DE69721559T2 - Geschmacksmaskierte pharmazeutische dosisform mit schneller freisetzung - Google Patents

Geschmacksmaskierte pharmazeutische dosisform mit schneller freisetzung

Info

Publication number
DE69721559T2
DE69721559T2 DE69721559T DE69721559T DE69721559T2 DE 69721559 T2 DE69721559 T2 DE 69721559T2 DE 69721559 T DE69721559 T DE 69721559T DE 69721559 T DE69721559 T DE 69721559T DE 69721559 T2 DE69721559 T2 DE 69721559T2
Authority
DE
Germany
Prior art keywords
pharmaceutical dosage
quick release
taste masked
masked pharmaceutical
taste
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69721559T
Other languages
English (en)
Other versions
DE69721559D1 (de
Inventor
Akinori Itoh
Toshiyuki Niwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE69721559D1 publication Critical patent/DE69721559D1/de
Publication of DE69721559T2 publication Critical patent/DE69721559T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69721559T 1997-01-06 1997-11-20 Geschmacksmaskierte pharmazeutische dosisform mit schneller freisetzung Expired - Fee Related DE69721559T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9700003 1997-01-06
PCT/IB1997/001471 WO1998030209A1 (en) 1997-01-06 1997-11-20 Rapidly releasing and taste-masking pharmaceutical dosage form

Publications (2)

Publication Number Publication Date
DE69721559D1 DE69721559D1 (de) 2003-06-05
DE69721559T2 true DE69721559T2 (de) 2003-11-27

Family

ID=11004515

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69721559T Expired - Fee Related DE69721559T2 (de) 1997-01-06 1997-11-20 Geschmacksmaskierte pharmazeutische dosisform mit schneller freisetzung

Country Status (36)

Country Link
EP (1) EP0941075B1 (de)
JP (1) JP3350059B2 (de)
KR (1) KR20000069899A (de)
CN (1) CN1244119A (de)
AP (1) AP802A (de)
AR (1) AR008553A1 (de)
AT (1) ATE238776T1 (de)
AU (1) AU715867B2 (de)
BG (1) BG103541A (de)
BR (1) BR9714253A (de)
CA (1) CA2277017C (de)
CO (1) CO4650099A1 (de)
DE (1) DE69721559T2 (de)
DK (1) DK0941075T3 (de)
EA (1) EA199900521A1 (de)
ES (1) ES2192265T3 (de)
HN (1) HN1997000151A (de)
HR (1) HRP980005A2 (de)
HU (1) HUP0002744A3 (de)
ID (1) ID21806A (de)
IL (1) IL130582A0 (de)
IS (1) IS5095A (de)
MA (1) MA26464A1 (de)
NO (1) NO993315D0 (de)
NZ (1) NZ336251A (de)
OA (1) OA11072A (de)
PA (1) PA8443301A1 (de)
PE (1) PE27999A1 (de)
PL (1) PL334439A1 (de)
SK (1) SK89599A3 (de)
TN (1) TNSN98002A1 (de)
TR (1) TR199901564T2 (de)
UY (1) UY24835A1 (de)
WO (1) WO1998030209A1 (de)
YU (1) YU31599A (de)
ZA (1) ZA9829B (de)

Families Citing this family (32)

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US6200591B1 (en) 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
DE19834507A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Pharmazeutische, wasserlösliche Tablettenformulierung zur Anwendung von Sildenafil
UA67802C2 (uk) * 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції
EP1133282A4 (de) * 1998-11-25 2006-03-29 Cima Labs Inc Geschmacksmaskierendes überzugssystem mit schneller freisetzung
FR2795962B1 (fr) * 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
US7501409B2 (en) 2000-09-06 2009-03-10 Mitsubishi Tanabe Pharma Corporation Preparations for oral administration
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
AR034813A1 (es) * 2001-07-20 2004-03-17 Novartis Ag Composiciones farmaceuticas y uso de las mismas
SE0202365D0 (sv) * 2002-08-05 2002-08-05 Pharmacia Ab New formulation and use thereof
US8039482B2 (en) 2004-03-25 2011-10-18 Astellas Pharma Inc. Composition of solifenacin or salt thereof for use in solid formulation
BG66010B1 (bg) * 2004-12-08 2010-10-29 "Софарма" Ад Лекарствена форма на силденафил
EP2098225B8 (de) * 2005-01-06 2011-06-22 Cima Labs Inc. Geschmacksunterdrückungssystem für nicht weichgemachte Arzneimittel
US7815939B2 (en) 2005-07-20 2010-10-19 Astellas Pharma Inc. Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms
JPWO2007010930A1 (ja) * 2005-07-20 2009-01-29 アステラス製薬株式会社 口腔内崩壊製剤用の薬物含有被覆微粒子及びその製造方法
JP2007031407A (ja) 2005-07-29 2007-02-08 Shin Etsu Chem Co Ltd 低置換度セルロースエーテル含有コーティング用組成物及び不快な味が隠蔽されたフィルムコーティング製剤
US20070098746A1 (en) * 2005-11-02 2007-05-03 Nichols William M Multi-layered coating technology for taste masking
JP4602949B2 (ja) * 2006-08-02 2010-12-22 和光堂株式会社 被覆粒子含有組成物及びその製造方法
JPWO2008059881A1 (ja) * 2006-11-14 2010-03-04 サンスター株式会社 水溶性物質で表面処理された結晶セルロースを含む口腔用組成物
JP5777273B2 (ja) * 2008-07-10 2015-09-09 大正製薬株式会社 不快な呈味を有する薬物を含有する製剤粒子
US20100136110A1 (en) * 2008-09-30 2010-06-03 Astellas Pharma Inc. Granular pharmaceutical composition for oral administration
WO2010067140A1 (es) 2008-12-12 2010-06-17 Siegfried Rhein S.A. De C.V. Composicion de liberacion pulsatil de sildenafil y proceso para prepararla
DE102009016584A1 (de) 2009-04-06 2010-10-07 Ratiopharm Gmbh Schmelztablette, enthaltend ein Sildenafil-Salz
EP2524689B1 (de) * 2009-12-28 2016-10-05 Nipro Corporation Herstellungsverfahren von Donepezil Tabletten
JP5226732B2 (ja) * 2010-05-20 2013-07-03 エスエス製薬株式会社 催眠用圧縮成型製剤
TWI462739B (zh) * 2010-11-02 2014-12-01 Univ Kaohsiung Medical Ｓｉｌｄｅｎａｆｉｌ－同族物四級銨哌嗪鹽類之製備及醫療用途
GB201119985D0 (en) * 2011-11-19 2012-01-04 Diurnal Ltd Treatment of adrenal insufficiency
CN103271940B (zh) * 2013-05-03 2014-03-12 湖北新济药业有限公司 复方金属离子补充剂及其制备方法
WO2017146052A1 (ja) * 2016-02-23 2017-08-31 ニプロ株式会社 医薬組成物粒子とそれを含む口腔内崩壊製剤、医薬組成物粒子の製造方法
EP3845219A4 (de) * 2018-08-28 2022-06-08 Towa Pharmaceutical Co., Ltd. Wirkstoffhaltiges teilchen
CN113559070B (zh) * 2021-08-18 2022-12-06 广州中冠动物药业有限公司 一种适用于宠物咳嗽的药物制备方法
CN116139088B (zh) * 2023-01-31 2024-04-16 南京海纳医药科技股份有限公司 一种含有枸橼酸西地那非的干混悬剂及其制备方法

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
JPS63258809A (ja) * 1987-04-16 1988-10-26 Towa Yakuhin Kk 医薬活性成分の放出性にすぐれ、かつ苦味を隠蔽した細粒剤
EP0458751A1 (de) * 1990-05-25 1991-11-27 Warner-Lambert Company System zur Freisetzung von cyclischen Aminosäuren mit verbessertem Geschmack, Struktur und Komprimierbarkeit
JP2576927B2 (ja) * 1992-05-15 1997-01-29 ファイザー製薬株式会社 細粒核
JP3350054B2 (ja) * 1994-07-08 2002-11-25 アストラゼネカ・アクチエボラーグ 複数単位の錠剤化された剤形▲ｉ▼

Also Published As

Publication number Publication date
AP9801173A0 (en) 1998-01-31
JP3350059B2 (ja) 2002-11-25
PL334439A1 (en) 2000-02-28
ID21806A (id) 1999-07-29
ATE238776T1 (de) 2003-05-15
MA26464A1 (fr) 2004-12-20
DK0941075T3 (da) 2003-07-14
NO993315L (no) 1999-07-05
OA11072A (en) 2002-02-27
IS5095A (is) 1999-06-25
JP2000514830A (ja) 2000-11-07
ES2192265T3 (es) 2003-10-01
HN1997000151A (es) 1997-12-20
TNSN98002A1 (fr) 2005-03-15
AU4880897A (en) 1998-08-03
EP0941075B1 (de) 2003-05-02
UY24835A1 (es) 2000-09-29
NO993315D0 (no) 1999-07-05
ZA9829B (en) 1999-07-05
CN1244119A (zh) 2000-02-09
BG103541A (en) 2000-03-31
HUP0002744A2 (hu) 2000-12-28
BR9714253A (pt) 2000-04-18
AU715867B2 (en) 2000-02-10
EA199900521A1 (ru) 1999-12-29
NZ336251A (en) 2001-01-26
AP802A (en) 2000-01-21
WO1998030209A1 (en) 1998-07-16
PA8443301A1 (es) 2000-05-24
EP0941075A1 (de) 1999-09-15
YU31599A (sh) 2000-03-21
CA2277017A1 (en) 1998-07-16
DE69721559D1 (de) 2003-06-05
AR008553A1 (es) 2000-01-19
HRP980005A2 (en) 1998-10-31
CA2277017C (en) 2002-11-26
IL130582A0 (en) 2000-06-01
KR20000069899A (ko) 2000-11-25
TR199901564T2 (xx) 1999-09-21
SK89599A3 (en) 2000-12-11
HUP0002744A3 (en) 2001-01-29
CO4650099A1 (es) 1998-09-03
PE27999A1 (es) 1999-03-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee