, Neuro-Muskelblocker, Antispasmo- dica, Antihistaminica, Antiallergica, Cardiotonica, Anti- arrhythmica, Diuretica, Hypotensiva, Vasopressoren, Anti- tussiva, Expectorantia, Thyroidhormone, Sexualhormone, An- tidiabetica, Antitumor-Wirkstoffe, Antibiotica sowie Chemo- therapeutica und Narcotica. Die im Film einzulagernde Menge von Wirkstoff hängt von dessen Art ab und beträgt üblicherweise zwischen 0,01 und 20 Gew.-%, sie kann jedoch, falls zur Erzielung des gewünschten Effektes notwendig, höher liegen.
Kosmetische Wirkstoffe umfassen Atemerfrischer wie Menthol, andere Geschmacks-, Aroma- oder Duftstoffe, wie sie üblicherweise für die Mundhygiene verwendet werden, und/oder Wirkstoffe für Zahnpflege und/oder Mundhygiene, beispielsweise quartäre Ammoniumbasen. Die Wirkung von Geschmacksund Aromastoffen kann durch Geschmacksverstärker wie Weinsäure, Zitronensäure, Vanillin oder dergleichen verstärkt werden.
Farbstoffe, welche wahlweise dem Film beigemischt werden, müssen hinsichtlich Toxizität sicher sein und sollten zur Verwendung in Kosmetika durch die zuständigen Behörden zugelassen sein.
Der erfindungsgemäße mukoadhäsive Film kann folgendermaßen hergestellt werden:
Der Polyalkohol, oberflächenaktive Stoffe, Weichmacher und andere mögliche Bestandteile außer dem/den wasserlöslichen oder wasserdispersiblen Polymeren werden mit einer genügenden Menge eines kompatiblen Lösungsmittels gelöst. Beispiele eines kompatiblen Lösungsmittels umfassen Wasser, Alkohole oder deren Mischungen. Nach Bildung einer klaren Lö- sung wird das wasserdispersible Polymer oder die Mischung wasserdispersibler Polymere langsam unter Rühren und, falls notwendig, Hitze zugegeben, bis eine klare und homogene Lösung gebildet ist. Diese wird auf einen Träger aufgetragen und zu einem Film getrocknet. Das Trägermaterial muß eine Oberflächenspannung haben, die es ermöglicht, die Polymer- lösung gleichmäßig über die vorgesehene Beschichtungsbreite zu verteilen, ohne daß die Lösung eingesaugt wird und somit eine destruktive Bindung zwischen Träger und Beschichtung entsteht .
Beispiele für geeignete Materialien umfassen nichtsilikoni- sierte Polyethylen-Terephthalat-Filme, nichtsiliconisiertes Kraftpapier, Polyethylen-imprägniertes Kraftpapier oder nichtsiliconisierten Polyethylenfilm.
Der Auftrag der Lösung auf das Trägermaterial kann mit jeder üblichen Vorrichtung ausgeführt werden. Eine speziell bevorzugte Auftragstechnik betrifft eine Walzenrakel- Streichmaschine .
Die Dicke der resultierenden Filmschicht hängt von der Konzentration der Feststoffe in der Beschichtungslösung sowie von der Spaltbreite der Beschichtungsmaschine ab und kann zwischen 5 und 200 um variieren. Die Trocknung des Films wird in einem Heißluftbad unter Verwendung eines Trok- kenofens, Trockentunnels, Vacuumtrockners oder anderer geeigneter Trockenvorrichtungen vorgenommen, welche die Wirkung des/der Wirkstoffs/Wirkstoffe oder der Geschmacksstof- fe nicht negativ beeinträchtigen. Um ein unangenehmes Gefühl im Mund zuverlässig zu vermeiden, soll die Filmdicke 70 um nicht überschreiten. Zur besseren Gebrauchserleichterung kann der Film in Stücke von geeigneter Größe und Form geschnitten und verpackt werden.
Die Erfindung wird anhand nachfolgender Beispiele veranschaulicht. Beispiel 1 :
15 g Sorbit, 6 g Glycerin, 0,5 g Polysorbat 80 (Tween 80),
2 g Brij 35, 25 g Zitronenminzearoma, 3 g Aspartam, 15 g 1-Menthol und 3 g Zitronensäure werden bei 60°C in einer Mixtur von 250 g Wasser und 250 g Ethanol solange gerührt, bis sich eine klare Lösung gebildet hat.
Zu der Lösung werden 30 g Hydroxypropylmethylcellulose langsam unter Rühren zugegeben, bis eine klare und homogene Lösung gebildet ist. Die resultierende Lösung wird dann bis auf Raumtemperatur abkühlen gelassen und unter Verwendung einer üblichen Beschichtungs-/Trocknungsvorrichtung auf ein geeignetes Trägermaterial aufgestrichen, beispielsweise nichtsiliconisiertes polyethylenbeschichtetes Kraftpapier. Beschichtungsspalt und Bahngeschwindigkeit müssen so geregelt werden, daß eine Trockenfilmdicke zwischen 20 und 50 um erreicht wird. Die Trockentemperatur hängt von der Länge des Trockenofens und der Materialgeschwindigkeit ab und soll so eingestellt werden, daß die Lösungsmittel vollständig, oder zumindest weitgehend vollständig vom Film entfernt werden. Der resultierende Film wird vom Träger abgelöst und zum Gebrauch in Stücke von geeigneter Größe und Form zerteilt.
Beispiel 2:
3 g Sorbit, 1,5 g Kollidon 30 (Lieferant: BASF), 5 g Glycerin, 5 g Propylenglycol, 5 g Polyethylenglycol, 4 g Polysorbat 80 (Tween 80), 8 g Brij 35, 12 g Pfefferminzaroma, 0,8 g Aspartam werden in einer Mischung von 400 g Wasser und 400 g Ethanol bei 60°C unter Rühren aufgelöst. Zu der klaren Lösung werden 28 g Hydroxypropylmethylcellulose unter Rühren langsam zugegeben. Nach völliger Auflösung des Polymers wird die Lösung auf Raumtemperatur abgekühlt und auf einen Träger unter den gleichen Beschichtungs- und TRocknungsbedingungen wie in Beispiel 1 aufgestrichen. Der trockene Film wird wieder in Stücke von geeigneter Größe und Form zerteilt.
Beispiel 3 :
15 g Sorbit, 22,5 g Glycerin, 2,5 Propylenglycol, 2,5 g Brij 35, 2,5 g Poloxamer 407, 3,5 g Cremophor RH 40, 9 g Krauterminzearoma, 0,5 g Aspartam werden unter ständigem Rühren bei 60°C in einer Mischung von 250 g Wasser und 250 g Ethanol gelöst. Zu der klaren Lösung werden 75 g Hydroxypropylcellulose unter ständigem Rühren langsam zugegeben. Mit der klaren Lösung wird wiederum beschichtet und unter den beschriebenen Bedingungen getrocknet, wie in Beispiel 1; der trockene Film wird in Stücke von geeigneter Größe und Form zerteilt.
Beispiel 4:
3,6 Tween 80, 3,6 g Glycerin, 39 g Menthol und 171 g Kollidon 30 werden bei Raumtemperatur und unter Rühren in einer Lösung aus 600 ml Wasser und 2800 ml Ethanol gelöst. 247,5 g Hydroxypropylmethylcellulose werden dann langsam und portionsweise bei 50-55 °C hinzugefügt; es wird bis zur vollständigen Auflösung gerührt. Nach Abkühlen der Mischung werden, in Folge, 90 g Zitronenminzearoma, gefolgt von einer Lösung/Suspension aus 27,13 g Aspartam, 18 g Zitronensäure und 0,17 g FD&C yellow #5 in 120 ml Wasser unter Rühren hinzugefügt. Die klare Lösung wird unter den in Beispiel 1 angegebenen Bedingungen aufgestrichen und getrocknet; der trockene Film wird in Stücke von für die beabsichtigte Verwendung geeigneter Größe und Form zerteilt.
Beispiel 5:
165,4 g Kollidon 30 werden bei Raumtemperatur in einer Lösung aus 720 ml Wasser und 2660 ml Ethanol unter Rühren ge- löst. Sodann werden 220,5 g Hydroxypropylmethylcellulose bei 55-60 °C hinzugefügt und so lange kräftig gerührt bis die Lösung klar und homogen ist. Nach Abkühlen der Mischung werden, in Folge, 78,75 g Geschmacksstoff, gefolgt von einer Mischung aus 26,88 g Nikotinsalicylat und 31,5 g Karamelflüssigkeit in 120 ml Wasser unter Rühren hinzugefügt. Die klare, gelbbraune Flüssigkeit wird unter den in Beispiel 1 beschriebenen Bedingungen aufgestrichen und getrocknet und der trockene Film in Stücke von geeigneter Form und Größe zerteilt, zur Abgabe einer Nikotindosis von 1-2 mg pro Stück.

Claims

P A T E N T A N S P R Ü C H E
1. Zubereitung zur Anwendung in der Mundhöhle mit einer/einem an der Schleimhaut haftklebenden Schicht oder Film, dadurch gekennzeichnet, daß die haftklebende Schicht oder der haftklebende Film eine homogene Mischung enthält, bestehend aus einem wasserlöslichen Polymer, einem Polyalkohol, einem kosmetischen oder pharmazeutischen Wirkstoff, und einem Geschmacks- oder Aromastoff.
2. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß das wasserlösliche Polymer Hydroxypropylmethylcellulose, Hydroxyethylcellulose, Hydroxypropylcellulose, Po- lyvinylpyrrolidon, Carboxylmethylcellulose, Polyvinylalko- hol, Natriumalginat, Polyethylenglycol, Xanthanharz, Traganth, Guarharz, Akazienharz, Gummiarabicum, Polyacrylsäu- re, Methylmethacrylatcopolymer, Carboxyvinylcopolymere oder deren Mischungen umfaßt.
3. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß die Konzentration des wasserlöslichen Polymers in der Trockenmasse der Filmschicht zwischen 20 und 75 Gew.-% beträgt .
4. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß die Mischung als wahlweise Bestandteile ein oder mehrere Weichmacher oder oberflächenaktive Stoffe enthält.
5. Zubereitung nach Anspruch 4, dadurch gekennzeichnet, daß die erste Komponente einer Mischung oberflächenaktiver Stoffe ein Polyethoxysorbitan-fettsäureester oder ein α- hydro-ω-hydroxypoly(ethoxy) -poly(propoxy) -poly(ethoxy) - Blockcopolymer ist.
6. Zubereitung nach Anspruch 4, dadurch gekennzeichnet, daß die zweite Komponente des oberflächenaktiven Stoffs ein Polyethoxyalkylether oder ein Polyethoxyrizinusölderivat ist.
7. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß der Polyalkohol ausgewählt ist aus Glycerin, Polyethy- lenglycol, Propylenglycol oder Glycerinmonoestern mit Fettsäuren.
8. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß der therapeutische Wirkstoff ausgewählt ist aus der Gruppe von Hypnotica, Sedativa, Antiepileptica, Weckaminen, Psy- choneurotropica, Neuro-Muskelblockern, Antispasmodica, An- tihistaminica, Antiallergica, Cardiotonica, Antiarrhythmi- ca, Diuretica, Hypotensiva, Vasopressoren, Antitussiva, Ex- pectorantia, Thyroidhormonen, Sexualhormonen, Antidiabeti- ca, Antitumor-Wirkstoffen, Antibiotica sowie Chemothera- peutica oder Narcotica.
9. Zubereitung nach Anspruch 1, dadurch gekennzeichnet, daß der kosmetische Wirkstoff Atemerf ischer wie Menthol, Geschmacks-, Aroma- oder Duftstoffe, wie sie üblicherweise für Mundhygiene verwendet werden, und/oder Wirkstoffe zur Zahn- oder Mundpflege umfaßt, wie quartäre Ammoniumbasen.
PCT/EP1997/005820 1996-11-11 1997-10-22 Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation WO1998020862A1 (de)

Priority Applications (19)

Application Number Priority Date Filing Date Title
JP52208898A JP4063331B2 (ja) 1996-11-11 1997-10-22 口部に適用される瞬時湿潤性の水溶性薄膜または水溶性層
HU9904207A HU228464B1 (en) 1996-11-11 1997-10-22 Immediate wettability water soluble film or water soluble layer for oral application
SI9730590T SI0936905T1 (en) 1996-11-11 1997-10-22 Immediate wettability water soluble film or water soluble layer for oral application
CZ0164799A CZ297354B6 (cs) 1996-11-11 1997-10-22 Prípravek pro aplikaci v ústní dutine s filmem nebo fólií s okamzitou smácitelností
DK03014213T DK1362584T3 (da) 1996-11-11 1997-10-22 Umiddelbar befugtning af vandoplöselig film eller vandoplöselig lag til oral anvendelse
SK622-99A SK285100B6 (sk) 1996-11-11 1997-10-22 Prípravok na aplikáciu v ústnej dutine s filmom alebo fóliou s okamžitou zmáčateľnosťou
IL12981997A IL129819A0 (en) 1996-11-11 1997-10-22 A mucoadhesive composition
SK5041-2005A SK285999B6 (sk) 1996-11-11 1997-10-22 Orálne aplikovateľný prípravok majúci okamžitú zmáčateľnosť a spôsob jeho výroby
HU0500666A HU230022B1 (hu) 1996-11-11 1997-10-22 Azonnal nedvesedő, vízoldható film vagy vízoldható réteg orális alkalmazás céljára
AU48682/97A AU739698B2 (en) 1996-11-11 1997-10-22 Water soluble film for oral administration with instant wettability
EP97911237A EP0936905B1 (de) 1996-11-11 1997-10-22 Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation
DE59710670T DE59710670D1 (de) 1996-11-11 1997-10-22 Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation
CA002265651A CA2265651C (en) 1996-11-11 1997-10-22 Immediate wettability water soluble film or water soluble layer for oral application
PL97333677A PL190376B1 (pl) 1996-11-11 1997-10-22 Preparat do stosowania w jamie ustnej
AT97911237T ATE247954T1 (de) 1996-11-11 1997-10-22 Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation
DK97911237T DK0936905T3 (da) 1996-11-11 1997-10-22 Vandopløselig film eller vandopløseligt lag med øjeblikkelig befugtelighed til brug ved oral indgivelse
NO19991921A NO325073B1 (no) 1996-11-11 1999-04-22 Preparat for anvendelse i munnhulen med en film eller sjikt som viser oyeblikkelig fuktbarhet.
HK00101167A HK1035316A1 (en) 1996-11-11 2000-02-25 Immediate wettability water soluble film or water soluble layer for oral application
NO20053307A NO20053307D0 (no) 1996-11-11 2005-07-06 Oralt administrerbart preparat for angivelse av virksomme stoffer i munnhulen og fremgangsmate for fremstilling derav.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19646392.0 1996-11-11
DE19646392A DE19646392A1 (de) 1996-11-11 1996-11-11 Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht

Publications (1)

Publication Number Publication Date
WO1998020862A1 true WO1998020862A1 (de) 1998-05-22

Family

ID=7811214

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/005820 WO1998020862A1 (de) 1996-11-11 1997-10-22 Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation

Country Status (26)

Country Link
US (8) US5948430A (de)
EP (2) EP1362584B1 (de)
JP (3) JP4063331B2 (de)
KR (2) KR100604995B1 (de)
AT (2) ATE422157T1 (de)
AU (1) AU739698B2 (de)
CA (1) CA2265651C (de)
CZ (1) CZ297354B6 (de)
DE (4) DE19646392A1 (de)
DK (2) DK0936905T3 (de)
ES (2) ES2206692T3 (de)
HK (1) HK1035316A1 (de)
HU (2) HU228464B1 (de)
ID (1) ID22526A (de)
IL (2) IL129819A0 (de)
MY (1) MY125548A (de)
NO (2) NO325073B1 (de)
NZ (1) NZ335063A (de)
PL (1) PL190376B1 (de)
PT (2) PT1362584E (de)
SI (1) SI0936905T1 (de)
SK (2) SK285100B6 (de)
TR (1) TR199901633T2 (de)
TW (2) TWI250029B (de)
WO (1) WO1998020862A1 (de)
ZA (1) ZA9710093B (de)

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000018365A2 (en) * 1998-09-25 2000-04-06 Warner-Lambert Company Fast dissolving orally consumable films
WO2000042992A2 (en) * 1999-01-21 2000-07-27 Lavipharm Laboratories, Inc. Compositions and methods for mucosal delivery
WO2000067595A1 (en) * 1999-05-06 2000-11-16 Zerbe Horst G Rapidly disintegrating flavor wafer for flavor enrichment
WO2002005789A2 (de) * 2000-07-15 2002-01-24 Scs Skin Care Systems Gmbh Lösung, dispersion oder emulsion bildende folien-dermatika
AU2002252685C1 (en) * 2001-04-20 2002-11-05 Lavipharm Laboratories Inc. Intraoral delivery of nicotine for smoking cessation
US6660292B2 (en) 2001-06-19 2003-12-09 Hf Flavoring Technology Llp Rapidly disintegrating flavored film for precooked foods
WO2004054551A1 (de) * 2002-12-05 2004-07-01 Lts Lohmann Therapie-Systeme Ag Filmförmige zubereitungen zur transmucosalen verabreichung von nicotin, sowie verfahren zu deren herstellung
JP2004532814A (ja) * 2001-01-09 2004-10-28 ラヴィファーム・ラボラトリーズ・インク 活性物質の局所的および全身的送達のための装置およびその製造方法
JP2005255694A (ja) * 2000-07-04 2005-09-22 Lts Lohmann Therapie-Systeme Ag 口腔または体腔内で有効成分を放出するための迅速分解性投与可能剤形
US7067116B1 (en) 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
US7314716B2 (en) 1999-11-19 2008-01-01 Mount Sinai School Of Medicine Gustducin γ subunit materials and methods
USRE40594E1 (en) 1998-12-23 2008-12-02 Mount Sinai School Of Medicine Of New York University Inhibitors of the bitter taste response
JP2009185078A (ja) * 2001-02-19 2009-08-20 Lts Lohmann Therapie-Systeme Ag 動物用及びヒト用医薬における活性物質の投与用の、粘膜接着性を有し、崩壊可能な医薬品調合剤
WO2011081625A1 (en) * 2009-12-30 2011-07-07 Novartis Ag Melt extruded thin strips containing coated pharmaceutical actives
EP2399574A1 (de) * 2009-01-29 2011-12-28 Nitto Denko Corporation Intraorales mittel auf filmartiger basis und formulierung
US8273405B2 (en) 2001-05-01 2012-09-25 A.V. Topcheiv Institute of Petrochemical Synthesis, Russian Academy of Sciences Water-absorbent adhesive compositions and associated methods of manufacture and use
US8481071B2 (en) 2001-05-01 2013-07-09 Corium International, Inc. Hydrogel compositions with an erodible backing member
US8481059B2 (en) 2001-05-01 2013-07-09 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences Hydrogel compositions
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
WO2013167742A1 (fr) 2012-05-11 2013-11-14 Pierre Fabre Medicament Film monocouche a desintegration rapide et son utilisation dans l'hygiene buccale
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8658201B2 (en) 2004-01-30 2014-02-25 Corium International, Inc. Rapidly dissolving film for delivery of an active agent
US8784879B2 (en) 2009-01-14 2014-07-22 Corium International, Inc. Transdermal administration of tamsulosin
US8821901B2 (en) 2001-05-01 2014-09-02 A.V. Topchiev Institute Of Petrochemical Synthesis Russian Academy Of Sciences Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
USRE45666E1 (en) 2000-07-07 2015-09-08 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US9198897B2 (en) 2005-01-19 2015-12-01 Neurohealing Pharmaceuticals, Inc. Methods and compositions for decreasing saliva production
US9498410B2 (en) 2002-12-30 2016-11-22 Colgate-Palmolive Company Oral and personal care compositions and methods
US9717682B2 (en) 2009-12-08 2017-08-01 Intelgenx Corporation Solid oral film dosage forms and methods for making same
US9724309B2 (en) 2010-03-30 2017-08-08 Nitto Denko Corporation Film-form preparation and method for producing the same
US10092505B2 (en) 2012-01-11 2018-10-09 Nitto Denko Corporation Oral film-form base and preparation
US10098376B2 (en) 2003-11-07 2018-10-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
US10829621B2 (en) 2013-01-11 2020-11-10 Monosol, Llc Edible water-soluble film

Families Citing this family (360)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19636001A1 (de) * 1996-09-05 1998-03-12 Hoechst Ag Sulfoxidgruppenhaltige Polymermischungen
US5800832A (en) * 1996-10-18 1998-09-01 Virotex Corporation Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
DE19646392A1 (de) * 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
US20050048102A1 (en) * 1997-10-16 2005-03-03 Virotex Corporation Pharmaceutical carrier device suitable for delivery of pharmaceutical compounds to mucosal surfaces
DE19832169A1 (de) * 1998-07-17 2000-01-27 Jenapharm Gmbh Lokal anwendbare pharmazeutische Präparate zur Prophylaxe und Therapie atrophischer Erscheinungen in der Mundhöhle
US20020098264A1 (en) * 1998-11-27 2002-07-25 Cherukuri Subraman R. Medicated chewing gum delivery system for nicotine
US6358060B2 (en) 1998-09-03 2002-03-19 Jsr Llc Two-stage transmucosal medicine delivery system for symptom relief
US20030206942A1 (en) * 1998-09-25 2003-11-06 Neema Kulkarni Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent
US20030211136A1 (en) * 1998-09-25 2003-11-13 Neema Kulkarni Fast dissolving orally consumable films containing a sweetener
JP4497725B2 (ja) * 1998-11-27 2010-07-07 ▲高▼田 ▲寛▼治 消化管用薬物送達経口製剤
DE19856101A1 (de) * 1998-12-04 2000-06-08 Labtec Gmbh Mundhöhlen-Matrixpflaster
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
EP1666026B2 (de) † 1999-02-08 2015-02-25 Intarcia Therapeutics, Inc Stabile nicht wässerige einphasige visköse Vehikel und Formulierungen die diese Vehikel verwenden
DE19911262C2 (de) * 1999-03-13 2003-04-10 Scs Skin Care Systems Gmbh Vorrichtung zur Abgabe kosmetischer Wirkstoffe
JP3927030B2 (ja) 1999-07-02 2007-06-06 ザ プロクター アンド ギャンブル カンパニー 取り外し可能なバッキングストリップを用いたオルガノシロキサン樹脂含有口腔ケア組成物用施与システム
DE10001096A1 (de) * 2000-01-13 2001-07-26 Lohmann Therapie Syst Lts TTS mit Reservoirschicht zur Aufnahme und Abgabe von Duftstoffen
US6387356B1 (en) 2000-01-27 2002-05-14 Colgate-Palmolive Company Cosmetic composition
US20020013331A1 (en) * 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
DE10050267A1 (de) * 2000-10-09 2001-12-06 Karen Croissant Mittel zum Reinigen der Zähne und/oder des Mundes
US20020131990A1 (en) * 2000-11-30 2002-09-19 Barkalow David G. Pullulan free edible film compositions and methods of making the same
US20040043013A1 (en) 2000-12-28 2004-03-04 Mccleary Edward Larry Metabolic uncoupling therapy
US20060062864A1 (en) * 2000-12-28 2006-03-23 Mccleary Edward L Weight loss composition and method
US20060110478A1 (en) * 2004-11-22 2006-05-25 Mccleary Edward L Delivery system and method for supporting and promoting healthy sexual function and prevention and treatment of sexual dysfunction
RU2286801C2 (ru) 2001-05-01 2006-11-10 Институт Нефтехимического Синтеза Имени А.В. Топчиева Российской Академии Наук Двухфазные биоадгезионные композиции, абсорбирующие воду
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US6656493B2 (en) * 2001-07-30 2003-12-02 Wm. Wrigley Jr. Company Edible film formulations containing maltodextrin
RU2004107501A (ru) * 2001-08-14 2005-02-20 Байотай Терапис Корпорейшн (Fi) Способ лечения алкоголизма или злоупотребления алкоголем
US6419903B1 (en) * 2001-08-20 2002-07-16 Colgate Palmolive Company Breath freshening film
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US20100021526A1 (en) * 2001-10-12 2010-01-28 Monosol Rx, Llc Ph modulated films for delivery of actives
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US20070154527A1 (en) * 2001-10-12 2007-07-05 Monosoirx, Llc Topical film compositions for delivery of actives
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
CA2473967C (en) 2001-10-12 2011-06-14 Monosolrx Llc Thin film with non-self-aggregating uniform heterogeneity, process for their production and drug delivery systems made therefrom
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US20060039958A1 (en) * 2003-05-28 2006-02-23 Monosolrx, Llc. Multi-layer films having uniform content
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US8663687B2 (en) 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US7666337B2 (en) * 2002-04-11 2010-02-23 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US7425292B2 (en) * 2001-10-12 2008-09-16 Monosol Rx, Llc Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom
US7910641B2 (en) * 2001-10-12 2011-03-22 Monosol Rx, Llc PH modulated films for delivery of actives
US20030099691A1 (en) * 2001-11-16 2003-05-29 Susan Lydzinski Films containing starch
US20050089548A1 (en) * 2001-11-16 2005-04-28 Virgalitto Margaret T. Edible film
KR100843001B1 (ko) * 2002-01-16 2008-07-01 동화약품공업주식회사 구강점막 부착형 필름제제
AU2003235716A1 (en) 2002-01-17 2003-07-30 Lts Lohmann Therapie-Systeme Ag Method for neutralizing or recycling carrier materials for film-like coatings
US20040247744A1 (en) * 2002-02-11 2004-12-09 Edizone, Lc Vitamin-containing orally soluble films
US20040247746A1 (en) * 2002-02-11 2004-12-09 Edizone, Lc Delivery units of thick orally soluble polymer
US20030224090A1 (en) * 2002-02-11 2003-12-04 Edizone, Lc Snacks of orally soluble edible films
US20050100640A1 (en) * 2002-02-11 2005-05-12 Pearce Tony M. Microcapsule edibles
US20050003048A1 (en) * 2002-02-11 2005-01-06 Edizone, Lc Electrolyte-containing orally soluble films
US20040247649A1 (en) * 2002-02-11 2004-12-09 Edizone, Lc Medicine-containing orally soluble films
CN100556762C (zh) * 2002-02-13 2009-11-04 迈克尔K·韦伯尔 药物剂型及其制造方法
KR20030075213A (ko) * 2002-03-16 2003-09-26 (주)케비젠 항암물질을 함유하는 수용성 필름제 및 이의 제조방법
US20030194420A1 (en) * 2002-04-11 2003-10-16 Richard Holl Process for loading a drug delivery device
US8017150B2 (en) 2002-04-11 2011-09-13 Monosol Rx, Llc Polyethylene oxide-based films and drug delivery systems made therefrom
AU2003240762A1 (en) * 2002-05-24 2003-12-12 Agfa-Gevaert At least partially degradable films containing an active ingredient and method for the production thereof
DE10224607B4 (de) * 2002-06-04 2008-03-13 Lts Lohmann Therapie-Systeme Ag Filmförmige, zerfallsfähige Zubereitungen zur Wirkstofffreisetzung und Verfahren zu deren Herstellung
US6937455B2 (en) * 2002-07-03 2005-08-30 Kronos Advanced Technologies, Inc. Spark management method and device
WO2004000235A2 (en) * 2002-06-25 2003-12-31 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product with magnolia bark extract
US7347985B2 (en) * 2002-06-25 2008-03-25 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product with magnolia bark extract
US7632525B2 (en) * 2002-06-25 2009-12-15 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents
US7595065B2 (en) * 2002-06-25 2009-09-29 Wm. Wrigley Jr. Company Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils
US7150780B2 (en) * 2004-01-08 2006-12-19 Kronos Advanced Technology, Inc. Electrostatic air cleaning device
US20030017208A1 (en) * 2002-07-19 2003-01-23 Francis Ignatious Electrospun pharmaceutical compositions
CA2505796C (en) * 2002-07-22 2012-01-03 Monosolrx Llc Packaging and dispensing of rapid dissolve dosage form
US6824829B2 (en) * 2002-08-23 2004-11-30 Acupac Packaging, Inc. Process for manufacturing thin film strips
US7241411B2 (en) * 2002-08-23 2007-07-10 Acupac Packaging, Inc. Thin film strips
DK1534252T3 (da) * 2002-08-27 2010-09-06 Wrigley W M Jun Co Mundfriskende og oralt renseprodukt anvendende kardemommeolie
WO2004019802A2 (en) * 2002-08-27 2004-03-11 Wm. Wrigley Jr. Company Breath freshening and oral cleansing product using carvacrol
US20040043134A1 (en) * 2002-08-27 2004-03-04 Corriveau Christine Leclair Rolled edible thin film products and methods of making same
US20040120991A1 (en) * 2002-09-07 2004-06-24 Mars Incorporated Edible films having distinct regions
US20050019277A1 (en) * 2002-09-11 2005-01-27 The Procter & Gamble Company Tooth whitening products
US8524200B2 (en) 2002-09-11 2013-09-03 The Procter & Gamble Company Tooth whitening products
US6916463B2 (en) * 2002-09-24 2005-07-12 The Procter & Gamble Company Oral products having an aesthetic layer
US6800295B2 (en) * 2002-10-09 2004-10-05 The Dial Corporation Water soluble sheet composition
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
GB0226076D0 (en) * 2002-11-08 2002-12-18 Rp Scherer Technologies Inc Improved formulations containing substituted imidazole derivatives
DE10252726B4 (de) * 2002-11-13 2008-05-08 Lts Lohmann Therapie-Systeme Ag Mehrschichtiges transmucosales therapeutisches System
US9561182B2 (en) * 2003-08-22 2017-02-07 Cure Pharmaceutical Corporation Edible films for administration of medicaments to animals, methods for their manufacture and methods for their use for the treatment of animals
US20040191302A1 (en) 2003-03-28 2004-09-30 Davidson Robert S. Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films
US20040131662A1 (en) 2003-11-12 2004-07-08 Davidson Robert S. Method and apparatus for minimizing heat, moisture, and shear damage to medicants and other compositions during incorporation of same with edible films
WO2004045537A2 (en) * 2002-11-14 2004-06-03 Zengen, Inc. Edible film for relief of cough or symptoms associated with pharyngitis
WO2004043165A1 (en) * 2002-11-14 2004-05-27 Givaudan Sa Edible film containing food acid
US8999372B2 (en) * 2002-11-14 2015-04-07 Cure Pharmaceutical Corporation Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use
US20040096569A1 (en) * 2002-11-15 2004-05-20 Barkalow David G. Edible film products and methods of making same
US20040111275A1 (en) * 2002-11-15 2004-06-10 Kroll David B. Methods for marketing and generating revenue from edible thin films
EP1568346B1 (de) * 2002-12-02 2016-06-22 Kyukyu Pharmaceutical Co., Ltd. Verfahren zur herstellung eines essbaren oral verabreichten mittels in form eines laminatfilms und kompressionsverbindungsgerät
DE60331948D1 (de) * 2002-12-04 2010-05-12 Hokkai Sankyo Co Ltd Verfahren zum schutz von weizen vor mykotoxinbefall
AU2003297752A1 (en) * 2002-12-06 2004-06-30 Monosolrx Llc Thin film delivery systems for volatile decongestants
US20040115137A1 (en) * 2002-12-17 2004-06-17 Verrall Andrew P. Water-soluble film for oral administration
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
CN100356908C (zh) * 2003-01-30 2007-12-26 莫诺索尔克斯有限公司 具有非自聚集一致不均匀性的薄膜及由其制造的给药系统
US20040156794A1 (en) * 2003-02-11 2004-08-12 Barkalow David G. Bioerodible and bioadhesive confectionery products and methods of making same
US20040228892A1 (en) * 2003-02-28 2004-11-18 Berry Craig J. Delivery system for cosmetic and skincare products
US7041311B2 (en) * 2003-02-28 2006-05-09 International Flavors & Fragrances Inc. Preparation for saliva flow
EP1605908A2 (de) * 2003-03-26 2005-12-21 The Procter & Gamble Company Schnell auflösende essbare filmzusammensetzungen mit verbesserter filmstärke und stabilität
CN1764434A (zh) * 2003-03-26 2006-04-26 宝洁公司 含有纤维素成膜聚合物的可迅速溶解的可食用薄膜组合物
US20040202698A1 (en) * 2003-04-02 2004-10-14 The Procter & Gamble Company Drug delivery systems comprising an encapsulated active ingredient
US20050019294A1 (en) * 2003-04-14 2005-01-27 Fmc Corporation Homogeneous, thermoreversible alginate films and soft capsules made therefrom
MXPA05011028A (es) * 2003-04-14 2005-12-12 Fmc Corp Sistemas de suministro de pelicula de gel termo-reversible homogenea que contiene carragenano kappa-2.
US20050013847A1 (en) * 2003-04-14 2005-01-20 Fmc Corporation Delivery systems of homogeneous, thermoreversible alginate films
US7306812B2 (en) 2003-05-09 2007-12-11 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
US7276246B2 (en) * 2003-05-09 2007-10-02 Cephalon, Inc. Dissolvable backing layer for use with a transmucosal delivery device
AU2004319243B2 (en) 2003-05-28 2010-06-03 Aquestive Therapeutics, Inc. Polyethylene oxide-based films and drug delivery systems made therefrom
GB0312425D0 (en) * 2003-05-30 2003-07-09 Boots Co Plc Use of a compound in the treatment of sleep disorders and the like,in providing refreshedness on waking and a method for the treatment of grogginess therewith
US20040241294A1 (en) * 2003-05-31 2004-12-02 Barabolak Roman M. Edible films including aspartame and methods of making same
US8703209B2 (en) * 2003-06-17 2014-04-22 Edward Larry McCleary Composition and method for modulating hydrogen ion physiology
US8287843B2 (en) * 2003-06-23 2012-10-16 Colgate-Palmolive Company Antiplaque oral care compositions
US20040258630A1 (en) * 2003-06-23 2004-12-23 Boyd Thomas J. Antiplaque breath freshening consumable film
DK1635774T4 (da) * 2003-06-23 2011-05-30 Colgate Palmolive Co Stabile tandplejesammensætninger
DE10328942A1 (de) * 2003-06-27 2005-01-27 Lts Lohmann Therapie-Systeme Ag Transmukosale Darreichungsformen mit verminderter Schleimhautirritation
PT1648421T (pt) 2003-07-24 2017-12-22 Glaxosmithkline Llc Películas de dissolução oral
US7666396B2 (en) * 2003-09-11 2010-02-23 Kimberly-Clark Worldwide, Inc. Single-use moisturizing product
US20050080039A1 (en) * 2003-10-14 2005-04-14 Cp Kelco, U.S., Inc. Pectin films prepared from gamma irradiated pectin
AU2004283721B2 (en) * 2003-10-24 2009-08-13 Adhesives Research, Inc. Rapidly disintegrating film
US7182964B2 (en) * 2003-11-13 2007-02-27 Dbc, Llc Dissolving thin film xanthone supplement
DE10354894A1 (de) * 2003-11-24 2005-07-07 Hf Arzneimittelforschung Gmbh Orale Formulierungen des Desoxypeganins und deren Anwendungen
DE10358747A1 (de) * 2003-12-12 2005-07-07 Lts Lohmann Therapie-Systeme Ag Darreichungsform basierend auf vernetzten hydrophilen Polymeren
CA2548386C (en) * 2003-12-16 2011-07-12 Colgate-Palmolive Company Oral and personal care compositions and methods
FR2865130B1 (fr) * 2004-01-21 2007-10-05 Oreal Film anhydre pour le maquillage ou le soin des levres.
DE102004002951A1 (de) * 2004-01-21 2005-08-11 Wella Ag Verfahren zur Herstellung haarfestigender Produkte in Folienform
US20050186256A1 (en) * 2004-02-20 2005-08-25 Dihel Deborah L. Dissolvable film comprising an active ingredient and method of manufacture
US20080003248A1 (en) * 2004-03-03 2008-01-03 Constantine Georgiades Whitening products
EP1737416A1 (de) * 2004-03-03 2007-01-03 Warner-Lambert Company LLC Folienzusammensetzungen
US20070190125A1 (en) * 2004-03-03 2007-08-16 Constantine Georgiades Positioning feature for aiding use of film or strip product
US20050196354A1 (en) * 2004-03-03 2005-09-08 Andre Soshinsky Film compositions
US20050196348A1 (en) * 2004-03-03 2005-09-08 Constantine Georgiades Stabilized peroxide compositions
US20050196355A1 (en) * 2004-03-03 2005-09-08 Constantine Georgiades Film products having controlled disintegration properties
US20070269519A1 (en) * 2004-03-03 2007-11-22 Constantine Georgiades Whitening products
US20050208108A1 (en) * 2004-03-19 2005-09-22 Jannusch Leonard C Thermoplastic films and methods for making
US20050226906A1 (en) * 2004-04-08 2005-10-13 Micro Nutrient, Llc Nutrient system for individualized responsive dosing regimens
US7850987B2 (en) * 2004-04-08 2010-12-14 Micronutrient, Llc Nutrient composition(s) and system(s) for individualized, responsive dosing regimens
US7785619B2 (en) * 2004-04-08 2010-08-31 Micro Nutrient, Llc Pharmanutrient composition(s) and system(s) for individualized, responsive dosing regimens
JP2007533697A (ja) * 2004-04-22 2007-11-22 デュオコート エービー グルココルチコイド救急治療用の医薬組成物
US20050249782A1 (en) * 2004-05-04 2005-11-10 Victor Perry Drug delivery device
US7399482B1 (en) 2004-05-07 2008-07-15 Christine Horner Biernacki Thin film medication device and kit
US7972589B2 (en) * 2004-05-17 2011-07-05 Akzo Nobel N.V. Hair fixative film
WO2005120455A1 (en) * 2004-06-12 2005-12-22 Passion For Life Healthcare Limited Soluble strip for oral or topical administration
CA2571553A1 (en) * 2004-06-22 2006-01-26 E-L Management Corp. Dissolvable film composition
US20060024425A1 (en) 2004-07-30 2006-02-02 Wm. Wrigley Jr. Company Edible film compositions
EP1791575B1 (de) 2004-08-05 2014-10-08 Corium International, Inc. Klebstoffzusammensetzung
DE102005003387A1 (de) * 2004-09-01 2006-03-02 LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH Atrium Patch
PT1791791T (pt) * 2004-09-27 2019-09-12 Special Water Patents B V Métodos e composições para tratamento de água
JP4813494B2 (ja) * 2004-09-30 2011-11-09 ザ ハーシー カンパニー 可食性パケット
JP4898113B2 (ja) * 2004-12-02 2012-03-14 リンテック株式会社 経口投与剤
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
DE102005007859A1 (de) * 2005-02-21 2006-08-24 Lts Lohmann Therapie-Systeme Ag Vefahren für eine medikamentöse Kombinations-Behandlung, sowie hierfür geeignete Arzneimittel-Kombinationen
US7992575B2 (en) * 2005-02-28 2011-08-09 U.S. Smokeless Tobacco Company Use of chlorate, sulfur or ozone to reduce tobacco specific nitrosamines
MX2007010966A (es) * 2005-03-10 2008-03-12 Mary Kay Inc Composiciones que comprenden agua retenida y agentes retenidos en matrices sensibles al agua.
DE102005015128B4 (de) * 2005-03-31 2008-12-11 Bayer Schering Pharma Aktiengesellschaft Wafer enthaltend Steroidhormone
WO2006107390A2 (en) 2005-04-04 2006-10-12 Kronos Advanced Technologies, Inc. An electrostatic fluid accelerator for and method of controlling a fluid flow
US20060228307A1 (en) * 2005-04-08 2006-10-12 Cao Group, Inc. Structures and methods for delivering topical compositions
US20070087036A1 (en) * 2005-05-03 2007-04-19 Durschlag Maurice E Edible film for transmucosal delivery of nutritional supplements
US20060260366A1 (en) * 2005-05-18 2006-11-23 I+Dcreative, Llc Laundry appliance for washing small quantities of clothing
CN101262786B (zh) * 2005-05-25 2015-04-08 美国无烟烟草有限责任公司 烟草组合物
US20060275364A1 (en) * 2005-05-26 2006-12-07 Ahmed Salah U Flexible Solid Dosage Forms and Methods of Making and Using the Same
US9023382B2 (en) * 2005-06-08 2015-05-05 Basf Corporation Medicament carrier composition and method of forming a film therefrom
DE102005033543A1 (de) * 2005-07-14 2007-01-18 Grünenthal GmbH Ein einen Duftstoff aufweisendes transdermales therapeutisches System
DE102005033943A1 (de) * 2005-07-20 2007-02-22 Hexal Ag Nicht-ausspuckbarer, oraler, schnell-zerfallender Film für ein Neuroleptikum
CA2614777C (en) * 2005-07-21 2012-04-17 Neurohealing Pharmaceuticals, Inc. Rapid onset and short term modafinil compositions and methods of use thereof
WO2007014476A1 (de) * 2005-08-02 2007-02-08 Drossapharm Ag Pharmazeutische zusammensetzung enthaltend indometacin und/oder acemetacin
EP3871693A1 (de) 2005-09-27 2021-09-01 Special Water Patents B.V. Zusammensetzungen zur mundpflege
US20070077300A1 (en) * 2005-09-30 2007-04-05 Wynn David W Oral compositions containing a salivation inducing agent
WO2007056066A2 (en) 2005-11-04 2007-05-18 Lifescience Plus, Inc. Bioabsorbable hemostatic gauze
US20070104769A1 (en) * 2005-11-04 2007-05-10 Lifescience Plus, Inc. Bioabsorbable hemostatic gauze
EP1957032A1 (de) * 2005-12-02 2008-08-20 GIC Innovations Company Vehikel für die mundpflege mit magnolienrinden-extrakt
CA2631501A1 (en) * 2005-12-02 2007-06-07 Gic Innovations Company Confectionary compositions with magnolia bark extract
CN101321560B (zh) * 2005-12-02 2012-10-31 Gic创新公司 具有快速释放的厚朴提取物的咀嚼性组合物
CA2630261A1 (en) * 2005-12-06 2007-06-14 Monosol Rx, Llc Topical film compositions for delivery of actives
US20070148213A1 (en) * 2005-12-22 2007-06-28 Sayed Ibrahim Film containing compositions
SE530184C2 (sv) * 2005-12-23 2008-03-18 Kjell Stenberg Bioadhesiv farmaceutisk filmkomposition innehållande lågviskösa alginater
CN101346135A (zh) * 2005-12-27 2009-01-14 莫诺索尔克斯有限公司 用于活性剂递送的已调节pH的膜
US20070154542A1 (en) * 2005-12-30 2007-07-05 Cogentus Pharmaceuticals, Inc. Oral pharmaceutical formulations containing non-steroidal anti-inflammatory drugs and acid inhibitors
CN101370477A (zh) * 2006-01-20 2009-02-18 莫诺索尔克斯有限公司 薄膜连接的包装及其制备方法
JP4668798B2 (ja) * 2006-01-25 2011-04-13 株式会社ツキオカ 水溶性洗浄用フィルム
AU2007214474B2 (en) * 2006-02-17 2011-01-20 Novartis Ag Disintegrable oral films
CN101404990B (zh) * 2006-03-16 2012-04-25 诺瓦提斯公司 含有味道被掩蔽的活性剂的固体剂型
MX2008012514A (es) 2006-04-04 2009-02-10 Cogentus Pharmaceuticals Inc Formas de dosis oral que incluyen un agente antiplaqueta y un inhibidor de acido.
US20070231387A1 (en) * 2006-04-04 2007-10-04 Luigi Levi Film-coated solid dosage forms
US20090022340A1 (en) * 2006-04-25 2009-01-22 Kronos Advanced Technologies, Inc. Method of Acoustic Wave Generation
IL175338A0 (en) * 2006-05-01 2006-09-05 Biota Ltd Orally administrable films and preparation thereof
DE602007009377D1 (de) 2006-05-30 2010-11-04 Intarcia Therapeutics Inc Zweiteiliger flussmodulator mit einem internen kanal für ein osmotisches ausgabesystem
US20080152761A1 (en) * 2006-12-20 2008-06-26 Shiji Shen Packaging of Food Products with Pullulan Films
CN103550136B (zh) 2006-07-21 2016-04-13 生物递送科学国际公司 吸收增强的经粘膜递送装置
US8642016B2 (en) * 2006-07-21 2014-02-04 Jsrnti, Llc Medicinal delivery system, and related methods
ES2398126T3 (es) 2006-08-09 2013-03-13 Intarcia Therapeutics, Inc Sistemas de liberación osmótica y unidades de pistón
JP5395663B2 (ja) * 2006-08-14 2014-01-22 ニューロヒーリング・ファーマシューティカルズ・インコーポレーテッド モダフィニルによる早漏の治療
KR101249120B1 (ko) * 2006-08-31 2013-03-29 킴벌리-클라크 월드와이드, 인크. 고도 통기성 생분해성 필름
CA2664097A1 (en) * 2006-09-20 2008-03-27 Monosol Rx, Llc Edible water-soluble film containing a foam reducing flavoring agent
CA2664615A1 (en) * 2006-09-29 2008-04-10 Monosol Rx, Llc Film embedded packaging and method of making same
US20080131467A1 (en) * 2006-11-30 2008-06-05 Dennis Nelson Film-coated solid dosage form
US20080233174A1 (en) * 2007-01-12 2008-09-25 Monosol Rx, Llc High dose film compositions and methods of preparation
EP2112923A1 (de) 2007-01-22 2009-11-04 Targacept Inc. Intranasale, orale und sublinguale verabreichung von metanikotin-analogen
US20100086495A1 (en) * 2007-02-15 2010-04-08 Derma-Young Ltd. Compositions and methods for enhancing transmucosal delivery
US20080220029A1 (en) * 2007-03-05 2008-09-11 Charlene Ng Fast-dissolving/disintegrating film preparation having high proportion of active
CA2678876C (en) * 2007-03-07 2015-11-24 Novartis Ag Orally administrable films
US20090011115A1 (en) * 2007-03-13 2009-01-08 Foss Carter D Edible Pullulan Films Containing Flavoring
US20090087468A1 (en) * 2007-03-28 2009-04-02 Serena Stephenson Semi-Rigid Gel Article For Disinfecting A Surface
WO2008127902A2 (en) * 2007-04-12 2008-10-23 Tate & Lyle Ingredients Americas, Inc. Pullulan film containing sweetener
MX2009011123A (es) 2007-04-23 2009-11-02 Intarcia Therapeutics Inc Formulaciones de suspensiones de peptidos insulinotropicos y sus usos.
US20080292683A1 (en) * 2007-05-24 2008-11-27 Monosolrx, Llc. Film shreds and delivery system incorporating same
US8765155B2 (en) * 2007-08-30 2014-07-01 Colgate-Palmolive Company Oral care strip or tape and methods of use and manufacture thereof
US9271524B1 (en) 2007-09-07 2016-03-01 U.S. Smokeless Tobacco Company Tobacco having reduced tobacco specific nitrosamine content
US20090098192A1 (en) * 2007-10-11 2009-04-16 Fuisz Richard C Extrudable and Extruded Compositions for Delivery of Bioactive Agents, Method of Making Same and Method of Using Same
US9125434B2 (en) 2007-10-11 2015-09-08 Philip Morris Products S.A. Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet
CN107048483A (zh) 2007-10-11 2017-08-18 菲利普莫里斯生产公司 无烟烟草产品
WO2009058557A2 (en) 2007-10-12 2009-05-07 Euthanix Corp. Method and apparatus for euthanizing animals
US8298583B2 (en) 2007-10-19 2012-10-30 Monosol Rx, Llc Film delivery system for tetrahydrolipstatin
US20090142452A1 (en) * 2007-11-19 2009-06-04 Michael David Campbell Dissolvable Orally Consumable Flavored Sensual Enhancement Films
WO2009073190A1 (en) * 2007-12-04 2009-06-11 Swedish Match North America, Inc. Fast dissolving films and coatings for controlled release of flavors, active pharmaceutical ingredients, food substances, and nicotine
US8227658B2 (en) 2007-12-14 2012-07-24 Kimberly-Clark Worldwide, Inc Film formed from a blend of biodegradable aliphatic-aromatic copolyesters
JP2011511816A (ja) * 2008-02-13 2011-04-14 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 安定化効果を有する薬物送達システム
WO2009101021A2 (en) * 2008-02-13 2009-08-20 Bayer Schering Pharma Aktiengesellschaft Estradiol-containing drug delivery system
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
US7998888B2 (en) * 2008-03-28 2011-08-16 Kimberly-Clark Worldwide, Inc. Thermoplastic starch for use in melt-extruded substrates
DE102008023345B4 (de) 2008-05-13 2014-12-04 Lts Lohmann Therapie-Systeme Ag Filmförmige Zubereitung mit öligen Substanzen zur oralen Verabreichung
US9265779B2 (en) 2008-05-13 2016-02-23 Lts Lohmann Therapie-Systeme Ag Method of using a film-shaped preparation comprising oily substances for oral administration
US8338508B2 (en) * 2008-05-14 2012-12-25 Kimberly-Clark Worldwide, Inc. Water-sensitive film containing an olefinic elastomer
US8147965B2 (en) 2008-05-14 2012-04-03 Kimberly-Clark Worldwide, Inc. Water-sensitive film containing thermoplastic polyurethane
MX2010013118A (es) 2008-06-04 2011-03-29 Colgate Palmolive Co Implemento de cuidado oral con sistema de cavitacion.
ES2663777T3 (es) * 2008-06-23 2018-04-17 Biodelivery Sciences International, Inc. Dispositivos de administración mucosa multidireccionales y métodos de uso
US8927617B2 (en) * 2008-06-30 2015-01-06 Kimberly-Clark Worldwide, Inc. Fragranced water-sensitive film
US8188185B2 (en) * 2008-06-30 2012-05-29 Kimberly-Clark Worldwide, Inc. Biodegradable packaging film
US8759279B2 (en) * 2008-06-30 2014-06-24 Kimberly-Clark Worldwide, Inc. Fragranced biodegradable film
WO2010002418A2 (en) * 2008-07-01 2010-01-07 The Johns Hopkins University Quick-dissolving oral thin film for targeted delivery of therapeutic agents
FR2933959B1 (fr) * 2008-07-16 2010-09-10 Roquette Freres Procede de fabrication de films directement en alveole.
US20100040727A1 (en) * 2008-08-18 2010-02-18 Monosol Rx, Llc Method for Improving Uniformity of Content in Edible Film Manufacturing
US8282954B2 (en) * 2008-12-15 2012-10-09 Monosol Rx, Llc Method for manufacturing edible film
US8283006B2 (en) * 2008-12-18 2012-10-09 Kimberly-Clark Worldwide, Inc. Injection molding material containing starch and plant protein
US8329601B2 (en) 2008-12-18 2012-12-11 Kimberly-Clark Worldwide, Inc. Biodegradable and renewable film
US20100183717A1 (en) 2009-01-16 2010-07-22 Kristin Arnold Controlled-release formulations
US9492505B2 (en) * 2009-01-21 2016-11-15 University Of Florida Research Foundation, Inc. Satiation peptide administration
JP5674480B2 (ja) * 2009-01-29 2015-02-25 日東電工株式会社 口腔内フィルム状基剤及び製剤
CN102413834B (zh) 2009-03-04 2016-11-09 瑞吉纳拉制药公司 聚合月桂烯的组合物
CA2754564C (en) 2009-03-04 2017-09-12 Regenera Pharma Ltd. Therapeutic uses of mastic gum fractions
US20100256215A1 (en) * 2009-04-02 2010-10-07 Silver Eagle Labs Nv, Llc Menthol-Melatonin Dissolving Film
US20100256197A1 (en) * 2009-04-02 2010-10-07 Silver Eagle Labs Nv, Llc Nicotine Dissolving Film With Or Without Menthol
US20100285130A1 (en) * 2009-05-06 2010-11-11 Monosol Rx, Llc Coating of complexed actives in film formulations
US20100297232A1 (en) * 2009-05-19 2010-11-25 Monosol Rx, Llc Ondansetron film compositions
CN105411869A (zh) 2009-05-26 2016-03-23 高露洁-棕榄公司 洁齿剂组合物
EP2435013B1 (de) 2009-05-26 2019-07-24 Colgate-Palmolive Company Zahnpasta zusammensetzung
TWI396554B (zh) 2009-05-26 2013-05-21 Colgate Palmolive Co 增進可溶性鋅的量之口腔保健調配物
US9044475B2 (en) 2009-06-12 2015-06-02 Cynapsus Therapeutics, Inc. Sublingual apomorphine
CA2767950C (en) 2009-07-27 2019-11-12 Suresensors Ltd Improvements relating to sensor devices
CA2769636A1 (en) * 2009-07-30 2011-02-03 The Procter & Gamble Company Oral care articles and methods
US8475832B2 (en) * 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
NZ747990A (en) 2009-09-28 2020-06-26 Intarcia Therapeutics Inc Rapid establishment and/or termination of substantial steady-state drug delivery
AU2010310946A1 (en) 2009-10-28 2012-05-17 Regenera Pharma Ltd. Therapeutic uses of oligomeric and polymeric monoterpenes
US8701671B2 (en) 2011-02-04 2014-04-22 Joseph E. Kovarik Non-surgical method and system for reducing snoring
US9549842B2 (en) 2011-02-04 2017-01-24 Joseph E. Kovarik Buccal bioadhesive strip and method of treating snoring and sleep apnea
US9408798B2 (en) * 2009-12-04 2016-08-09 Colgate-Palmolive Company Dissolvable films containing high concentrations of nonionic surfactants such as polysorbates to enhance high solid loadings
CN102753196A (zh) * 2009-12-10 2012-10-24 莫诺索尔克斯有限公司 口服薄膜条内掩味的pH敏感性化合物
HUE025446T2 (en) 2009-12-30 2016-04-28 Novartis Ag Melt extruded nicotine thin strips
AR079890A1 (es) * 2010-01-13 2012-02-29 Colgate Palmolive Co Estabilizacion de peliculas de oxido de zinc en composiciones bucales
TWI435733B (zh) 2010-01-29 2014-05-01 Colgate Palmolive Co 用於口臭控制之口腔保健調配物
US20110276522A1 (en) * 2010-03-31 2011-11-10 Kehoe Gary S Standardization and reconstitution of phytochemicals for medical dispensation
US20110263606A1 (en) * 2010-04-26 2011-10-27 Horst Zerbe Solid oral dosage forms comprising tadalafil
US20110268809A1 (en) 2010-04-28 2011-11-03 Paul Andrew Brinkley Nicotine-Containing Pharmaceutical Compositions
US20110269844A1 (en) * 2010-05-03 2011-11-03 Innoteq, Inc. Thin film with propofol active ingredient
US20110269841A1 (en) * 2010-05-03 2011-11-03 Innoteq, Inc. Thin film with methadone active ingredient
US20110274628A1 (en) 2010-05-07 2011-11-10 Borschke August J Nicotine-containing pharmaceutical compositions
WO2011156711A1 (en) 2010-06-10 2011-12-15 Schobel Alexander M Nanoparticle film delivery systems
US9161890B2 (en) 2010-06-30 2015-10-20 Colgate-Palmolive Company Multilayer films for delivery of flavor
CA2810472A1 (en) 2010-09-07 2012-03-15 Regenera Pharma Ltd. Compositions comprising acidic extracts of mastic gum
DE102010048408A1 (de) 2010-10-15 2012-04-19 Lts Lohmann Therapie-Systeme Ag Laminat mit verbessertem Wasserretentionsverhalten
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
US10238684B2 (en) 2010-11-18 2019-03-26 Foundational Biosystems, Llc Micro- and nano-quantity sleep enhancing nutrient composition and method of enhancing central nervous system protein clearance using same
AU2010365038B2 (en) 2010-12-07 2015-08-20 Colgate-Palmolive Company Oral and personal care compositions comprising zinc containing films
JP5786195B2 (ja) 2010-12-16 2015-09-30 シナプサス セラピューティクス，インコーポレーテッド 舌下フィルム
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US11129799B2 (en) * 2011-04-12 2021-09-28 Aquestive Therapeutics, Inc. Dual lane coating
WO2012149326A1 (en) 2011-04-29 2012-11-01 Massachusetts Institute Of Technology Layer processing for pharmaceuticals
US8241661B1 (en) * 2011-06-24 2012-08-14 Fuisz Richard C Biocompatible film with variable cross-sectional properties
KR101303479B1 (ko) * 2011-07-28 2013-09-06 (주)씨엘팜 가식성 필름형성 조성물 및 약물이 함유된 가식성 필름형 제제
CN103889508B (zh) 2011-08-18 2017-09-12 拜欧帝力威瑞科学有限公司 用于传递丁丙诺啡的防滥用性粘膜粘附剂装置
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
US9907748B2 (en) 2011-10-21 2018-03-06 Niconovum Usa, Inc. Excipients for nicotine-containing therapeutic compositions
WO2013114153A2 (en) 2011-12-14 2013-08-08 Lts Lohmann Therapie-Systeme Ag Wafer and capsule formulations with enhanced dissolution rates for fenofibrate
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
US10806703B2 (en) 2012-01-20 2020-10-20 Lts Lohmann Therapie-System Ag Transmucosal administration system for a pharmaceutical drug
US9763928B2 (en) 2012-02-10 2017-09-19 Niconovum Usa, Inc. Multi-layer nicotine-containing pharmaceutical composition
JP6050031B2 (ja) * 2012-06-01 2016-12-21 森下仁丹株式会社 フィルム製剤
RU2510558C1 (ru) * 2012-07-19 2014-03-27 Александр Викторович Атаманов Беспроводная зарядная система для маломощных потребителей электрической энергии
CA2878680C (en) 2012-07-23 2019-09-17 Crayola, Llc Dissolvable films and methods of using the same
US20140275194A1 (en) 2013-03-15 2014-09-18 Monosol Rx, Llc Films and drug delivery systems for rizatriptan
WO2014145699A1 (en) 2013-03-15 2014-09-18 New Jersey Institute Of Technology System and method for fabrication of uniform polymer films containing nano and micro particles via continuous drying process
CN105050629B (zh) 2013-03-15 2018-09-25 史密夫和内修公司 用于递送活性剂的可溶解的形成凝胶的膜
US9303918B2 (en) 2013-03-15 2016-04-05 Monosol Rx, Llc Process for drying a wet film with control of loss on drying
US9278050B2 (en) 2013-04-01 2016-03-08 Trevor Anderson Dissolvable medication administration bag and method of using the same
SG11201600455XA (en) 2013-07-31 2016-02-26 Intelgenx Corp Instantly wettable oral film dosage form without surfactant or polyalcohol
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
AU2014374107B2 (en) 2013-12-31 2020-02-06 Johnson & Johnson Consumer Inc. Process for forming a shaped film product
RU2676288C2 (ru) 2013-12-31 2018-12-27 Джонсон энд Джонсон Консьюмер Инк. Способ формирования многослойного формованного пленочного продукта в один проход
JP6588020B2 (ja) 2013-12-31 2019-10-09 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッド 多層賦形フィルムを形成するための方法
EP3125893B1 (de) 2014-04-04 2023-09-20 Intra-Cellular Therapies, Inc. Deuterierte heterozyklus-anelierte gamma-carboline als antagonisten von 5-ht2a-rezeptoren
US10213960B2 (en) 2014-05-20 2019-02-26 Massachusetts Institute Of Technology Plasticity induced bonding
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
CA2969466A1 (en) * 2014-12-09 2016-06-16 Monosolrx Llc Linear polysaccharide based film products
KR101695071B1 (ko) 2014-12-26 2017-01-11 연세대학교 산학협력단 액상으로 약물을 분산시킨 필름형태의 약제학적 조성물
EP3285771A4 (de) 2015-04-21 2018-12-05 Sunovion Pharmaceuticals Inc. Verfahren zur behandlung von morbus parkinson durch verabreichung von apomorphin an eine mundschleimhaut
NZ738102A (en) 2015-06-03 2024-02-23 Intarcia Therapeutics Inc Implant placement and removal systems
US10532046B2 (en) 2015-12-03 2020-01-14 Niconovum Usa, Inc. Multi-phase delivery compositions and products incorporating such compositions
US20170165252A1 (en) 2015-12-10 2017-06-15 Niconovum Usa Inc. Protein-enriched therapeutic composition
CN108697152B (zh) * 2015-12-30 2022-01-11 下一代实验室有限责任公司 包含合成尼古丁的尼古丁替代疗法产品
CA3011983A1 (en) 2016-01-26 2017-08-03 Intra-Cellular Therapies, Inc. Organic compounds
WO2017165843A1 (en) 2016-03-25 2017-09-28 Intra-Cellular Therapies, Inc. Organic compounds
US11311633B2 (en) 2016-04-16 2022-04-26 University Of Florida Research Foundation, Incorporated Satiation peptides for weight loss and altered taste sensitivity
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
BR112018072539A2 (pt) 2016-05-05 2019-03-26 Aquestive Therapeutics, Inc. composições de epinefrina de administração aumentada
TWI814219B (zh) 2016-05-16 2023-09-01 美商因塔希亞治療公司 升糖素受體選擇性多肽和彼之使用方法
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
WO2018085495A2 (en) * 2016-11-02 2018-05-11 Board Of Regents, The University Of Texas System Dissolvable films and methods of their use
US10961245B2 (en) 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
EP3562484B1 (de) 2016-12-29 2021-08-25 Intra-Cellular Therapies, Inc. Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalinderivate zur behandlung von erkrankungen des zns
US10835580B2 (en) 2017-01-03 2020-11-17 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug
US10716786B2 (en) 2017-03-24 2020-07-21 Intra-Cellular Therapies, Inc. Transmucosal and subcutaneous compositions
US9901545B1 (en) 2017-04-13 2018-02-27 Richard C. Fuisz Method and composition for making an oral soluble film, containing at least one active agent
US10238600B2 (en) 2017-04-13 2019-03-26 Richard C. Fuisz Package, system and methods for custody and control of drugs, and method and composition for making an oral soluble film, containing at least one active agent
WO2019006010A1 (en) * 2017-06-27 2019-01-03 The Coca-Cola Company ORAL SWEETENER COMPOSITIONS AND ASSOCIATED METHODS
EP3658110B1 (de) 2017-12-20 2023-04-05 Firmenich SA Mundpflegezusammensetzungen
US11980617B2 (en) 2018-03-16 2024-05-14 Intra-Cellular Therapies, Inc. Methods of treating acute depression and/or acute anxiety
US11911492B2 (en) 2018-05-14 2024-02-27 The Procter & Gamble Company Oral care compositions comprising metal ions
CN112135600B (zh) 2018-05-14 2024-01-02 宝洁公司 发泡口腔护理组合物
EP3807260A1 (de) 2018-06-15 2021-04-21 R. J. Reynolds Tobacco Company Reinigung von nikotin
GB2574878A (en) * 2018-06-22 2019-12-25 Biofilm Ltd Oral compositions and mucoadhesive thin films formed therefrom
GB2575625A (en) 2018-06-22 2020-01-22 Church & Dwight Co Inc Oral care compositions comprising benzocaine and mucoadhesive thin films formed therefrom
JP2021536453A (ja) 2018-08-31 2021-12-27 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 新規方法
BR112021003838A2 (pt) 2018-08-31 2021-05-18 Intra-Cellular Therapies, Inc. métodos novos
US11235013B2 (en) 2018-09-04 2022-02-01 Babak Ghalili Cannabinoid, menthol and caffeine dissolvable film compositions, devices and methods
US10813889B2 (en) 2018-09-04 2020-10-27 Babak Ghalili Cannabinoid and menthol compositions and methods
JP2022505313A (ja) * 2018-10-18 2022-01-14 アビオール、インコーポレイテッド 慢性腎疾患随伴掻痒を処置する方法及びデバイス
JP7388075B2 (ja) * 2019-02-18 2023-11-29 富士フイルムビジネスイノベーション株式会社 造形装置
AU2020263240B2 (en) 2019-04-25 2023-11-02 The Procter & Gamble Company Systems and methods for delivering active agents
WO2020219322A1 (en) 2019-04-25 2020-10-29 The Procter & Gamble Company Rinseable multi-phase compositions
BR112021019731A2 (pt) 2019-04-25 2021-12-14 Procter & Gamble Composições para tratamento bucal para liberação de agente ativo
MX2021011297A (es) 2019-04-25 2021-10-13 Procter & Gamble Composiciones para el cuidado bucal para el suministro de agente activo.
WO2021168684A1 (en) 2020-02-26 2021-09-02 The Procter & Gamble Company Oral care compositions for gum health
WO2021168696A1 (en) 2020-02-26 2021-09-02 The Procter & Gamble Company Oral care compositions for gum health
WO2021177937A1 (en) * 2020-03-02 2021-09-10 Babak Ghalili Cannabinoid and menthol compositions and methods
WO2021177941A1 (en) * 2020-03-03 2021-09-10 Babak Ghalili Cannabinoid, menthol and caffeine dissolvable film compositions, devices and methods
DE102020112143B4 (de) 2020-05-05 2022-03-17 Lts Lohmann Therapie-Systeme Ag Nicotin - Corona
US11173114B1 (en) 2020-07-10 2021-11-16 Nova Thin Film Pharmaceuticals Llc Method and system for manufacturing and oral soluble films and oral soluble films made by thereby
EP4294368A1 (de) * 2021-02-19 2023-12-27 Nova Thin Film Pharmaceuticals LLC Verfahren und system zur herstellung oraler löslicher folien, zusammensetzungen oraler löslicher folien, damit hergestellte orale lösliche folien und verfahren zur verwendung davon
CA3229223A1 (en) 2021-08-23 2023-03-02 The Procter & Gamble Company Oral care compositions for gum health
WO2023023886A1 (en) 2021-08-23 2023-03-02 The Procter & Gamble Company Oral care compositions for gum health

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2432925A1 (de) * 1974-07-05 1976-01-22 Schering Ag Arzneimittelwirkstofftraeger in folienform mit inkorporiertem wirkstoff
US4713239A (en) * 1979-05-29 1987-12-15 Vsesojuny Kardiologichesky Nauchny Tsentr Adkaemii Meditsinski Nauk Sssr Antianginal film and method of treating ischemic heart disease
EP0250187A2 (de) * 1986-06-16 1987-12-23 JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. Bioadhäsiver, extrudierter Film zur intra-oralen Wirkstoffabgabe und Verfahren
EP0259749A1 (de) * 1986-09-09 1988-03-16 Desitin Arzneimittel GmbH Darreichungs- und Dosierungsform für Arzneimittelwirkstoffe, Reagentien oder dergleichen sowie Verfahren zu deren Herstellung
WO1991005540A1 (de) * 1989-10-14 1991-05-02 Desitin Arzneimittel Gmbh Mund- und zahnpflegemittel
WO1992015289A1 (en) * 1991-02-27 1992-09-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5462749A (en) * 1991-09-25 1995-10-31 Mcnell-Ppc, Inc. Bioadhesive pharmaceutical carrier
EP0781550A1 (de) * 1995-12-29 1997-07-02 Adir Et Compagnie Bioadhäsives Arzneimittel zur kontrollierten Freisetzung von Wirkstoffen

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3931824A (en) * 1973-09-10 1976-01-13 Celanese Corporation Smoking materials
US4007290A (en) * 1974-01-09 1977-02-08 General Foods Corporation Caffeine antagonim
US4136162A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
IN142428B (de) * 1974-07-05 1977-07-09 Schering Ag
US4136145A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
DE2449865B2 (de) * 1974-10-17 1981-06-19 Schering Ag Berlin Und Bergkamen, 1000 Berlin Folienförmiges Arzneimittel
US4082841A (en) * 1975-10-10 1978-04-04 Lever Brothers Company Dentifrice
US4332789A (en) * 1975-12-15 1982-06-01 Hoffmann-La Roche Inc. Pharmaceutical unit dosage forms
US4029758A (en) * 1975-12-15 1977-06-14 Hoffmann-La Roche Inc. Preparation of pharmaceutical unit dosage forms
US4029757A (en) * 1975-12-15 1977-06-14 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
US4031200A (en) * 1975-12-15 1977-06-21 Hoffmann-La Roche Inc. Manufacture of pharmaceutical unit dosage forms
ZA767136B (en) * 1975-12-15 1977-10-26 Hoffmann La Roche Novel dosage form
JPS5758615A (en) * 1980-09-26 1982-04-08 Nippon Soda Co Ltd Film agnent and its preparation
US4486436A (en) * 1982-07-22 1984-12-04 Analgesic Associates Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same
GB8301659D0 (en) 1983-01-21 1983-02-23 Leo Ab Smoking substitutes
JPS6130516A (ja) * 1984-07-20 1986-02-12 Nichiban Co Ltd 粘膜付着製剤
JPS6185315A (ja) * 1984-10-04 1986-04-30 Teikoku Seiyaku Kk シ−ト状製剤
US4900556A (en) 1985-04-26 1990-02-13 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
DE3681754D1 (de) * 1985-04-27 1991-11-07 Nitto Denko Corp Klebepflaster und arzneimittel fuer die mundhoehle.
US5783207A (en) 1985-05-01 1998-07-21 University Of Utah Research Foundation Selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US5785989A (en) 1985-05-01 1998-07-28 University Utah Research Foundation Compositions and methods of manufacturing of oral dissolvable medicaments
JPS61280423A (ja) * 1985-06-05 1986-12-11 Kiyuukiyuu Yakuhin Kogyo Kk 口腔内粘膜貼付剤
EP0219762B1 (de) * 1985-10-09 1990-12-27 Desitin Arzneimittel GmbH Verfahren zur Herstellung einer Darreichungs- und Dosierungsform für Arzneimittel-Wirkstoffe, Reagentien oder andere Wirkstoffe
US5229164A (en) * 1985-12-19 1993-07-20 Capsoid Pharma Gmbh Process for producing individually dosed administration forms
JPH0729915B2 (ja) * 1986-02-01 1995-04-05 帝國製薬株式会社 シ−ト状口腔内貼付剤
US4764378A (en) * 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
US5032387A (en) * 1986-11-06 1991-07-16 Princeton Pharmaceutical Inc. Dental and oral hygiene preparations
GB8630273D0 (en) * 1986-12-18 1987-01-28 Til Medical Ltd Pharmaceutical delivery systems
US4855142A (en) * 1987-02-27 1989-08-08 Ciba-Geigy Corporation Pharmaceutical plaster
US5446070A (en) 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5656286A (en) 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US4900552A (en) * 1988-03-30 1990-02-13 Watson Laboratories, Inc. Mucoadhesive buccal dosage forms
US5047244A (en) * 1988-06-03 1991-09-10 Watson Laboratories, Inc. Mucoadhesive carrier for delivery of therapeutical agent
DE3827561C1 (de) * 1988-08-13 1989-12-28 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
JP2656338B2 (ja) * 1989-01-31 1997-09-24 日東電工株式会社 口腔粘膜貼付製剤
JPH02258718A (ja) * 1989-03-31 1990-10-19 Nippon Kayaku Co Ltd ペースト状基剤及び製剤
US5824334A (en) 1989-09-05 1998-10-20 University Of Utah Research Foundation Tobacco substitute
US5354551A (en) * 1989-10-14 1994-10-11 Desitin Arzneimittel Gmbh Oral and dental hygiene preparation
US5525351A (en) * 1989-11-07 1996-06-11 Dam; Anders Nicotine containing stimulant unit
JPH03209327A (ja) * 1990-01-11 1991-09-12 Teikoku Seiyaku Kk ニコチン含有口腔粘膜貼付剤
GB9009390D0 (en) 1990-04-26 1990-06-20 Smith Kline French Lab Pharmaceutical compositions
US5147854A (en) * 1990-05-22 1992-09-15 Hoffmann-La Roche Inc. Tgf-b compositions and method
DE4018247A1 (de) 1990-06-07 1991-12-12 Lohmann Therapie Syst Lts Herstellungsverfahren fuer schnellzerfallende folienfoermige darreichungsformen
US5147654A (en) 1990-07-23 1992-09-15 Alza Corporation Oral osmotic device for delivering nicotine
JPH06502622A (ja) * 1990-07-23 1994-03-24 アルザ・コーポレーション ニコチンを投与するための口腔浸透デバイス
US5686094A (en) * 1991-04-01 1997-11-11 Theratech, Inc. Controlled release formulations for the treatment of xerostomia
ES2071336T3 (es) * 1990-10-25 1995-06-16 Boots Co Plc Colutorio.
SE466134B (sv) * 1990-11-22 1992-01-07 Kabi Pharmacia Ab Gelbildande flytande baerarkomposition samt anvaendning daerav i farmaceutiska kompositioner
IT1250421B (it) * 1991-05-30 1995-04-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato con proprieta' bio-adesive.
JPH05236885A (ja) 1991-07-17 1993-09-17 Tazawa Toshihiko フィルム化した芳香清涼食品
JPH0541602A (ja) 1991-08-06 1993-02-19 Fujitsu General Ltd 円偏波及び直線偏波共用一次放射器
NZ244862A (en) * 1991-10-23 1995-07-26 Block Drug Co Use of vitamin e in topical pharmaceuticals to enhance penetration of the active agent
US5414005A (en) 1993-10-28 1995-05-09 Dynagen, Inc. Methods and articles of manufacture for the treatment of nicotine withdrawal and as an aid in smoking cessation
EP0641192B1 (de) * 1992-05-18 1997-07-23 Minnesota Mining And Manufacturing Company Einrichtung zur transmucosalen wirkstoffabgabe
US5346701A (en) * 1993-02-22 1994-09-13 Theratech, Inc. Transmucosal delivery of macromolecular drugs
US5565466A (en) 1993-08-13 1996-10-15 Zonagen, Inc. Methods for modulating the human sexual response
AU7568394A (en) * 1993-08-19 1995-03-14 Cygnus Therapeutic Systems Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavity
WO1995018046A1 (en) 1993-12-28 1995-07-06 Frank Richard D Pakaging and dispensing device for sterile articles
CN1131018C (zh) 1994-03-07 2003-12-17 瑟拉技术有限公司 含药物的粘着复合的透皮给药药贴及其制备方法
WO1995034582A1 (en) 1994-06-16 1995-12-21 Pharmacia S.P.A. Bioadhesive starches and process for their preparation
WO1996000072A1 (en) 1994-06-23 1996-01-04 The Procter & Gamble Company Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine
US6436407B1 (en) 1994-08-26 2002-08-20 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic adjuvant
WO1996025910A1 (en) * 1995-02-23 1996-08-29 Cygnus, Inc. Water-soluble pressure-sensitive mucoadhesive
FR2733684B1 (fr) 1995-05-03 1997-05-30 Cird Galderma Utilisation de retinoides dans une composition cosmetique ou pour la fabrication d'une composition pharmaceutique
JP2791317B2 (ja) 1995-12-26 1998-08-27 株式会社三和化学研究所 多層フィルム製剤
DE19615820A1 (de) * 1996-04-06 1997-10-09 Holger Specht Zahnpflegemittel und Verfahren zu seiner Herstellung
US5955098A (en) 1996-04-12 1999-09-21 Flemington Pharmaceutical Corp. Buccal non polar spray or capsule
US5955096A (en) * 1996-06-25 1999-09-21 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US5853740A (en) 1996-08-07 1998-12-29 Abbott Laboratories Delivery system for pharmaceutical agents encapsulated with oils
US5871905A (en) 1996-09-04 1999-02-16 Epitope, Inc. Reduction of false positives in oral-fluid based immunoassays
DE19646392A1 (de) 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht
JP3460538B2 (ja) 1997-10-08 2003-10-27 救急薬品工業株式会社 速溶性フィルム製剤
DE19837073A1 (de) 1998-08-17 2000-03-23 Lohmann Therapie Syst Lts Folienförmige Wirkstoffträger
US6165512A (en) * 1998-10-30 2000-12-26 Fuisz Technologies Ltd. Dosage forms containing taste masked active agents
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US6342496B1 (en) 1999-03-01 2002-01-29 Sepracor Inc. Bupropion metabolites and methods of use
US6489341B1 (en) 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
US6335023B1 (en) 1999-06-30 2002-01-01 Ruey J. Yu Oligosaccharide aldonic acids and their topical use
DE19932603A1 (de) 1999-07-13 2001-01-25 Gruenenthal Gmbh Wirkstoffhaltiger Mehrschichtfilm aus in situ vernetzten hydrophilen Polymeren
EA006861B1 (ru) 1999-07-22 2006-04-28 Варнер-Ламберт Компани Композиции пуллулановых пленок
US6264981B1 (en) 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
JP4044709B2 (ja) 1999-11-19 2008-02-06 信越化学工業株式会社 水系フィルムコーティング剤及び経口固形製剤
DE10032456A1 (de) 2000-07-04 2002-01-31 Lohmann Therapie Syst Lts Schnell zerfallende Darreichungsform zur Freisetzung von Wirkstoffen im Mundraum oder in Körperhöhlen
DE10107659B4 (de) 2001-02-19 2008-03-13 Lts Lohmann Therapie-Systeme Ag Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin
EP1389910A4 (de) 2001-04-20 2005-11-02 Lavipharm Lab Inc Intraorale verabreichung von nikotin zum abgewöhnen des rauchens
JP4267926B2 (ja) 2001-04-24 2009-05-27 リンテック株式会社 経口投与剤及び経口投与剤保持体
US20030118653A1 (en) 2001-07-06 2003-06-26 Lavipharm Laboratories Inc. Quick dissolving oral mucosal drug delivery device with moisture barrier coating
US6585997B2 (en) 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
JP5089840B2 (ja) 2001-09-25 2012-12-05 救急薬品工業株式会社 ニコチン含有フィルム製剤
WO2003030883A1 (en) 2001-10-12 2003-04-17 Kosmos Pharma Uniform films for rapid dissolve dosage form incorporating taste-masking compositions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2432925A1 (de) * 1974-07-05 1976-01-22 Schering Ag Arzneimittelwirkstofftraeger in folienform mit inkorporiertem wirkstoff
US4713239A (en) * 1979-05-29 1987-12-15 Vsesojuny Kardiologichesky Nauchny Tsentr Adkaemii Meditsinski Nauk Sssr Antianginal film and method of treating ischemic heart disease
EP0250187A2 (de) * 1986-06-16 1987-12-23 JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. Bioadhäsiver, extrudierter Film zur intra-oralen Wirkstoffabgabe und Verfahren
EP0259749A1 (de) * 1986-09-09 1988-03-16 Desitin Arzneimittel GmbH Darreichungs- und Dosierungsform für Arzneimittelwirkstoffe, Reagentien oder dergleichen sowie Verfahren zu deren Herstellung
WO1991005540A1 (de) * 1989-10-14 1991-05-02 Desitin Arzneimittel Gmbh Mund- und zahnpflegemittel
WO1992015289A1 (en) * 1991-02-27 1992-09-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5462749A (en) * 1991-09-25 1995-10-31 Mcnell-Ppc, Inc. Bioadhesive pharmaceutical carrier
EP0781550A1 (de) * 1995-12-29 1997-07-02 Adir Et Compagnie Bioadhäsives Arzneimittel zur kontrollierten Freisetzung von Wirkstoffen

Cited By (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491406B2 (en) 1998-09-25 2009-02-17 Mcneil-Ppc, Inc. Fast dissolving orally consumable films
EP1676557A2 (de) 1998-09-25 2006-07-05 Warner-Lambert Company LLC Schnelllösliche oral konsumierbare Filme
WO2000018365A3 (en) * 1998-09-25 2000-11-16 Warner Lambert Co Fast dissolving orally consumable films
US7025983B2 (en) 1998-09-25 2006-04-11 Warner-Lambert Company Llc Fast dissolving orally consumable films
CN101810547A (zh) * 1998-09-25 2010-08-25 沃尼尔·朗伯有限责任公司 快速溶解口腔消耗膜
WO2000018365A2 (en) * 1998-09-25 2000-04-06 Warner-Lambert Company Fast dissolving orally consumable films
US6596298B2 (en) 1998-09-25 2003-07-22 Warner-Lambert Company Fast dissolving orally comsumable films
US7407669B2 (en) 1998-09-25 2008-08-05 Mcneil-Ppc, Inc. Fast dissolving orally consumable films
USRE40594E1 (en) 1998-12-23 2008-12-02 Mount Sinai School Of Medicine Of New York University Inhibitors of the bitter taste response
WO2000042992A2 (en) * 1999-01-21 2000-07-27 Lavipharm Laboratories, Inc. Compositions and methods for mucosal delivery
WO2000042992A3 (en) * 1999-01-21 2000-10-19 Lavipharm Lab Inc Compositions and methods for mucosal delivery
CN100389755C (zh) * 1999-01-21 2008-05-28 拉维法姆实验室公司 粘膜传递的组合物及方法
JP2002535269A (ja) * 1999-01-21 2002-10-22 ラヴィファーム ラボラトリーズ， インコーポレイテッド 粘膜分配用組成物と方法
US6231957B1 (en) 1999-05-06 2001-05-15 Horst G. Zerbe Rapidly disintegrating flavor wafer for flavor enrichment
WO2000067595A1 (en) * 1999-05-06 2000-11-16 Zerbe Horst G Rapidly disintegrating flavor wafer for flavor enrichment
US7314716B2 (en) 1999-11-19 2008-01-01 Mount Sinai School Of Medicine Gustducin γ subunit materials and methods
US7648712B2 (en) 2000-03-23 2010-01-19 Mcneil-Ppc, Inc. Fast dissolving orally consumable films containing a taste masking agent
US7067116B1 (en) 2000-03-23 2006-06-27 Warner-Lambert Company Llc Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1
EP1674078A2 (de) 2000-03-23 2006-06-28 Warner-Lambert Company LLC Schnellzerfallende essbare Filme mit einem Ionenaustauscherharz als geschmacksmaskierenden Stoff
JP2005255694A (ja) * 2000-07-04 2005-09-22 Lts Lohmann Therapie-Systeme Ag 口腔または体腔内で有効成分を放出するための迅速分解性投与可能剤形
JP4870316B2 (ja) * 2000-07-04 2012-02-08 エルテーエス ローマン テラピー−ジステーメ アーゲー 口腔または体腔内で有効成分を放出するための迅速分解性投与可能剤形
USRE45666E1 (en) 2000-07-07 2015-09-08 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
WO2002005789A3 (de) * 2000-07-15 2002-05-10 Scs Skin Care Systems Gmbh Lösung, dispersion oder emulsion bildende folien-dermatika
AU2001283909B2 (en) * 2000-07-15 2006-12-21 Scs Skin Care Systems Gmbh Solution-, Dispersion-or emulsion-producing film dermatics
WO2002005789A2 (de) * 2000-07-15 2002-01-24 Scs Skin Care Systems Gmbh Lösung, dispersion oder emulsion bildende folien-dermatika
JP2004532814A (ja) * 2001-01-09 2004-10-28 ラヴィファーム・ラボラトリーズ・インク 活性物質の局所的および全身的送達のための装置およびその製造方法
JP2009185078A (ja) * 2001-02-19 2009-08-20 Lts Lohmann Therapie-Systeme Ag 動物用及びヒト用医薬における活性物質の投与用の、粘膜接着性を有し、崩壊可能な医薬品調合剤
EP1389910A4 (de) * 2001-04-20 2005-11-02 Lavipharm Lab Inc Intraorale verabreichung von nikotin zum abgewöhnen des rauchens
EP1389910A1 (de) * 2001-04-20 2004-02-25 Lavipharm Laboratories, Inc. Intraorale verabreichung von nikotin zum abgewöhnen des rauchens
AU2002252685C1 (en) * 2001-04-20 2002-11-05 Lavipharm Laboratories Inc. Intraoral delivery of nicotine for smoking cessation
US8481059B2 (en) 2001-05-01 2013-07-09 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences Hydrogel compositions
US9532935B2 (en) 2001-05-01 2017-01-03 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US10835454B2 (en) 2001-05-01 2020-11-17 Corium, Inc. Hydrogel compositions with an erodible backing member
US9089481B2 (en) 2001-05-01 2015-07-28 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions demonstrating phase separation on contact with aqueous media
US8273405B2 (en) 2001-05-01 2012-09-25 A.V. Topcheiv Institute of Petrochemical Synthesis, Russian Academy of Sciences Water-absorbent adhesive compositions and associated methods of manufacture and use
US8481071B2 (en) 2001-05-01 2013-07-09 Corium International, Inc. Hydrogel compositions with an erodible backing member
US9127140B2 (en) 2001-05-01 2015-09-08 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Water-absorbent adhesive compositions and associated methods of manufacture and use
US10179096B2 (en) 2001-05-01 2019-01-15 Corium International, Inc. Hydrogel compositions for tooth whitening
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US9687428B2 (en) 2001-05-01 2017-06-27 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US8617647B2 (en) 2001-05-01 2013-12-31 A.V. Topchiev Institutes of Petrochemical Synthesis, Russian Academy of Sciences Water-absorbent adhesive compositions and associated methods of manufacture and use
US10869947B2 (en) 2001-05-01 2020-12-22 Corium, Inc. Hydrogel compositions
US9084723B2 (en) 2001-05-01 2015-07-21 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions with an erodible backing member
US8728445B2 (en) 2001-05-01 2014-05-20 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences Hydrogel Compositions
US8741331B2 (en) 2001-05-01 2014-06-03 A. V. Topchiev Institute of Petrochemicals Synthesis, Russian Academy of Sciences Hydrogel compositions with an erodible backing member
US9259504B2 (en) 2001-05-01 2016-02-16 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Non-electrically conductive hydrogel composition
US8821901B2 (en) 2001-05-01 2014-09-02 A.V. Topchiev Institute Of Petrochemical Synthesis Russian Academy Of Sciences Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US7132113B2 (en) 2001-06-19 2006-11-07 Intelgenx Corp. Flavored film
US6660292B2 (en) 2001-06-19 2003-12-09 Hf Flavoring Technology Llp Rapidly disintegrating flavored film for precooked foods
WO2004054551A1 (de) * 2002-12-05 2004-07-01 Lts Lohmann Therapie-Systeme Ag Filmförmige zubereitungen zur transmucosalen verabreichung von nicotin, sowie verfahren zu deren herstellung
US9498410B2 (en) 2002-12-30 2016-11-22 Colgate-Palmolive Company Oral and personal care compositions and methods
US9827172B2 (en) 2002-12-30 2017-11-28 Colgate-Palmolive Company Dentifrice containing functional film flakes
US9918909B2 (en) 2002-12-30 2018-03-20 Colgate-Palmolive Company Oral and personal care compositions and methods
US8627828B2 (en) 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10098376B2 (en) 2003-11-07 2018-10-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10945454B2 (en) 2003-11-07 2021-03-16 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US10765140B2 (en) 2003-11-07 2020-09-08 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8658201B2 (en) 2004-01-30 2014-02-25 Corium International, Inc. Rapidly dissolving film for delivery of an active agent
US9144552B2 (en) 2004-01-30 2015-09-29 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences Rapidly dissolving film for delivery of an active agent
US9433616B2 (en) 2005-01-19 2016-09-06 Neurohealing Pharmaceuticals, Inc. Methods and compositions for decreasing saliva production
US9198897B2 (en) 2005-01-19 2015-12-01 Neurohealing Pharmaceuticals, Inc. Methods and compositions for decreasing saliva production
US10238612B2 (en) 2009-01-14 2019-03-26 Corium International, Inc. Transdermal administration of tamsulosin
US8784879B2 (en) 2009-01-14 2014-07-22 Corium International, Inc. Transdermal administration of tamsulosin
US9610253B2 (en) 2009-01-14 2017-04-04 Corium International, Inc. Transdermal administration of tamsulosin
EP2399574A4 (de) * 2009-01-29 2013-08-28 Nitto Denko Corp Intraorales mittel auf filmartiger basis und formulierung
US9289386B2 (en) 2009-01-29 2016-03-22 Nitto Denko Corporation Oral film-form base and oral film-form preparation
EP2399574A1 (de) * 2009-01-29 2011-12-28 Nitto Denko Corporation Intraorales mittel auf filmartiger basis und formulierung
US9717682B2 (en) 2009-12-08 2017-08-01 Intelgenx Corporation Solid oral film dosage forms and methods for making same
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
WO2011081625A1 (en) * 2009-12-30 2011-07-07 Novartis Ag Melt extruded thin strips containing coated pharmaceutical actives
US9724309B2 (en) 2010-03-30 2017-08-08 Nitto Denko Corporation Film-form preparation and method for producing the same
US10092505B2 (en) 2012-01-11 2018-10-09 Nitto Denko Corporation Oral film-form base and preparation
WO2013167742A1 (fr) 2012-05-11 2013-11-14 Pierre Fabre Medicament Film monocouche a desintegration rapide et son utilisation dans l'hygiene buccale
US11945936B2 (en) 2013-01-11 2024-04-02 Monosol, Llc Edible water-soluble film
US10829621B2 (en) 2013-01-11 2020-11-10 Monosol, Llc Edible water-soluble film

Also Published As

Publication number Publication date
AU4868297A (en) 1998-06-03
ES2206692T3 (es) 2004-05-16
US6177096B1 (en) 2001-01-23
HU0500666D0 (en) 2005-09-28
AU739698B2 (en) 2001-10-18
CZ297354B6 (cs) 2006-11-15
DE29724755U1 (de) 2003-10-02
ATE422157T1 (de) 2009-02-15
HK1035316A1 (en) 2002-02-01
TR199901633T2 (xx) 1999-09-21
EP0936905B1 (de) 2003-08-27
KR20000053184A (ko) 2000-08-25
KR100569847B1 (ko) 2006-04-12
NO991921L (no) 1999-04-22
JP4063331B2 (ja) 2008-03-19
SK62299A3 (en) 2000-03-13
US6284264B1 (en) 2001-09-04
HU230022B1 (hu) 2015-05-28
DK1362584T3 (da) 2009-06-02
PL190376B1 (pl) 2005-12-30
US6709671B2 (en) 2004-03-23
IL129819A0 (en) 2000-02-29
KR20050088161A (ko) 2005-09-01
SK285100B6 (sk) 2006-06-01
US6592887B2 (en) 2003-07-15
ZA9710093B (en) 1998-05-25
CA2265651C (en) 2004-03-16
EP0936905A1 (de) 1999-08-25
CZ164799A3 (cs) 1999-08-11
US20120114705A1 (en) 2012-05-10
US20010046511A1 (en) 2001-11-29
US5948430A (en) 1999-09-07
EP1362584A1 (de) 2003-11-19
DE59710670D1 (de) 2003-10-02
ES2322699T3 (es) 2009-06-25
NO20053307L (no) 1999-04-02
DE19646392A1 (de) 1998-05-14
SI0936905T1 (en) 2004-02-29
PT1362584E (pt) 2009-05-07
CA2265651A1 (en) 1998-05-22
HUP9904207A3 (en) 2001-04-28
IL169984A (en) 2012-06-28
JP4817721B2 (ja) 2011-11-16
EP1362584B1 (de) 2009-02-04
ID22526A (id) 1999-10-28
HUP9904207A2 (hu) 2000-04-28
JP2010006832A (ja) 2010-01-14
NZ335063A (en) 2000-12-22
TW533083B (en) 2003-05-21
JP2005247876A (ja) 2005-09-15
US20020127190A1 (en) 2002-09-12
MY125548A (en) 2006-08-30
NO991921D0 (no) 1999-04-22
HU228464B1 (en) 2013-03-28
JP2001504106A (ja) 2001-03-27
DE59712993D1 (de) 2009-03-19
PT936905E (pt) 2004-01-30
NO325073B1 (no) 2008-01-28
NO20053307D0 (no) 2005-07-06
US20020150544A1 (en) 2002-10-17
US8865202B2 (en) 2014-10-21
US20040156885A1 (en) 2004-08-12
IL169984A0 (en) 2009-02-11
SK285999B6 (sk) 2008-01-07
DK0936905T3 (da) 2003-11-24
KR100604995B1 (ko) 2006-07-26
ATE247954T1 (de) 2003-09-15
TW200305444A (en) 2003-11-01
TWI250029B (en) 2006-03-01

Similar Documents

Publication Publication Date Title
EP0936905B1 (de) Sofortige benetzbarkeit aufweisende(r) wasserlöslicher film oder wasserlösliche schicht zur oralen applikation
EP1904029B2 (de) Nicht-ausspuckbarer, oraler, schnell-zerfallender film enthaltend olanzapin
DE102008023345B4 (de) Filmförmige Zubereitung mit öligen Substanzen zur oralen Verabreichung
EP1906917A2 (de) Nicht-ausspuckbarer, oraler, schnell-zerfallender film für antiemetikum oder antimigränemittel
DE19745208A1 (de) Mundfilm
WO2004054551A1 (de) Filmförmige zubereitungen zur transmucosalen verabreichung von nicotin, sowie verfahren zu deren herstellung
DE102021106491A1 (de) Gerollte oral thin films mit hoher wirkstoffbeladung

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU CA CZ HU ID IL JP KR MX NO NZ PL SG SI SK TR US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2265651

Country of ref document: CA

Ref document number: 2265651

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1997911237

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 1998 522088

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 335063

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: PA/a/1999/004068

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 62299

Country of ref document: SK

Ref document number: PV1999-1647

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 1019997004145

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 1999/01633

Country of ref document: TR

WWP Wipo information: published in national office

Ref document number: PV1999-1647

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 1997911237

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1019997004145

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 1997911237

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: PV2005-304

Country of ref document: CZ

WWE Wipo information: entry into national phase

Ref document number: 2005/01821

Country of ref document: TR

WWE Wipo information: entry into national phase

Ref document number: 50412005

Country of ref document: SK

WWR Wipo information: refused in national office

Ref document number: 1019997004145

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: PV1999-1647

Country of ref document: CZ