ATE129406T1 - Rotogranulate und geschmacksabdeckende überzüge zur herstellung pharmazeutischer kautabletten. - Google Patents

Rotogranulate und geschmacksabdeckende überzüge zur herstellung pharmazeutischer kautabletten.

Info

Publication number
ATE129406T1
ATE129406T1 AT90308552T AT90308552T ATE129406T1 AT E129406 T1 ATE129406 T1 AT E129406T1 AT 90308552 T AT90308552 T AT 90308552T AT 90308552 T AT90308552 T AT 90308552T AT E129406 T1 ATE129406 T1 AT E129406T1
Authority
AT
Austria
Prior art keywords
rotogranules
flavoring
coatings
chewable tablets
producing pharmaceutical
Prior art date
Application number
AT90308552T
Other languages
English (en)
Inventor
Edward J Roche
Joseph P Reo
Original Assignee
Mcneil Ppc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc
Application granted granted Critical
Publication of ATE129406T1 publication Critical patent/ATE129406T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • General Preparation And Processing Of Foods (AREA)
AT90308552T 1989-08-04 1990-08-03 Rotogranulate und geschmacksabdeckende überzüge zur herstellung pharmazeutischer kautabletten. ATE129406T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38964589A 1989-08-04 1989-08-04

Publications (1)

Publication Number Publication Date
ATE129406T1 true ATE129406T1 (de) 1995-11-15

Family

ID=23539113

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90308552T ATE129406T1 (de) 1989-08-04 1990-08-03 Rotogranulate und geschmacksabdeckende überzüge zur herstellung pharmazeutischer kautabletten.

Country Status (13)

Country Link
US (1) US5215755A (de)
EP (1) EP0411952B1 (de)
KR (1) KR0166064B1 (de)
AT (1) ATE129406T1 (de)
AU (1) AU646399B2 (de)
CA (1) CA2022640C (de)
DE (1) DE69023183T2 (de)
ES (1) ES2081349T3 (de)
GR (1) GR1001171B (de)
IE (1) IE69042B1 (de)
NZ (1) NZ234587A (de)
PT (1) PT94898B (de)
ZA (1) ZA906143B (de)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5460825A (en) * 1990-05-23 1995-10-24 Mcneil-Ppc, Inc. Taste mask coatings for preparing chewable pharmaceutical tablets
EP0537139B1 (de) * 1990-07-02 1994-05-18 Roche Diagnostics GmbH Verfahren zur herstellung geformter, verpresster dosiseinheiten mit retardierter freisetzung und entsprechende dosiseinheit
EP0574424A1 (de) * 1991-03-04 1993-12-22 Warner-Lambert Company Salz/ionpaare von nicht-steroiden enzündungshemmenden arzneimitteln in verschiedenen dosierungsformen
CA2079934C (en) * 1991-10-15 2002-09-03 Edward J. Roche Taste mask coatings for preparing chewable pharmaceutical tablets
US5429825A (en) * 1992-06-26 1995-07-04 Mcneil-Ppc, Inc. Rotomelt granulation
ZA945944B (en) * 1993-08-13 1996-02-08 Eurand America Inc Procedure for encapsulating nsaids
GB9405856D0 (en) * 1994-03-24 1994-05-11 Smithkline Beecham Plc Pharmaceutical formulation
US5399356A (en) * 1994-03-24 1995-03-21 The Procter & Gamble Company Process for making solid dose forms containing bismuth
AUPM814994A0 (en) * 1994-09-14 1994-10-06 Sterling Winthrop Inc. Codeine-containing formulations
US5529783A (en) * 1994-12-19 1996-06-25 Mcneil-Ppc, Inc. Rotor granulation and coating of acetaminophen, pseudoephedrine, chlorpheniramine, and, optionally dextromethorphan
US5639475A (en) * 1995-02-03 1997-06-17 Eurand America, Incorporated Effervescent microcapsules
US5518738A (en) * 1995-02-09 1996-05-21 Nanosystem L.L.C. Nanoparticulate nsaid compositions
US5560927A (en) * 1995-07-28 1996-10-01 Isp Investments Inc. Co-processing method for making a free-flowing compressible powder and tablet therefrom
FR2738833B1 (fr) * 1995-09-14 1997-12-05 Seppic Sa Composition filmogene pour le masquage de gout destinee a l'enrobage de formes solides ingerables telles qu'en particulier des comprimes pharmaceutiques
US6312724B1 (en) * 1997-04-04 2001-11-06 Isa Odidi Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof
NZ503086A (en) * 1997-08-29 2002-03-01 Upjohn Co An orally administrable pharmaceutical composition comprising an inner core and two outer layers, which render it substantially free of unpleasant tastes
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
NZ333474A (en) * 1998-01-02 1999-06-29 Mcneil Ppc Inc A chewable tablet containing ibuprofen, fumaric acid and a non hydrocolloid binder e.g. a wax or a fat
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
FR2785539B1 (fr) * 1998-11-06 2004-04-09 Prographarm Laboratoires Particules enrobees d'ibuprofene cristallin granule
FR2785538B1 (fr) 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
US6251945B1 (en) * 1999-01-14 2001-06-26 Knoll Aktiengesellschaft Pharmaceutical mixture comprising a combination of a profen and other active compounds
US6270807B1 (en) 1999-03-02 2001-08-07 L. Perrigo Company Taste-masked pharmaceutical composition
GB9910505D0 (en) * 1999-05-06 1999-07-07 Electrosols Ltd A method and apparatus for manufacturing consumable tablets
US6211246B1 (en) * 1999-06-10 2001-04-03 Mcneil-Ppc, Inc. Rapidly absorbed liquid compositions
US6726922B1 (en) 1999-06-28 2004-04-27 Minu, L.L.C. Process and composition for temporarily suppressing pain
US6258381B1 (en) * 2000-02-11 2001-07-10 Mcneil-Ppc, Inc. Tablet and process for making the same
EP1317533A1 (de) * 2000-09-08 2003-06-11 Novozymes A/S Durch eine schmierschicht charakterisiertes granulat
US20020119201A1 (en) * 2000-09-08 2002-08-29 Novozymes A/S Lubricated granules
WO2002036077A2 (en) * 2000-11-06 2002-05-10 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
US20040213839A1 (en) * 2001-02-05 2004-10-28 Andrew Favara Methods and compositions for reducing the taste of pharmaceutically active agents
PT1411899E (pt) * 2001-08-01 2009-04-24 Novartis Ag Composição de mascaramento de sabor
WO2003039516A1 (en) * 2001-11-07 2003-05-15 Fujisawa Pharmaceuticla Co., Ltd. Method for improving dissolution of poorly dispersible medicaments
US20060068003A1 (en) 2002-11-06 2006-03-30 Herz Rachel S System for increasing compliance with medication regime
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
US20070092583A1 (en) * 2003-04-30 2007-04-26 Tim Clarot Cold remedy composition comprising zinc salts
US7632521B2 (en) 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
US7282217B1 (en) 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
US7165510B2 (en) 2003-11-04 2007-01-23 Dennis Lee Hakes Bovine germicide application device
ITMI20042356A1 (it) * 2004-12-10 2005-03-10 Acraf Composizione farmaceutica orodisperdibile e procedimento per prepararla
CN1883456B (zh) * 2005-06-20 2010-12-15 常州市第四制药厂有限公司 掩味药物颗粒及其制备方法和用途
KR101157267B1 (ko) * 2005-12-28 2012-07-03 두산인프라코어 주식회사 굴삭기의 주행복합제어용 유압시스템
EP1837020A1 (de) * 2006-03-24 2007-09-26 Bioalliance Pharma Bioadhäsive Schleimhautträger zur langsamen Verabreichung von aktiven Substanzen
US20070286903A1 (en) * 2006-06-13 2007-12-13 Becicka Brian T Composition and method for taste masking
US20090060983A1 (en) * 2007-08-30 2009-03-05 Bunick Frank J Method And Composition For Making An Orally Disintegrating Dosage Form
BRPI0819231B8 (pt) * 2007-10-31 2021-05-25 Mcneil Ppc Inc processo para preparo de forma farmacêutica de desintegração rápida por moldagem a quente na presença de sal inorgânico hidratado
CA2748728C (en) * 2009-01-05 2017-01-03 Mcneil-Ppc, Inc. Tablet containing cetirizine, pseudoephedrine, and naproxen containing a barrier layer
WO2010078541A1 (en) * 2009-01-05 2010-07-08 Mcneil-Ppc, Inc. Tablet containing coated particles of cetirizine, pseudoephedrine, and/or naproxen
WO2010078542A1 (en) * 2009-01-05 2010-07-08 Mcneil-Ppc, Inc. Three layer tablet containing cetirizine, pseudoephedrine, and naproxen
US20110070301A1 (en) 2009-09-24 2011-03-24 Luber Joseph R Orally transformable tablets
US20110070286A1 (en) * 2009-09-24 2011-03-24 Andreas Hugerth Process for the manufacture of nicotine-comprising chewing gum and nicotine-comprising chewing gum manufactured according to said process
US8858210B2 (en) 2009-09-24 2014-10-14 Mcneil-Ppc, Inc. Manufacture of variable density dosage forms utilizing radiofrequency energy
US8313768B2 (en) 2009-09-24 2012-11-20 Mcneil-Ppc, Inc. Manufacture of tablet having immediate release region and sustained release region
US9233491B2 (en) 2012-05-01 2016-01-12 Johnson & Johnson Consumer Inc. Machine for production of solid dosage forms
US9511028B2 (en) 2012-05-01 2016-12-06 Johnson & Johnson Consumer Inc. Orally disintegrating tablet
US9445971B2 (en) 2012-05-01 2016-09-20 Johnson & Johnson Consumer Inc. Method of manufacturing solid dosage form
AU2015204763A1 (en) 2014-01-10 2016-07-21 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
US10493026B2 (en) 2017-03-20 2019-12-03 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
CN110314150A (zh) * 2018-03-30 2019-10-11 洛阳惠中兽药有限公司 一种替米沙坦风味咀嚼片及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3594470A (en) * 1968-02-19 1971-07-20 Abbott Lab Chewable tablets including coated particles of pseudoephedrine-weak cation exchange resin
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
GB8606762D0 (en) * 1986-03-19 1986-04-23 Boots Co Plc Therapeutic agents
US4800087A (en) * 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
US4835187A (en) * 1987-06-15 1989-05-30 American Home Products Corporation Spray dried ibuprofen
US4837031A (en) * 1987-09-17 1989-06-06 Mallinckrodt, Inc. Compositions containing ibuprofen
US4851226A (en) * 1987-11-16 1989-07-25 Mcneil Consumer Products Company Chewable medicament tablet containing means for taste masking
NZ226822A (en) * 1987-11-16 1990-03-27 Mcneil Consumer Prod Chewable medicament tablet containing means for taste masking
US4835188A (en) * 1987-12-08 1989-05-30 American Home Products Corporation Spray dried ibuprofen

Also Published As

Publication number Publication date
KR0166064B1 (ko) 1999-01-15
EP0411952A3 (en) 1991-10-23
AU6018190A (en) 1991-02-07
NZ234587A (en) 1991-11-26
ES2081349T3 (es) 1996-03-01
KR910004180A (ko) 1991-03-28
US5215755A (en) 1993-06-01
DE69023183T2 (de) 1996-04-18
ZA906143B (en) 1992-04-29
IE902823A1 (en) 1991-02-27
DE69023183D1 (de) 1995-11-30
CA2022640C (en) 1997-02-11
CA2022640A1 (en) 1991-02-05
PT94898A (pt) 1991-04-18
GR900100587A (en) 1991-12-30
EP0411952A2 (de) 1991-02-06
EP0411952B1 (de) 1995-10-25
GR1001171B (el) 1993-06-07
AU646399B2 (en) 1994-02-24
PT94898B (pt) 1997-03-31
IE69042B1 (en) 1996-08-07

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee