BRPI0410029B8 - composto dihidroquinazolina substituído, processo para sua preparação, medicamento compreendendo o referido composto e uso do referido composto - Google Patents

composto dihidroquinazolina substituído, processo para sua preparação, medicamento compreendendo o referido composto e uso do referido composto

Info

Publication number
BRPI0410029B8
BRPI0410029B8 BRPI0410029A BRPI0410029A BRPI0410029B8 BR PI0410029 B8 BRPI0410029 B8 BR PI0410029B8 BR PI0410029 A BRPI0410029 A BR PI0410029A BR PI0410029 A BRPI0410029 A BR PI0410029A BR PI0410029 B8 BRPI0410029 B8 BR PI0410029B8
Authority
BR
Brazil
Prior art keywords
compound
preparation
substituted
medicine
dihydroquinazoline
Prior art date
Application number
BRPI0410029A
Other languages
English (en)
Portuguese (pt)
Inventor
Lang Dieter
Süssmeier Frank
Hewlett Guy
Zimmermann Holger
Baumeister Judith
Keldenich Jörg
Reefschläger Jürgen
Henninger Kerstin
Jeske Mario
Nell Peter
Grosser Rolf
Schohe-Loop Rudolf
Nikolic Susanne
Lampe Thomas
Wunberg Tobias
Betz Ulrich
Original Assignee
Aicuris Anti Infective Cures Gmbh
Aicuris Gmbh & Co Kg
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33305099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0410029(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Anti Infective Cures Gmbh, Aicuris Gmbh & Co Kg, Bayer Healthcare Ag filed Critical Aicuris Anti Infective Cures Gmbh
Publication of BRPI0410029A publication Critical patent/BRPI0410029A/pt
Publication of BRPI0410029B1 publication Critical patent/BRPI0410029B1/pt
Publication of BRPI0410029B8 publication Critical patent/BRPI0410029B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BRPI0410029A 2003-05-02 2004-04-17 composto dihidroquinazolina substituído, processo para sua preparação, medicamento compreendendo o referido composto e uso do referido composto BRPI0410029B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline
PCT/EP2004/004103 WO2004096778A1 (de) 2003-05-02 2004-04-17 Substituierte dihydrochinazoline mit antiviralen eigenschaften

Publications (3)

Publication Number Publication Date
BRPI0410029A BRPI0410029A (pt) 2006-04-25
BRPI0410029B1 BRPI0410029B1 (pt) 2019-12-31
BRPI0410029B8 true BRPI0410029B8 (pt) 2021-06-15

Family

ID=33305099

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410029A BRPI0410029B8 (pt) 2003-05-02 2004-04-17 composto dihidroquinazolina substituído, processo para sua preparação, medicamento compreendendo o referido composto e uso do referido composto

Country Status (38)

Country Link
US (4) US7196086B2 (enExample)
EP (1) EP1622880B3 (enExample)
JP (1) JP4733631B2 (enExample)
KR (1) KR100927063B1 (enExample)
CN (1) CN100393706C (enExample)
AR (1) AR044078A1 (enExample)
AT (1) ATE355280T1 (enExample)
AU (1) AU2004233978B2 (enExample)
BR (1) BRPI0410029B8 (enExample)
CA (1) CA2524069C (enExample)
CL (1) CL2004000930A1 (enExample)
CO (1) CO5700764A2 (enExample)
CY (2) CY1106476T1 (enExample)
DE (2) DE10319612A1 (enExample)
DK (1) DK1622880T6 (enExample)
EC (1) ECSP056138A (enExample)
EG (1) EG25273A (enExample)
ES (1) ES2284007T7 (enExample)
FR (1) FR18C1029I2 (enExample)
HN (1) HN2004000146A (enExample)
HU (2) HUS1800018I1 (enExample)
IL (1) IL171513A (enExample)
MA (1) MA27794A1 (enExample)
MX (1) MXPA05011707A (enExample)
MY (1) MY144616A (enExample)
NL (1) NL300933I2 (enExample)
NO (2) NO333265B3 (enExample)
NZ (1) NZ543317A (enExample)
PE (1) PE20050145A1 (enExample)
PL (1) PL1622880T6 (enExample)
PT (1) PT1622880E (enExample)
RU (1) RU2360912C2 (enExample)
SI (1) SI1622880T1 (enExample)
TW (1) TWI335912B (enExample)
UA (1) UA82519C2 (enExample)
UY (1) UY28294A1 (enExample)
WO (1) WO2004096778A1 (enExample)
ZA (1) ZA200508710B (enExample)

Families Citing this family (32)

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Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) * 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101680A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
HUE043721T2 (hu) * 2013-06-19 2019-09-30 Aicuris Anti Infective Cures Gmbh Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra
US9890128B2 (en) 2013-12-12 2018-02-13 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
WO2017091453A1 (en) * 2015-11-24 2017-06-01 Merck Sharp & Dohme Corp. Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts
EP3498715B1 (en) * 2016-08-08 2021-06-09 Medshine Discovery Inc. Anti-hcmv virus compound
AU2019218150B2 (en) * 2018-02-08 2021-05-13 Phaeno Therapeutics Co., Ltd. Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor
EP3527209A1 (en) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Pharmaceutical 6,5 heterobicyclic ring derivatives
TWI838401B (zh) 2018-09-12 2024-04-11 瑞士商諾華公司 抗病毒性吡啶并吡𠯤二酮化合物
TWI867053B (zh) 2019-09-26 2024-12-21 瑞士商諾華公司 抗病毒吡唑并吡啶酮化合物
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
AR121440A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales
UY39097A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético
UY39095A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2- [(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
AR121439A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
WO2022038457A1 (en) 2020-08-17 2022-02-24 Lupin Limited A precipitation process for amorphous letermovir
CN115403528B (zh) * 2021-05-27 2025-01-07 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
WO2023185597A1 (zh) * 2022-04-01 2023-10-05 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用
TW202535393A (zh) 2023-12-21 2025-09-16 德商Ａｉｃ246股份兩合公司 2-[(4r,s)-8-氟-2-[4-(3-甲氧基苯基)哌嗪-1-基]-3-[2-甲氧基-5-(三氟甲基)苯基]-3,4-二氫喹唑啉-4-基]乙酸之非鏡像異構物胺基醇鹽及胺基醚鹽及其於鏡像異構物分離之用途

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DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
ATE245641T1 (de) 1998-02-17 2003-08-15 Tularik Inc Antivirale pyrimidinderivate
WO2000063194A1 (en) 1999-04-19 2000-10-26 Shionogi & Co., Ltd. Sulfonamide derivatives having oxadiazole rings
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) * 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
EP1325008B1 (en) * 2000-07-31 2005-10-05 F. Hoffmann-La Roche Ag Piperazine derivatives
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
HUP0303813A3 (en) 2001-04-19 2005-05-30 Bayer Ag Arylsulfonamides as antiviral agents, process for preparation of the compounds and pharmaceutical compositions containing them
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) * 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) * 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
KR20080009048A (ko) * 2005-01-25 2008-01-24 프롤렉시스 파마슈티칼스, 인크. 항종양제로서 퀴녹살린 유도체
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
BRPI0613604A2 (pt) * 2005-07-21 2011-01-18 Hoffmann La Roche compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de ptp-1b, e utilização dos compostos
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
HUE043721T2 (hu) * 2013-06-19 2019-09-30 Aicuris Anti Infective Cures Gmbh Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra

Also Published As

Publication number Publication date
BRPI0410029A (pt) 2006-04-25
USRE49698E1 (en) 2023-10-17
ZA200508710B (en) 2006-12-27
USRE46791E1 (en) 2018-04-17
AU2004233978A1 (en) 2004-11-11
KR20060009883A (ko) 2006-02-01
FR18C1029I2 (fr) 2020-07-17
US20050065160A1 (en) 2005-03-24
NO20055649L (no) 2006-01-31
PL1622880T6 (pl) 2018-08-31
WO2004096778A1 (de) 2004-11-11
UA82519C2 (uk) 2008-04-25
HK1092463A1 (zh) 2007-02-09
NO333265B3 (no) 2019-06-03
US20070191387A1 (en) 2007-08-16
HUS1800028I1 (hu) 2018-07-30
ES2284007T3 (es) 2007-11-01
SI1622880T1 (sl) 2007-08-31
ES2284007T7 (es) 2018-06-20
EP1622880A1 (de) 2006-02-08
CA2524069C (en) 2011-11-08
PT1622880E (pt) 2007-06-04
HUS1800018I1 (hu) 2018-05-28
RU2360912C2 (ru) 2009-07-10
AU2004233978B2 (en) 2010-02-11
DK1622880T6 (da) 2018-06-18
US7196086B2 (en) 2007-03-27
PE20050145A1 (es) 2005-05-22
JP4733631B2 (ja) 2011-07-27
FR18C1029I1 (enExample) 2018-08-17
CO5700764A2 (es) 2006-11-30
DK1622880T3 (da) 2007-06-25
TW200510343A (en) 2005-03-16
NO333265B1 (no) 2013-04-22
NO20055649D0 (no) 2005-11-30
JP2006525249A (ja) 2006-11-09
ECSP056138A (es) 2006-04-19
KR100927063B1 (ko) 2009-11-13
ATE355280T1 (de) 2006-03-15
CY1106476T1 (el) 2012-01-25
PL1622880T3 (pl) 2007-08-31
UY28294A1 (es) 2004-11-30
BRPI0410029B1 (pt) 2019-12-31
CY2018019I1 (el) 2018-12-12
US8513255B2 (en) 2013-08-20
CL2004000930A1 (es) 2005-03-18
EP1622880B3 (de) 2018-05-23
CY2018019I2 (el) 2018-12-12
AR044078A1 (es) 2005-08-24
MY144616A (en) 2011-10-14
TWI335912B (en) 2011-01-11
RU2005137276A (ru) 2006-07-27
MXPA05011707A (es) 2006-02-13
DE10319612A1 (de) 2004-11-18
EP1622880B1 (de) 2007-02-28
NL300933I2 (nl) 2018-04-26
CN1784390A (zh) 2006-06-07
CN100393706C (zh) 2008-06-11
HN2004000146A (es) 2008-06-24
NZ543317A (en) 2008-05-30
EG25273A (en) 2011-12-04
DE502004003052D1 (de) 2007-04-12
MA27794A1 (fr) 2006-03-01
IL171513A (en) 2011-11-30
NO2018022I1 (no) 2018-07-04
CA2524069A1 (en) 2004-11-11

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