TWI805109B - 對cd19具專一性之抗體及嵌合抗原受體 - Google Patents

對cd19具專一性之抗體及嵌合抗原受體 Download PDF

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TWI805109B
TWI805109B TW110145262A TW110145262A TWI805109B TW I805109 B TWI805109 B TW I805109B TW 110145262 A TW110145262 A TW 110145262A TW 110145262 A TW110145262 A TW 110145262A TW I805109 B TWI805109 B TW I805109B
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antibody
amino acid
seq
cdr
antigen
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TW110145262A
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TW202210521A (zh
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岩 陳
史帝夫 夏曼
沙巴 帕茲曼尼
賽門斯 裘 杜塔
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美商奇諾治療有限公司
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
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    • A—HUMAN NECESSITIES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A61K40/4211—CD19 or B4
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

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TW110145262A 2014-08-28 2015-08-27 對cd19具專一性之抗體及嵌合抗原受體 TWI805109B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462043273P 2014-08-28 2014-08-28
US62/043,273 2014-08-28
US201462078942P 2014-11-12 2014-11-12
US62/078,942 2014-11-12

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TW202210521A TW202210521A (zh) 2022-03-16
TWI805109B true TWI805109B (zh) 2023-06-11

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TW104128254A TWI751102B (zh) 2014-08-28 2015-08-27 對ｃｄ１９具專一性之抗體及嵌合抗原受體

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