MY144616A - Substituted dihydroquinazolines - Google Patents

Substituted dihydroquinazolines

Info

Publication number
MY144616A
MY144616A MYPI20041603A MYPI20041603A MY144616A MY 144616 A MY144616 A MY 144616A MY PI20041603 A MYPI20041603 A MY PI20041603A MY PI20041603 A MYPI20041603 A MY PI20041603A MY 144616 A MY144616 A MY 144616A
Authority
MY
Malaysia
Prior art keywords
dihydroquinazolines
substituted
substituted dihydroquinazolines
prophylaxis
diseases
Prior art date
Application number
MYPI20041603A
Other languages
English (en)
Inventor
Tobias Dr Wunberg
Holger Dr Zimmermann
Rolf Dr Grosser
Kerstin Dr Henninger
Guy Dr Hewlett
Jorg Dr Keldenich
Dieter Lang
Peter Dr Nell
Judith Dr Baumeister
Ulrich Dr Betz
Mario Dr Jeske
Thomas Dr Lampe
Susanne Dr Nikolic
Jurgen Dr Reefschlager
Rudolf Dr Schohe-Loop
Frank Submeier
Original Assignee
Aicuris Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33305099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY144616(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aicuris Gmbh & Co Kg filed Critical Aicuris Gmbh & Co Kg
Publication of MY144616A publication Critical patent/MY144616A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MYPI20041603A 2003-05-02 2004-04-29 Substituted dihydroquinazolines MY144616A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline

Publications (1)

Publication Number Publication Date
MY144616A true MY144616A (en) 2011-10-14

Family

ID=33305099

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20041603A MY144616A (en) 2003-05-02 2004-04-29 Substituted dihydroquinazolines

Country Status (38)

Country Link
US (4) US7196086B2 (enExample)
EP (1) EP1622880B3 (enExample)
JP (1) JP4733631B2 (enExample)
KR (1) KR100927063B1 (enExample)
CN (1) CN100393706C (enExample)
AR (1) AR044078A1 (enExample)
AT (1) ATE355280T1 (enExample)
AU (1) AU2004233978B2 (enExample)
BR (1) BRPI0410029B8 (enExample)
CA (1) CA2524069C (enExample)
CL (1) CL2004000930A1 (enExample)
CO (1) CO5700764A2 (enExample)
CY (2) CY1106476T1 (enExample)
DE (2) DE10319612A1 (enExample)
DK (1) DK1622880T6 (enExample)
EC (1) ECSP056138A (enExample)
EG (1) EG25273A (enExample)
ES (1) ES2284007T7 (enExample)
FR (1) FR18C1029I2 (enExample)
HN (1) HN2004000146A (enExample)
HU (2) HUS1800018I1 (enExample)
IL (1) IL171513A (enExample)
MA (1) MA27794A1 (enExample)
MX (1) MXPA05011707A (enExample)
MY (1) MY144616A (enExample)
NL (1) NL300933I2 (enExample)
NO (2) NO333265B3 (enExample)
NZ (1) NZ543317A (enExample)
PE (1) PE20050145A1 (enExample)
PL (1) PL1622880T6 (enExample)
PT (1) PT1622880E (enExample)
RU (1) RU2360912C2 (enExample)
SI (1) SI1622880T1 (enExample)
TW (1) TWI335912B (enExample)
UA (1) UA82519C2 (enExample)
UY (1) UY28294A1 (enExample)
WO (1) WO2004096778A1 (enExample)
ZA (1) ZA200508710B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) * 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) * 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
UA117755C2 (uk) * 2013-06-19 2018-09-25 Айкуріс Анти-Інфектів Курес Гмбх Аморфний летермовір і тверді фармацевтичні препарати, що містять його, призначені для перорального введення
WO2015088931A1 (en) * 2013-12-12 2015-06-18 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
US10392353B2 (en) * 2015-11-24 2019-08-27 Merck Sharp & Dohme Corp. Processes for making substituted quinazoline compounds using hydrogen bonding catalysts
JP6951418B2 (ja) * 2016-08-08 2021-10-20 メッドシャイン ディスカバリー インコーポレイテッド 抗ｈｃｍｖウイルス化合物
US11174270B2 (en) 2018-02-08 2021-11-16 Phaeno Therapeutics Co., Ltd. Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method thereof
EP3527209A1 (en) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Pharmaceutical 6,5 heterobicyclic ring derivatives
EP3849979A1 (en) 2018-09-12 2021-07-21 Novartis AG Antiviral pyridopyrazinedione compounds
TW202535873A (zh) 2019-09-26 2025-09-16 瑞士商諾華公司 抗病毒吡唑并吡啶酮化合物
UY39098A (es) 2020-02-27 2021-09-30 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, su preparación y uso
AR121438A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
AR121437A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acético
AR121439A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
CA3189271A1 (en) 2020-08-17 2022-02-24 Girij Pal Singh A precipitation process for amorphous letermovir
CN115403528B (zh) * 2021-05-27 2025-01-07 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
CN118974026A (zh) * 2022-04-01 2024-11-15 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用
WO2025133248A1 (en) 2023-12-21 2025-06-26 Aic246 Ag & Co. Kg Diastereomeric aminoalcohol and aminoether salts of 2-[(4r,s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-3,4-dihydroquinazolin-4-yl]acetic acid and their use for enantiomeric separation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4320347A1 (de) 1993-06-19 1994-12-22 Boehringer Mannheim Gmbh Quinazolin-Derivate und diese enthaltende Arzneimittel
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
WO1999041253A1 (en) 1998-02-17 1999-08-19 Tularik Inc. Anti-viral pyrimidine derivatives
WO2000063194A1 (en) 1999-04-19 2000-10-26 Shionogi & Co., Ltd. Sulfonamide derivatives having oxadiazole rings
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) * 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
AU2001283955B2 (en) * 2000-07-31 2006-05-18 F. Hoffmann-La Roche Ag Piperazine derivatives
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
RU2003133750A (ru) 2001-04-19 2005-05-10 Байер АГ (DE) Арилсульфонамиды в качестве антивирусных агентов
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) * 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) * 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
NZ560320A (en) * 2005-01-25 2011-02-25 Prolexys Pharmaceuticals Inc Quinoxaline derivatives as antitumor agents
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
MX2008000885A (es) * 2005-07-21 2008-03-18 Hoffmann La Roche Compuestos de pirido[2,3-d]pirimidin-2,4-diamina como inhibidores de la proteina tirosina fosfatasa 1b.
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
UA117755C2 (uk) * 2013-06-19 2018-09-25 Айкуріс Анти-Інфектів Курес Гмбх Аморфний летермовір і тверді фармацевтичні препарати, що містять його, призначені для перорального введення

Also Published As

Publication number Publication date
RU2360912C2 (ru) 2009-07-10
RU2005137276A (ru) 2006-07-27
BRPI0410029B8 (pt) 2021-06-15
DE502004003052D1 (de) 2007-04-12
CA2524069C (en) 2011-11-08
USRE49698E1 (en) 2023-10-17
HN2004000146A (es) 2008-06-24
USRE46791E1 (en) 2018-04-17
ZA200508710B (en) 2006-12-27
CN1784390A (zh) 2006-06-07
PT1622880E (pt) 2007-06-04
US7196086B2 (en) 2007-03-27
PE20050145A1 (es) 2005-05-22
UA82519C2 (uk) 2008-04-25
EG25273A (en) 2011-12-04
PL1622880T6 (pl) 2018-08-31
TW200510343A (en) 2005-03-16
UY28294A1 (es) 2004-11-30
CY1106476T1 (el) 2012-01-25
CY2018019I2 (el) 2018-12-12
KR100927063B1 (ko) 2009-11-13
CA2524069A1 (en) 2004-11-11
DK1622880T6 (da) 2018-06-18
NO20055649L (no) 2006-01-31
EP1622880B3 (de) 2018-05-23
WO2004096778A1 (de) 2004-11-11
CL2004000930A1 (es) 2005-03-18
DE10319612A1 (de) 2004-11-18
NO20055649D0 (no) 2005-11-30
AU2004233978A1 (en) 2004-11-11
AU2004233978B2 (en) 2010-02-11
US20070191387A1 (en) 2007-08-16
IL171513A (en) 2011-11-30
ECSP056138A (es) 2006-04-19
MXPA05011707A (es) 2006-02-13
TWI335912B (en) 2011-01-11
ATE355280T1 (de) 2006-03-15
JP2006525249A (ja) 2006-11-09
BRPI0410029A (pt) 2006-04-25
US20050065160A1 (en) 2005-03-24
ES2284007T3 (es) 2007-11-01
BRPI0410029B1 (pt) 2019-12-31
FR18C1029I2 (fr) 2020-07-17
JP4733631B2 (ja) 2011-07-27
EP1622880B1 (de) 2007-02-28
CN100393706C (zh) 2008-06-11
KR20060009883A (ko) 2006-02-01
NL300933I2 (nl) 2018-04-26
HK1092463A1 (zh) 2007-02-09
FR18C1029I1 (enExample) 2018-08-17
NO333265B3 (no) 2019-06-03
SI1622880T1 (sl) 2007-08-31
US8513255B2 (en) 2013-08-20
HUS1800018I1 (hu) 2018-05-28
MA27794A1 (fr) 2006-03-01
HUS1800028I1 (hu) 2018-07-30
EP1622880A1 (de) 2006-02-08
NZ543317A (en) 2008-05-30
CY2018019I1 (el) 2018-12-12
NO333265B1 (no) 2013-04-22
DK1622880T3 (da) 2007-06-25
ES2284007T7 (es) 2018-06-20
PL1622880T3 (pl) 2007-08-31
NO2018022I1 (no) 2018-07-04
AR044078A1 (es) 2005-08-24
CO5700764A2 (es) 2006-11-30

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