BR112012024247A2 - polimorfos cristalinos, sal ácido e composição farmacêutica - Google Patents
polimorfos cristalinos, sal ácido e composição farmacêuticaInfo
- Publication number
- BR112012024247A2 BR112012024247A2 BR112012024247A BR112012024247A BR112012024247A2 BR 112012024247 A2 BR112012024247 A2 BR 112012024247A2 BR 112012024247 A BR112012024247 A BR 112012024247A BR 112012024247 A BR112012024247 A BR 112012024247A BR 112012024247 A2 BR112012024247 A2 BR 112012024247A2
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- acid salt
- crystalline polymorphs
- polymorphs
- crystalline
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/40—Unsaturated compounds containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10158954 | 2010-04-01 | ||
| PCT/EP2011/053694 WO2011120778A1 (en) | 2010-04-01 | 2011-03-11 | Novel polymorphs and salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012024247A2 true BR112012024247A2 (pt) | 2016-07-12 |
Family
ID=44079474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012024247A BR112012024247A2 (pt) | 2010-04-01 | 2011-03-11 | polimorfos cristalinos, sal ácido e composição farmacêutica |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US8673978B2 (pt) |
| EP (2) | EP2647618A1 (pt) |
| KR (1) | KR20130036210A (pt) |
| CN (2) | CN106431900A (pt) |
| AR (1) | AR081752A1 (pt) |
| BR (1) | BR112012024247A2 (pt) |
| CA (1) | CA2794940A1 (pt) |
| RU (1) | RU2573384C2 (pt) |
| WO (1) | WO2011120778A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9592210B2 (en) | 2011-12-22 | 2017-03-14 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment |
| WO2015173133A1 (en) * | 2014-05-12 | 2015-11-19 | Chiesi Farmaceutici S.P.A. | Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4368198A (en) * | 1976-03-03 | 1983-01-11 | Sumitomo Chemical Company Limited | Cephalosporins |
| ITMI20030311A1 (it) * | 2003-02-21 | 2004-08-22 | Chiesi Farma Spa | Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer. |
| EP1594833B1 (en) | 2003-02-21 | 2008-09-24 | CHIESI FARMACEUTICI S.p.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases |
| US20070078114A1 (en) | 2005-09-02 | 2007-04-05 | Myriad Genetics, Incorporated | Combination therapy for alzheimer's disease and other diseases |
| WO2008036733A2 (en) | 2006-09-19 | 2008-03-27 | Myriad Genetics, Inc. | Methods for treatment of vesicle transport disorders |
| EP2133322A1 (en) | 2008-06-11 | 2009-12-16 | CHIESI FARMACEUTICI S.p.A. | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
| WO2011015287A2 (en) | 2009-08-04 | 2011-02-10 | Chiesi Farmaceutici S.P.A. | Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
-
2011
- 2011-03-11 CN CN201610850785.0A patent/CN106431900A/zh active Pending
- 2011-03-11 BR BR112012024247A patent/BR112012024247A2/pt not_active IP Right Cessation
- 2011-03-11 CN CN2011800163408A patent/CN102869643A/zh active Pending
- 2011-03-11 WO PCT/EP2011/053694 patent/WO2011120778A1/en active Application Filing
- 2011-03-11 RU RU2012141644/04A patent/RU2573384C2/ru not_active IP Right Cessation
- 2011-03-11 KR KR1020127025179A patent/KR20130036210A/ko active Search and Examination
- 2011-03-11 CA CA2794940A patent/CA2794940A1/en not_active Abandoned
- 2011-03-11 EP EP13172571.5A patent/EP2647618A1/en not_active Withdrawn
- 2011-03-11 EP EP11712195A patent/EP2552881A1/en not_active Withdrawn
- 2011-03-31 AR ARP110101069A patent/AR081752A1/es unknown
- 2011-04-01 US US13/078,039 patent/US8673978B2/en not_active Expired - Fee Related
-
2014
- 2014-01-23 US US14/162,038 patent/US20140135399A1/en not_active Abandoned
-
2016
- 2016-03-17 US US15/072,567 patent/US20160193165A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2794940A1 (en) | 2011-10-06 |
| EP2552881A1 (en) | 2013-02-06 |
| RU2012141644A (ru) | 2014-04-10 |
| CN102869643A (zh) | 2013-01-09 |
| US20110245346A1 (en) | 2011-10-06 |
| EP2647618A1 (en) | 2013-10-09 |
| US20160193165A1 (en) | 2016-07-07 |
| AR081752A1 (es) | 2012-10-17 |
| KR20130036210A (ko) | 2013-04-11 |
| US20140135399A1 (en) | 2014-05-15 |
| US8673978B2 (en) | 2014-03-18 |
| RU2573384C2 (ru) | 2016-01-20 |
| CN106431900A (zh) | 2017-02-22 |
| WO2011120778A1 (en) | 2011-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |