ES8105705A1 - Un procedimiento para la preparacion de sulfonamidas. - Google Patents
Un procedimiento para la preparacion de sulfonamidas.Info
- Publication number
- ES8105705A1 ES8105705A1 ES491762A ES491762A ES8105705A1 ES 8105705 A1 ES8105705 A1 ES 8105705A1 ES 491762 A ES491762 A ES 491762A ES 491762 A ES491762 A ES 491762A ES 8105705 A1 ES8105705 A1 ES 8105705A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrrolidine
- dimethyl
- ethyl
- bromophenylsulphonamido
- chlorine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE SULFONAMIDAS DE FORMULA (I), O UNA SAL DE LAS MISMAS, DONDE NR2 REPRESENTA UN GRUPO PIPERIDILICO, PIRROLIDILO, MORFOLINO O N-METILPIPERAZILO; R ELEVADO A 1, R ELEVADO A 2 Y R ELEVADO A 3 PUEDEN SER DIVERSOS COMPUESTOS Y "N" ES 2, 3, 4. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA R2N-(CH2)N-NH2, O UNA SAL DEL MISMO, CON UN COMPUESTO DE FORMULA (II). LA REACCION SE LLEVA A CABO, A TEMPERATURA AMBIENTE Y PRESION NORMAL, EN UN DISOLVENTE COMO BENCENO O TOLUENO. SEPARANDO EL DISOLVENTE SE OBTIENE EL PRODUCTO CRUDO INICIAL QUE POSTERIORMENTE SE PURIFICA. PARA OBTENER UNA SAL DEL COMPUESTO, LA REACCION SE LLEVA A CABO EN PRESENCIA DE UNA BASE. EL COMPUESTO OBTENIDO TIENE APLICACION COMO AGENTE ANTIARRITMICO. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7917892 | 1979-05-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES491762A0 ES491762A0 (es) | 1981-06-16 |
ES8105705A1 true ES8105705A1 (es) | 1981-06-16 |
Family
ID=10505365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES491762A Expired ES8105705A1 (es) | 1979-05-23 | 1980-05-22 | Un procedimiento para la preparacion de sulfonamidas. |
Country Status (11)
Country | Link |
---|---|
US (2) | US4396622A (es) |
EP (1) | EP0021592B1 (es) |
JP (1) | JPS55157564A (es) |
AU (1) | AU531504B2 (es) |
CA (1) | CA1152508A (es) |
DE (1) | DE3065026D1 (es) |
DK (1) | DK222980A (es) |
ES (1) | ES8105705A1 (es) |
IE (1) | IE49817B1 (es) |
IL (1) | IL60129A0 (es) |
ZA (1) | ZA803096B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3276313D1 (en) * | 1981-09-24 | 1987-06-19 | Beecham Wuelfing Gmbh & Co Kg | Sulphonamides |
JPS58124758A (ja) * | 1982-01-20 | 1983-07-25 | Fujisawa Pharmaceut Co Ltd | ベンゼンスルホンアミド誘導体 |
DK101683A (da) * | 1982-03-12 | 1983-09-13 | Duphar Int Res | Phenylpiperazinderivater og fremgangsmaade til fremstilling heraf |
DE3363289D1 (de) * | 1982-09-28 | 1986-06-05 | Beecham Wuelfing Gmbh & Co Kg | Sulfon amides |
FR2534912B1 (fr) * | 1982-10-26 | 1985-06-28 | Lafon Labor | Nouveaux derives de (2,4,6-trimethoxyphenyl) - (3-piperidinopropyl) -cetone, utilisation en therapeutique et procede de preparation |
GB2160201B (en) * | 1984-06-14 | 1988-05-11 | Wyeth John & Brother Ltd | Quinazoline and cinnoline derivatives |
US4603133A (en) * | 1985-11-06 | 1986-07-29 | Merck & Co., Inc. | Amides and esters of 2-[N-(morpholinoalkyl)aminosulfonyl]-6-nitrobenzoic acids and compositions useful as adjuncts to radiation therapy |
US4731369A (en) * | 1985-11-06 | 1988-03-15 | Merck & Co. Inc. | Amides and esters of 2-(N-(hydroxypiperidinoalkyl) and (hydroxypyrrolidinoalkyl)-aminosulfonyl)-6-nitrobenzoic acids useful as adjuncts to radiation therapy |
JP2556722B2 (ja) * | 1988-02-18 | 1996-11-20 | 興和株式会社 | 新規なスルホンアミド化合物 |
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
US5264420A (en) * | 1990-09-27 | 1993-11-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
US5321034A (en) * | 1991-05-07 | 1994-06-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
WO1992019595A1 (en) * | 1991-05-07 | 1992-11-12 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5389631A (en) * | 1991-10-29 | 1995-02-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5272158A (en) * | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5416099A (en) * | 1991-10-29 | 1995-05-16 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5358956A (en) * | 1992-10-14 | 1994-10-25 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DE69327536T2 (de) * | 1992-10-14 | 2000-07-06 | Merck & Co., Inc. | Fibrinogenrezeptor-antagonisten |
JPH08504194A (ja) * | 1992-12-01 | 1996-05-07 | メルク エンド カンパニー インコーポレーテッド | フィブリノーゲンレセプターアンタゴニスト |
US5441952A (en) * | 1993-04-05 | 1995-08-15 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5334596A (en) * | 1993-05-11 | 1994-08-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5397791A (en) * | 1993-08-09 | 1995-03-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5821241A (en) * | 1994-02-22 | 1998-10-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5719144A (en) * | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5789421A (en) * | 1995-10-26 | 1998-08-04 | Merck & Co., Inc. | Fibrinogen receptor antagonist |
US5780480A (en) * | 1996-02-28 | 1998-07-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5889023A (en) * | 1996-05-10 | 1999-03-30 | Merck & Co., Inc. | Fibrinogen receptor antagonist |
US5981584A (en) * | 1997-02-06 | 1999-11-09 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
GB9803536D0 (en) * | 1998-02-19 | 1998-04-15 | Black James Foundation | Histamine H,receptor ligands |
SE0004780D0 (sv) | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2313918A1 (fr) * | 1975-06-09 | 1977-01-07 | Choay Sa | Methoxy-2 benzenesulfonamides n-substitues, procede pour les preparer et medicaments les contenant |
JPS5829784B2 (ja) * | 1975-08-22 | 1983-06-24 | 萬有製薬株式会社 | オメガ − ( アリ−ルスルホンアミド )− アルキルアミンノ セイホウ |
-
1980
- 1980-05-20 EP EP80301643A patent/EP0021592B1/en not_active Expired
- 1980-05-20 IL IL60129A patent/IL60129A0/xx unknown
- 1980-05-20 DE DE8080301643T patent/DE3065026D1/de not_active Expired
- 1980-05-21 DK DK222980A patent/DK222980A/da not_active Application Discontinuation
- 1980-05-22 ES ES491762A patent/ES8105705A1/es not_active Expired
- 1980-05-23 AU AU58720/80A patent/AU531504B2/en not_active Ceased
- 1980-05-23 CA CA000352567A patent/CA1152508A/en not_active Expired
- 1980-05-23 ZA ZA00803096A patent/ZA803096B/xx unknown
- 1980-05-23 JP JP6877680A patent/JPS55157564A/ja active Pending
- 1980-05-25 IE IE1070/80A patent/IE49817B1/en unknown
-
1982
- 1982-02-12 US US06/348,212 patent/US4396622A/en not_active Expired - Fee Related
-
1985
- 1985-05-31 US US06/740,175 patent/US4622331A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU531504B2 (en) | 1983-08-25 |
US4396622A (en) | 1983-08-02 |
CA1152508A (en) | 1983-08-23 |
ES491762A0 (es) | 1981-06-16 |
IL60129A0 (en) | 1980-07-31 |
EP0021592A1 (en) | 1981-01-07 |
IE49817B1 (en) | 1985-12-25 |
EP0021592B1 (en) | 1983-09-28 |
IE801070L (en) | 1980-11-23 |
AU5872080A (en) | 1980-11-27 |
JPS55157564A (en) | 1980-12-08 |
US4622331A (en) | 1986-11-11 |
DK222980A (da) | 1980-11-24 |
DE3065026D1 (en) | 1983-11-03 |
ZA803096B (en) | 1981-05-27 |
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