HK1087398A1 - 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases - Google Patents

1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases

Info

Publication number
HK1087398A1
HK1087398A1 HK06107643.0A HK06107643A HK1087398A1 HK 1087398 A1 HK1087398 A1 HK 1087398A1 HK 06107643 A HK06107643 A HK 06107643A HK 1087398 A1 HK1087398 A1 HK 1087398A1
Authority
HK
Hong Kong
Prior art keywords
treatment
acid derivatives
neurodegenerative diseases
phenylalkanecarboxylic acid
phenylalkanecarboxylic
Prior art date
Application number
HK06107643.0A
Other languages
English (en)
Inventor
Luca Raveglia
Llaria Peretto
Stefano Radaelli
Bruno Pietro Imbimbo
Rizzi A Andrea
Gino Villetti
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI20030311 external-priority patent/ITMI20030311A1/it
Priority claimed from ITMI20032068 external-priority patent/ITMI20032068A1/it
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of HK1087398A1 publication Critical patent/HK1087398A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C15/00—Cyclic hydrocarbons containing only six-membered aromatic rings as cyclic parts
    • C07C15/12—Polycyclic non-condensed hydrocarbons
    • C07C15/14—Polycyclic non-condensed hydrocarbons all phenyl groups being directly linked
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
HK06107643.0A 2003-02-21 2006-07-07 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases HK1087398A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20030311 ITMI20030311A1 (it) 2003-02-21 2003-02-21 Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
ITMI20032068 ITMI20032068A1 (it) 2003-10-23 2003-10-23 Derivati dell'acido 1-fenilcicloalcancarbossilico per il trattamento delle malattie neurodegenerative.
PCT/EP2004/001596 WO2004074232A1 (en) 2003-02-21 2004-02-19 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases

Publications (1)

Publication Number Publication Date
HK1087398A1 true HK1087398A1 (en) 2006-10-13

Family

ID=32910543

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06107643.0A HK1087398A1 (en) 2003-02-21 2006-07-07 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases

Country Status (17)

Country Link
US (3) US7662995B2 (xx)
EP (1) EP1594833B1 (xx)
JP (1) JP4472691B2 (xx)
KR (2) KR101152448B1 (xx)
AT (1) ATE409176T1 (xx)
AU (1) AU2004213145B2 (xx)
BR (1) BRPI0407662B8 (xx)
CA (1) CA2514384C (xx)
CY (1) CY1108514T1 (xx)
DE (1) DE602004016729D1 (xx)
DK (1) DK1594833T3 (xx)
ES (1) ES2312964T3 (xx)
HK (1) HK1087398A1 (xx)
NO (1) NO333118B1 (xx)
PT (1) PT1594833E (xx)
SI (1) SI1594833T1 (xx)
WO (1) WO2004074232A1 (xx)

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AU2001257022B2 (en) * 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
EP1603548A4 (en) * 2003-02-05 2007-10-10 Myriad Genetics Inc COMPOSITION AND METHOD FOR TREATING NEURODEGENERATIVE DISORDERS
KR101152448B1 (ko) * 2003-02-21 2012-07-02 키에시 파르마슈티시 엣스. 피. 에이. 신경 퇴행성 질환의 치료를 위한 1-페닐알캔카복실산 추출물의 제조방법
AU2004311577A1 (en) * 2003-07-11 2005-07-21 Myriad Genetics, Inc. Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease
US20070293538A1 (en) * 2004-04-13 2007-12-20 Myriad Genetics, Incorporated Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders
MXPA06012165A (es) * 2004-04-29 2007-01-17 Keystone Retaining Wall System Chapas para muros, muros de contencion y similares.
US7531692B2 (en) 2004-08-03 2009-05-12 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases
WO2006020850A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020853A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
WO2006020852A2 (en) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Pharmaceutical composition and method for treating neurodegenerative disorders
KR20080039876A (ko) * 2005-07-22 2008-05-07 미리어드 제네틱스, 인크. 높은 약물 충진 제형 및 투여형
WO2008006099A2 (en) * 2006-07-07 2008-01-10 Myriad Genetics, Inc. Treatment of psychiatric disorders
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
RU2527177C2 (ru) 2007-12-20 2014-08-27 Энвиво Фармасьютикалз, Инк. Четырехзамещенные бензолы
EP2133322A1 (en) 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
MY152980A (en) * 2009-08-04 2014-12-15 Chiesi Farma Spa Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
MX336742B (es) 2010-02-03 2016-01-29 Infinity Pharmaceuticals Inc Inhibidores de amida hidrolasa de acido graso.
BR112012024247A2 (pt) * 2010-04-01 2016-07-12 Chiesi Farma Spa polimorfos cristalinos, sal ácido e composição farmacêutica
WO2011131661A1 (en) 2010-04-21 2011-10-27 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid derivatives for the therapy of transthyretin amyloidosis
BR112012028841A2 (pt) 2010-06-04 2016-07-26 Chiesi Farma Spa composto derivado do ácido 1-(2-fluobifenil-4-il) - ciclopropanocarboxílico para a terapia de doenças priônicas
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
BR112014023670A8 (pt) 2012-04-04 2017-07-25 Chiesi Farm Spa Composto, composição farmacêutica e suo de um composto
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
JP6064062B2 (ja) 2013-03-15 2017-01-18 ファイザー・インク Ａｍｐｋを活性化させるインダゾール化合物
EP2818460A1 (en) 2013-06-24 2014-12-31 ZaCh System S.p.A. Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
WO2014206898A1 (en) 2013-06-24 2014-12-31 Chiesi Farmaceutici S.P.A. Improved process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2015173133A1 (en) 2014-05-12 2015-11-19 Chiesi Farmaceutici S.P.A. Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy
US20150335596A1 (en) 2014-05-26 2015-11-26 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
MX2024002472A (es) 2021-08-31 2024-03-12 Cerespir Incorporated Cocristales.

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JPS5046669A (xx) 1973-03-28 1975-04-25
JPS58177977A (ja) 1982-04-09 1983-10-18 Grelan Pharmaceut Co Ltd ４−フエニルピラゾ−ル類
AU2936295A (en) * 1994-07-13 1996-02-16 Taisho Pharmaceutical Co., Ltd. Thiopheneacetic acid derivative
JPH0994680A (ja) * 1995-07-24 1997-04-08 Toyota Motor Corp 摩擦圧接装置
US5994379A (en) 1998-02-13 1999-11-30 Merck Frosst Canada, Inc. Bisaryl COX-2 inhibiting compounds, compositions and methods of use
AU2001257022B2 (en) 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
WO2004064771A2 (en) * 2003-01-14 2004-08-05 Merck & Co., Inc. Geminally di-substituted nsaid derivatives as abeta 42 lowering agents
KR101152448B1 (ko) * 2003-02-21 2012-07-02 키에시 파르마슈티시 엣스. 피. 에이. 신경 퇴행성 질환의 치료를 위한 1-페닐알캔카복실산 추출물의 제조방법
US7531692B2 (en) * 2004-08-03 2009-05-12 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenylalkanecarboxylic acids for the treatment of neurodegenerative diseases
EP2133322A1 (en) * 2008-06-11 2009-12-16 CHIESI FARMACEUTICI S.p.A. Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Also Published As

Publication number Publication date
US20110288175A1 (en) 2011-11-24
US8022250B2 (en) 2011-09-20
NO333118B1 (no) 2013-03-04
BRPI0407662B1 (pt) 2019-11-12
EP1594833B1 (en) 2008-09-24
ATE409176T1 (de) 2008-10-15
PT1594833E (pt) 2008-12-03
DK1594833T3 (da) 2008-12-15
WO2004074232A8 (en) 2005-09-09
AU2004213145B2 (en) 2010-05-13
BRPI0407662B8 (pt) 2021-05-25
KR20110057227A (ko) 2011-05-31
NO20053855D0 (no) 2005-08-18
DE602004016729D1 (de) 2008-11-06
KR101152448B1 (ko) 2012-07-02
KR101088272B1 (ko) 2011-11-30
US7662995B2 (en) 2010-02-16
EP1594833A1 (en) 2005-11-16
BRPI0407662A (pt) 2006-03-01
US20100099768A1 (en) 2010-04-22
US8314268B2 (en) 2012-11-20
SI1594833T1 (sl) 2008-12-31
NO20053855L (no) 2005-11-21
WO2004074232A1 (en) 2004-09-02
AU2004213145A1 (en) 2004-09-02
JP2006518351A (ja) 2006-08-10
CA2514384C (en) 2012-04-10
JP4472691B2 (ja) 2010-06-02
CY1108514T1 (el) 2014-04-09
US20070060752A1 (en) 2007-03-15
KR20050104369A (ko) 2005-11-02
ES2312964T3 (es) 2009-03-01
CA2514384A1 (en) 2004-09-02

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220219