PE20040597A1 - Proteinas de fusion de trombomodulina dirigidas al factor tisular como anticoagulantes - Google Patents

Proteinas de fusion de trombomodulina dirigidas al factor tisular como anticoagulantes

Info

Publication number
PE20040597A1
PE20040597A1 PE2003000426A PE2003000426A PE20040597A1 PE 20040597 A1 PE20040597 A1 PE 20040597A1 PE 2003000426 A PE2003000426 A PE 2003000426A PE 2003000426 A PE2003000426 A PE 2003000426A PE 20040597 A1 PE20040597 A1 PE 20040597A1
Authority
PE
Peru
Prior art keywords
domain
fusion protein
protein
tissue factor
analogs
Prior art date
Application number
PE2003000426A
Other languages
English (en)
Inventor
David Light
Kirk Mclean
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29401364&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20040597(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20040597A1 publication Critical patent/PE20040597A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF] (urogastrone)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE REFIERE A UNA PROTEINA DE FUSION ANTICOAGULANTE, CARACTERIZADA PORQUE, COMPRENDE UNA PROTEINA DIRECCIONADORA, QUE INTERACTUA CON EL FACTOR TISULAR (TF) O EL COMPLEJO DE FACTOR VIIa/TF (FVIIa/TF), LIGADA OPERATIVAMENTE AL DOMINIO EGF456 DE LA TROMBOMODULINA (TM) O ANALOGOS, FRAGMENTOS, DERIVADOS O VARIANTES DE LAS MISMAS, SOLA O COMBINADA CON AL MENOS UN DOMINIO ADICIONAL DE TM SELECCIONADO DEL GRUPO FORMADO POR EL BUCLE DE INTERDOMINIO ENTRE EGF3 Y EGF4, EL DOMINIO EGF123, EL DOMINIO DE GLUCOSILACION O-LIGADO Y EL DOMINIO HIDROFOBICO DE LA REGION N-TERMINAL, O ANALOGOS, FRAGMENTOS, DERIVADOS O VARIANTES DE LAS MISMAS. DICHA PROTEINA DE FUSION ESTA GLICOSILADA O ESTA BIOTINILADA PARA SU UNION CON ESTREPTAVIDINA. DICHO DOMINIO EGF456 CONTIENE MUTACIONES PUNTUALES QUE VUELVEN MAS RESISTENTE A DICHA PROTEINA DE FUSION A LOS DANOS OXIDATIVOS O LA ACTIVIDAD PROTEASA O INCREMENTAN LA EFICACIOA CATALITICA. DICHA PROTEINA DIRECCIONADORA ES FVIIai O TFPI. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE O SECUENCIAS DE ADN, SECUENCIA DE AMINOACIDOS DE LA SEQ ID Nº2 O SEQ ID Nº3, EN COMBINACION CON UN VECTOR DE TERAPIA GENETICA, QUE CODIFICAN LOS COMPONENTES DE PROTEINA DE FUSION. ESTA PROTEINA ES UTIL PARA PREVENIR Y TRATAR LA TROMBOSIS VENOSA PROFUNDA (DVT), LA COAGULACION INTRAVASCULAR DISEMINADA (DIC), SINDROME CORONARIO AGUDO O CANCER CON EVIDENCIA DE COAGULOPATIAS, RESPUESTA INFLAMATORIA POR SEPSIS, INJERTOS DE PIEL Y VENAS Y TRANSPLANTES DE ORGANOS
PE2003000426A 2002-05-01 2003-04-30 Proteinas de fusion de trombomodulina dirigidas al factor tisular como anticoagulantes PE20040597A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37656602P 2002-05-01 2002-05-01

Publications (1)

Publication Number Publication Date
PE20040597A1 true PE20040597A1 (es) 2004-10-06

Family

ID=29401364

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000426A PE20040597A1 (es) 2002-05-01 2003-04-30 Proteinas de fusion de trombomodulina dirigidas al factor tisular como anticoagulantes

Country Status (29)

Country Link
US (3) US7250168B2 (es)
EP (2) EP1549341B1 (es)
JP (2) JP4460443B2 (es)
KR (2) KR101013697B1 (es)
CN (2) CN100412090C (es)
AR (1) AR039515A1 (es)
AT (2) ATE427121T1 (es)
AU (2) AU2003225255B2 (es)
BR (2) BR0304659A (es)
CA (2) CA2483910A1 (es)
CR (1) CR7584A (es)
DE (2) DE60326970D1 (es)
DK (2) DK1549341T3 (es)
EC (2) ECSP045468A (es)
ES (2) ES2323056T3 (es)
HK (1) HK1080372A1 (es)
IL (3) IL164733A0 (es)
MX (2) MXPA04010851A (es)
NO (2) NO20035849L (es)
NZ (2) NZ536242A (es)
PE (1) PE20040597A1 (es)
PL (2) PL373945A1 (es)
PT (2) PT1503785E (es)
RS (2) RS104504A (es)
RU (2) RU2320366C2 (es)
TW (1) TWI343388B (es)
UA (2) UA81114C2 (es)
WO (2) WO2003092602A2 (es)
ZA (2) ZA200409692B (es)

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Also Published As

Publication number Publication date
IL164733A (en) 2011-05-31
WO2003092602A3 (en) 2004-08-26
CN1665526A (zh) 2005-09-07
JP2005532045A (ja) 2005-10-27
ATE427121T1 (de) 2009-04-15
RS104504A (sr) 2007-02-05
EP1503785A4 (en) 2007-02-14
ECSP045467A (es) 2005-01-28
UA81114C2 (en) 2007-12-10
KR20050045944A (ko) 2005-05-17
US20040063632A1 (en) 2004-04-01
RU2004135306A (ru) 2005-07-10
EP1549341B1 (en) 2009-04-01
PT1549341E (pt) 2009-05-29
AU2003225255A1 (en) 2003-11-17
CR7584A (es) 2006-05-30
CN100563709C (zh) 2009-12-02
PT1503785E (pt) 2011-01-17
ECSP045468A (es) 2005-01-28
PL373945A1 (en) 2005-09-19
IL164733A0 (en) 2005-12-18
JP2005538046A (ja) 2005-12-15
EP1503785A2 (en) 2005-02-09
ZA200409692B (en) 2006-07-26
NZ536243A (en) 2006-06-30
AR039515A1 (es) 2005-02-23
DE60326970D1 (de) 2009-05-14
RS102404A (sr) 2006-12-15
AU2003225256A1 (en) 2003-11-17
EP1503785B1 (en) 2010-10-13
KR101080587B1 (ko) 2011-11-04
NO20035848L (no) 2004-02-27
ATE484524T1 (de) 2010-10-15
IL164732A0 (en) 2005-12-18
KR20050045945A (ko) 2005-05-17
TWI343388B (en) 2011-06-11
US7250168B2 (en) 2007-07-31
JP4567437B2 (ja) 2010-10-20
ES2354419T3 (es) 2011-03-14
PL210582B1 (pl) 2012-02-29
MXPA04010851A (es) 2005-02-14
WO2003093422A2 (en) 2003-11-13
EP1549341A4 (en) 2006-10-18
HK1080372A1 (zh) 2006-04-28
UA85996C2 (ru) 2009-03-25
DK1549341T3 (da) 2009-07-06
RU2345789C2 (ru) 2009-02-10
RU2320366C2 (ru) 2008-03-27
DE60334538D1 (de) 2010-11-25
NO20035849L (no) 2004-02-27
CN1665534A (zh) 2005-09-07
EP1549341A2 (en) 2005-07-06
WO2003092602A2 (en) 2003-11-13
CA2483909A1 (en) 2003-11-13
KR101013697B1 (ko) 2011-02-10
JP4460443B2 (ja) 2010-05-12
TW200307043A (en) 2003-12-01
US20080019985A1 (en) 2008-01-24
PL373960A1 (en) 2005-09-19
AU2003225256B2 (en) 2009-06-04
BR0304660A (pt) 2005-06-07
ES2323056T3 (es) 2009-07-06
BR0304659A (pt) 2004-09-21
US7622122B2 (en) 2009-11-24
ZA200409694B (en) 2006-02-22
CN100412090C (zh) 2008-08-20
CA2483910A1 (en) 2003-11-13
US7622457B2 (en) 2009-11-24
US20080020965A1 (en) 2008-01-24
DK1503785T3 (da) 2011-02-07
RU2004135308A (ru) 2005-08-10
MXPA04010795A (es) 2005-03-07
WO2003093422A3 (en) 2004-07-15
AU2003225255B2 (en) 2008-07-31
NZ536242A (en) 2006-04-28

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