TWI735002B - 作為BET蛋白抑制劑之1H-吡咯并[2,3-c]吡啶-7(6H)-酮及吡唑并[3,4-c]吡啶-7(6H)-酮 - Google Patents

作為BET蛋白抑制劑之1H-吡咯并[2,3-c]吡啶-7(6H)-酮及吡唑并[3,4-c]吡啶-7(6H)-酮 Download PDF

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TWI735002B
TWI735002B TW108123445A TW108123445A TWI735002B TW I735002 B TWI735002 B TW I735002B TW 108123445 A TW108123445 A TW 108123445A TW 108123445 A TW108123445 A TW 108123445A TW I735002 B TWI735002 B TW I735002B
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methyl
dihydro
mmol
pyridin
benzoxazine
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TW108123445A
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TW201938559A (zh
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安德魯 P 康堡
湯瑪士 P 馬德斯奎
尼可 法拉哈皮遜
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美商英塞特公司
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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TW108123445A 2014-04-23 2015-04-22 作為BET蛋白抑制劑之1H-吡咯并[2,3-c]吡啶-7(6H)-酮及吡唑并[3,4-c]吡啶-7(6H)-酮 TWI735002B (zh)

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Application Number Priority Date Filing Date Title
US201461983289P 2014-04-23 2014-04-23
US61/983,289 2014-04-23

Publications (2)

Publication Number Publication Date
TW201938559A TW201938559A (zh) 2019-10-01
TWI735002B true TWI735002B (zh) 2021-08-01

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Application Number Title Priority Date Filing Date
TW108123445A TWI735002B (zh) 2014-04-23 2015-04-22 作為BET蛋白抑制劑之1H-吡咯并[2,3-c]吡啶-7(6H)-酮及吡唑并[3,4-c]吡啶-7(6H)-酮
TW104112916A TWI672301B (zh) 2014-04-23 2015-04-22 作為ＢＥＴ蛋白抑制劑之１Ｈ-吡咯并［２，３-ｃ］吡啶-７（６Ｈ）-酮及吡唑并［３，４-ｃ］吡啶-７（６Ｈ）-酮

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TW104112916A TWI672301B (zh) 2014-04-23 2015-04-22 作為ＢＥＴ蛋白抑制劑之１Ｈ-吡咯并［２，３-ｃ］吡啶-７（６Ｈ）-酮及吡唑并［３，４-ｃ］吡啶-７（６Ｈ）-酮

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JP6599979B2 (ja) 2014-09-15 2019-10-30 インサイト・コーポレイション Ｂｅｔタンパク質阻害剤として用いるための三環式複素環化合物
MA40940A (fr) 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
MA40943A (fr) 2014-11-10 2017-09-19 Constellation Pharmaceuticals Inc Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines
CN107108613B (zh) 2014-11-10 2020-02-25 基因泰克公司 布罗莫结构域抑制剂及其用途
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AR104259A1 (es) 2015-04-15 2017-07-05 Celgene Quanticel Res Inc Inhibidores de bromodominio
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KR102784592B1 (ko) 2015-08-12 2025-03-19 에피제네틱스, 인크. 치환된 벤즈이미다졸, 그의 제조법 및 제약으로서의 그의 용도
US10501459B2 (en) 2015-10-21 2019-12-10 Neomed Institute Substituted imidazo[1,2-a]pyridines as bromodomain inhibitors
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