DE69101141D1 - Neue Guanidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen. - Google Patents

Neue Guanidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.

Info

Publication number
DE69101141D1
DE69101141D1 DE91403230T DE69101141T DE69101141D1 DE 69101141 D1 DE69101141 D1 DE 69101141D1 DE 91403230 T DE91403230 T DE 91403230T DE 69101141 T DE69101141 T DE 69101141T DE 69101141 D1 DE69101141 D1 DE 69101141D1
Authority
DE
Germany
Prior art keywords
group
denotes
processes
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE91403230T
Other languages
English (en)
Other versions
DE69101141T2 (de
Inventor
Charles Malen
Jean-Michel Lacoste
Nanteuil Guillaume De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of DE69101141D1 publication Critical patent/DE69101141D1/de
Application granted granted Critical
Publication of DE69101141T2 publication Critical patent/DE69101141T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/52—Nitrogen atoms not forming part of a nitro radical with hetero atoms directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69101141T 1990-11-29 1991-11-29 Neue Guanidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen. Expired - Fee Related DE69101141T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9014898A FR2669927B1 (fr) 1990-11-29 1990-11-29 Nouveaux derives de guanidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

Publications (2)

Publication Number Publication Date
DE69101141D1 true DE69101141D1 (de) 1994-03-17
DE69101141T2 DE69101141T2 (de) 1994-08-04

Family

ID=9402693

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69101141T Expired - Fee Related DE69101141T2 (de) 1990-11-29 1991-11-29 Neue Guanidinderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen.

Country Status (14)

Country Link
US (2) US5494934A (de)
EP (1) EP0488897B1 (de)
JP (1) JPH0669999B2 (de)
AT (1) ATE101128T1 (de)
AU (1) AU638879B2 (de)
CA (1) CA2056560A1 (de)
DE (1) DE69101141T2 (de)
DK (1) DK0488897T3 (de)
ES (1) ES2063471T3 (de)
FR (1) FR2669927B1 (de)
IE (1) IE65632B1 (de)
NZ (1) NZ240789A (de)
PT (1) PT99644B (de)
ZA (1) ZA919410B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612332A (en) * 1984-03-19 1997-03-18 Alteon Inc. Di- and triaminoguanidines, and methods of use
US5852009A (en) * 1984-03-19 1998-12-22 The Rockefeller University Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon
JPH0778038B2 (ja) * 1989-01-18 1995-08-23 日東紡績株式会社 Ｌ―アルギニナールジ低級アルキルアセタールの製造法
US5380945A (en) * 1989-06-21 1995-01-10 Abbott Laboratories Guanidino compounds as regulators of nitric oxide synthase
US5478946A (en) * 1989-06-21 1995-12-26 Abbott Laboratories Guanidino compounds as regulators of nitric oxide synthase
HUT64023A (en) * 1991-03-22 1993-11-29 Sandoz Ag Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds
US5441984A (en) * 1994-01-06 1995-08-15 Eli Lilly And Company Urea, thiourea and guanidine derivatives
WO1995028377A1 (en) * 1994-04-18 1995-10-26 Abbott Laboratories Guanidine compounds as regulators of nitric oxide synthase
US5972948A (en) * 1994-07-01 1999-10-26 Solvay Pharmaceuticals Gmbh Method of inhibiting hyperglycemia and pharmaceutical composition for use therein
DE4423177A1 (de) * 1994-07-01 1996-01-04 Kali Chemie Pharma Gmbh Antihyperglykämisch wirksame Arzneimittel
IT1279386B1 (it) * 1994-11-07 1997-12-10 Sigma Tau Ind Farmaceuti 1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
US5850840A (en) * 1995-11-15 1998-12-22 Alteon Inc. Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
US5877217A (en) * 1995-12-26 1999-03-02 Alteon Inc. N-acylaminoalkyl-hydrazinecarboximidamides
US6110968A (en) * 1995-12-26 2000-08-29 The Picower Institute For Medical Research Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts
ES2273365T3 (es) * 1996-03-29 2007-05-01 Ortho-Mcneil Pharmaceutical, Inc. Amidinohidrazonas utiles como inhibidores de proteasa.
EP0997492B1 (de) * 1998-10-29 2007-03-28 RHEIN-CHEMIE RHEINAU GmbH Verwendung von Arylguanidiniumxanthogenaten als Vulkanisationsbeschleuniger und Verfahren zur Herstellung

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1205521B (de) * 1960-06-20 1965-11-25 Ciba Geigy Verfahren zur Herstellung von Guanylhydrazonen
US3658993A (en) * 1967-10-12 1972-04-25 Shell Oil Co Methods of inducing a cardiovascular hypotensive response
GB1223492A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3816531A (en) * 1970-07-01 1974-06-11 American Home Prod (2,6-disubstituted benzylidene)amino guanidines and related compounds
US4102890A (en) * 1972-12-28 1978-07-25 Science-Union Et Cie, Societe Francaise De Recherche Medicale 2-Amino oxazolines and process for making the same
GB1453703A (en) * 1972-12-28 1976-10-27 Science Union & Cie Substituted cyclopropylmethylamines processes for their preparation and pharmaceutical compositions containing them
US3916531A (en) * 1974-01-02 1975-11-04 Paul S Morton Leveling method and device for motor home
US4136188A (en) * 1976-06-25 1979-01-23 Daiichi Seiyaku Co., Ltd. Treatment of diabetes with 2-substituted-1,3-diazacyclic compounds
JPS54115330A (en) * 1978-02-27 1979-09-07 Tamio Nishimura Nnsubstituted amidinohydrazones and their manufacture
FR2444673A1 (fr) * 1978-12-20 1980-07-18 Science Union & Cie Nouvelles trifluoroethylamines, leurs procedes d'obtention et leur emploi comme medicament
JPS55151570A (en) * 1979-05-15 1980-11-26 Takeda Chem Ind Ltd Pyrimidine derivatives, their preparation and antimicrobial for agriculture
ES511134A0 (es) * 1981-04-06 1983-02-16 Hexachimie "procedimiento de preparacion de nuevos derivados de la hidrazina, utiles como fungicidas y bactericidas".
EP0101411B1 (de) * 1982-08-11 1989-01-25 Ciba-Geigy Ag Verfahren zur chemischen Bindung von Stabilisatoren an Polymere
FR2549049B1 (fr) * 1983-07-13 1986-06-20 Chauvin Blache Lab Nouvelles amidines, leur procede de preparation et leur application therapeutique
HU190639B (en) * 1983-12-12 1986-09-29 Gyogyszerkutato Intezet Kv,Hu Process for production of new aminoguanidin derivatives
DE3416695A1 (de) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
EP0362135A3 (de) * 1988-09-28 1990-10-17 Ciba-Geigy Ag Schädlingsbekämpfungsmittel

Also Published As

Publication number Publication date
PT99644B (pt) 1999-05-31
JPH04308561A (ja) 1992-10-30
AU8824391A (en) 1992-06-04
FR2669927B1 (fr) 1994-04-08
AU638879B2 (en) 1993-07-08
DE69101141T2 (de) 1994-08-04
ATE101128T1 (de) 1994-02-15
IE914139A1 (en) 1992-06-03
PT99644A (pt) 1992-10-30
DK0488897T3 (da) 1994-05-02
CA2056560A1 (fr) 1992-05-30
US5494934A (en) 1996-02-27
IE65632B1 (en) 1995-11-01
FR2669927A1 (fr) 1992-06-05
ES2063471T3 (es) 1995-01-01
NZ240789A (en) 1993-02-25
ZA919410B (en) 1993-04-28
EP0488897B1 (de) 1994-02-02
EP0488897A1 (de) 1992-06-03
US5296498A (en) 1994-03-22
JPH0669999B2 (ja) 1994-09-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee