CY1106476T1 - Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες - Google Patents
Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητεςInfo
- Publication number
- CY1106476T1 CY1106476T1 CY20071100709T CY071100709T CY1106476T1 CY 1106476 T1 CY1106476 T1 CY 1106476T1 CY 20071100709 T CY20071100709 T CY 20071100709T CY 071100709 T CY071100709 T CY 071100709T CY 1106476 T1 CY1106476 T1 CY 1106476T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antiviral properties
- dihydroquinazolines
- substituted
- substituted dihydroquinazolines
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10319612A DE10319612A1 (de) | 2003-05-02 | 2003-05-02 | Substituierte Dihydrochinazoline |
| PCT/EP2004/004103 WO2004096778A1 (de) | 2003-05-02 | 2004-04-17 | Substituierte dihydrochinazoline mit antiviralen eigenschaften |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106476T1 true CY1106476T1 (el) | 2012-01-25 |
Family
ID=33305099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071100709T CY1106476T1 (el) | 2003-05-02 | 2007-05-25 | Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες |
| CY2018019C CY2018019I2 (el) | 2003-05-02 | 2018-06-29 | Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY2018019C CY2018019I2 (el) | 2003-05-02 | 2018-06-29 | Υποκατεστημενες διυδροκιναζολινες με αντι-ιικες ιδιοτητες |
Country Status (38)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10319612A1 (de) | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| DE10305785A1 (de) * | 2003-02-12 | 2004-08-26 | Bayer Healthcare Ag | Dihydrochinazoline |
| DE10320780A1 (de) | 2003-05-09 | 2005-01-20 | Bayer Healthcare Ag | Heterocyclyl-substituierte Dihydrochinazoline |
| DE10352499A1 (de) * | 2003-11-11 | 2005-06-09 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline II |
| DE102004022672A1 (de) | 2004-05-07 | 2005-11-24 | Bayer Healthcare Ag | Substituierte Azachinazoline |
| DE102005027517A1 (de) * | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Verfahren zur Herstellung von Dihydrochinazolinen |
| DE102011101446A1 (de) * | 2011-05-10 | 2012-11-15 | Aicuris Gmbh & Co. Kg | Herstellung von "Dense Bodies" (DB) |
| DE102012101680A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat |
| DE102012101659A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| DE102012101673A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| HUE043721T2 (hu) * | 2013-06-19 | 2019-09-30 | Aicuris Anti Infective Cures Gmbh | Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra |
| US9890128B2 (en) | 2013-12-12 | 2018-02-13 | Merck Sharp & Dohme Corp. | Process for making substituted quinazoline compounds |
| WO2017091453A1 (en) * | 2015-11-24 | 2017-06-01 | Merck Sharp & Dohme Corp. | Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts |
| EP3498715B1 (en) * | 2016-08-08 | 2021-06-09 | Medshine Discovery Inc. | Anti-hcmv virus compound |
| AU2019218150B2 (en) * | 2018-02-08 | 2021-05-13 | Phaeno Therapeutics Co., Ltd. | Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor |
| EP3527209A1 (en) * | 2018-02-16 | 2019-08-21 | UCB Biopharma SPRL | Pharmaceutical 6,5 heterobicyclic ring derivatives |
| TWI838401B (zh) | 2018-09-12 | 2024-04-11 | 瑞士商諾華公司 | 抗病毒性吡啶并吡𠯤二酮化合物 |
| TWI867053B (zh) | 2019-09-26 | 2024-12-21 | 瑞士商諾華公司 | 抗病毒吡唑并吡啶酮化合物 |
| UY39099A (es) | 2020-02-27 | 2021-08-31 | Aic246 Gmbh & Co Kg | 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo |
| AR121440A1 (es) | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales |
| UY39097A (es) | 2020-02-27 | 2021-09-30 | Aic246 Gmbh & Co Kg | Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético |
| UY39095A (es) | 2020-02-27 | 2021-09-30 | Aic246 Gmbh & Co Kg | Composiciones farmacéuticas que comprenden acetato de 2- [(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio |
| AR121439A1 (es) * | 2020-02-27 | 2022-06-08 | Aic246 Gmbh & Co Kg | Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato |
| EP3906929A1 (en) | 2020-05-08 | 2021-11-10 | AiCuris GmbH & Co. KG | Letermovir for use in the prevention and the treatment of coronavirus infections |
| WO2022038457A1 (en) | 2020-08-17 | 2022-02-24 | Lupin Limited | A precipitation process for amorphous letermovir |
| CN115403528B (zh) * | 2021-05-27 | 2025-01-07 | 南京正大天晴制药有限公司 | 无定形3,4-二氢喹唑啉衍生物的制备方法 |
| CN114031560B (zh) * | 2021-11-16 | 2022-10-04 | 山东诚创蓝海医药科技有限公司 | 一种来特莫韦钠盐的制备方法 |
| AR128035A1 (es) | 2021-12-21 | 2024-03-20 | Aic246 Ag & Co Kg | Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio |
| WO2023185597A1 (zh) * | 2022-04-01 | 2023-10-05 | 上海迪赛诺化学制药有限公司 | 莱特莫韦中间体及其制备方法 |
| CN115322157B (zh) * | 2022-06-02 | 2023-12-05 | 浙江车头制药股份有限公司 | 来特莫韦中间体化合物及其制备方法和应用 |
| CN117229223A (zh) * | 2022-06-08 | 2023-12-15 | 苏州远智医药科技有限公司 | 一种杂环衍生物及其药物组合物、应用 |
| TW202535393A (zh) | 2023-12-21 | 2025-09-16 | 德商Ａｉｃ246股份兩合公司 | 2-[(4r,s)-8-氟-2-[4-(3-甲氧基苯基)哌嗪-1-基]-3-[2-甲氧基-5-(三氟甲基)苯基]-3,4-二氫喹唑啉-4-基]乙酸之非鏡像異構物胺基醇鹽及胺基醚鹽及其於鏡像異構物分離之用途 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4320347A1 (de) | 1993-06-19 | 1994-12-22 | Boehringer Mannheim Gmbh | Quinazolin-Derivate und diese enthaltende Arzneimittel |
| US5854245A (en) * | 1996-06-28 | 1998-12-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| DE19802437A1 (de) | 1998-01-23 | 1999-07-29 | Bayer Ag | Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe |
| ATE245641T1 (de) | 1998-02-17 | 2003-08-15 | Tularik Inc | Antivirale pyrimidinderivate |
| WO2000063194A1 (en) | 1999-04-19 | 2000-10-26 | Shionogi & Co., Ltd. | Sulfonamide derivatives having oxadiazole rings |
| DE19930075A1 (de) | 1999-06-30 | 2001-01-04 | Bayer Ag | Neue Amino- und Amidosulfonamide als antivirale Mittel |
| US6730682B2 (en) * | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| EP1325008B1 (en) * | 2000-07-31 | 2005-10-05 | F. Hoffmann-La Roche Ag | Piperazine derivatives |
| EP1201765A3 (en) * | 2000-10-16 | 2003-08-27 | Axxima Pharmaceuticals Aktiengesellschaft | Cellular kinases involved in cytomegalovirus infection and their inhibition |
| HUP0303813A3 (en) | 2001-04-19 | 2005-05-30 | Bayer Ag | Arylsulfonamides as antiviral agents, process for preparation of the compounds and pharmaceutical compositions containing them |
| DE10138578A1 (de) | 2001-08-06 | 2003-02-27 | Bayer Ag | Heterocyclylarylsulfonamide |
| DE10251914A1 (de) | 2002-11-08 | 2004-05-19 | Bayer Ag | Substituierte Chinazoline |
| DE10319612A1 (de) | 2003-05-02 | 2004-11-18 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline |
| DE10305785A1 (de) * | 2003-02-12 | 2004-08-26 | Bayer Healthcare Ag | Dihydrochinazoline |
| DE10320780A1 (de) * | 2003-05-09 | 2005-01-20 | Bayer Healthcare Ag | Heterocyclyl-substituierte Dihydrochinazoline |
| DE10352499A1 (de) * | 2003-11-11 | 2005-06-09 | Bayer Healthcare Ag | Substituierte Dihydrochinazoline II |
| KR100610731B1 (ko) | 2004-02-24 | 2006-08-09 | 한국과학기술연구원 | Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법 |
| DE102004022672A1 (de) * | 2004-05-07 | 2005-11-24 | Bayer Healthcare Ag | Substituierte Azachinazoline |
| KR20080009048A (ko) * | 2005-01-25 | 2008-01-24 | 프롤렉시스 파마슈티칼스, 인크. | 항종양제로서 퀴녹살린 유도체 |
| DE102005027517A1 (de) | 2005-06-15 | 2006-12-21 | Bayer Healthcare Ag | Verfahren zur Herstellung von Dihydrochinazolinen |
| BRPI0613604A2 (pt) * | 2005-07-21 | 2011-01-18 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de ptp-1b, e utilização dos compostos |
| DE102006009928A1 (de) | 2006-03-03 | 2007-09-06 | Aicuris Gmbh & Co. Kg | Substituierte Arylsulfonamide |
| DE102012101680A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat |
| DE102012101659A1 (de) * | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| DE102012101673A1 (de) | 2012-02-29 | 2013-08-29 | Aicuris Gmbh & Co. Kg | Salze eines Dihydrochinazolinderivats |
| HUE043721T2 (hu) * | 2013-06-19 | 2019-09-30 | Aicuris Anti Infective Cures Gmbh | Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra |
-
2003
- 2003-05-02 DE DE10319612A patent/DE10319612A1/de not_active Withdrawn
-
2004
- 2004-04-17 DE DE502004003052T patent/DE502004003052D1/de not_active Expired - Lifetime
- 2004-04-17 NZ NZ543317A patent/NZ543317A/en not_active IP Right Cessation
- 2004-04-17 ES ES04728119.1T patent/ES2284007T7/es active Active
- 2004-04-17 JP JP2006505178A patent/JP4733631B2/ja not_active Expired - Lifetime
- 2004-04-17 AT AT04728119T patent/ATE355280T1/de active
- 2004-04-17 DK DK04728119.1T patent/DK1622880T6/da active
- 2004-04-17 MX MXPA05011707A patent/MXPA05011707A/es active IP Right Grant
- 2004-04-17 PT PT04728119T patent/PT1622880E/pt unknown
- 2004-04-17 CA CA2524069A patent/CA2524069C/en not_active Expired - Lifetime
- 2004-04-17 AU AU2004233978A patent/AU2004233978B2/en active Active
- 2004-04-17 UA UAA200511418A patent/UA82519C2/uk unknown
- 2004-04-17 EP EP04728119.1A patent/EP1622880B3/de not_active Expired - Lifetime
- 2004-04-17 KR KR1020057020720A patent/KR100927063B1/ko not_active Expired - Lifetime
- 2004-04-17 WO PCT/EP2004/004103 patent/WO2004096778A1/de not_active Ceased
- 2004-04-17 BR BRPI0410029A patent/BRPI0410029B8/pt not_active IP Right Cessation
- 2004-04-17 RU RU2005137276/04A patent/RU2360912C2/ru active
- 2004-04-17 PL PL04728119T patent/PL1622880T6/pl unknown
- 2004-04-17 CN CNB2004800119284A patent/CN100393706C/zh not_active Expired - Lifetime
- 2004-04-17 SI SI200430301T patent/SI1622880T1/sl unknown
- 2004-04-23 AR ARP040101391A patent/AR044078A1/es active IP Right Grant
- 2004-04-26 US US10/832,109 patent/US7196086B2/en not_active Ceased
- 2004-04-28 UY UY28294A patent/UY28294A1/es not_active IP Right Cessation
- 2004-04-29 MY MYPI20041603A patent/MY144616A/en unknown
- 2004-04-29 HN HN2004000146A patent/HN2004000146A/es unknown
- 2004-04-30 CL CL200400930A patent/CL2004000930A1/es unknown
- 2004-04-30 PE PE2004000432A patent/PE20050145A1/es active IP Right Grant
- 2004-04-30 TW TW093112100A patent/TWI335912B/zh active
-
2005
- 2005-10-20 IL IL171513A patent/IL171513A/en active IP Right Grant
- 2005-10-27 ZA ZA2005/08710A patent/ZA200508710B/en unknown
- 2005-10-29 EG EGNA2005000688 patent/EG25273A/xx active
- 2005-11-01 EC EC2005006138A patent/ECSP056138A/es unknown
- 2005-11-02 CO CO05111848A patent/CO5700764A2/es active IP Right Grant
- 2005-11-08 MA MA28581A patent/MA27794A1/fr unknown
- 2005-11-30 NO NO20055649A patent/NO333265B3/no active Protection Beyond IP Right Term
-
2007
- 2007-03-26 US US11/728,896 patent/US8513255B2/en active Active
- 2007-05-25 CY CY20071100709T patent/CY1106476T1/el unknown
-
2015
- 2015-04-09 US US14/682,512 patent/USRE46791E1/en active Active
-
2018
- 2018-04-17 NL NL300933C patent/NL300933I2/nl unknown
- 2018-04-21 HU HUS1800018C patent/HUS1800018I1/hu unknown
- 2018-06-15 HU HUS1800028C patent/HUS1800028I1/hu unknown
- 2018-06-29 CY CY2018019C patent/CY2018019I2/el unknown
- 2018-07-04 NO NO2018022C patent/NO2018022I1/no unknown
- 2018-07-06 FR FR18C1029C patent/FR18C1029I2/fr active Active
-
2020
- 2020-07-21 US US16/934,363 patent/USRE49698E1/en not_active Expired - Lifetime
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