SI1594833T1 - Derivati 1-fenilalkankarboksilne kisline za zdravljenje nevrodegenerativnih bolezni - Google Patents
Derivati 1-fenilalkankarboksilne kisline za zdravljenje nevrodegenerativnih bolezniInfo
- Publication number
- SI1594833T1 SI1594833T1 SI200430900T SI200430900T SI1594833T1 SI 1594833 T1 SI1594833 T1 SI 1594833T1 SI 200430900 T SI200430900 T SI 200430900T SI 200430900 T SI200430900 T SI 200430900T SI 1594833 T1 SI1594833 T1 SI 1594833T1
- Authority
- SI
- Slovenia
- Prior art keywords
- treatment
- acid derivatives
- neurodegenerative diseases
- phenylalkanecarboxylic acid
- phenylalkanecarboxylic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
- C07C15/12—Polycyclic non-condensed hydrocarbons
- C07C15/14—Polycyclic non-condensed hydrocarbons all phenyl groups being directly linked
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/65—Halogen-containing esters of unsaturated acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/40—Unsaturated compounds containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI20030311 ITMI20030311A1 (it) | 2003-02-21 | 2003-02-21 | Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer. |
ITMI20032068 ITMI20032068A1 (it) | 2003-10-23 | 2003-10-23 | Derivati dell'acido 1-fenilcicloalcancarbossilico per il trattamento delle malattie neurodegenerative. |
EP04712483A EP1594833B1 (en) | 2003-02-21 | 2004-02-19 | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases |
PCT/EP2004/001596 WO2004074232A1 (en) | 2003-02-21 | 2004-02-19 | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1594833T1 true SI1594833T1 (sl) | 2008-12-31 |
Family
ID=32910543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200430900T SI1594833T1 (sl) | 2003-02-21 | 2004-02-19 | Derivati 1-fenilalkankarboksilne kisline za zdravljenje nevrodegenerativnih bolezni |
Country Status (17)
Country | Link |
---|---|
US (3) | US7662995B2 (sl) |
EP (1) | EP1594833B1 (sl) |
JP (1) | JP4472691B2 (sl) |
KR (2) | KR101088272B1 (sl) |
AT (1) | ATE409176T1 (sl) |
AU (1) | AU2004213145B2 (sl) |
BR (1) | BRPI0407662B8 (sl) |
CA (1) | CA2514384C (sl) |
CY (1) | CY1108514T1 (sl) |
DE (1) | DE602004016729D1 (sl) |
DK (1) | DK1594833T3 (sl) |
ES (1) | ES2312964T3 (sl) |
HK (1) | HK1087398A1 (sl) |
NO (1) | NO333118B1 (sl) |
PT (1) | PT1594833E (sl) |
SI (1) | SI1594833T1 (sl) |
WO (1) | WO2004074232A1 (sl) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001257022B2 (en) * | 2000-04-13 | 2005-02-03 | Mayo Foundation For Medical Education And Research | Abeta 42 lowering agents |
EP1603548A4 (en) * | 2003-02-05 | 2007-10-10 | Myriad Genetics Inc | COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS |
CA2514384C (en) * | 2003-02-21 | 2012-04-10 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases |
KR20060040676A (ko) * | 2003-07-11 | 2006-05-10 | 미리어드 제네틱스, 인크. | 알츠하이머병을 치료하기 위한 약제학적 방법, 투약 방법및 제형 |
US20070293538A1 (en) * | 2004-04-13 | 2007-12-20 | Myriad Genetics, Incorporated | Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders |
CN1946906A (zh) * | 2004-04-29 | 2007-04-11 | 吉斯通护岸系统股份有限公司 | 用于墙、护墙和类似物的饰面 |
WO2006016219A2 (en) | 2004-08-03 | 2006-02-16 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases |
WO2006020853A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
WO2006020852A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
JP2009502807A (ja) * | 2005-07-22 | 2009-01-29 | ミリアド ジェネティクス, インコーポレイテッド | 薬剤含有率の高い製剤および投与量形態 |
WO2008006099A2 (en) * | 2006-07-07 | 2008-01-10 | Myriad Genetics, Inc. | Treatment of psychiatric disorders |
JO3598B1 (ar) * | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
US8217064B2 (en) | 2007-12-20 | 2012-07-10 | Envivo Pharmaceuticals, Inc. | Tetrasubstituted benzenes |
EP2133322A1 (en) * | 2008-06-11 | 2009-12-16 | CHIESI FARMACEUTICI S.p.A. | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
MX2012001411A (es) * | 2009-08-04 | 2012-03-29 | Chiesi Farma Spa | Proceso para la preparacion de derivados de acido 1-(2-halobifenil-4-il)-ciclopropanocarboxilico. |
EP2531511A1 (en) | 2010-02-03 | 2012-12-12 | Infinity Pharmaceuticals, Inc. | Fatty acid amide hydrolase inhibitors |
WO2011120778A1 (en) * | 2010-04-01 | 2011-10-06 | Chiesi Farmaceutici S.P.A. | Novel polymorphs and salts |
WO2011131661A1 (en) * | 2010-04-21 | 2011-10-27 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid derivatives for the therapy of transthyretin amyloidosis |
WO2011151330A1 (en) | 2010-06-04 | 2011-12-08 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the therapy of prion diseases |
US9592210B2 (en) | 2011-12-22 | 2017-03-14 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment |
KR20140144178A (ko) | 2012-04-04 | 2014-12-18 | 키에시 파르마슈티시 엣스. 피. 에이. | 신경퇴행성 질환의 치료를 위한 1-(2-할로-비페닐-4-일)알칸카복실산의 유도체 |
US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
WO2014206898A1 (en) | 2013-06-24 | 2014-12-31 | Chiesi Farmaceutici S.P.A. | Improved process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid |
EP2818460A1 (en) | 2013-06-24 | 2014-12-31 | ZaCh System S.p.A. | Cyclopropanation of substituted phenylacetonitriles or phenyl acetates |
WO2015109109A1 (en) | 2014-01-15 | 2015-07-23 | Forum Pharmaceuticals Inc. | Fused morpholinopyrimidines and methods of use thereof |
US20150320706A1 (en) | 2014-05-12 | 2015-11-12 | Chiesi Farmaceutici S.P.A. | Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy |
WO2015181094A1 (en) | 2014-05-26 | 2015-12-03 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome |
US9802927B2 (en) | 2015-06-10 | 2017-10-31 | Denali Therapeutics, Inc. | Oxadiazine compounds and methods of use thereof |
MX2024002472A (es) | 2021-08-31 | 2024-03-12 | Cerespir Incorporated | Cocristales. |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1933985A1 (de) * | 1968-07-04 | 1970-01-15 | Takeda Chemical Industries Ltd | Neue Cycloalkancarbonsaeurederivate und Verfahren zu ihrer Herstellung |
JPS4994680A (sl) | 1973-01-22 | 1974-09-09 | ||
JPS5046669A (sl) | 1973-03-28 | 1975-04-25 | ||
JPS58177977A (ja) | 1982-04-09 | 1983-10-18 | Grelan Pharmaceut Co Ltd | 4−フエニルピラゾ−ル類 |
WO1996002529A1 (fr) * | 1994-07-13 | 1996-02-01 | Taisho Pharmaceutical Co., Ltd. | Derive de l'acide thiophene acetique |
JPH0994680A (ja) * | 1995-07-24 | 1997-04-08 | Toyota Motor Corp | 摩擦圧接装置 |
US5994379A (en) * | 1998-02-13 | 1999-11-30 | Merck Frosst Canada, Inc. | Bisaryl COX-2 inhibiting compounds, compositions and methods of use |
AU2001257022B2 (en) | 2000-04-13 | 2005-02-03 | Mayo Foundation For Medical Education And Research | Abeta 42 lowering agents |
WO2004064771A2 (en) * | 2003-01-14 | 2004-08-05 | Merck & Co., Inc. | Geminally di-substituted nsaid derivatives as abeta 42 lowering agents |
CA2514384C (en) * | 2003-02-21 | 2012-04-10 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases |
WO2006016219A2 (en) * | 2004-08-03 | 2006-02-16 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases |
EP2133322A1 (en) * | 2008-06-11 | 2009-12-16 | CHIESI FARMACEUTICI S.p.A. | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
-
2004
- 2004-02-19 CA CA2514384A patent/CA2514384C/en not_active Expired - Fee Related
- 2004-02-19 KR KR1020057014850A patent/KR101088272B1/ko active IP Right Grant
- 2004-02-19 EP EP04712483A patent/EP1594833B1/en not_active Expired - Lifetime
- 2004-02-19 AU AU2004213145A patent/AU2004213145B2/en not_active Ceased
- 2004-02-19 ES ES04712483T patent/ES2312964T3/es not_active Expired - Lifetime
- 2004-02-19 WO PCT/EP2004/001596 patent/WO2004074232A1/en active IP Right Grant
- 2004-02-19 DE DE602004016729T patent/DE602004016729D1/de not_active Expired - Lifetime
- 2004-02-19 BR BRPI0407662A patent/BRPI0407662B8/pt not_active IP Right Cessation
- 2004-02-19 DK DK04712483T patent/DK1594833T3/da active
- 2004-02-19 AT AT04712483T patent/ATE409176T1/de active
- 2004-02-19 SI SI200430900T patent/SI1594833T1/sl unknown
- 2004-02-19 KR KR1020117008239A patent/KR101152448B1/ko active IP Right Grant
- 2004-02-19 US US10/546,190 patent/US7662995B2/en active Active
- 2004-02-19 PT PT04712483T patent/PT1594833E/pt unknown
- 2004-02-19 JP JP2006501896A patent/JP4472691B2/ja not_active Expired - Lifetime
-
2005
- 2005-08-18 NO NO20053855A patent/NO333118B1/no not_active IP Right Cessation
-
2006
- 2006-07-07 HK HK06107643.0A patent/HK1087398A1/xx not_active IP Right Cessation
-
2008
- 2008-11-14 CY CY20081101310T patent/CY1108514T1/el unknown
-
2009
- 2009-12-24 US US12/647,069 patent/US8022250B2/en not_active Expired - Lifetime
-
2011
- 2011-08-08 US US13/204,989 patent/US8314268B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1087398A1 (en) | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases | |
WO2004006858A3 (en) | Compounds, compositions, and methods employing same | |
WO2006035237A3 (en) | Methods and compositions relating to alzheimer's disease | |
WO2005004803A3 (en) | Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease | |
WO2004062625A3 (en) | Macrocyclic beta-secretase inhibitors for treatment of alzheimer's disease | |
HRP20130602T1 (en) | 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases | |
GB0318447D0 (en) | Therapeutic agents | |
EP1562897A4 (en) | PHENYL ACARBOXAMIDE AS A BETA SEKRETASE INHIBITOR FOR THE TREATMENT OF ALZHEIMER | |
EP2213684A3 (en) | Nogo-a antibodies for the treatment of Alzheimer disease | |
GB0223038D0 (en) | Therapeutic compounds | |
WO2005004802A3 (en) | N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease | |
HK1092467A1 (en) | N-alkyl-hydroxamic acid-isoindolyl compounds and their pharmaceutical uses n- | |
IL216579A0 (en) | Aminocyclohexyl ether derivatives and pharmaceutical compositions containing the same | |
WO2005018545A3 (en) | Macrocyclic beta-secretase inhibitors for the treatment of alzheimer's disease | |
MY144616A (en) | Substituted dihydroquinazolines | |
AU2003231252A1 (en) | Methods and compositions for the treatment and prevention of intermittent claudication or alzheimer's disease | |
HK1104280A1 (en) | Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases | |
WO2005003103A3 (en) | 2, 4, 6-tri-substituted 6-membered heterocycles and their use in the treatment of neurodegenerative diseases | |
AU2002315131A1 (en) | Aminediols as agents for the treatment of alzheimer's disease | |
WO2007017146A3 (en) | Use of collismycin and derivatives thereof as oxidative stress inhibitors | |
IL167848A (en) | Use of brimonidine in the manufacture of a medicament for treating neurodegenerative conditions | |
WO2007048034A3 (en) | Use of androgens for the treatment of parkinson' s disease | |
WO2003024996A3 (de) | Antibakterielle makrozyklen | |
WO2005023288A8 (en) | Treatment of fibrotic disease | |
SI1656372T1 (sl) | Spojine 2,4-pirimidindiamina za uporabo pri zdravljenju ali preventivi avtoimunih bolezni |