UY24835A1 - Forma de dosificacion farmaceutica que enmascara el sabor y que se libera rapidamente - Google Patents
Forma de dosificacion farmaceutica que enmascara el sabor y que se libera rapidamenteInfo
- Publication number
- UY24835A1 UY24835A1 UY24835A UY24835A UY24835A1 UY 24835 A1 UY24835 A1 UY 24835A1 UY 24835 A UY24835 A UY 24835A UY 24835 A UY24835 A UY 24835A UY 24835 A1 UY24835 A1 UY 24835A1
- Authority
- UY
- Uruguay
- Prior art keywords
- flavor
- core
- layer
- masking
- masks
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención proporciona una forma de dosificación farmacéutica que enmascara el sabor y que se libera rápidamente, comprendiendo un núcleo que contiene un ingrediente farmacéuticamente activo, hidroxipropilcelulosa poco sustituida y celulosa microcristalina, siendo la cantidad de la celulosa microcristalina por lo menos un 26,0% en peso, basado en el peso total del núcleo, una capa de un recubrimiento interior, formada sobre el núcleo que contiene un polímero soluble en agua, y una capa de recubrimiento exterior, formada sobre la capa del recubrimiento interior y que contiene un polímero insoluble en la saliva. La capa enmascarante del sabor puede causar perfiles bajos de liberación del fármaco, por lo que es difícil que el diseno de la formulación proporcione formas de dosificacion que tengan buenas propiedades de enmascaramiento del sabor y buenas propiedades de liberación del fármaco. Esta invención si logra ambos cometidos, comprendiendo un núcleo y una capa de recubrimiento interior antes definidas. La capa exterior es la que enmascara el sabor para evitar que un ingrediente activo sea liberado cuabdo el paciente retenga en su boca un fármaco recubierto, la capa adecuada de recubrimiento comprende 70.0 a 100% en peso de un polímero insoluble o soluble en agua , basándose en los porcentajes en el peso total de la capa de recubrimiento
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB9700003 | 1997-01-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY24835A1 true UY24835A1 (es) | 2000-09-29 |
Family
ID=11004515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY24835A UY24835A1 (es) | 1997-01-06 | 1998-01-02 | Forma de dosificacion farmaceutica que enmascara el sabor y que se libera rapidamente |
Country Status (36)
Country | Link |
---|---|
EP (1) | EP0941075B1 (es) |
JP (1) | JP3350059B2 (es) |
KR (1) | KR20000069899A (es) |
CN (1) | CN1244119A (es) |
AP (1) | AP802A (es) |
AR (1) | AR008553A1 (es) |
AT (1) | ATE238776T1 (es) |
AU (1) | AU715867B2 (es) |
BG (1) | BG103541A (es) |
BR (1) | BR9714253A (es) |
CA (1) | CA2277017C (es) |
CO (1) | CO4650099A1 (es) |
DE (1) | DE69721559T2 (es) |
DK (1) | DK0941075T3 (es) |
EA (1) | EA199900521A1 (es) |
ES (1) | ES2192265T3 (es) |
HN (1) | HN1997000151A (es) |
HR (1) | HRP980005A2 (es) |
HU (1) | HUP0002744A3 (es) |
ID (1) | ID21806A (es) |
IL (1) | IL130582A0 (es) |
IS (1) | IS5095A (es) |
MA (1) | MA26464A1 (es) |
NO (1) | NO993315D0 (es) |
NZ (1) | NZ336251A (es) |
OA (1) | OA11072A (es) |
PA (1) | PA8443301A1 (es) |
PE (1) | PE27999A1 (es) |
PL (1) | PL334439A1 (es) |
SK (1) | SK89599A3 (es) |
TN (1) | TNSN98002A1 (es) |
TR (1) | TR199901564T2 (es) |
UY (1) | UY24835A1 (es) |
WO (1) | WO1998030209A1 (es) |
YU (1) | YU31599A (es) |
ZA (1) | ZA9829B (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6200591B1 (en) | 1998-06-25 | 2001-03-13 | Anwar A. Hussain | Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction |
DE19834506A1 (de) * | 1998-07-31 | 2000-02-03 | Hexal Ag | Transmucosales therapeutisches System zur Anwendung von Sildenafil |
DE19834507A1 (de) * | 1998-07-31 | 2000-02-03 | Hexal Ag | Pharmazeutische, wasserlösliche Tablettenformulierung zur Anwendung von Sildenafil |
UA67802C2 (uk) * | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції |
ES2601855T3 (es) * | 1998-11-25 | 2017-02-16 | Cima Labs Inc. | Comprimido de liberación rápida con núcleo recubierto que contiene el fármaco y capa circundante de enmascaramiento del sabor |
FR2795962B1 (fr) * | 1999-07-08 | 2003-05-09 | Prographarm Laboratoires | Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif |
KR100610131B1 (ko) | 2000-09-06 | 2006-08-09 | 다나베 세이야꾸 가부시키가이샤 | 경구 투여용 제제 |
GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
AR034813A1 (es) * | 2001-07-20 | 2004-03-17 | Novartis Ag | Composiciones farmaceuticas y uso de las mismas |
SE0202365D0 (sv) * | 2002-08-05 | 2002-08-05 | Pharmacia Ab | New formulation and use thereof |
CZ23088U1 (cs) | 2004-03-25 | 2011-12-19 | Astellas Pharma Inc. | Kompozice pevného farmaceutického prípravku solifenacinu nebo jeho soli |
BG66010B1 (bg) * | 2004-12-08 | 2010-10-29 | "Софарма" Ад | Лекарствена форма на силденафил |
ATE500822T1 (de) * | 2005-01-06 | 2011-03-15 | Cima Labs Inc | Geschmacksunterdrückungssystem für nicht weichgemachte arzneimittel |
EP1911444A1 (en) * | 2005-07-20 | 2008-04-16 | Astellas Pharma Inc. | Drug-containing coated fine particle for intrabuccally disintegrating preparation and method of producing the same |
US7815939B2 (en) | 2005-07-20 | 2010-10-19 | Astellas Pharma Inc. | Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms |
JP2007031407A (ja) | 2005-07-29 | 2007-02-08 | Shin Etsu Chem Co Ltd | 低置換度セルロースエーテル含有コーティング用組成物及び不快な味が隠蔽されたフィルムコーティング製剤 |
US20070098746A1 (en) * | 2005-11-02 | 2007-05-03 | Nichols William M | Multi-layered coating technology for taste masking |
JP4602949B2 (ja) * | 2006-08-02 | 2010-12-22 | 和光堂株式会社 | 被覆粒子含有組成物及びその製造方法 |
TWI419708B (zh) * | 2006-11-14 | 2013-12-21 | Sunstar Inc | And an oral composition containing crystalline cellulose which is surface-treated with a water-soluble substance |
JP5777273B2 (ja) * | 2008-07-10 | 2015-09-09 | 大正製薬株式会社 | 不快な呈味を有する薬物を含有する製剤粒子 |
US20100136110A1 (en) * | 2008-09-30 | 2010-06-03 | Astellas Pharma Inc. | Granular pharmaceutical composition for oral administration |
WO2010067140A1 (es) | 2008-12-12 | 2010-06-17 | Siegfried Rhein S.A. De C.V. | Composicion de liberacion pulsatil de sildenafil y proceso para prepararla |
DE102009016584A1 (de) | 2009-04-06 | 2010-10-07 | Ratiopharm Gmbh | Schmelztablette, enthaltend ein Sildenafil-Salz |
JP5933268B2 (ja) * | 2009-12-28 | 2016-06-08 | ニプロ株式会社 | 品質が向上した経口剤 |
JP5226732B2 (ja) * | 2010-05-20 | 2013-07-03 | エスエス製薬株式会社 | 催眠用圧縮成型製剤 |
TWI462739B (zh) * | 2010-11-02 | 2014-12-01 | Univ Kaohsiung Medical | Sildenafil-同族物四級銨哌嗪鹽類之製備及醫療用途 |
GB201119985D0 (en) * | 2011-11-19 | 2012-01-04 | Diurnal Ltd | Treatment of adrenal insufficiency |
CN103271940B (zh) * | 2013-05-03 | 2014-03-12 | 湖北新济药业有限公司 | 复方金属离子补充剂及其制备方法 |
EP3421032A4 (en) * | 2016-02-23 | 2019-10-23 | Nipro Corporation | PARTICULARS OF A PHARMACEUTICAL COMPOSITION, ORAL DECOMPOSITION PREPARATION THEREOF AND METHOD FOR PRODUCING PARTICLES OF A PHARMACEUTICAL COMPOSITION |
US20210196635A1 (en) * | 2018-08-28 | 2021-07-01 | Towa Pharmaceutical Co., Ltd. | Drug-containing particle |
CN113559070B (zh) * | 2021-08-18 | 2022-12-06 | 广州中冠动物药业有限公司 | 一种适用于宠物咳嗽的药物制备方法 |
CN116139088B (zh) * | 2023-01-31 | 2024-04-16 | 南京海纳医药科技股份有限公司 | 一种含有枸橼酸西地那非的干混悬剂及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63258809A (ja) * | 1987-04-16 | 1988-10-26 | Towa Yakuhin Kk | 医薬活性成分の放出性にすぐれ、かつ苦味を隠蔽した細粒剤 |
EP0458751A1 (en) * | 1990-05-25 | 1991-11-27 | Warner-Lambert Company | Delivery system for cyclic amino acids with improved taste, texture and compressibility |
JP2576927B2 (ja) * | 1992-05-15 | 1997-01-29 | ファイザー製薬株式会社 | 細粒核 |
CZ289804B6 (cs) * | 1994-07-08 | 2002-04-17 | Astrazeneca Ab | Multijednotková tabletovaná dávková forma I |
-
1997
- 1997-11-20 HU HU0002744A patent/HUP0002744A3/hu unknown
- 1997-11-20 AT AT97911402T patent/ATE238776T1/de not_active IP Right Cessation
- 1997-11-20 DE DE69721559T patent/DE69721559T2/de not_active Expired - Fee Related
- 1997-11-20 WO PCT/IB1997/001471 patent/WO1998030209A1/en active IP Right Grant
- 1997-11-20 JP JP53068398A patent/JP3350059B2/ja not_active Expired - Fee Related
- 1997-11-20 NZ NZ336251A patent/NZ336251A/xx unknown
- 1997-11-20 DK DK97911402T patent/DK0941075T3/da active
- 1997-11-20 EP EP97911402A patent/EP0941075B1/en not_active Expired - Lifetime
- 1997-11-20 BR BR9714253-0A patent/BR9714253A/pt not_active Application Discontinuation
- 1997-11-20 AU AU48808/97A patent/AU715867B2/en not_active Ceased
- 1997-11-20 ID IDW990633A patent/ID21806A/id unknown
- 1997-11-20 SK SK895-99A patent/SK89599A3/sk unknown
- 1997-11-20 TR TR1999/01564T patent/TR199901564T2/xx unknown
- 1997-11-20 YU YU31599A patent/YU31599A/sh unknown
- 1997-11-20 ES ES97911402T patent/ES2192265T3/es not_active Expired - Lifetime
- 1997-11-20 IL IL13058297A patent/IL130582A0/xx unknown
- 1997-11-20 EA EA199900521A patent/EA199900521A1/ru unknown
- 1997-11-20 CA CA002277017A patent/CA2277017C/en not_active Expired - Lifetime
- 1997-11-20 PL PL97334439A patent/PL334439A1/xx unknown
- 1997-11-20 CN CN97181252A patent/CN1244119A/zh active Pending
- 1997-11-20 KR KR1019997006093A patent/KR20000069899A/ko not_active Application Discontinuation
- 1997-11-21 HN HN1997000151A patent/HN1997000151A/es unknown
- 1997-12-18 CO CO97073877A patent/CO4650099A1/es unknown
- 1997-12-19 PA PA19978443301A patent/PA8443301A1/es unknown
- 1997-12-30 PE PE1997001188A patent/PE27999A1/es not_active Application Discontinuation
-
1998
- 1998-01-02 UY UY24835A patent/UY24835A1/es unknown
- 1998-01-05 ZA ZA9829A patent/ZA9829B/xx unknown
- 1998-01-05 HR HRPCT/IB97/00003A patent/HRP980005A2/hr not_active Application Discontinuation
- 1998-01-05 AR ARP980100030A patent/AR008553A1/es not_active Application Discontinuation
- 1998-01-05 MA MA24919A patent/MA26464A1/fr unknown
- 1998-01-05 TN TNTNSN98002A patent/TNSN98002A1/fr unknown
- 1998-01-06 AP APAP/P/1998/001173A patent/AP802A/en active
-
1999
- 1999-06-25 IS IS5095A patent/IS5095A/is unknown
- 1999-06-30 BG BG103541A patent/BG103541A/xx unknown
- 1999-07-02 OA OA9900150A patent/OA11072A/en unknown
- 1999-07-05 NO NO993315A patent/NO993315D0/no not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ABAN | Application deemed to be withdrawn (no publication fee paid) |
Effective date: 20090526 |