DE3670639D1 - Neue biphosphonische abkoemmlinge, deren herstellung und arzneimittelzubereitung. - Google Patents

Neue biphosphonische abkoemmlinge, deren herstellung und arzneimittelzubereitung.

Info

Publication number
DE3670639D1
DE3670639D1 DE8787900075T DE3670639T DE3670639D1 DE 3670639 D1 DE3670639 D1 DE 3670639D1 DE 8787900075 T DE8787900075 T DE 8787900075T DE 3670639 T DE3670639 T DE 3670639T DE 3670639 D1 DE3670639 D1 DE 3670639D1
Authority
DE
Germany
Prior art keywords
biphosphonic
bodies
preparation
new
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787900075T
Other languages
English (en)
Inventor
Torndal Binderup
Sven Liisberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of DE3670639D1 publication Critical patent/DE3670639D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6544—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8787900075T 1985-12-12 1986-12-10 Neue biphosphonische abkoemmlinge, deren herstellung und arzneimittelzubereitung. Expired - Fee Related DE3670639D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858530603A GB8530603D0 (en) 1985-12-12 1985-12-12 Chemical compounds
PCT/DK1986/000132 WO1987003598A1 (en) 1985-12-12 1986-12-10 Novel bisphosphonic derivatives, a method for their production and a pharmaceutical composition

Publications (1)

Publication Number Publication Date
DE3670639D1 true DE3670639D1 (de) 1990-05-31

Family

ID=10589647

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787900075T Expired - Fee Related DE3670639D1 (de) 1985-12-12 1986-12-10 Neue biphosphonische abkoemmlinge, deren herstellung und arzneimittelzubereitung.

Country Status (8)

Country Link
US (1) US4870063A (de)
EP (1) EP0248854B1 (de)
JP (1) JPS63501956A (de)
CA (1) CA1287350C (de)
DE (1) DE3670639D1 (de)
DK (1) DK169678B1 (de)
GB (1) GB8530603D0 (de)
WO (1) WO1987003598A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86951A (en) * 1987-07-06 1996-07-23 Procter & Gamble Pharma Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them
DE69023844T2 (de) * 1989-09-06 1996-06-20 Merck & Co Inc Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
US5227506A (en) * 1989-09-06 1993-07-13 Merck & Co., Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
FI89366C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
CA2060790A1 (en) * 1991-02-07 1992-08-08 Yoshitaka Ohishi Bisphosphonic acid derivatives, their intermediates and bone resorption inhibitors containing them as active ingredients
JPH05163150A (ja) * 1991-05-13 1993-06-29 E R Squibb & Sons Inc アテローム性動脈硬化症の抑制・治療剤
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
US5616571A (en) * 1995-06-06 1997-04-01 Merck & Co., Inc. Bisphosphonates prevent bone loss associated with immunosuppressive therapy
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6416737B1 (en) 1998-11-19 2002-07-09 Board Of Trustees Of The University Of Arkansas Increasing bone strength with selected bisphosphonates
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
US20070003608A1 (en) * 2005-04-08 2007-01-04 Almond Merrick R Compounds, compositions and methods for the treatment of viral infections and other medical disorders
EP1868628B1 (de) 2005-04-08 2014-06-11 Chimerix, Inc. Verbindungen, zusammensetzungen und verfahren zur behandlung von pockenvirus-infektionen
JP5562255B2 (ja) * 2008-01-25 2014-07-30 キメリクス，インコーポレイテッド ウイルス感染を治療する方法
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011017253A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
US9006218B2 (en) 2010-02-12 2015-04-14 Chimerix Inc. Nucleoside phosphonate salts
US9278135B2 (en) 2010-04-26 2016-03-08 Chimerix Inc. Methods of treating retroviral infections and related dosage regimes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH9776A (en) * 1967-12-11 1976-03-17 M Francis Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue and method of use
JPS5095227A (de) * 1973-12-26 1975-07-29
US4311663A (en) * 1978-08-09 1982-01-19 Petrolite Corporation α-1,4-Thiazine alkanephosphonic acids as corrosion inhibitors
US4264768A (en) * 1978-08-09 1981-04-28 Petrolite Corporation Di-quaternary ammonium salts of α-1,4-thiazine alkanephosphonic acids
DE3225469A1 (de) * 1982-07-05 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
DE3232998A1 (de) * 1982-09-04 1984-03-08 Henkel KGaA, 4000 Düsseldorf Diphosphonsaeuren

Also Published As

Publication number Publication date
DK169678B1 (da) 1995-01-09
JPS63501956A (ja) 1988-08-04
US4870063A (en) 1989-09-26
DK406987A (da) 1987-08-05
GB8530603D0 (en) 1986-01-22
DK406987D0 (da) 1987-08-05
WO1987003598A1 (en) 1987-06-18
EP0248854B1 (de) 1990-04-25
EP0248854A1 (de) 1987-12-16
CA1287350C (en) 1991-08-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee