EA200700055A1 - Препаративные формы пероральных лекарственных форм мемантина с немедленным высвобождением - Google Patents

Препаративные формы пероральных лекарственных форм мемантина с немедленным высвобождением

Info

Publication number
EA200700055A1
EA200700055A1 EA200700055A EA200700055A EA200700055A1 EA 200700055 A1 EA200700055 A1 EA 200700055A1 EA 200700055 A EA200700055 A EA 200700055A EA 200700055 A EA200700055 A EA 200700055A EA 200700055 A1 EA200700055 A1 EA 200700055A1
Authority
EA
Eurasian Patent Office
Prior art keywords
forms
memantine
preparative
formal
oral
Prior art date
Application number
EA200700055A
Other languages
English (en)
Other versions
EA011290B1 (ru
Inventor
Ян Янг
Раджив Джанджикхел
Нираньян Рао
Антонио Периклоу
Ваттанапорн Абрамовитц
Махендра Г. Дедихия
Эрхард Зайллер
Бернхард Хауптмайер
Original Assignee
Мерц Фарма Гмбх Унд Ко. Кгаа
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерц Фарма Гмбх Унд Ко. Кгаа filed Critical Мерц Фарма Гмбх Унд Ко. Кгаа
Publication of EA200700055A1 publication Critical patent/EA200700055A1/ru
Publication of EA011290B1 publication Critical patent/EA011290B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к твердой пероральной лекарственной форме с немедленным высвобождением, содержащей 1-аминоциклогексаны, предпочтительно мемантин или нерамексан, и необязательно фармацевтически приемлемое покрытие, где активный ингредиент проявляет пропорциональность дозы и высвобождается со скоростью растворения более приблизительно 80% в пределах первых приблизительно 60 мин после поступления указанной формы в среду применения. Лекарственная форма подвергается прямому прессованию и имеет твердость от приблизительно 3 до приблизительно 40 Kр, показывает среднее Tот приблизительно 2 до приблизительно 8 ч с нагрузкой активного ингредиента от приблизительно 2,5 до приблизительно 150 мг. Препаративная форма позволяет создавать композиции с пропорциональными дозами для приема один или два раза в день, а также поддерживать устойчивый средний диапазон T.
EA200700055A 2004-06-17 2005-06-16 Препаративные формы пероральных лекарственных форм мемантина с немедленным высвобождением EA011290B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58124404P 2004-06-17 2004-06-17
PCT/US2005/021284 WO2006096194A2 (en) 2004-06-17 2005-06-16 Drinkable immediate release tablet made with direct compression of memantine or neramexane

Publications (2)

Publication Number Publication Date
EA200700055A1 true EA200700055A1 (ru) 2007-10-26
EA011290B1 EA011290B1 (ru) 2009-02-27

Family

ID=36953777

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700055A EA011290B1 (ru) 2004-06-17 2005-06-16 Препаративные формы пероральных лекарственных форм мемантина с немедленным высвобождением

Country Status (11)

Country Link
EP (3) EP2601937A1 (ru)
JP (1) JP5025468B2 (ru)
KR (1) KR20090033410A (ru)
CN (1) CN101389315A (ru)
AU (1) AU2005328701B2 (ru)
BR (1) BRPI0512263A (ru)
CA (1) CA2568445C (ru)
EA (1) EA011290B1 (ru)
ES (1) ES2483126T3 (ru)
IL (1) IL179992A (ru)
WO (1) WO2006096194A2 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2203163B1 (en) 2007-09-12 2014-08-27 Merz Pharma GmbH & Co. KGaA Titration package for neramexane and its use in the treatment of an inner ear disorder
US20120116125A1 (en) * 2009-06-29 2012-05-10 Merz Pharma Gmbh & Co. Kgaa Method of preparing neramexane
SI2448910T1 (sl) * 2009-06-29 2013-07-31 Merz Pharma Gmbh & Co. Kgaa Postopek za pripravo nerameksana
US20120130131A1 (en) * 2009-06-29 2012-05-24 Herbert Koller Method of preparing 1-amino-1,3,3,5,5-pentamethylcyclohexane
EP2316434A1 (en) * 2009-10-22 2011-05-04 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Orally disintegrating tablets of memantine
US20110294890A1 (en) * 2010-05-28 2011-12-01 Merz Pharma Gmbh & Co. Kgaa Neramexane for the treatment or prevention of inner ear disorders
WO2011160839A1 (en) * 2010-06-24 2011-12-29 Merz Pharma Gmbh & Co. Kgaa Neramexane multiple unit dosage form
WO2012048871A1 (en) 2010-10-12 2012-04-19 Merz Pharma Gmbh & Co. Kgaa Memantine for improving cognitive performance in subjects
MX2013004123A (es) 2010-10-12 2013-12-16 Univ Johns Hopkins Composiciones antitusigenas que comprenden memantina.
EP2526925A1 (en) 2011-05-23 2012-11-28 Deva Holding Anonim Sirketi A dose adjustable oral pump spray or aerosol spray containing memantine
CN107334744B (zh) * 2017-07-24 2020-09-04 湖南洞庭药业股份有限公司 盐酸美金刚药物组合物和制法
CN114199812A (zh) * 2021-12-28 2022-03-18 南通联亚药业有限公司 一种盐酸美金刚缓释制剂中盐酸美金刚的检测方法

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Also Published As

Publication number Publication date
JP2008509089A (ja) 2008-03-27
AU2005328701B2 (en) 2009-08-13
WO2006096194A2 (en) 2006-09-14
WO2006096194A8 (en) 2007-01-11
EP2397122A2 (en) 2011-12-21
IL179992A (en) 2012-02-29
BRPI0512263A (pt) 2008-02-26
AU2005328701A1 (en) 2006-09-14
EA011290B1 (ru) 2009-02-27
JP5025468B2 (ja) 2012-09-12
ES2483126T3 (es) 2014-08-05
WO2006096194A3 (en) 2007-11-22
IL179992A0 (en) 2007-05-15
KR20090033410A (ko) 2009-04-02
EP2397122A3 (en) 2012-01-25
EP2397122B1 (en) 2014-05-14
CA2568445A1 (en) 2006-09-14
CN101389315A (zh) 2009-03-18
EP1765287A2 (en) 2007-03-28
CA2568445C (en) 2011-05-24
EP2601937A1 (en) 2013-06-12

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU