TWI718992B - 使用cll-1嵌合抗原受體治療癌症 - Google Patents

使用cll-1嵌合抗原受體治療癌症 Download PDF

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TWI718992B
TWI718992B TW104123638A TW104123638A TWI718992B TW I718992 B TWI718992 B TW I718992B TW 104123638 A TW104123638 A TW 104123638A TW 104123638 A TW104123638 A TW 104123638A TW I718992 B TWI718992 B TW I718992B
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seq
cll
cdr1
cdr3
cdr2
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TW104123638A
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TW201619380A (zh
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珍妮佛 布拉格登
希爾瑪 愛伯斯巴赫
薩爾 吉兒
大衛 葛雷斯
茱莉亞 賈斯庫爾
薩德 肯德雷恩
瓊安 曼尼克
麥克Ｃ 米隆
里昂 墨菲
瑟雷斯特 理查德森
瑞許瑪 星
魏來
期隆 吳
楊秋梅
張繼全
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瑞士商諾華公司
賓夕法尼亞大學董事會
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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TW104123638A 2014-07-21 2015-07-21 使用cll-1嵌合抗原受體治療癌症 TWI718992B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
WOPCT/CN2014/082602 2014-07-21
CN2014082602 2014-07-21
CN2014090500 2014-11-06
WOPCT/CN2014/090500 2014-11-06

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TW201619380A TW201619380A (zh) 2016-06-01
TWI718992B true TWI718992B (zh) 2021-02-21

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US (2) US10568947B2 (enExample)
EP (1) EP3171882A1 (enExample)
JP (2) JP6736540B2 (enExample)
KR (1) KR20170037625A (enExample)
CN (1) CN107109420A (enExample)
AR (1) AR101829A1 (enExample)
AU (2) AU2015292811B2 (enExample)
BR (1) BR112017000939A2 (enExample)
CA (1) CA2955465A1 (enExample)
CO (1) CO2017000506A2 (enExample)
IL (1) IL250116B (enExample)
MX (1) MX2017001013A (enExample)
RU (1) RU2741120C2 (enExample)
SG (2) SG10201913782UA (enExample)
TW (1) TWI718992B (enExample)
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