UY28294A1 - Dihidroquinazolinas sustituidas - Google Patents

Dihidroquinazolinas sustituidas

Info

Publication number
UY28294A1
UY28294A1 UY28294A UY28294A UY28294A1 UY 28294 A1 UY28294 A1 UY 28294A1 UY 28294 A UY28294 A UY 28294A UY 28294 A UY28294 A UY 28294A UY 28294 A1 UY28294 A1 UY 28294A1
Authority
UY
Uruguay
Prior art keywords
substituted
dihydroquinazolins
preparation
prophylaxis
medicaments
Prior art date
Application number
UY28294A
Other languages
English (en)
Spanish (es)
Inventor
Dr Kerstin Henninger
Dr Tobias Wunberg
Dr Judith Baumeister
Dr Ulrich Betz
Dr Mario Jeske
Dr Thomas Lampe
Dr Susanne Nikolic
Dr Jurgen Reefschlager
Dr Rudolf Schohe-Loop
Frank Submeier
Dr Holger Zimmermann
Dr Rolf Grosser
Dr Guy Hewlett
Dr Jorg Keldenich
Dr Dieter Lang
Dr Peter Nell
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33305099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY28294(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of UY28294A1 publication Critical patent/UY28294A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
UY28294A 2003-05-02 2004-04-28 Dihidroquinazolinas sustituidas UY28294A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline

Publications (1)

Publication Number Publication Date
UY28294A1 true UY28294A1 (es) 2004-11-30

Family

ID=33305099

Family Applications (1)

Application Number Title Priority Date Filing Date
UY28294A UY28294A1 (es) 2003-05-02 2004-04-28 Dihidroquinazolinas sustituidas

Country Status (38)

Country Link
US (4) US7196086B2 (enExample)
EP (1) EP1622880B3 (enExample)
JP (1) JP4733631B2 (enExample)
KR (1) KR100927063B1 (enExample)
CN (1) CN100393706C (enExample)
AR (1) AR044078A1 (enExample)
AT (1) ATE355280T1 (enExample)
AU (1) AU2004233978B2 (enExample)
BR (1) BRPI0410029B8 (enExample)
CA (1) CA2524069C (enExample)
CL (1) CL2004000930A1 (enExample)
CO (1) CO5700764A2 (enExample)
CY (2) CY1106476T1 (enExample)
DE (2) DE10319612A1 (enExample)
DK (1) DK1622880T6 (enExample)
EC (1) ECSP056138A (enExample)
EG (1) EG25273A (enExample)
ES (1) ES2284007T7 (enExample)
FR (1) FR18C1029I2 (enExample)
HN (1) HN2004000146A (enExample)
HU (2) HUS1800018I1 (enExample)
IL (1) IL171513A (enExample)
MA (1) MA27794A1 (enExample)
MX (1) MXPA05011707A (enExample)
MY (1) MY144616A (enExample)
NL (1) NL300933I2 (enExample)
NO (2) NO333265B3 (enExample)
NZ (1) NZ543317A (enExample)
PE (1) PE20050145A1 (enExample)
PL (1) PL1622880T6 (enExample)
PT (1) PT1622880E (enExample)
RU (1) RU2360912C2 (enExample)
SI (1) SI1622880T1 (enExample)
TW (1) TWI335912B (enExample)
UA (1) UA82519C2 (enExample)
UY (1) UY28294A1 (enExample)
WO (1) WO2004096778A1 (enExample)
ZA (1) ZA200508710B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) * 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
SMT201900327T1 (it) * 2013-06-19 2019-07-11 Aicuris Anti Infective Cures Gmbh Letermovir amorfo e formulazioni farmaceutiche solide per somministrazione orale dello stesso
WO2015088931A1 (en) * 2013-12-12 2015-06-18 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
US10392353B2 (en) * 2015-11-24 2019-08-27 Merck Sharp & Dohme Corp. Processes for making substituted quinazoline compounds using hydrogen bonding catalysts
ES2882531T3 (es) 2016-08-08 2021-12-02 Phaeno Therapeutics Co Ltd Compuesto anti-virus CMVH
EP3753942B1 (en) * 2018-02-08 2024-01-03 Phaeno Therapeutics Co., Ltd. Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor
EP3527209A1 (en) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Pharmaceutical 6,5 heterobicyclic ring derivatives
WO2020053654A1 (en) 2018-09-12 2020-03-19 Novartis Ag Antiviral pyridopyrazinedione compounds
CA3155287A1 (en) 2019-09-26 2021-04-01 Novartis Ag Antiviral pyrazolopyridinone compounds
AR121439A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
UY39097A (es) * 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
AR121438A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
UY39098A (es) * 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, su preparación y uso
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
WO2022038457A1 (en) 2020-08-17 2022-02-24 Lupin Limited A precipitation process for amorphous letermovir
CN115403528B (zh) * 2021-05-27 2025-01-07 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
UY40078A (es) * 2021-12-21 2023-06-30 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin
WO2023185597A1 (zh) * 2022-04-01 2023-10-05 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用
WO2025133248A1 (en) 2023-12-21 2025-06-26 Aic246 Ag & Co. Kg Diastereomeric aminoalcohol and aminoether salts of 2-[(4r,s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl]acetic acid and their use for enantiomeric separation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
CA2321153A1 (en) 1998-02-17 1999-08-19 Timothy D. Cushing Anti-viral pyrimidine derivatives
US6495578B1 (en) 1999-04-19 2002-12-17 Shionogi & Co., Ltd. Sulfonamide derivatives having oxadiazole rings
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) * 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
DE60113865T2 (de) * 2000-07-31 2006-07-20 Vernalis Research Ltd., Winnersh Piperazin derivate
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
ES2252455T3 (es) 2001-04-19 2006-05-16 Bayer Healthcare Ag Arilsulfonamidas como agentes antivirales.
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) * 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) * 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
KR20080009048A (ko) * 2005-01-25 2008-01-24 프롤렉시스 파마슈티칼스, 인크. 항종양제로서 퀴녹살린 유도체
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
ATE449097T1 (de) * 2005-07-21 2009-12-15 Hoffmann La Roche Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
SMT201900327T1 (it) * 2013-06-19 2019-07-11 Aicuris Anti Infective Cures Gmbh Letermovir amorfo e formulazioni farmaceutiche solide per somministrazione orale dello stesso

Also Published As

Publication number Publication date
JP4733631B2 (ja) 2011-07-27
CA2524069A1 (en) 2004-11-11
NZ543317A (en) 2008-05-30
BRPI0410029B1 (pt) 2019-12-31
BRPI0410029A (pt) 2006-04-25
TW200510343A (en) 2005-03-16
ES2284007T3 (es) 2007-11-01
DK1622880T3 (da) 2007-06-25
CN100393706C (zh) 2008-06-11
RU2360912C2 (ru) 2009-07-10
US20070191387A1 (en) 2007-08-16
MA27794A1 (fr) 2006-03-01
IL171513A (en) 2011-11-30
NO333265B1 (no) 2013-04-22
CY2018019I2 (el) 2018-12-12
AR044078A1 (es) 2005-08-24
CO5700764A2 (es) 2006-11-30
EP1622880A1 (de) 2006-02-08
DE10319612A1 (de) 2004-11-18
CL2004000930A1 (es) 2005-03-18
KR100927063B1 (ko) 2009-11-13
FR18C1029I1 (enExample) 2018-08-17
CY1106476T1 (el) 2012-01-25
FR18C1029I2 (fr) 2020-07-17
NO333265B3 (no) 2019-06-03
USRE46791E1 (en) 2018-04-17
NO2018022I1 (no) 2018-07-04
USRE49698E1 (en) 2023-10-17
MXPA05011707A (es) 2006-02-13
EP1622880B1 (de) 2007-02-28
US8513255B2 (en) 2013-08-20
WO2004096778A1 (de) 2004-11-11
HN2004000146A (es) 2008-06-24
DE502004003052D1 (de) 2007-04-12
PL1622880T6 (pl) 2018-08-31
DK1622880T6 (da) 2018-06-18
NO20055649L (no) 2006-01-31
UA82519C2 (uk) 2008-04-25
HUS1800028I1 (hu) 2018-07-30
HK1092463A1 (zh) 2007-02-09
SI1622880T1 (sl) 2007-08-31
BRPI0410029B8 (pt) 2021-06-15
KR20060009883A (ko) 2006-02-01
ES2284007T7 (es) 2018-06-20
AU2004233978A1 (en) 2004-11-11
CY2018019I1 (el) 2018-12-12
HUS1800018I1 (hu) 2018-05-28
CN1784390A (zh) 2006-06-07
NL300933I2 (nl) 2018-04-26
RU2005137276A (ru) 2006-07-27
EP1622880B3 (de) 2018-05-23
US20050065160A1 (en) 2005-03-24
TWI335912B (en) 2011-01-11
MY144616A (en) 2011-10-14
ECSP056138A (es) 2006-04-19
AU2004233978B2 (en) 2010-02-11
PL1622880T3 (pl) 2007-08-31
ZA200508710B (en) 2006-12-27
NO20055649D0 (no) 2005-11-30
ATE355280T1 (de) 2006-03-15
JP2006525249A (ja) 2006-11-09
EG25273A (en) 2011-12-04
CA2524069C (en) 2011-11-08
PE20050145A1 (es) 2005-05-22
PT1622880E (pt) 2007-06-04
US7196086B2 (en) 2007-03-27

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Effective date: 20240428