ES2054174T3 - Preparado farmaceutico de particulas para via oral que se liberan rapidamente con un sabor desagradable enmascarado. - Google Patents

Preparado farmaceutico de particulas para via oral que se liberan rapidamente con un sabor desagradable enmascarado.

Info

Publication number
ES2054174T3
ES2054174T3 ES90113942T ES90113942T ES2054174T3 ES 2054174 T3 ES2054174 T3 ES 2054174T3 ES 90113942 T ES90113942 T ES 90113942T ES 90113942 T ES90113942 T ES 90113942T ES 2054174 T3 ES2054174 T3 ES 2054174T3
Authority
ES
Spain
Prior art keywords
particles
unpleasant
pharmaceutical preparation
oral use
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90113942T
Other languages
English (en)
Inventor
Yoshimi Shirai
Kiyomi Sogo
Yasuhiko Nakamura
Hiroshi Fujioka
Hirokazu Makita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Pharmaceutical Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2054174T3 publication Critical patent/ES2054174T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPRENDE UN NUCLEO CON UNA PELICULA QUE LO RECUBRE. EL NUCLEO CONTIENE UNA DROGA CON SABOR DESAGRADABLE Y UN AGENTE PARA INGERIRLO CON AGUA, LA CAPA DE RECUBRIMIENTO CONTIENE AL MENOS ETILCELULOSA Y UNA SUSTANCIA SOLUBLE EN AGUA, LA CANTIDAD DE DROGA EN EL NUCLEO SERA COMO MAXIMO DEL 40% (BASADO EN LA PREPRACION FINAL DE LAS PARTICULAS), LA CANTIDAD DE AGENTE DIGERIBLE CON AGUA SERA DESDE EL 35% HASTA EL 70%, LA CANTIDAD DE ETILCELULOSA EN LA PELICULA COBERTORA SERA DE ENTRE EL 3 Y EL 11 %, Y LA CANTIDAD DE SUSTANCIA SOLUBLE EN AGUA SERA ENTRE 0.1 Y 0.8 VECES EL PESO DE LA ETILCELULOSA.
ES90113942T 1989-07-20 1990-07-20 Preparado farmaceutico de particulas para via oral que se liberan rapidamente con un sabor desagradable enmascarado. Expired - Lifetime ES2054174T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19000989 1989-07-20

Publications (1)

Publication Number Publication Date
ES2054174T3 true ES2054174T3 (es) 1994-08-01

Family

ID=16250859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90113942T Expired - Lifetime ES2054174T3 (es) 1989-07-20 1990-07-20 Preparado farmaceutico de particulas para via oral que se liberan rapidamente con un sabor desagradable enmascarado.

Country Status (5)

Country Link
US (1) US5082669A (es)
EP (1) EP0409254B1 (es)
CA (1) CA2021574C (es)
DE (1) DE69000997T2 (es)
ES (1) ES2054174T3 (es)

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US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
JP2000508339A (ja) * 1996-10-01 2000-07-04 シーマ・ラブス・インコーポレイテッド 味隠蔽マイクロカプセル組成物及び製造方法
NZ503086A (en) 1997-08-29 2002-03-01 Upjohn Co An orally administrable pharmaceutical composition comprising an inner core and two outer layers, which render it substantially free of unpleasant tastes
US6221402B1 (en) 1997-11-20 2001-04-24 Pfizer Inc. Rapidly releasing and taste-masking pharmaceutical dosage form
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
DE19961897A1 (de) * 1999-12-20 2001-06-28 Basf Ag Verwendung eines Filmüberzuges als geschmacksmaskierendes Coating von pharmazeutischen Darreichungsformen
US6451345B1 (en) 2000-01-20 2002-09-17 Eurand Pharmaceuticals Ltd. Functional coating of linezolid microcapsules for taste-masking and associated formulation for oral administration
EP1286663B1 (en) * 2000-05-18 2006-01-18 Therics, Inc. Encapsulating a toxic core within a non-toxic region in an oral dosage form
GB0025208D0 (en) * 2000-10-13 2000-11-29 Euro Celtique Sa Delayed release pharmaceutical formulations
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US20030070584A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
US6592901B2 (en) * 2001-10-15 2003-07-15 Hercules Incorporated Highly compressible ethylcellulose for tableting
US20040208936A1 (en) * 2002-07-22 2004-10-21 Roland Chorin Novel compositions
US7429619B2 (en) * 2002-08-02 2008-09-30 Mcneil Consumer Healthcare Polyacrylic film forming compositions
US8367111B2 (en) * 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
KR101004187B1 (ko) * 2003-01-13 2010-12-24 다이닛본 스미토모 세이야꾸 가부시끼가이샤 1,2-디클로로에탄 프리 조니사미드 결정 및 고순도조니사미드 결정의 제조방법
US20040258752A1 (en) * 2003-01-31 2004-12-23 Paruthi Manoj Kumar Taste masking pharmaceutical composition and process for its preparation
US20040191326A1 (en) * 2003-03-31 2004-09-30 Reo Joseph P. Taste-masking vehicle for coated oxazolidinone particles
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
US20050175689A1 (en) * 2003-10-27 2005-08-11 Yamanouchi Pharmaceutical Co., Ltd. Coated fine particles containing drug for intrabuccally fast disintegrating tablet
GB0403628D0 (en) * 2004-02-18 2004-03-24 Arrow Group Ltd Compression-coated tablets and the manufacture thereof
KR101156406B1 (ko) * 2004-03-25 2012-06-13 아스텔라스세이야쿠 가부시키가이샤 솔리페나신 또는 그의 염의 고형 제제용 조성물
MXPA06011765A (es) * 2004-04-12 2006-12-15 Pfizer Prod Inc Farmacos de sabor enmascarado en multiparticulados que se rompen.
US8545881B2 (en) * 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
US8747895B2 (en) * 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ589750A (en) 2004-10-21 2012-07-27 Aptalis Pharmatech Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
CN101141961B (zh) * 2004-12-27 2011-07-06 安斯泰来制药株式会社 索非那新或其盐的稳定的颗粒状药物组合物
EP1913935A1 (en) * 2005-01-21 2008-04-23 Teva Pharmaceutical Industries Ltd Stable pharmaceutical formulations of zonisamide and methods for their manufacture
CA2595483A1 (en) * 2005-01-21 2006-07-27 Teva Pharmaceutical Industries Ltd. Stable pharmaceutical formulations of zonisamide and methods for their manufacture
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US7815939B2 (en) * 2005-07-20 2010-10-19 Astellas Pharma Inc. Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms
US20070286903A1 (en) * 2006-06-13 2007-12-13 Becicka Brian T Composition and method for taste masking
US11116728B2 (en) 2006-11-30 2021-09-14 Bend Research, Inc. Multiparticulates of spray-coated drug and polymer on a meltable core
US10357462B2 (en) * 2006-11-30 2019-07-23 Ben Research, Inc. Multiparticulates of spray-coated drug and polymer on a meltable core
US20080260836A1 (en) * 2007-04-18 2008-10-23 Thomas James Boyd Films Comprising a Plurality of Polymers
EP2486917B1 (en) * 2009-10-09 2020-11-25 Asahi Kasei Kabushiki Kaisha Coating film, and granules and tablets each utilizing same
TWI471146B (zh) 2009-12-02 2015-02-01 Aptalis Pharma Ltd 菲索特芬那定（ｆｅｘｏｆｅｎａｄｉｎｅ）微膠囊及包含其之組合物
AR079862A1 (es) * 2010-01-08 2012-02-22 Eurand Inc Composicion de topiramato con sabor enmascarado, un comprimido desintegrable oralmente que comprende la misma y metodo de preparacion
CA2843100A1 (en) 2011-08-12 2013-02-21 Boehringer Ingelheim Vetmedica Gmbh Funny current (if) inhibitors for use in a method of treating and preventing heart failure in feline
CN104274408A (zh) * 2013-07-10 2015-01-14 北京科信必成医药科技发展有限公司 一种熔融包衣的速释药物微粒及其制备方法
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ITUA20163981A1 (it) * 2016-05-31 2017-12-01 Zambon Spa Composizioni farmaceutiche comprendenti safinamide
US10653690B1 (en) 2019-07-09 2020-05-19 Orexo Ab Pharmaceutical composition for nasal delivery
US10729687B1 (en) 2019-07-09 2020-08-04 Orexo Ab Pharmaceutical composition for nasal delivery
SI3962455T1 (sl) 2020-05-18 2022-11-30 Orexo Ab Nov farmacevtski sestavek za dostavo zdravil
EP4236921A1 (en) 2021-11-25 2023-09-06 Orexo AB Pharmaceutical composition comprising adrenaline

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FR1426194A (fr) * 1964-10-20 1966-01-28 Ile De France Nouvelle technique d'enrobage des comprimés
JPS5840529B2 (ja) * 1975-09-29 1983-09-06 明治製菓株式会社 ケイコウヨウセイザイノセイホウ
JPS5758631A (en) * 1980-09-24 1982-04-08 Toyo Jozo Co Ltd Coating composition
JPS5858146A (ja) * 1981-10-05 1983-04-06 Tanabe Seiyaku Co Ltd 速放性マイクロカプセル
GB8518301D0 (en) * 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
JPS63188621A (ja) * 1987-01-30 1988-08-04 Taisho Pharmaceut Co Ltd 矯味経口製剤
JPS63258809A (ja) * 1987-04-16 1988-10-26 Towa Yakuhin Kk 医薬活性成分の放出性にすぐれ、かつ苦味を隠蔽した細粒剤

Also Published As

Publication number Publication date
DE69000997D1 (de) 1993-04-08
DE69000997T2 (de) 1993-07-15
US5082669A (en) 1992-01-21
CA2021574C (en) 2000-05-23
EP0409254A1 (en) 1991-01-23
CA2021574A1 (en) 1991-01-21
EP0409254B1 (en) 1993-03-03

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