ATE450259T1 - Orale dosierungsform enthaltend einen therapeutischen wirkstoff und einen gegenwirdenden wirkstoff - Google Patents
Orale dosierungsform enthaltend einen therapeutischen wirkstoff und einen gegenwirdenden wirkstoffInfo
- Publication number
- ATE450259T1 ATE450259T1 AT02761250T AT02761250T ATE450259T1 AT E450259 T1 ATE450259 T1 AT E450259T1 AT 02761250 T AT02761250 T AT 02761250T AT 02761250 T AT02761250 T AT 02761250T AT E450259 T1 ATE450259 T1 AT E450259T1
- Authority
- AT
- Austria
- Prior art keywords
- active ingredient
- dosage form
- oral dosage
- counteractive
- soluble layer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30979101P | 2001-08-06 | 2001-08-06 | |
US10/208,817 US20030044458A1 (en) | 2001-08-06 | 2002-08-01 | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
PCT/US2002/024889 WO2003013538A1 (en) | 2001-08-06 | 2002-08-05 | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE450259T1 true ATE450259T1 (de) | 2009-12-15 |
Family
ID=23199688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02761250T ATE450259T1 (de) | 2001-08-06 | 2002-08-05 | Orale dosierungsform enthaltend einen therapeutischen wirkstoff und einen gegenwirdenden wirkstoff |
Country Status (19)
Country | Link |
---|---|
US (3) | US20030044458A1 (de) |
EP (1) | EP1414459B1 (de) |
JP (3) | JP5143995B2 (de) |
KR (2) | KR20090005247A (de) |
AT (1) | ATE450259T1 (de) |
AU (1) | AU2008202531A1 (de) |
BR (1) | BR0211781A (de) |
CA (1) | CA2456601C (de) |
CY (1) | CY1109816T1 (de) |
DE (1) | DE20220838U1 (de) |
DK (1) | DK1414459T3 (de) |
ES (1) | ES2337664T3 (de) |
HK (1) | HK1067524A1 (de) |
HU (1) | HUP0401066A2 (de) |
MX (1) | MXPA04001098A (de) |
PT (1) | PT1414459E (de) |
RU (1) | RU2004106620A (de) |
SI (1) | SI1414459T1 (de) |
WO (1) | WO2003013538A1 (de) |
Families Citing this family (185)
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DE60238756D1 (de) | 2001-05-11 | 2011-02-10 | Endo Pharmaceuticals Inc | Opioid enthaltende arzneiform gegen missbrauch |
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BR0205721A (pt) * | 2001-07-06 | 2003-09-30 | Endo Pharmaceuticals Inc | Formulações de oximorfona de liberação controlada |
US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
US20030044458A1 (en) * | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
US20030091635A1 (en) * | 2001-09-26 | 2003-05-15 | Baichwal Anand R. | Opioid formulations having reduced potential for abuse |
CA2478523A1 (en) * | 2002-04-05 | 2003-10-16 | Euro-Celtique S.A. | Matrix for sustained, invariant and independent release of active compounds |
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-
2002
- 2002-08-01 US US10/208,817 patent/US20030044458A1/en not_active Abandoned
- 2002-08-05 EP EP02761250A patent/EP1414459B1/de not_active Expired - Lifetime
- 2002-08-05 ES ES02761250T patent/ES2337664T3/es not_active Expired - Lifetime
- 2002-08-05 RU RU2004106620/15A patent/RU2004106620A/ru not_active Application Discontinuation
- 2002-08-05 PT PT02761250T patent/PT1414459E/pt unknown
- 2002-08-05 CA CA2456601A patent/CA2456601C/en not_active Expired - Lifetime
- 2002-08-05 HU HU0401066A patent/HUP0401066A2/hu unknown
- 2002-08-05 AT AT02761250T patent/ATE450259T1/de active
- 2002-08-05 WO PCT/US2002/024889 patent/WO2003013538A1/en active Application Filing
- 2002-08-05 DE DE20220838U patent/DE20220838U1/de not_active Expired - Lifetime
- 2002-08-05 KR KR1020087030854A patent/KR20090005247A/ko not_active Application Discontinuation
- 2002-08-05 JP JP2003518547A patent/JP5143995B2/ja not_active Expired - Lifetime
- 2002-08-05 KR KR1020047001854A patent/KR100893895B1/ko active IP Right Grant
- 2002-08-05 SI SI200230884T patent/SI1414459T1/sl unknown
- 2002-08-05 MX MXPA04001098A patent/MXPA04001098A/es active IP Right Grant
- 2002-08-05 BR BR0211781-9A patent/BR0211781A/pt not_active Application Discontinuation
- 2002-08-05 DK DK02761250.6T patent/DK1414459T3/da active
-
2004
- 2004-09-23 US US10/948,575 patent/US7384653B2/en not_active Ceased
- 2004-11-03 HK HK04108654.6A patent/HK1067524A1/xx not_active IP Right Cessation
-
2008
- 2008-06-06 AU AU2008202531A patent/AU2008202531A1/en not_active Abandoned
- 2008-11-19 JP JP2008295477A patent/JP5485538B2/ja not_active Expired - Fee Related
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2010
- 2010-02-12 CY CY20101100149T patent/CY1109816T1/el unknown
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2013
- 2013-05-13 JP JP2013101285A patent/JP2013189447A/ja active Pending
- 2013-10-28 US US13/923,362 patent/USRE45822E1/en active Active
Also Published As
Publication number | Publication date |
---|---|
HK1067524A1 (en) | 2005-04-15 |
WO2003013538A1 (en) | 2003-02-20 |
HUP0401066A2 (hu) | 2004-08-30 |
US20030044458A1 (en) | 2003-03-06 |
PT1414459E (pt) | 2010-03-03 |
MXPA04001098A (es) | 2004-05-20 |
US7384653B2 (en) | 2008-06-10 |
KR100893895B1 (ko) | 2009-04-20 |
CA2456601C (en) | 2012-04-24 |
USRE45822E1 (en) | 2015-12-22 |
US20050063909A1 (en) | 2005-03-24 |
RU2004106620A (ru) | 2005-04-10 |
CA2456601A1 (en) | 2003-02-20 |
DE20220838U1 (de) | 2004-05-19 |
EP1414459A1 (de) | 2004-05-06 |
DK1414459T3 (da) | 2010-04-12 |
ES2337664T3 (es) | 2010-04-28 |
JP5485538B2 (ja) | 2014-05-07 |
JP5143995B2 (ja) | 2013-02-13 |
JP2013189447A (ja) | 2013-09-26 |
JP2009132711A (ja) | 2009-06-18 |
KR20090005247A (ko) | 2009-01-12 |
JP2005520783A (ja) | 2005-07-14 |
CY1109816T1 (el) | 2014-09-10 |
SI1414459T1 (sl) | 2010-04-30 |
BR0211781A (pt) | 2004-07-27 |
AU2008202531A1 (en) | 2008-07-03 |
KR20040043181A (ko) | 2004-05-22 |
EP1414459B1 (de) | 2009-12-02 |
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