UA42669A - Антагоністи ангіотензину ii, спосіб їх отримання (варіанти), проміжна сполука (варіанти), спосіб їх отримання та фармацевтична композиція - Google Patents

Антагоністи ангіотензину ii, спосіб їх отримання (варіанти), проміжна сполука (варіанти), спосіб їх отримання та фармацевтична композиція

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Publication number
UA42669A
UA42669A UA5010343A UA5010343A UA42669A UA 42669 A UA42669 A UA 42669A UA 5010343 A UA5010343 A UA 5010343A UA 5010343 A UA5010343 A UA 5010343A UA 42669 A UA42669 A UA 42669A
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Ukraine
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phenyl
group
hydrogen
atom
cyano
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UA5010343A
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English (en)
Russian (ru)
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Клод БЕРНАР
Жан-Клод Брельєр
Жан-Клод БРЕЛЬЕР
Жак Клєман
Жак Клеман
Діно Нісато
Дино Нисато
П'єр Перро
Пьер Перро
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Санофі-Сінтелябо
Санофи-Синтелябо
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Priority claimed from FR9003563A external-priority patent/FR2659967B1/fr
Priority claimed from FR9010144A external-priority patent/FR2665702B1/fr
Application filed by Санофі-Сінтелябо, Санофи-Синтелябо filed Critical Санофі-Сінтелябо
Publication of UA42669A publication Critical patent/UA42669A/uk

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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

Антагоністи ангіотензину II формули (I) де: R1 являє собою атом водню, карбоксигрупу, (С1-С4)алкоксикарбонільну групу, тетразоліл, метилтетразоліл, трифторметилсульфоніламіногрупу, трифторметилсульфоніламінометил, ціано, N-ціанокарбамоїл, N-гідроксикарбамоїл, N-(4-карбокси-1,3-тіазол-2-іл)карбамоїл, уреїдо, 2-ціаногуанідинкарбоніл, імідазол-1-ілкарбоніл, 2-ціаногуанідинометил, ціано-метилізотіоуреїдометил, за умови, що щонайменше один із заступників R1 або R2 відрізняється від водню, R2 являє собою атом водню або -СООН, R3 являє собою водень, (С1-С4)алкіл, незаміщений або заміщений одним або декількома атомами галогену, С4-алкеніл, циклопентил, феніл, феніл(С1-С3)алкіл, R4 і R5 являють собою, кожний незалежно, метил або феніл, або R4 і R5 разом утворять групу формули =СR7R8, у якій R7 являє собою водень, (С1-С2)алкіл, феніл, і R8 являє собою (С1-С2)алкіл, феніл, причому зазначені фенільні групи не заміщені або заміщені атомом галогену або трифторметилом, або R4 і R5, з'єднані разом, являють собою групу формули (СН2)n, де n= 2-11, або групу формули -(CH2)2Y(CH2)2-, у якій Y являє собою атом кисню, атом вуглецю, заміщений метилом або фенілом, або групу N-R6, у якій R6 являє собою водень, ацетил, трифторметилкарбоніл, бензил, бензоїл, -аміноацил, N-захисну групу, або R4 і R5, з'єднані разом з атомом вуглецю, з яким вони зв'язані, утворюють індан або адамантан, Х являє собою атом кисню або сірки, z і t дорівнюють нулю або один із цих індексів дорівнює нулю, а інший - одиниці, та їхні солі.
UA5010343A 1990-03-20 1991-03-20 Антагоністи ангіотензину ii, спосіб їх отримання (варіанти), проміжна сполука (варіанти), спосіб їх отримання та фармацевтична композиція UA42669A (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9003563A FR2659967B1 (fr) 1990-03-20 1990-03-20 Derives d'imidazolinone n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
FR9010144A FR2665702B1 (fr) 1990-08-08 1990-08-08 Derives heterocycliques n-substitues, leur preparation, les compositions pharmaceutiques en contenant.
PCT/FR1991/000224 WO1991014679A1 (fr) 1990-03-20 1991-03-20 Derives heterocycliques n-substitues, leur preparation, les compostions pharmaceutiques en contenant

Publications (1)

Publication Number Publication Date
UA42669A true UA42669A (uk) 2001-11-15

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ID=26227935

Family Applications (1)

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UA5010343A UA42669A (uk) 1990-03-20 1991-03-20 Антагоністи ангіотензину ii, спосіб їх отримання (варіанти), проміжна сполука (варіанти), спосіб їх отримання та фармацевтична композиція

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EP (1) EP0454511B1 (uk)
JP (2) JP2868313B2 (uk)
KR (1) KR0175310B1 (uk)
AT (1) ATE167475T1 (uk)
AU (1) AU641005B2 (uk)
CA (1) CA2057913C (uk)
CZ (2) CZ287064B6 (uk)
DE (2) DE19975029I2 (uk)
DK (1) DK0454511T3 (uk)
ES (1) ES2119764T3 (uk)
FI (1) FI103407B1 (uk)
HK (1) HK1008918A1 (uk)
HU (3) HUT67648A (uk)
IE (1) IE910913A1 (uk)
IL (3) IL110820A (uk)
LU (2) LU90279I2 (uk)
LV (1) LV10439B (uk)
MX (1) MX9203586A (uk)
MY (1) MY115638A (uk)
NL (2) NL980039I2 (uk)
NO (3) NO301977B1 (uk)
NZ (1) NZ237476A (uk)
PL (3) PL166581B1 (uk)
PT (1) PT97078B (uk)
RU (1) RU2099331C1 (uk)
SG (1) SG49053A1 (uk)
SK (2) SK283197B6 (uk)
TW (1) TW201738B (uk)
UA (1) UA42669A (uk)
WO (1) WO1991014679A1 (uk)

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EP0577025A3 (de) * 1992-07-01 1998-02-04 Hoechst Aktiengesellschaft Angiotensin-II-Rezeptorantagonisten zur Behandlung und Prophylaxe von koronaren Herzerkrankungen
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