DE3575929D1 - Methylenbisphosphonsaeure-derivate, deren herstellung und arzneimittel. - Google Patents

Methylenbisphosphonsaeure-derivate, deren herstellung und arzneimittel.

Info

Publication number
DE3575929D1
DE3575929D1 DE8585903807T DE3575929T DE3575929D1 DE 3575929 D1 DE3575929 D1 DE 3575929D1 DE 8585903807 T DE8585903807 T DE 8585903807T DE 3575929 T DE3575929 T DE 3575929T DE 3575929 D1 DE3575929 D1 DE 3575929D1
Authority
DE
Germany
Prior art keywords
production
acid derivatives
bisphosphonic acid
medicinal products
methylene bisphosphonic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585903807T
Other languages
English (en)
Inventor
Torndal Binderup
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Application granted granted Critical
Publication of DE3575929D1 publication Critical patent/DE3575929D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE8585903807T 1984-07-31 1985-07-25 Methylenbisphosphonsaeure-derivate, deren herstellung und arzneimittel. Expired - Fee Related DE3575929D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848419489A GB8419489D0 (en) 1984-07-31 1984-07-31 Chemical compounds
PCT/DK1985/000071 WO1986000902A1 (en) 1984-07-31 1985-07-25 Derivatives of methylene-bisphosphonic acid, process for their preparation and a pharmaceutical composition

Publications (1)

Publication Number Publication Date
DE3575929D1 true DE3575929D1 (de) 1990-03-15

Family

ID=10564711

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585903807T Expired - Fee Related DE3575929D1 (de) 1984-07-31 1985-07-25 Methylenbisphosphonsaeure-derivate, deren herstellung und arzneimittel.

Country Status (15)

Country Link
US (1) US4732998A (de)
EP (1) EP0191044B1 (de)
JP (1) JPH068303B2 (de)
KR (1) KR860700254A (de)
AU (1) AU583848B2 (de)
DE (1) DE3575929D1 (de)
DK (1) DK167808B1 (de)
ES (1) ES8707964A1 (de)
FI (1) FI861357A (de)
GB (1) GB8419489D0 (de)
GR (1) GR851865B (de)
IE (1) IE58614B1 (de)
PT (1) PT80886B (de)
WO (1) WO1986000902A1 (de)
ZA (1) ZA855264B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3805663A1 (de) * 1988-02-24 1989-09-07 Henkel Kgaa Oxaalkanpolyphosphonsaeuren, ihre verwendung als thresholder sowie diese verbindungen enthaltende, komplexierend wirkende zusammensetzungen
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5266722A (en) * 1988-11-09 1993-11-30 W. R. Grace & Co.-Conn. Polyether bis-phosphonic acid compounds
PH26923A (en) * 1989-03-08 1992-12-03 Ciba Geigy N-substituted amino alkanediphosphonic acids
FI83421C (fi) * 1989-06-21 1991-07-10 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
US5227506A (en) * 1989-09-06 1993-07-13 Merck & Co., Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
DE69023844T2 (de) * 1989-09-06 1996-06-20 Merck & Co Inc Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
GB9024345D0 (en) * 1990-11-08 1990-12-19 Merck Sharp & Dohme Therapeutic agents
JP3141053B2 (ja) * 1991-12-26 2001-03-05 アベンティス ファーマ株式会社 ビスホスホン酸誘導体
US5200554A (en) * 1992-01-21 1993-04-06 Nasman Jan Anders H Bisphosphonic acid derivatives and their use
DE69330114T2 (de) * 1992-07-10 2001-08-02 Toray Industries, Inc. Methandiphosphonat-derivat, dessen produktion und dessen verwendung als arzneimittel
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
US6315566B1 (en) 1999-05-18 2001-11-13 3M Innovative Properties Company Dental materials
US6143919A (en) * 1999-05-18 2000-11-07 3M Innovative Properties Company Polymerizable acidic compounds and methods of preparation
EP1435970A4 (de) * 2001-10-18 2005-05-04 Ilex Products Inc Verfahren zur behandlung der haut mit diphosphonat-derivaten
DE102004032781A1 (de) * 2004-01-23 2005-08-11 Mcs Micro Carrier Systems Gmbh Bisphosphonsäurederivate
JP2006028024A (ja) * 2004-07-12 2006-02-02 Toray Ind Inc リン含有有機化合物の製造方法。
EP2289900A1 (de) * 2009-08-26 2011-03-02 Humboldt Universität zu Berlin Bisphosphonate als Hemmer für Acid-Sphingomyelinase
AU2013286683B2 (en) * 2012-07-05 2017-07-13 University Of Iowa Research Foundation Therapeutic bisphosphonates
WO2017144480A1 (fr) * 2016-02-22 2017-08-31 Surfactis Technologies Compositions a base de composes bisphosphoniques dissous dans un solvant fluore ainsi que leur utilisation pour recouvrir la surface d'une piece

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA777769A (en) * 1963-03-18 1968-02-06 H. Roy Clarence Substituted methylene diphosphonic acid compounds and detergent compositions
US3400131A (en) * 1964-03-05 1968-09-03 Hoffmann La Roche 1, 3-di (4-pyridyl)-2-propanol derivatives
GB1115044A (en) * 1964-08-06 1968-05-22 Albright & Wilson Mfg Ltd Derivatives of hydroxy diphosphonic acids
AT279051B (de) * 1966-12-29 1970-02-25 Procter & Gamble Mundpflegemittel
US3400151A (en) * 1967-12-28 1968-09-03 Procter & Gamble Bicyclic dimer of ethane-1-hydroxy-1, 1-diphosphonic acid and salts thereof
US4014959A (en) * 1975-04-24 1977-03-29 Monsanto Company Phosphonoether carboxylates
SU772152A1 (ru) * 1977-07-20 1983-02-15 Центральный научно-исследовательский институт оловянной промышленности 1-Алкоксиалкилиден-1,1-дифосфоновые кислоты или их калиевые,натриевые или аммониевые соли в качестве собирателей дл флотации касситерита и способ их получени
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche

Also Published As

Publication number Publication date
AU4673685A (en) 1986-02-25
GB8419489D0 (en) 1984-09-05
PT80886B (pt) 1987-11-30
ES8707964A1 (es) 1987-09-01
IE58614B1 (en) 1993-10-20
KR860700254A (ko) 1986-08-01
DK147386D0 (da) 1986-04-01
JPS61503034A (ja) 1986-12-25
FI861357A0 (fi) 1986-03-27
GR851865B (de) 1985-12-02
EP0191044A1 (de) 1986-08-20
FI861357A (fi) 1986-03-27
ZA855264B (en) 1986-03-26
JPH068303B2 (ja) 1994-02-02
IE851717L (en) 1986-01-31
US4732998A (en) 1988-03-22
ES545783A0 (es) 1987-09-01
DK147386A (da) 1986-04-01
AU583848B2 (en) 1989-05-11
PT80886A (en) 1985-08-01
DK167808B1 (da) 1993-12-20
WO1986000902A1 (en) 1986-02-13
EP0191044B1 (de) 1990-02-07

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee