US20040234602A1 - Polymer release system - Google Patents

Polymer release system Download PDF

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Publication number
US20040234602A1
US20040234602A1 US10/490,308 US49030804A US2004234602A1 US 20040234602 A1 US20040234602 A1 US 20040234602A1 US 49030804 A US49030804 A US 49030804A US 2004234602 A1 US2004234602 A1 US 2004234602A1
Authority
US
United States
Prior art keywords
acid
composition
carvedilol
active substance
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/490,308
Other languages
English (en)
Inventor
Gina Fischer
Daniel Bar-Shalom
Lillian Slot
Anne-Marie Lademann
Christine Jensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egalet AS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Assigned to EGALET A/S reassignment EGALET A/S ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BAR-SHALOM, DANIEL, FISCHER, GINA, JENSEN, CHRISTINE, LADEMANN, ANNE-MARIE, SLOT, LILLIAN
Publication of US20040234602A1 publication Critical patent/US20040234602A1/en
Priority to US12/073,692 priority Critical patent/US8617605B2/en
Priority to US13/974,689 priority patent/US9694080B2/en
Assigned to EGALET LTD. reassignment EGALET LTD. CHANGE OF ADDRESS Assignors: EGALET LTD.
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
US10/490,308 2001-09-21 2002-09-23 Polymer release system Abandoned US20040234602A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/073,692 US8617605B2 (en) 2001-09-21 2008-03-07 Polymer release system
US13/974,689 US9694080B2 (en) 2001-09-21 2013-08-23 Polymer release system

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200101377 2001-09-21
DKPA200101377 2001-09-21
DKPA200201044 2002-07-03
DKPA200201044 2002-07-03
PCT/DK2002/000620 WO2003024429A1 (fr) 2001-09-21 2002-09-23 Systeme de liberation a base de polymere

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2002/000620 A-371-Of-International WO2003024429A1 (fr) 2001-09-21 2002-09-23 Systeme de liberation a base de polymere

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/073,692 Continuation US8617605B2 (en) 2001-09-21 2008-03-07 Polymer release system

Publications (1)

Publication Number Publication Date
US20040234602A1 true US20040234602A1 (en) 2004-11-25

Family

ID=26069068

Family Applications (3)

Application Number Title Priority Date Filing Date
US10/490,308 Abandoned US20040234602A1 (en) 2001-09-21 2002-09-23 Polymer release system
US12/073,692 Expired - Fee Related US8617605B2 (en) 2001-09-21 2008-03-07 Polymer release system
US13/974,689 Expired - Fee Related US9694080B2 (en) 2001-09-21 2013-08-23 Polymer release system

Family Applications After (2)

Application Number Title Priority Date Filing Date
US12/073,692 Expired - Fee Related US8617605B2 (en) 2001-09-21 2008-03-07 Polymer release system
US13/974,689 Expired - Fee Related US9694080B2 (en) 2001-09-21 2013-08-23 Polymer release system

Country Status (3)

Country Link
US (3) US20040234602A1 (fr)
EP (2) EP2957281A1 (fr)
WO (1) WO2003024429A1 (fr)

Cited By (47)

* Cited by examiner, † Cited by third party
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US20040052754A1 (en) * 2000-11-14 2004-03-18 West Simon Michael Complexes of phosphate derivatives
US20040071777A1 (en) * 2000-12-22 2004-04-15 Laura Trespidi Solid dispersions of nitrate active principles
US20040096493A1 (en) * 2001-06-06 2004-05-20 West Simon Michael Formulation containing phopshate derivatives of electron transfer agents
US20040253318A1 (en) * 2001-07-27 2004-12-16 West Simon Michael Dermal therapy using phosphate derivatives of electron transfer agents
US20050089495A1 (en) * 2001-12-13 2005-04-28 West Simon M. Transdermal transport of compounds
US20050089569A1 (en) * 1998-04-03 2005-04-28 Bm Research A/S Controlled release composition
US20060099168A1 (en) * 2004-11-05 2006-05-11 Italo Corzani Polymeric compositions for sustained release of volatile materials
US20060241085A1 (en) * 2003-01-17 2006-10-26 West Simon M Compounds having anti-proliferative properties
US20060257459A1 (en) * 2002-08-09 2006-11-16 West Simon M Carrier
US20060281716A1 (en) * 2004-03-03 2006-12-14 West Simon M Alkaloid formulations
US20070003617A1 (en) * 2003-03-26 2007-01-04 Egalet A/S Morphine controlled release system
US20070042044A1 (en) * 2003-03-26 2007-02-22 Egalet A/S Matrix compositions for controlled delivery of drug substances
US20070135390A1 (en) * 2003-04-15 2007-06-14 West Micheal S Phosphate derivatives
US20070178152A1 (en) * 2005-11-04 2007-08-02 Shelton Michael C Carboxyalkylcellulose esters for administration of poorly soluble pharmaceutically active agents
US20080056235A1 (en) * 2006-08-31 2008-03-06 Syniverse Technologies, Inc. Cellular-to-VoIP call establishment systems, methods, devices, and computer software
US20080254122A1 (en) * 2001-09-21 2008-10-16 Egalet A/S Polymer release system
US20080254123A1 (en) * 2001-09-21 2008-10-16 Egalet A/S Morphine polymer release system
US20080268057A1 (en) * 2002-11-08 2008-10-30 Egalet A/S Controlled release carvedilol compositions
US20080292695A1 (en) * 2006-12-01 2008-11-27 Kristin Arnold Carvedilol forms, compositions, and methods of preparation thereof
US20090005348A1 (en) * 2005-12-23 2009-01-01 Vital Health Sciences Pty Ltd Compounds Having Cytokine Modulating Properties
US20090023778A1 (en) * 2005-04-28 2009-01-22 Eisai R&D Management Co., Ltd. Composition Containing Anti-Dementia Drug
US20090028935A1 (en) * 2006-12-01 2009-01-29 Kristin Arnold Carvedilol forms, compositions, and methods of preparation thereof
US20090036354A1 (en) * 2005-06-17 2009-02-05 Paul Gavin Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof
WO2009110004A1 (fr) 2008-03-04 2009-09-11 Lupin Limited Compositions pharmaceutiques stables de carvédilol
US20090233881A1 (en) * 2005-03-03 2009-09-17 Vital Health Sciences Pty. Ltd Compounds having anti-cancer properties
US20090274759A1 (en) * 2005-06-03 2009-11-05 Egalet A/S Solid pharmaceutical composition with a first fraction of a dispersion medium and a second fraction of a matrix, the latter being at least partially first exposed to gastrointestinal fluids
US20090317473A1 (en) * 2008-06-20 2009-12-24 Naringrekar Gandha V Controlled-release formulations, method of manufacture, and use thereof
US20090317471A1 (en) * 2008-06-20 2009-12-24 Naringrekar Gandha V Controlled-release formulations, method of manufacture, and use thereof
US20100047340A1 (en) * 2008-08-20 2010-02-25 Board Of Regents, The University Of Texas System Hot-melt extrusion of modified release multi-particulates
US20100196427A1 (en) * 2009-01-30 2010-08-05 Nitec Pharma Ag Delayed-release glucocorticoid treatment of rheumatoid arthritis by improving signs and symptoms, showing major or complete clinical response and by preventing from joint damage
US20100203129A1 (en) * 2009-01-26 2010-08-12 Egalet A/S Controlled release formulations with continuous efficacy
US20100291205A1 (en) * 2007-01-16 2010-11-18 Egalet A/S Pharmaceutical compositions and methods for mitigating risk of alcohol induced dose dumping or drug abuse
US20110142905A1 (en) * 2008-08-14 2011-06-16 Bioneer A/S Coated tablets with remaining degradation surface over the time
US20110223244A1 (en) * 2010-03-09 2011-09-15 Elan Pharma International Limited Alcohol resistant enteric pharmaceutical compositions
US20120083734A1 (en) * 2009-05-18 2012-04-05 Encapson B.V. Balloon catheter comprising pressure sensitive microparticles
US8481565B2 (en) 2004-12-27 2013-07-09 Eisai R&D Management Co., Ltd. Method for stabilizing anti-dementia drug
US8652511B2 (en) 2010-03-30 2014-02-18 Phosphagenics Limited Transdermal delivery patch
US8920838B2 (en) 2006-08-03 2014-12-30 Horizon Pharma Ag Delayed-release glucocorticoid treatment of rheumatoid disease
US9005660B2 (en) 2009-02-06 2015-04-14 Egalet Ltd. Immediate release composition resistant to abuse by intake of alcohol
US9023394B2 (en) 2009-06-24 2015-05-05 Egalet Ltd. Formulations and methods for the controlled release of active drug substances
US9044402B2 (en) 2012-07-06 2015-06-02 Egalet Ltd. Abuse-deterrent pharmaceutical compositions for controlled release
US20160058868A1 (en) * 2013-04-24 2016-03-03 Temple University - Of The Commonwealth System Of Higher Education Solid dosage form containing arabinogalactan
US9561243B2 (en) 2011-03-15 2017-02-07 Phosphagenics Limited Composition comprising non-neutralised tocol phosphate and a vitamin A compound
US9642809B2 (en) 2007-06-04 2017-05-09 Egalet Ltd. Controlled release pharmaceutical compositions for prolonged effect
US10071030B2 (en) 2010-02-05 2018-09-11 Phosphagenics Limited Carrier comprising non-neutralised tocopheryl phosphate
US10973761B2 (en) 2015-12-09 2021-04-13 Phosphagenics Limited Pharmaceutical formulation
US11753435B2 (en) 2016-12-21 2023-09-12 Avecho Biotechnology Limited Process

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EP1604666A1 (fr) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioides pour le traitement de la bronchopneumopathie chronique obstructive
EP1702558A1 (fr) 2005-02-28 2006-09-20 Euro-Celtique S.A. Procédé et dispositif pour évaluer la fonction de l'activité intestinale
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JP5886632B2 (ja) 2009-03-10 2016-03-16 ユーロ−セルティーク エス．エイ． オキシコドンおよびナロキソンを含む即時放出医薬組成物
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BR112015030612B1 (pt) 2013-06-21 2020-07-21 Ferrosan Medical Devices A/S método para preparar uma composição seca
JP2016525138A (ja) 2013-07-23 2016-08-22 ユーロ−セルティーク エス．エイ． 疼痛および腸内ディスバイオシスをもたらす疾患および／または腸内細菌移行に対するリスクを高める疾患に罹患している患者における痛みの治療への使用のためのオキシコドンおよびナロキソンの組み合わせ
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BR112017007466B1 (pt) 2014-10-13 2021-03-02 Ferrosan Medical Devices A/S método para preparar uma composição seca, método para reconstituir a composição seca, pasta, composição seca, recipiente, kit homeostático, e, uso de uma composição seca
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JP6747650B2 (ja) 2014-12-24 2020-08-26 フェロサン メディカル デバイシーズ エイ／エス 第１の物質と第２の物質を保持し混合するためのシリンジ
WO2017005590A1 (fr) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Seringue pour mélanger deux composants et pour conserver un vide dans une condition de stockage
US11491114B2 (en) 2016-10-12 2022-11-08 Curioralrx, Llc Formulations for enteric delivery of therapeutic agents
EP4321182A2 (fr) 2018-05-09 2024-02-14 Ferrosan Medical Devices A/S Procédé de préparation d'une composition hémostatique
WO2020122928A1 (fr) * 2018-12-14 2020-06-18 National Taiwan University Solution cardioplégique stable pour chirurgie cardiaque

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US20080254122A1 (en) 2008-10-16

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