EA199900521A1 - Быстрорастворимая и маскирующая вкус фармацевтическая дозированная лекарственная форма - Google Patents

Быстрорастворимая и маскирующая вкус фармацевтическая дозированная лекарственная форма

Info

Publication number
EA199900521A1
EA199900521A1 EA199900521A EA199900521A EA199900521A1 EA 199900521 A1 EA199900521 A1 EA 199900521A1 EA 199900521 A EA199900521 A EA 199900521A EA 199900521 A EA199900521 A EA 199900521A EA 199900521 A1 EA199900521 A1 EA 199900521A1
Authority
EA
Eurasian Patent Office
Prior art keywords
coating layer
core
medical form
quickly soluble
dosage form
Prior art date
Application number
EA199900521A
Other languages
English (en)
Inventor
Акинори Итох
Тосиюки Нива
Original Assignee
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Инк. filed Critical Пфайзер Инк.
Publication of EA199900521A1 publication Critical patent/EA199900521A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

Настоящее изобретение предусматривает быстрорастворимую и маскирующую вкус фармацевтическую дозированную лекарственную форму, включающую в себя ядро, содержащее фармацевтически активный ингредиент, низкозамещенную гидроксипропилцеллюлозу и микрокристаллическую целлюлозу, при этом количество микрокристаллической целлюлозы составляет, по меньшей мере, 26,0 мас.% от общей массы ядра; внутренний покрывающий слой, нанесенный на ядро и содержащий водорастворимый полимер; а также наружный покрывающий слой, нанесенный на внутренний покрывающий слой и содержащий нерастворимый в слюне полимер. Также раскрывается способ получения такой лекарственной формы для перорального применения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900521A 1997-01-06 1997-11-20 Быстрорастворимая и маскирующая вкус фармацевтическая дозированная лекарственная форма EA199900521A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9700003 1997-01-06
PCT/IB1997/001471 WO1998030209A1 (en) 1997-01-06 1997-11-20 Rapidly releasing and taste-masking pharmaceutical dosage form

Publications (1)

Publication Number Publication Date
EA199900521A1 true EA199900521A1 (ru) 1999-12-29

Family

ID=11004515

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900521A EA199900521A1 (ru) 1997-01-06 1997-11-20 Быстрорастворимая и маскирующая вкус фармацевтическая дозированная лекарственная форма

Country Status (36)

Country Link
EP (1) EP0941075B1 (ru)
JP (1) JP3350059B2 (ru)
KR (1) KR20000069899A (ru)
CN (1) CN1244119A (ru)
AP (1) AP802A (ru)
AR (1) AR008553A1 (ru)
AT (1) ATE238776T1 (ru)
AU (1) AU715867B2 (ru)
BG (1) BG103541A (ru)
BR (1) BR9714253A (ru)
CA (1) CA2277017C (ru)
CO (1) CO4650099A1 (ru)
DE (1) DE69721559T2 (ru)
DK (1) DK0941075T3 (ru)
EA (1) EA199900521A1 (ru)
ES (1) ES2192265T3 (ru)
HN (1) HN1997000151A (ru)
HR (1) HRP980005A2 (ru)
HU (1) HUP0002744A3 (ru)
ID (1) ID21806A (ru)
IL (1) IL130582A0 (ru)
IS (1) IS5095A (ru)
MA (1) MA26464A1 (ru)
NO (1) NO993315D0 (ru)
NZ (1) NZ336251A (ru)
OA (1) OA11072A (ru)
PA (1) PA8443301A1 (ru)
PE (1) PE27999A1 (ru)
PL (1) PL334439A1 (ru)
SK (1) SK89599A3 (ru)
TN (1) TNSN98002A1 (ru)
TR (1) TR199901564T2 (ru)
UY (1) UY24835A1 (ru)
WO (1) WO1998030209A1 (ru)
YU (1) YU31599A (ru)
ZA (1) ZA9829B (ru)

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DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
DE19834507A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Pharmazeutische, wasserlösliche Tablettenformulierung zur Anwendung von Sildenafil
UA67802C2 (ru) * 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ ДЛЯ ПЕРОРАЛЬНОГО ПРИМЕНЕНИЯ С КОНТРОЛИРУЕМЫМ ВЫСВОБОЖДЕНИЕМ ИНГИБИТОРА цГМФ ФДЭ-5 (ВАРИАНТЫ), СПОСОБ ЕЕ ПОЛУЧЕНИЯ И СПОСОБ ЛЕЧЕНИЯ ЭРЕКТИЛЬНОЙ ДИСФУНКЦИИ
EP1133282A4 (en) * 1998-11-25 2006-03-29 Cima Labs Inc TASTE-MAKING DELIVERY SYSTEM WITH FAST RELEASE
FR2795962B1 (fr) * 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
US7501409B2 (en) 2000-09-06 2009-03-10 Mitsubishi Tanabe Pharma Corporation Preparations for oral administration
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
AR034813A1 (es) * 2001-07-20 2004-03-17 Novartis Ag Composiciones farmaceuticas y uso de las mismas
SE0202365D0 (sv) * 2002-08-05 2002-08-05 Pharmacia Ab New formulation and use thereof
US8039482B2 (en) 2004-03-25 2011-10-18 Astellas Pharma Inc. Composition of solifenacin or salt thereof for use in solid formulation
BG66010B1 (bg) * 2004-12-08 2010-10-29 "Софарма" Ад Лекарствена форма на силденафил
EP2098225B8 (en) * 2005-01-06 2011-06-22 Cima Labs Inc. Taste masking system for non-plasticizing drugs
US7815939B2 (en) 2005-07-20 2010-10-19 Astellas Pharma Inc. Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms
JPWO2007010930A1 (ja) * 2005-07-20 2009-01-29 アステラス製薬株式会社 口腔内崩壊製剤用の薬物含有被覆微粒子及びその製造方法
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US20070098746A1 (en) * 2005-11-02 2007-05-03 Nichols William M Multi-layered coating technology for taste masking
JP4602949B2 (ja) * 2006-08-02 2010-12-22 和光堂株式会社 被覆粒子含有組成物及びその製造方法
JPWO2008059881A1 (ja) * 2006-11-14 2010-03-04 サンスター株式会社 水溶性物質で表面処理された結晶セルロースを含む口腔用組成物
JP5777273B2 (ja) * 2008-07-10 2015-09-09 大正製薬株式会社 不快な呈味を有する薬物を含有する製剤粒子
US20100136110A1 (en) * 2008-09-30 2010-06-03 Astellas Pharma Inc. Granular pharmaceutical composition for oral administration
WO2010067140A1 (es) 2008-12-12 2010-06-17 Siegfried Rhein S.A. De C.V. Composicion de liberacion pulsatil de sildenafil y proceso para prepararla
DE102009016584A1 (de) 2009-04-06 2010-10-07 Ratiopharm Gmbh Schmelztablette, enthaltend ein Sildenafil-Salz
EP2524689B1 (en) * 2009-12-28 2016-10-05 Nipro Corporation Method for producing donepezil tablets
JP5226732B2 (ja) * 2010-05-20 2013-07-03 エスエス製薬株式会社 催眠用圧縮成型製剤
TWI462739B (zh) * 2010-11-02 2014-12-01 Univ Kaohsiung Medical Ｓｉｌｄｅｎａｆｉｌ－同族物四級銨哌嗪鹽類之製備及醫療用途
GB201119985D0 (en) * 2011-11-19 2012-01-04 Diurnal Ltd Treatment of adrenal insufficiency
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WO2017146052A1 (ja) * 2016-02-23 2017-08-31 ニプロ株式会社 医薬組成物粒子とそれを含む口腔内崩壊製剤、医薬組成物粒子の製造方法
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Also Published As

Publication number Publication date
AP9801173A0 (en) 1998-01-31
JP3350059B2 (ja) 2002-11-25
PL334439A1 (en) 2000-02-28
ID21806A (id) 1999-07-29
ATE238776T1 (de) 2003-05-15
MA26464A1 (fr) 2004-12-20
DK0941075T3 (da) 2003-07-14
NO993315L (no) 1999-07-05
OA11072A (en) 2002-02-27
IS5095A (is) 1999-06-25
JP2000514830A (ja) 2000-11-07
ES2192265T3 (es) 2003-10-01
HN1997000151A (es) 1997-12-20
TNSN98002A1 (fr) 2005-03-15
AU4880897A (en) 1998-08-03
EP0941075B1 (en) 2003-05-02
UY24835A1 (es) 2000-09-29
DE69721559T2 (de) 2003-11-27
NO993315D0 (no) 1999-07-05
ZA9829B (en) 1999-07-05
CN1244119A (zh) 2000-02-09
BG103541A (en) 2000-03-31
HUP0002744A2 (hu) 2000-12-28
BR9714253A (pt) 2000-04-18
AU715867B2 (en) 2000-02-10
NZ336251A (en) 2001-01-26
AP802A (en) 2000-01-21
WO1998030209A1 (en) 1998-07-16
PA8443301A1 (es) 2000-05-24
EP0941075A1 (en) 1999-09-15
YU31599A (sh) 2000-03-21
CA2277017A1 (en) 1998-07-16
DE69721559D1 (de) 2003-06-05
AR008553A1 (es) 2000-01-19
HRP980005A2 (en) 1998-10-31
CA2277017C (en) 2002-11-26
IL130582A0 (en) 2000-06-01
KR20000069899A (ko) 2000-11-25
TR199901564T2 (xx) 1999-09-21
SK89599A3 (en) 2000-12-11
HUP0002744A3 (en) 2001-01-29
CO4650099A1 (es) 1998-09-03
PE27999A1 (es) 1999-03-12

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