HUP0002744A2 - Gyors hatóanyag-leadású és ízmaszkírozó gyógyászati dózisforma - Google Patents

Gyors hatóanyag-leadású és ízmaszkírozó gyógyászati dózisforma

Info

Publication number
HUP0002744A2
HUP0002744A2 HU0002744A HUP0002744A HUP0002744A2 HU P0002744 A2 HUP0002744 A2 HU P0002744A2 HU 0002744 A HU0002744 A HU 0002744A HU P0002744 A HUP0002744 A HU P0002744A HU P0002744 A2 HUP0002744 A2 HU P0002744A2
Authority
HU
Hungary
Prior art keywords
dosage form
weight
coating layer
taste
core
Prior art date
Application number
HU0002744A
Other languages
English (en)
Inventor
Akinori Itoh
Toshiyuki Niwa
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HUP0002744A2 publication Critical patent/HUP0002744A2/hu
Publication of HUP0002744A3 publication Critical patent/HUP0002744A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány gyors hatóanyag-leadású és ízmaszkírozó gyógyászatidózisformára vonatkozik, amely gyógyászati hatóanyagot, alacsonyszubsztitúciós fokú hidroxi-propil-cellulózt - amely legalább 5,0tömeg% és legfeljebb 16,0 tömeg% hidroxi-propoxi-csoportot tartalmazszárazanyagra vonatkoztatva - és a mag össztömegére vonatkoztatvalegalább 26,0 tömeg% mikrokristályos cellulózt tartalmazó magot, amagon kialakított, vízoldható polimert tartalmazó belső bevonórétegetés a belső bevonórétegen kialakított és nyálban oldhatatlan polimerttartalmazó külső bevonóréteget tartalmaz, ahol a mag, a belsőbevonóréteg és a külső bevonóréteg mennyisége 60,0-87,0, 4,0-31,0,illetve 9,0-36,0 tömeg% a dózisforma össztömegére vonatkoztatva.Ismertetik a fenti orális dózisforma előállítását is. Ó
HU0002744A 1997-01-06 1997-11-20 Rapidly releasing and taste-masking pharmaceutical dosage form HUP0002744A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9700003 1997-01-06

Publications (2)

Publication Number Publication Date
HUP0002744A2 true HUP0002744A2 (hu) 2000-12-28
HUP0002744A3 HUP0002744A3 (en) 2001-01-29

Family

ID=11004515

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0002744A HUP0002744A3 (en) 1997-01-06 1997-11-20 Rapidly releasing and taste-masking pharmaceutical dosage form

Country Status (36)

Country Link
EP (1) EP0941075B1 (hu)
JP (1) JP3350059B2 (hu)
KR (1) KR20000069899A (hu)
CN (1) CN1244119A (hu)
AP (1) AP802A (hu)
AR (1) AR008553A1 (hu)
AT (1) ATE238776T1 (hu)
AU (1) AU715867B2 (hu)
BG (1) BG103541A (hu)
BR (1) BR9714253A (hu)
CA (1) CA2277017C (hu)
CO (1) CO4650099A1 (hu)
DE (1) DE69721559T2 (hu)
DK (1) DK0941075T3 (hu)
EA (1) EA199900521A1 (hu)
ES (1) ES2192265T3 (hu)
HN (1) HN1997000151A (hu)
HR (1) HRP980005A2 (hu)
HU (1) HUP0002744A3 (hu)
ID (1) ID21806A (hu)
IL (1) IL130582A0 (hu)
IS (1) IS5095A (hu)
MA (1) MA26464A1 (hu)
NO (1) NO993315D0 (hu)
NZ (1) NZ336251A (hu)
OA (1) OA11072A (hu)
PA (1) PA8443301A1 (hu)
PE (1) PE27999A1 (hu)
PL (1) PL334439A1 (hu)
SK (1) SK89599A3 (hu)
TN (1) TNSN98002A1 (hu)
TR (1) TR199901564T2 (hu)
UY (1) UY24835A1 (hu)
WO (1) WO1998030209A1 (hu)
YU (1) YU31599A (hu)
ZA (1) ZA9829B (hu)

Families Citing this family (32)

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US6200591B1 (en) * 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
DE19834506A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Transmucosales therapeutisches System zur Anwendung von Sildenafil
DE19834507A1 (de) * 1998-07-31 2000-02-03 Hexal Ag Pharmazeutische, wasserlösliche Tablettenformulierung zur Anwendung von Sildenafil
UA67802C2 (uk) 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції
WO2000030617A1 (en) * 1998-11-25 2000-06-02 Cima Labs Inc. Taste masking rapid release coating system
FR2795962B1 (fr) * 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
KR100610131B1 (ko) 2000-09-06 2006-08-09 다나베 세이야꾸 가부시키가이샤 경구 투여용 제제
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
AR034813A1 (es) * 2001-07-20 2004-03-17 Novartis Ag Composiciones farmaceuticas y uso de las mismas
SE0202365D0 (sv) * 2002-08-05 2002-08-05 Pharmacia Ab New formulation and use thereof
CA2561167C (en) 2004-03-25 2012-09-11 Astellas Pharma Inc. Composition of solifenacin or salt thereof for use in solid formulation
BG66010B1 (bg) * 2004-12-08 2010-10-29 "Софарма" Ад Лекарствена форма на силденафил
CA2593016C (en) * 2005-01-06 2012-05-15 Cima Labs Inc. Taste masking system for non-plasticizing drugs
CA2616012A1 (en) * 2005-07-20 2007-01-25 Astellas Pharma Inc. Drug-containing coated fine particle for intrabuccally disintegrating preparation and method of producing the same
US7815939B2 (en) 2005-07-20 2010-10-19 Astellas Pharma Inc. Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms
JP2007031407A (ja) 2005-07-29 2007-02-08 Shin Etsu Chem Co Ltd 低置換度セルロースエーテル含有コーティング用組成物及び不快な味が隠蔽されたフィルムコーティング製剤
US20070098746A1 (en) * 2005-11-02 2007-05-03 Nichols William M Multi-layered coating technology for taste masking
JP4602949B2 (ja) * 2006-08-02 2010-12-22 和光堂株式会社 被覆粒子含有組成物及びその製造方法
KR20090086433A (ko) * 2006-11-14 2009-08-12 선스타 가부시키가이샤 수용성 물질로 표면-처리된 미세결정 셀룰로오즈를 함유하는 구강 위생용 조성물
JP5777273B2 (ja) * 2008-07-10 2015-09-09 大正製薬株式会社 不快な呈味を有する薬物を含有する製剤粒子
WO2010038691A1 (ja) * 2008-09-30 2010-04-08 アステラス製薬株式会社 経口投与用粒子状医薬組成物
US20110244050A1 (en) 2008-12-12 2011-10-06 Siegfried Rhein S.A. De C.V. Pulsed-release sildenafil composition and method for preparing said composition
DE102009016584A1 (de) 2009-04-06 2010-10-07 Ratiopharm Gmbh Schmelztablette, enthaltend ein Sildenafil-Salz
WO2011081199A1 (ja) * 2009-12-28 2011-07-07 ニプロ株式会社 品質が向上した経口剤
JP5226732B2 (ja) * 2010-05-20 2013-07-03 エスエス製薬株式会社 催眠用圧縮成型製剤
TWI462739B (zh) * 2010-11-02 2014-12-01 Univ Kaohsiung Medical Ｓｉｌｄｅｎａｆｉｌ－同族物四級銨哌嗪鹽類之製備及醫療用途
GB201119985D0 (en) * 2011-11-19 2012-01-04 Diurnal Ltd Treatment of adrenal insufficiency
CN103271940B (zh) * 2013-05-03 2014-03-12 湖北新济药业有限公司 复方金属离子补充剂及其制备方法
WO2017146052A1 (ja) * 2016-02-23 2017-08-31 ニプロ株式会社 医薬組成物粒子とそれを含む口腔内崩壊製剤、医薬組成物粒子の製造方法
US20210196635A1 (en) * 2018-08-28 2021-07-01 Towa Pharmaceutical Co., Ltd. Drug-containing particle
CN113559070B (zh) * 2021-08-18 2022-12-06 广州中冠动物药业有限公司 一种适用于宠物咳嗽的药物制备方法
CN116139088B (zh) * 2023-01-31 2024-04-16 南京海纳医药科技股份有限公司 一种含有枸橼酸西地那非的干混悬剂及其制备方法

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JPS63258809A (ja) * 1987-04-16 1988-10-26 Towa Yakuhin Kk 医薬活性成分の放出性にすぐれ、かつ苦味を隠蔽した細粒剤
EP0458751A1 (en) * 1990-05-25 1991-11-27 Warner-Lambert Company Delivery system for cyclic amino acids with improved taste, texture and compressibility
JP2576927B2 (ja) * 1992-05-15 1997-01-29 ファイザー製薬株式会社 細粒核
EP1078628B1 (en) * 1994-07-08 2008-11-19 AstraZeneca AB Multiple unit tableted dosage form

Also Published As

Publication number Publication date
HN1997000151A (es) 1997-12-20
HUP0002744A3 (en) 2001-01-29
ATE238776T1 (de) 2003-05-15
KR20000069899A (ko) 2000-11-25
PE27999A1 (es) 1999-03-12
AP9801173A0 (en) 1998-01-31
PA8443301A1 (es) 2000-05-24
BG103541A (en) 2000-03-31
NO993315L (no) 1999-07-05
JP3350059B2 (ja) 2002-11-25
AP802A (en) 2000-01-21
HRP980005A2 (en) 1998-10-31
EP0941075A1 (en) 1999-09-15
NO993315D0 (no) 1999-07-05
ZA9829B (en) 1999-07-05
DK0941075T3 (da) 2003-07-14
AU4880897A (en) 1998-08-03
DE69721559T2 (de) 2003-11-27
IL130582A0 (en) 2000-06-01
OA11072A (en) 2002-02-27
DE69721559D1 (de) 2003-06-05
CN1244119A (zh) 2000-02-09
BR9714253A (pt) 2000-04-18
WO1998030209A1 (en) 1998-07-16
CA2277017A1 (en) 1998-07-16
TNSN98002A1 (fr) 2005-03-15
JP2000514830A (ja) 2000-11-07
IS5095A (is) 1999-06-25
CO4650099A1 (es) 1998-09-03
TR199901564T2 (xx) 1999-09-21
UY24835A1 (es) 2000-09-29
EA199900521A1 (ru) 1999-12-29
AU715867B2 (en) 2000-02-10
ID21806A (id) 1999-07-29
NZ336251A (en) 2001-01-26
EP0941075B1 (en) 2003-05-02
PL334439A1 (en) 2000-02-28
AR008553A1 (es) 2000-01-19
ES2192265T3 (es) 2003-10-01
MA26464A1 (fr) 2004-12-20
CA2277017C (en) 2002-11-26
YU31599A (sh) 2000-03-21
SK89599A3 (en) 2000-12-11

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