UA61880C2 - SYNTHESIS OF g-LINOLENIC ACID UNDER THE ACTION OF DELTA-6-DESATURASE - Google Patents
SYNTHESIS OF g-LINOLENIC ACID UNDER THE ACTION OF DELTA-6-DESATURASE Download PDFInfo
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- UA61880C2 UA61880C2 UA97063197A UA97063197A UA61880C2 UA 61880 C2 UA61880 C2 UA 61880C2 UA 97063197 A UA97063197 A UA 97063197A UA 97063197 A UA97063197 A UA 97063197A UA 61880 C2 UA61880 C2 UA 61880C2
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- desaturase
- gamma
- plant
- linolenic acid
- acid
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- 150000003626 triacylglycerols Chemical class 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19003—Linoleoyl-CoA desaturase (1.14.19.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Medicinal Chemistry (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/366,779 US5614393A (en) | 1991-10-10 | 1994-12-30 | Production of γ-linolenic acid by a Δ6-desaturase |
| PCT/IB1995/001167 WO1996021022A2 (en) | 1994-12-30 | 1995-12-28 | Production of gamma linolenic acid by a δ6-desaturase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA61880C2 true UA61880C2 (en) | 2003-12-15 |
Family
ID=23444458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA97063197A UA61880C2 (en) | 1994-12-30 | 1995-12-28 | SYNTHESIS OF g-LINOLENIC ACID UNDER THE ACTION OF DELTA-6-DESATURASE |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5614393A (de) |
| EP (1) | EP0801680B1 (de) |
| JP (2) | JP4422211B2 (de) |
| CN (1) | CN1117864C (de) |
| AR (1) | AR000582A1 (de) |
| AU (1) | AU707061B2 (de) |
| BR (1) | BR9510411A (de) |
| CA (1) | CA2207906C (de) |
| DE (1) | DE69535064T2 (de) |
| ES (1) | ES2262146T3 (de) |
| RO (1) | RO121387B1 (de) |
| RU (1) | RU2181772C2 (de) |
| UA (1) | UA61880C2 (de) |
| WO (1) | WO1996021022A2 (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2484137C2 (ru) * | 2006-01-04 | 2013-06-10 | Монсанто С.А.С. | Мутанты fad-2 и высокоолеиновые растения |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070130654A1 (en) * | 1991-10-10 | 2007-06-07 | Thomas Terry L | Production of gamma linolenic acid by a delta6-desaturase |
| US20090077692A1 (en) * | 1991-10-10 | 2009-03-19 | Thomas Terry L | Production of gamma linolenic acid by a delta6-desaturase |
| US5614393A (en) * | 1991-10-10 | 1997-03-25 | Rhone-Poulenc Agrochimie | Production of γ-linolenic acid by a Δ6-desaturase |
| US7109392B1 (en) | 1996-10-09 | 2006-09-19 | Cargill, Incorporated | Methods for increasing oleic acid content in seeds from transgenic plants containing a mutant delta 12 desaturase |
| US5977436A (en) * | 1997-04-09 | 1999-11-02 | Rhone Poulenc Agrochimie | Oleosin 5' regulatory region for the modification of plant seed lipid composition |
| US5959175A (en) * | 1997-04-09 | 1999-09-28 | Thomas; Terry L. | Sunflower albumin 5' regulatory region for the modification of plant seed lipid composition |
| US5968809A (en) * | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| WO1998046764A1 (en) * | 1997-04-11 | 1998-10-22 | Calgene Llc | Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants |
| US6075183A (en) * | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US6051754A (en) * | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US7745694B1 (en) | 1997-04-11 | 2010-06-29 | Monsanto Technology Llc | Methods and compositions for synthesis of long chain polyunsaturated fatty acids in plants |
| US6100450A (en) * | 1997-10-22 | 2000-08-08 | Rhone-Poulenc Agrochimie | Seed specific promoters based on arabidopsis genes |
| GB9724783D0 (en) * | 1997-11-24 | 1998-01-21 | Inst Arable Crops Research | Novel polypeptides |
| AU761152B2 (en) * | 1998-03-17 | 2003-05-29 | Cargill Incorporated | Genes for mutant microsomal delta-12 fatty acid desaturases and related enzymes from plants |
| US6635806B1 (en) * | 1998-05-14 | 2003-10-21 | Dekalb Genetics Corporation | Methods and compositions for expression of transgenes in plants |
| WO1999061602A1 (en) * | 1998-05-29 | 1999-12-02 | Ohio University | Compositions and methods for the synthesis of fatty acids, their derivatives and downstream products |
| WO1999064614A2 (en) | 1998-06-12 | 1999-12-16 | Calgene Llc | Polyunsaturated fatty acids in plants |
| DE19828850A1 (de) * | 1998-06-27 | 1999-12-30 | Gvs Ges Fuer Erwerb Und Verwer | Sphingolipid-Desaturase |
| ATE375712T1 (de) * | 1998-08-04 | 2007-11-15 | Cargill Inc | Promotoren der fettsäure-desaturase aus pflanzen |
| AU1097900A (en) * | 1998-10-05 | 2000-04-26 | Abbott Laboratories | Delta 6 and delta 12 desaturases and modified fatty acid biosynthesis and products produced therefrom |
| CA2346006A1 (en) * | 1998-10-09 | 2000-04-20 | Merck & Co., Inc. | Delta 6 fatty acid desaturase |
| AU2163100A (en) * | 1998-12-03 | 2000-06-19 | E.I. Du Pont De Nemours And Company | Membrane-bound desaturases |
| US6864077B1 (en) | 1998-12-03 | 2005-03-08 | Edgar B. Cahoon | Membrane-bound desaturases |
| US6825017B1 (en) | 1998-12-07 | 2004-11-30 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| US8791327B2 (en) | 1998-12-07 | 2014-07-29 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| CA2791961A1 (en) * | 1998-12-07 | 2000-06-15 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| ATE273373T1 (de) | 1999-02-26 | 2004-08-15 | Martek Biosciences Corp | Verfahren zum abtrennen von einem docosahexaensäure enthaltenden triglyerid aus einem triglyceridgemisch |
| WO2000075341A1 (de) | 1999-06-07 | 2000-12-14 | Basf Plant Science Gmbh | Δ6-acetylenase und δ6-desaturase aus ceratodon purpureus |
| DE10030976A1 (de) | 2000-06-30 | 2002-01-10 | Basf Ag | DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren |
| WO2001002591A1 (de) * | 1999-07-06 | 2001-01-11 | Basf Plant Science Gmbh | Δ6-desaturasegene exprimierende pflanzen und pufas enthaltende öle aus diesen pflanzen und ein verfahren zur herstellung ungesättigter fettsäuren |
| WO2001004622A1 (en) * | 1999-07-13 | 2001-01-18 | The Dow Chemical Company | Method for chemical analysis of biological material |
| US7135623B1 (en) * | 1999-09-10 | 2006-11-14 | Nutrinova Nutrition Specialties & Food Engredients Gmbh | Nucleic acid which is obtained from Tetrahymena and which codes for a delta-6-desaturase, the production thereof and use |
| CA2301158A1 (en) * | 2000-03-24 | 2001-09-24 | Stephen J. Allen | Screening methods for compounds useful for modulating lipid metabolism in disease |
| US7087432B2 (en) * | 2000-09-28 | 2006-08-08 | Bioriginal Food & Science Corp. | Fad4, Fad5, Fad5-2 and Fad6, novel fatty acid desaturase family members and uses thereof |
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| US7211656B2 (en) * | 2002-01-30 | 2007-05-01 | Abbott Laboratories | Desaturase genes, enzymes encoded thereby, and uses thereof |
| GB2385852A (en) * | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
| DE10219203A1 (de) | 2002-04-29 | 2003-11-13 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen |
| EP2216405A1 (de) | 2002-05-03 | 2010-08-11 | Monsanto Technology LLC | Saatspezifische USP-Promotoren zur Expression von Genen in Pflanzen |
| US7078234B2 (en) | 2002-12-18 | 2006-07-18 | Monsanto Technology Llc | Maize embryo-specific promoter compositions and methods for use thereof |
| BR0317304A (pt) * | 2002-12-19 | 2005-11-08 | Univ Bristol | Processo para a produção de compostos, sequência de ácido nucleico isolada, sequência de aminoácidos, construção gênica, vetor, e, organismo |
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| CN1836045B (zh) | 2003-03-28 | 2012-05-09 | 孟山都技术有限公司 | 用于早期种子发育的新型植物启动子 |
| CA2868312A1 (en) | 2003-03-31 | 2004-10-14 | University Of Bristol | Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids |
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| AU2003252958A1 (en) * | 2003-07-31 | 2005-02-25 | The University Of York | Fatty acid biosynthesis 3 |
| US11952581B2 (en) | 2003-08-01 | 2024-04-09 | Basf Plant Science Gmbh | Process for the production of polyunsaturated fatty acids in transgenic organisms |
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| CA2450000A1 (en) | 2003-12-18 | 2005-06-18 | Alberta Research Council Inc. | Method of creating plants with reduced level of saturated fatty acid in seed oil |
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| CA2804925A1 (en) | 2010-06-25 | 2011-12-29 | Basf Plant Science Company Gmbh | Acyltransferases from thraustochytrium species and uses thereof in fatty acid production |
| CN102250928A (zh) * | 2011-04-07 | 2011-11-23 | 中国农业科学院北京畜牧兽医研究所 | Δ-6脂肪酸脱氢酶突变基因及其表达载体和应用 |
| ES2769448T3 (es) | 2012-04-12 | 2020-06-25 | Rothamsted Res Limited | Producción de ácidos grasos poliinsaturados omega-3 de cadena larga |
| UA127917C2 (uk) | 2012-06-15 | 2024-02-14 | Коммонвелт Сайнтіфік Енд Індастріел Рісерч Організейшн | Рекомбінантна клітина brassica napus, яка містить довголанцюгові поліненасичені жирні кислоти, трансгенна рослина та насіння brassica napus, спосіб отримання екстрагованого ліпіду рослин, харчового продукту та етилового ефіру поліненасичених жирних кислот |
| KR101437605B1 (ko) * | 2012-06-29 | 2014-09-15 | 대한민국 | 형질 전환된 유채를 제조하는 방법 |
| GB201217524D0 (en) | 2012-10-01 | 2012-11-14 | Rothamsted Res Ltd | Recombinant organisms |
| JP6554099B2 (ja) | 2013-08-07 | 2019-07-31 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． | ｐ５３変異体を再活性化することの可能なペプチド |
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| WO2023108250A1 (en) * | 2021-12-16 | 2023-06-22 | Bioriginal Food & Science Corp. | Plants with ehnhanced gamma linolenic acid production |
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| US4736866A (en) * | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
| NZ221259A (en) * | 1986-07-31 | 1990-05-28 | Calgene Inc | Seed specific transcriptional regulation |
| DE69033816T2 (de) * | 1989-02-24 | 2002-08-08 | Monsanto Technology Llc., St. Louis | Synthetische pflanzengene und verfahren zu ihrer herstellung |
| US5260379A (en) * | 1991-09-13 | 1993-11-09 | Eastman Kodak Company | Polyester blends with improved processability |
| PH31293A (en) * | 1991-10-10 | 1998-07-06 | Rhone Poulenc Agrochimie | Production of y-linolenic acid by a delta6-desaturage. |
| US5614393A (en) * | 1991-10-10 | 1997-03-25 | Rhone-Poulenc Agrochimie | Production of γ-linolenic acid by a Δ6-desaturase |
| US7205457B1 (en) * | 1993-02-05 | 2007-04-17 | Monsanto Technology Llc | Altered linolenic and linoleic acid content in plants |
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1994
- 1994-12-30 US US08/366,779 patent/US5614393A/en not_active Expired - Lifetime
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1995
- 1995-12-28 CN CN95197728A patent/CN1117864C/zh not_active Expired - Lifetime
- 1995-12-28 UA UA97063197A patent/UA61880C2/uk unknown
- 1995-12-28 ES ES95944464T patent/ES2262146T3/es not_active Expired - Lifetime
- 1995-12-28 CA CA002207906A patent/CA2207906C/en not_active Expired - Lifetime
- 1995-12-28 BR BR9510411A patent/BR9510411A/pt not_active IP Right Cessation
- 1995-12-28 RO RO97-01202A patent/RO121387B1/ro unknown
- 1995-12-28 WO PCT/IB1995/001167 patent/WO1996021022A2/en active IP Right Grant
- 1995-12-28 AU AU46735/96A patent/AU707061B2/en not_active Ceased
- 1995-12-28 DE DE69535064T patent/DE69535064T2/de not_active Expired - Lifetime
- 1995-12-28 JP JP52082796A patent/JP4422211B2/ja not_active Expired - Fee Related
- 1995-12-28 AR AR33486195A patent/AR000582A1/es active IP Right Grant
- 1995-12-28 EP EP95944464A patent/EP0801680B1/de not_active Expired - Lifetime
- 1995-12-28 RU RU97112919/13A patent/RU2181772C2/ru not_active IP Right Cessation
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1997
- 1997-01-28 US US08/789,936 patent/US5789220A/en not_active Expired - Lifetime
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2484137C2 (ru) * | 2006-01-04 | 2013-06-10 | Монсанто С.А.С. | Мутанты fad-2 и высокоолеиновые растения |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69535064T2 (de) | 2006-12-07 |
| US5614393A (en) | 1997-03-25 |
| JP2007330267A (ja) | 2007-12-27 |
| WO1996021022A2 (en) | 1996-07-11 |
| AU707061B2 (en) | 1999-07-01 |
| US5789220A (en) | 1998-08-04 |
| RU2181772C2 (ru) | 2002-04-27 |
| JPH10511848A (ja) | 1998-11-17 |
| CA2207906C (en) | 2009-12-01 |
| RO121387B1 (ro) | 2007-04-30 |
| EP0801680B1 (de) | 2006-06-14 |
| AR000582A1 (es) | 1997-07-10 |
| AU4673596A (en) | 1996-07-24 |
| BR9510411A (pt) | 1998-05-19 |
| JP4422211B2 (ja) | 2010-02-24 |
| ES2262146T3 (es) | 2006-11-16 |
| CN1177379A (zh) | 1998-03-25 |
| EP0801680A2 (de) | 1997-10-22 |
| CN1117864C (zh) | 2003-08-13 |
| WO1996021022A3 (en) | 1996-09-12 |
| CA2207906A1 (en) | 1996-07-11 |
| DE69535064D1 (de) | 2006-07-27 |
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