UA81114C2 - Novel antibodies to tissue factor as anticoagulants - Google Patents

Novel antibodies to tissue factor as anticoagulants Download PDF

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Publication number
UA81114C2
UA81114C2 UA20041109787A UA20041109787A UA81114C2 UA 81114 C2 UA81114 C2 UA 81114C2 UA 20041109787 A UA20041109787 A UA 20041109787A UA 20041109787 A UA20041109787 A UA 20041109787A UA 81114 C2 UA81114 C2 UA 81114C2
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UA
Ukraine
Prior art keywords
antibody
antibodies
binding
complex
zeo
Prior art date
Application number
UA20041109787A
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English (en)
Ukrainian (uk)
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Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29401364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA81114(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of UA81114C2 publication Critical patent/UA81114C2/uk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/485Epidermal growth factor [EGF], i.e. urogastrone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/7455Thrombomodulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
UA20041109787A 2002-05-01 2003-04-30 Novel antibodies to tissue factor as anticoagulants UA81114C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37656602P 2002-05-01 2002-05-01
PCT/US2003/013521 WO2003093422A2 (fr) 2002-05-01 2003-04-30 Nouveaux anticorps diriges contre le facteur tissulaire comme anticoagulants

Publications (1)

Publication Number Publication Date
UA81114C2 true UA81114C2 (en) 2007-12-10

Family

ID=29401364

Family Applications (2)

Application Number Title Priority Date Filing Date
UA20041109787A UA81114C2 (en) 2002-05-01 2003-04-30 Novel antibodies to tissue factor as anticoagulants
UA20041109788A UA85996C2 (ru) 2002-05-01 2003-04-30 Слитый антикоагулянтный белок тромбомодулина, который обеспечивает направленное перенесение к тканевому фактору

Family Applications After (1)

Application Number Title Priority Date Filing Date
UA20041109788A UA85996C2 (ru) 2002-05-01 2003-04-30 Слитый антикоагулянтный белок тромбомодулина, который обеспечивает направленное перенесение к тканевому фактору

Country Status (29)

Country Link
US (3) US7250168B2 (fr)
EP (2) EP1549341B1 (fr)
JP (2) JP4567437B2 (fr)
KR (2) KR101080587B1 (fr)
CN (2) CN100563709C (fr)
AR (1) AR039515A1 (fr)
AT (2) ATE427121T1 (fr)
AU (2) AU2003225256B2 (fr)
BR (2) BR0304659A (fr)
CA (2) CA2483909A1 (fr)
CR (1) CR7584A (fr)
DE (2) DE60326970D1 (fr)
DK (2) DK1549341T3 (fr)
EC (2) ECSP045467A (fr)
ES (2) ES2323056T3 (fr)
HK (1) HK1080372A1 (fr)
IL (3) IL164733A0 (fr)
MX (2) MXPA04010795A (fr)
NO (2) NO20035849L (fr)
NZ (2) NZ536243A (fr)
PE (1) PE20040597A1 (fr)
PL (2) PL210582B1 (fr)
PT (2) PT1549341E (fr)
RS (2) RS102404A (fr)
RU (2) RU2320366C2 (fr)
TW (1) TWI343388B (fr)
UA (2) UA81114C2 (fr)
WO (2) WO2003092602A2 (fr)
ZA (2) ZA200409692B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1188830B1 (fr) * 1999-06-02 2010-01-20 Chugai Seiyaku Kabushiki Kaisha Proteine receptrice d'hemopoietine
ES2254224T3 (es) * 1999-09-27 2006-06-16 Chugai Seiyaku Kabushiki Kaisha Nueva proteina del receptor de hematopoyetina, nr12.
EP2351855A1 (fr) 2000-09-26 2011-08-03 Duke University Aptamères d'ARN et leurs procédés d'identification
US7579000B2 (en) * 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants
ES2323056T3 (es) * 2002-05-01 2009-07-06 Bayer Schering Pharma Aktiengesellschaft Anticuerpos dirigidos contra factor tisular como anticoagulantes.
EP1539235A2 (fr) * 2002-07-01 2005-06-15 Human Genome Sciences, Inc. Anticorps qui se lient specifiquement a reg iv
US7425328B2 (en) 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
US7833978B2 (en) * 2004-02-20 2010-11-16 Emory University Thrombomodulin derivatives and conjugates
DK1745062T3 (da) 2004-04-22 2014-08-11 Regado Biosciences Inc Forbedrede modulatorer af koagulationsfaktorer
CN103665168A (zh) * 2005-06-03 2014-03-26 持田制药株式会社 抗cd14抗体融合蛋白质
US20090130104A1 (en) * 2005-10-05 2009-05-21 The Trustees Of The University Of Pennsylvania Fusion proteins for inhibition and dissolution of coagulation
JP5759102B2 (ja) * 2006-04-07 2015-08-05 ノボ ノルディスク ヘルス ケア アーゲー Vii因子・組織因子共有結合複合体
MX2008015568A (es) 2006-06-08 2009-01-13 Chugai Pharmaceutical Co Ltd Agentes para prevenir o tratar enfermedades inflamatorias.
BRPI0720158A2 (pt) * 2006-10-06 2014-05-20 Asahi Kasei Pharma Corp Agentes para terapia e/ou melhora de coagulação intravascular disseminada, para reduzir a probabilidade de morte em pacientes sofrendo da mesma, métodos para selecionar pacientes, e, para tratar e/ou melhorar coagulação intravascular disseminada
EP2129473B1 (fr) * 2007-03-28 2019-07-03 Medtronic ATS Medical, Inc. Procédé pour inhiber l'interaction des plaquettes avec les surfaces de biomatériaux
US20100316563A1 (en) * 2007-09-20 2010-12-16 Bracco Imaging S.P.A. Method For The Preparation Of New Oligoclonal Antibodies
CN104162155A (zh) 2007-12-05 2014-11-26 中外制药株式会社 搔痒症治疗药
US8333973B2 (en) * 2008-01-02 2012-12-18 The Trustees Of The University Of Pennsylvania Targeting recombinant therapeutics to circulating red blood cells
UA112050C2 (uk) * 2008-08-04 2016-07-25 БАЄР ХЕЛСКЕР ЛЛСі Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi)
AU2009282234A1 (en) * 2008-08-14 2010-02-18 Merck Sharp & Dohme Corp. Methods for purifying antibodies using protein a affinity chromatography
WO2010045518A1 (fr) * 2008-10-16 2010-04-22 The Trustees Of The University Of Pennsylvania Compositions contenant des domaines de la thrombomoduline et leurs utilisations
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
EP2230251A1 (fr) * 2009-03-19 2010-09-22 Bracco Imaging S.p.A Anticorps particulièrement actifs dans la plaque coronaire et leur procédé d'identification
US20120178693A1 (en) * 2009-08-28 2012-07-12 Bayer Healthcare Llc Cofactors for Thrombin Activation of Factor VII and Uses Thereof
GB201007356D0 (en) 2010-04-30 2010-06-16 Leverton Licence Holdings Ltd Conjugated factor VIIa
EP2576625B1 (fr) 2010-06-04 2018-04-25 TiumBio Co., Ltd. Protéine de fusion ayant une activité de facteur vii
WO2011157741A2 (fr) 2010-06-15 2011-12-22 Genmab A/S Conjugués anticorps humain-médicament contre le facteur tissulaire
AR082588A1 (es) * 2010-08-05 2012-12-19 Council Scient Ind Res Construcciones de proteinas de fusion con propiedades tromboliticas y anticoagulantes
RU2445365C1 (ru) * 2010-11-03 2012-03-20 Общество с ограниченной ответственностью "Инновационный Центр "Новые Технологии и Материалы" (ООО "ИЦ Новтехмат") Штамм гибридных культивируемых клеток mus musculus - продуцент моноклональных антител, специфичных к протеину с человека (варианты)
KR20170134748A (ko) 2015-04-14 2017-12-06 추가이 세이야쿠 가부시키가이샤 Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물
WO2016176440A2 (fr) * 2015-04-28 2016-11-03 Saint Louis University Protéines de fusion de thrombine-thrombomoduline en tant qu'activateurs de la protéine c
US11085031B2 (en) 2016-04-28 2021-08-10 Saint Louis University Thrombin-thrombomodulin fusion proteins as a powerful anticoagulant
EP3541834A1 (fr) * 2016-11-16 2019-09-25 Bayer Healthcare LLC Facteur viii ciblé de globules rouges et son procédé d'utilisation
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
JP2022513332A (ja) * 2018-10-04 2022-02-07 スロムボシス アンド コアグラシヨン アーべー プロテインsレベルの決定方法
CA3156713A1 (fr) 2019-11-20 2021-05-27 Daisuke Kameoka Preparation pharmaceutique comprenant un anticorps
CN114686444B (zh) * 2020-12-31 2024-05-31 广州万孚生物技术股份有限公司 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用
CN114686443B (zh) * 2020-12-31 2023-11-03 广州万孚生物技术股份有限公司 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) * 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
ZA862768B (en) * 1985-04-17 1986-12-30 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US5589173A (en) 1986-11-04 1996-12-31 Genentech, Inc. Method and therapeutic compositions for the treatment of myocardial infarction
US5437864A (en) * 1987-03-31 1995-08-01 The Scripps Research Institute Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor
US5223427A (en) * 1987-03-31 1993-06-29 The Scripps Research Institute Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
US4912207A (en) 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da) 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
US5298599A (en) * 1988-12-30 1994-03-29 Oklahoma Medical Research Foundation Expression and purification of recombinant soluble tissue factor
EP0458903A4 (en) * 1989-02-17 1992-06-17 Codon Soluble analogs of thrombomodulin
US5466668A (en) 1989-04-28 1995-11-14 Schering Aktiengesellschaft Superior thrombomodulin analogs for pharmaceutical use
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US6063763A (en) 1989-04-28 2000-05-16 Schering Aktiengesellschaft Protease-resistant thrombomodulin analogs
KR930008093B1 (ko) 1990-08-03 1993-08-25 아사히가세이고오교 가부시끼가이샤 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물
US5843442A (en) * 1990-10-22 1998-12-01 Corvas International, Inc. Blood coagulation protein antagonists and uses therefor
US5506134A (en) * 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
JPH0578397A (ja) * 1991-01-29 1993-03-30 Sumitomo Pharmaceut Co Ltd 血栓溶解タンパク質
JPH06133780A (ja) * 1992-10-23 1994-05-17 Sumitomo Pharmaceut Co Ltd 新規なt−PA改変体
US5916874A (en) 1994-04-20 1999-06-29 Asahi Kasei Kogyo Kabushiki Kaisha Method for treating liver injury
US5736364A (en) 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
US5986065A (en) 1997-03-10 1999-11-16 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
HUP0101160A2 (hu) * 1998-04-03 2001-08-28 Chugai Seiyaku Kabushiki Kaisha Humán szöveti faktor (TF) elleni humanizált antitest és eljárás előállítására
AU2001250814B2 (en) * 2000-03-16 2007-02-15 Genentech, Inc. Anti-tissue factor antibodies with enhanced anticoagulant potency
US6632791B1 (en) 2000-06-21 2003-10-14 Schering Aktiengesellschaft Thrombomodulin analogs for pharmaceutical use
TWI338009B (en) * 2001-10-29 2011-03-01 Genentech Inc Antibodies for inhibiting blood coagulation and methods of use thereof
AU2003201159A1 (en) 2002-01-08 2003-07-24 Bayer Healthcare Ag Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy
ES2323056T3 (es) * 2002-05-01 2009-07-06 Bayer Schering Pharma Aktiengesellschaft Anticuerpos dirigidos contra factor tisular como anticoagulantes.
US7579000B2 (en) 2002-05-01 2009-08-25 Bayer Schering Pharma Ag Tissue factor targeted antibodies as anticoagulants

Also Published As

Publication number Publication date
KR101080587B1 (ko) 2011-11-04
RS104504A (sr) 2007-02-05
EP1549341B1 (fr) 2009-04-01
PE20040597A1 (es) 2004-10-06
ECSP045467A (es) 2005-01-28
RU2320366C2 (ru) 2008-03-27
AR039515A1 (es) 2005-02-23
EP1503785A2 (fr) 2005-02-09
KR20050045945A (ko) 2005-05-17
KR101013697B1 (ko) 2011-02-10
CN100412090C (zh) 2008-08-20
NZ536242A (en) 2006-04-28
RS102404A (sr) 2006-12-15
US20040063632A1 (en) 2004-04-01
ECSP045468A (es) 2005-01-28
CA2483910A1 (fr) 2003-11-13
JP4460443B2 (ja) 2010-05-12
RU2345789C2 (ru) 2009-02-10
BR0304659A (pt) 2004-09-21
MXPA04010851A (es) 2005-02-14
ATE484524T1 (de) 2010-10-15
PT1549341E (pt) 2009-05-29
DE60326970D1 (de) 2009-05-14
WO2003092602A3 (fr) 2004-08-26
BR0304660A (pt) 2005-06-07
EP1549341A4 (fr) 2006-10-18
JP2005532045A (ja) 2005-10-27
NO20035849L (no) 2004-02-27
RU2004135306A (ru) 2005-07-10
DK1503785T3 (da) 2011-02-07
US20080019985A1 (en) 2008-01-24
WO2003092602A2 (fr) 2003-11-13
JP4567437B2 (ja) 2010-10-20
MXPA04010795A (es) 2005-03-07
AU2003225255B2 (en) 2008-07-31
WO2003093422A3 (fr) 2004-07-15
PL373945A1 (en) 2005-09-19
CN1665526A (zh) 2005-09-07
PL210582B1 (pl) 2012-02-29
ATE427121T1 (de) 2009-04-15
AU2003225256A1 (en) 2003-11-17
EP1503785B1 (fr) 2010-10-13
CA2483909A1 (fr) 2003-11-13
ZA200409692B (en) 2006-07-26
WO2003093422A2 (fr) 2003-11-13
IL164733A (en) 2011-05-31
ZA200409694B (en) 2006-02-22
JP2005538046A (ja) 2005-12-15
AU2003225256B2 (en) 2009-06-04
NO20035848L (no) 2004-02-27
RU2004135308A (ru) 2005-08-10
US7250168B2 (en) 2007-07-31
TW200307043A (en) 2003-12-01
EP1503785A4 (fr) 2007-02-14
DK1549341T3 (da) 2009-07-06
US20080020965A1 (en) 2008-01-24
IL164732A0 (en) 2005-12-18
CN100563709C (zh) 2009-12-02
HK1080372A1 (zh) 2006-04-28
KR20050045944A (ko) 2005-05-17
NZ536243A (en) 2006-06-30
DE60334538D1 (de) 2010-11-25
PL373960A1 (en) 2005-09-19
PT1503785E (pt) 2011-01-17
ES2323056T3 (es) 2009-07-06
CN1665534A (zh) 2005-09-07
AU2003225255A1 (en) 2003-11-17
EP1549341A2 (fr) 2005-07-06
CR7584A (es) 2006-05-30
IL164733A0 (en) 2005-12-18
TWI343388B (en) 2011-06-11
UA85996C2 (ru) 2009-03-25
US7622457B2 (en) 2009-11-24
ES2354419T3 (es) 2011-03-14
US7622122B2 (en) 2009-11-24

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